scholarly journals Changes in Urologic Operative Practice at the Beginning of the COVID-19 Pandemic in a Large, National Cohort

2021 ◽  
Vol 11 ◽  
Author(s):  
Patrick Lewicki ◽  
Camilo Arenas-Gallo ◽  
Spyridon P. Basourakos ◽  
Nahid Punjani ◽  
Siv Venkat ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Elective Surgery ◽  
Population Level ◽  
Reference Region ◽  
Hospital Level ◽  
Urologic Oncology ◽  
Average Change ◽  
The Face ◽  
National Cohort ◽  
Using Data

ObjectiveTo analyze population-level changes in operative practice since the onset of the COVID-19 pandemic to contextualize observations made by individual practices and optimize future responses.Materials and MethodsThis US retrospective analysis used the Premier Perspectives Database. We investigated changes in operative volume through March 2020. Baseline operative volume for urologic surgery was calculated using data from the preceding 12 months and compared on a total and by procedure basis. Multivariable linear regression was used to identify hospital-level predictors of change in response to the pandemic.ResultsAt baseline, we captured 23,788 urologic procedural encounters per month as compared with 19,071 during March 2020– a 19.9% decrease. Urologic oncology-related cases were relatively preserved as compared to others (average change in March 2020: +1.1% versus -32.2%). Northeastern (β = -5.66, 95% confidence interval [CI]: -10.2 to -1.18, p = 0.013) and Midwestern hospitals (β = -4.17, 95% CI: -7.89 to -0.45, p = 0.027; both with South as reference region), and those with an increasing percentage of patients insured by Medicaid (β= -0.17 per percentage point, 95% CI: -0.33 to -0.01, p = 0.04) experienced a significantly larger decrease in volume.ConclusionsThere was a 20% decline in urologic operative volume in March 2020, compared with baseline, that preferentially affected hospitals serving Medicaid patients, and those in Northeast and Midwest. In the face of varying mandates on elective surgery, widespread declines in operative volume may also represent hesitancy on behalf of patients to interface with healthcare during the pandemic.

scholarly journals Age and product dependent vaccine effectiveness against SARS-CoV-2 infection and hospitalisation among adults in Norway: a national cohort study, January to September 2021.

2021 ◽  
Author(s):  
Jostein Starrfelt ◽  
Eirik Alnes Buanes ◽  
Lene Kristine Juvet ◽  
Trude Marie Lyngstad ◽  
Gunnar Oyvind Isaksson Ro ◽  
...  
Keyword(s):  
Severe Disease ◽  
Population Level ◽  
Vaccine Effectiveness ◽  
Proportional Hazard ◽  
Icu Admission ◽  
Cox Proportional Hazard ◽  
National Cohort ◽  
Cox Proportional Hazard Models ◽  
Using Data ◽  
Protection Against Infection

Background: SARS-CoV-2 vaccines show high effectiveness against infection and (severe) disease. However, few studies estimate population level vaccine effectiveness against multiple COVID-19 outcomes, by age and including homologous and heterologous vaccine regimens. Methods: Using Cox proportional hazard models on data from 4 293 544 individuals (99% of Norwegian adults), we estimated overall, age-, and product-specific vaccine effectiveness against SARS-CoV-2 infection, hospitalisation, ICU admission and death in Norway, using data from national registries. Vaccine status was included as time-dependent variable and we adjusted for sex, pre-existing medical conditions, country of birth, county of residence, and crowded living conditions. Results: Adjusted vaccine effectiveness among fully vaccinated is 72.1% (71.2-73.0) against SARS-CoV-2 infection, 92.9% (91.2-94.2) against hospitalisation, 95.5% (92.6-97.2) against ICU admission, and 88.0% (82.5-91.8) against death. Among partially vaccinated, the effectiveness is 24.3% (22.3-26-2) against infection and 82.7% (77.7-86.6) against hospitalisation. Vaccine effectiveness against infection is 84.7% (83.1-86.1) for heterologous mRNA vaccine regimens, 78.3% (76.8-79.7) for Spikevax (Moderna; mRNA-1273), 69.7% (68.6-70.8) for Comirnaty (Pfizer/BioNTech; BNT162b2), and 60.7% (57.5-63.6) for Vaxzevria (AstraZeneca; ChAdOx nCoV-19; AZD1222) with a mRNA dose among fully vaccinated. Conclusion: We demonstrate good protection against SARS-CoV-2 infection and severe disease in fully vaccinated, including heterologous vaccine regimens, which could facilitate rapid immunization. Partially vaccinated were less likely to get severe disease than unvaccinated, though protection against infection was not as high, which could be essential in making vaccine prioritisation policies especially when availability is limited.

