Tocotrienol Supplementation Led to Higher Serum Levels of Lysophospholipids but Lower Acylcarnitines in Postmenopausal Women: A Randomized Double-Blinded Placebo-Controlled Clinical Trial

Osteoporosis is a major health problem in postmenopausal women. Herein we evaluated the effects of 12-week tocotrienols (TT) supplementation on serum metabolites in postmenopausal, osteopenic women. Eighty-nine participants (59.7 ± 6.8 yr, BMI 28.7 ± 5.7 kg/m2) were assigned to 3 treatments: placebo (860 mg olive oil/day), 300mg TT (300 mg TT/day), and 600mg TT (600 mg TT/day) for 12 weeks. TT consisted of 90% δ-TT and 10% γ-TT. In this metabolomic study, we evaluated the placebo and 600mgTT at baseline and 12 weeks. As expected, TT and its metabolite levels were higher in the supplemented group after 12 weeks. At baseline, there were no differences in demographic parameters or comprehensive metabolic panels (CMP). Metabolomics analysis of serum samples revealed that 48 biochemicals were higher and 65 were lower in the 600mg TT group at 12 weeks, compared to baseline. The results confirmed higher serum levels of tocotrienols and lysophospholipids, but lower acylcarnitines and catabolites of tryptophan and steroids in subjects given 600mg TT. In summary, 12-week TT supplementation altered many serum metabolite levels in postmenopausal women. The present study supports our previous findings that TT supplementation helps reduce bone loss in postmenopausal osteopenic women by suppressing inflammation and oxidative stress. Furthermore, the body incorporates TT which restructures biomembranes and modifies phospholipid metabolism, a response potentially linked to reduced inflammation and oxidative stress.

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Evaluation of the Effects ofVaccinium arctostaphylosL. Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in Adult Patients with Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2014/217451 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 21

Author(s):

Rasool Soltani ◽

Mustafa Hakimi ◽

Sedigheh Asgary ◽

Syed Mustafa Ghanadian ◽

Mahtab Keshvari ◽

...

Keyword(s):

Oxidative Stress ◽

Clinical Trial ◽

Serum Levels ◽

Adult Patients ◽

Controlled Clinical Trial ◽

Fruit Extract ◽

Double Blind ◽

Double Blind Placebo ◽

Hs Crp ◽

And Oxidative Stress

Background.Dyslipidemia produces atherosclerosis, which in turn results in coronary artery disease (CAD). Atherosclerosis is being considered as an inflammatory disease.Vaccinium arctostaphylosL. is a plant with fruits rich in anthocyanins. The aim of this study was to evaluate the effects of fruit extract of this plant on serum levels of lipids, hs-CRP, and malondialdehyde (MDA) as a marker of oxidative stress, in hyperlipidemic adult patients.Methods.In this randomized, double-blind, placebo-controlled clinical trial, 50 hyperlipidemic adult patients were randomly and equally assigned to receive either medicinal (V. arctostaphylosfruit extract) or placebo capsules twice daily for 4 weeks. Each medicinal capsule contained 45 ± 2 mg of anthocyanins. Fasting serum levels of total cholesterol, TG, LDL-C, HDL-C, hs-CRP, and MDA were obtained before and after the intervention and compared.Results. V. arctostaphylosfruit extract significantly reduced total cholesterol (P<0.001), LDL-C (P=0.004), TG (P<0.001), and MDA (P=0.013) compared to placebo but did not have any significant effect on HDL-C (P=0.631) and hs-CRP (P=0.190).Conclusion.Fruit extract ofVaccinium arctostaphyloshas beneficial effects on serum lipid profile and oxidative stress in hyperlipidemic adult patients. Therefore, it could be considered as a supplement for treatment of dyslipidemia and prevention of atherosclerosis development.

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Açaí (Euterpe oleracea Mart.) beverage consumption improves biomarkers for inflammation but not glucose- or lipid-metabolism in individuals with metabolic syndrome in a randomized, double-blinded, placebo-controlled clinical trial

Food & Function ◽

10.1039/c8fo00595h ◽

2018 ◽

Vol 9 (6) ◽

pp. 3097-3103 ◽

Cited By ~ 15

Author(s):

Hyemee Kim ◽

Sunday Y. Simbo ◽

Chuo Fang ◽

Lilly McAlister ◽

Andrea Roque ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Clinical Trial ◽

Lipid Metabolism ◽

Controlled Clinical Trial ◽

Euterpe Oleracea ◽

Beverage Consumption ◽

Double Blinded ◽

And Oxidative Stress ◽

Euterpe Oleracea Mart

Açaí beverage consumption may reduce biomarkers for inflammation and oxidative stress in metabolic syndrome.

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Circulatory Levels of RANKL, OPG, and Oxidative Stress Markers in Postmenopausal Women With Normal or Low Bone Mineral Density

Biomarker Insights ◽

10.1177/1177271919843825 ◽

2019 ◽

Vol 14 ◽

pp. 117727191984382 ◽

Cited By ~ 2

Author(s):

Fawaz Y Azizieh ◽

Diaa Shehab ◽

Khaled Al Jarallah ◽

Renu Gupta ◽

Raj Raghupathy

Keyword(s):

Oxidative Stress ◽

Bone Mineral Density ◽

Superoxide Dismutase ◽

Postmenopausal Women ◽

Bone Mineral ◽

Serum Levels ◽

Oxidative Stress Markers ◽

Mineral Density ◽

Stress Markers ◽

And Oxidative Stress

Introduction: Receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and oxidative stress markers are suggested to contribute to bone loss in osteoporosis that occurs in menopause. However, the association between these markers and bone mineral density (BMD) is controversial. The aim of this study was to measure circulatory levels of these parameters in postmenopausal women with normal or low BMD. Methods: The study population included 71 postmenopausal women, of whom 25 had normal BMD, 31 had osteopenia, and 15 had osteoporosis. Serum levels of RANKL, OPG, and 5 oxidative stress markers (catalase, peroxiredoxin 2 [PRX2], superoxide dismutase 1 [SOD1], superoxide dismutase 2 [SOD2], and thioredoxin [TRx1]) were measured using the Multiplex system. Results: As compared with subjects having normal BMD, subjects with low BMD had significantly lower median serum levels of OPG, catalase, SOD2, and PRX2 ( P = .004, .031, .044, and .041 respectively). Although levels of RANKL were not different between the 2 groups, the RANKL/OPG ratio was higher in women with low BMD ( P = .027). Conclusions: These data provide insights into the possible roles of OPG, RANKL, and oxidative stress in the pathogenesis of postmenopausal osteoporosis. However, the lack of association between these markers and BMD indicates that osteoporosis is complex and multivariate.

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Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trial

Redox Biology ◽

10.1016/j.redox.2016.05.007 ◽

2016 ◽

Vol 9 ◽

pp. 32-38 ◽

Cited By ~ 39

Author(s):

Sanne Tofte Rasmussen ◽

Jon Trærup Andersen ◽

Torben Kjær Nielsen ◽

Vanja Cejvanovic ◽

Kasper Meidahl Petersen ◽

...

Keyword(s):

Oxidative Stress ◽

Clinical Trial ◽

Controlled Clinical Trial ◽

Double Blinded ◽

And Oxidative Stress

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Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Male Smokers

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207322666190806123616 ◽

2019 ◽

Vol 22 (7) ◽

pp. 496-501

Author(s):

Fatemeh Ahmadi-Motamayel ◽

Parisa Falsafi ◽

Hamidreza Abolsamadi ◽

Mohammad T. Goodarzi ◽

Jalal Poorolajal

Keyword(s):

Oxidative Stress ◽

Uric Acid ◽

Free Radicals ◽

Antioxidant Capacity ◽

Cigarette Smoke ◽

Total Antioxidant Capacity ◽

The Body ◽

Total Antioxidant ◽

The Mean ◽

And Oxidative Stress

Background: Cigarette smoke free radicals can cause cellular damage and different diseases. All the body fluids have antioxidants which protect against free radicals. Objective: The aim of this study was to evaluate salivary total antioxidant capacity and peroxidase, uric acid and malondialdehyde levels in smokers and a nonsmoking control group. Methods: Unstimulated saliva was collected from 510 males. A total of 259 subjects were current smokers and 251 were non-smokers. The levels of salivary total antioxidant capacity, uric acid, peroxidase and malondialdehyde were measured using standard procedures. Data were analyzed with t test and ANOVA. Results: The smokers were younger and dental hygiene index was higher than healthy nonsmoking controls. The mean total antioxidant capacity in smokers and nonsmokers was 0.13±0.07 and 0.21±011, respectively (P=0.001). Smokers had significantly lower peroxidase and uric acid levels than healthy controls. In addition, the mean malondialdehyde levels in the smokers and nonsmokers were 4.55 ±2.61 and 2.79 ±2.21, respectively (P=0.001). Conclusion: Cigarette smoke produces free radical and oxidative stress, causing many side effects. Salivary antioxidant levels decreased and malondialdehyde levels increased in smokers, indicating the high oxidative stress among smokers compared to nonsmokers. Cigarette smoke had deleterious effects on main salivary antioxidants levels.

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Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models

Antioxidants ◽

10.3390/antiox10020229 ◽

2021 ◽

Vol 10 (2) ◽

pp. 229

Author(s):

JunHyuk Woo ◽

Hyesun Cho ◽

YunHee Seol ◽

Soon Ho Kim ◽

Chanhyeok Park ◽

...

Keyword(s):

Oxidative Stress ◽

Mitochondrial Dysfunction ◽

Computational Models ◽

Neuronal Damage ◽

Living Organism ◽

The Body ◽

Mitochondrial Functions ◽

A Cell ◽

The Brain ◽

And Oxidative Stress

The brain needs more energy than other organs in the body. Mitochondria are the generator of vital power in the living organism. Not only do mitochondria sense signals from the outside of a cell, but they also orchestrate the cascade of subcellular events by supplying adenosine-5′-triphosphate (ATP), the biochemical energy. It is known that impaired mitochondrial function and oxidative stress contribute or lead to neuronal damage and degeneration of the brain. This mini-review focuses on addressing how mitochondrial dysfunction and oxidative stress are associated with the pathogenesis of neurodegenerative disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and Parkinson’s disease. In addition, we discuss state-of-the-art computational models of mitochondrial functions in relation to oxidative stress and neurodegeneration. Together, a better understanding of brain disease-specific mitochondrial dysfunction and oxidative stress can pave the way to developing antioxidant therapeutic strategies to ameliorate neuronal activity and prevent neurodegeneration.

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Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s285597 ◽

2021 ◽

Vol Volume 14 ◽

pp. 525-534

Author(s):

Laine de Carvalho Guerra Pessoa Mamede ◽

Rafaela Lira Formiga Cavalcanti de Lima ◽

Alexandre Sérgio Silva ◽

João Carlos Lima Rodrigues Pita ◽

Nadjeanny Ingrid Galdino Gomes ◽

...

Keyword(s):

Oxidative Stress ◽

Clinical Trial ◽

Vitamin D3 ◽

Controlled Clinical Trial ◽

Oxidative Stress Markers ◽

Obese Women ◽

Double Blind ◽

Double Blind Placebo ◽

Stress Markers ◽

And Oxidative Stress

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Correlation between bone mineral density and oxidative stress in postmenopausal women

Indian Journal of Endocrinology and Metabolism ◽

10.4103/2230-8210.159053 ◽

2015 ◽

Vol 19 (4) ◽

pp. 491 ◽

Cited By ~ 18

Author(s):

Jamal Ahmad ◽

Nishat Akhtar ◽

Mujahid Beg ◽

Tripti Sharma ◽

Najmul Islam

Keyword(s):

Oxidative Stress ◽

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Mineral Density ◽

And Oxidative Stress

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Exercise Training Attenuates Sympathetic Activation and Oxidative Stress in Diet-Induced Obesity

Physiological Research ◽

10.33549/physiolres.932851 ◽

2015 ◽

pp. 355-367 ◽

Cited By ~ 5

Author(s):

G. LI ◽

J.-Y. LIU ◽

H.-X. ZHANG ◽

Q. LI ◽

S.-W. ZHANG

Keyword(s):

Oxidative Stress ◽

Exercise Training ◽

Sympathetic Activity ◽

The Body ◽

Plasma Norepinephrine ◽

Sympathetic Activation ◽

Sprague Dawley ◽

Tissue Mass ◽

Diet Induced Obesity ◽

And Oxidative Stress

It is known that excessive sympathetic activity and oxidative stress are enhanced in obesity. This study aimed to clarify whether exercise training (ET) attenuates sympathetic activation and oxidative stress in obesity. The obesity was induced by high-fat diet (HFD) for 12 weeks. Male Sprague-Dawley rats were assigned to four groups: regular diet (RD) plus sedentary (RD-S), RD plus ET (RD-ET), HFD plus sedentary (HFD-S), and HFD plus ET (HFD-ET). The rats in RD-ET and HFD-ET groups were trained on a motorized treadmill for 60 min/day, five days/week for 8 weeks. The sympathetic activity was evaluated by the plasma norepinephrine (NE) level. The superoxide anion, malondialdehyde and F2-isoprostanes levels in serum and muscles were measured to evaluate oxidative stress. The ET prevented the increases in the body weight, arterial pressure and white adipose tissue mass in HFD rats. The NE level in plasma and oxidative stress related parameters got lower in HFD-ET group compared with HFD-S group. We have found decreased mRNA and protein levels of toll-like receptor (TLR)-2 and TLR-4 by ET in HFD rats. These findings suggest that ET may be effective for attenuating sympathetic activation and oxidative stress in diet-induced obesity.

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