scholarly journals Quantitative Trait Loci: A Meta-analysis

Genetics ◽  
2000 ◽  
Vol 155 (1) ◽  
pp. 463-473
Author(s):  
Bruno Goffinet ◽  
Sophie Gerber
Keyword(s):  
Quantitative Trait Loci ◽  
Confidence Interval ◽  
Quantitative Trait ◽  
Meta Analysis ◽  
Trait Loci ◽  
Akaike Criterion ◽  
Using Data

Abstract This article presents a method to combine QTL results from different independent analyses. This method provides a modified Akaike criterion that can be used to decide how many QTL are actually represented by the QTL detected in different experiments. This criterion is computed to choose between models with one, two, three, etc., QTL. Simulations are carried out to investigate the quality of the model obtained with this method in various situations. It appears that the method allows the length of the confidence interval of QTL location to be consistently reduced when there are only very few “actual” QTL locations. An application of the method is given using data from the maize database available online at http://www.agron.missouri.edu/.

scholarly journals Healthy ageing, resilience and wellbeing

2017 ◽  
Vol 26 (6) ◽  
pp. 579-583 ◽  
Author(s):  
T. D. Cosco ◽  
K. Howse ◽  
C. Brayne
Keyword(s):  
Population Level ◽  
Healthy Ageing ◽  
Ageing Population ◽  
Environmental Resources ◽  
Great Achievement ◽  
Health Concept ◽  
Ageing Model ◽  
The Face ◽  
The Individual ◽  
High Level

The extension of life does not appear to be slowing, representing a great achievement for mankind as well as a challenge for ageing populations. As we move towards an increasingly older population we will need to find novel ways for individuals to make the best of the challenges they face, as the likelihood of encountering some form of adversity increases with age. Resilience theories share a common idea that individuals who manage to navigate adversity and maintain high levels of functioning demonstrate resilience. Traditional models of healthy ageing suggest that having a high level of functioning across a number of domains is a requirement. The addition of adversity to the healthy ageing model via resilience makes this concept much more accessible and more amenable to the ageing population. Through asset-based approaches, such as the invoking of individual, social and environmental resources, it is hoped that greater resilience can be fostered at a population level. Interventions aimed at fostering greater resilience may take many forms; however, there is great potential to increase social and environmental resources through public policy interventions. The wellbeing of the individual must be the focus of these efforts; quality of life is an integral component to the enjoyment of additional years and should not be overlooked. Therefore, it will become increasingly important to use resilience as a public health concept and to intervene through policy to foster greater resilience by increasing resources available to older people. Fostering wellbeing in the face of increasing adversity has significant implications for ageing individuals and society as a whole.

ADAB PEMBELAJARAN AL-QURAN: STUDI KITAB AT-TIBYAN FI ADABI HAMALATIL QURAN

2020 ◽  
Vol 18 (2) ◽  
pp. 219
Author(s):  
Ismail Ismail ◽  
Abdulloh Hamid
Keyword(s):  
Data Collection ◽  
Research Methods ◽  
Secondary Data ◽  
Study Data ◽  
Library Research ◽  
The Face ◽  
Using Data

This research is an attempt to know the courtesy reading the Quran in the book of At-Tibyan fi Adabi Hamalatil Quran by Imam Nawawi. The question that is to be answered through this study is (1) how the courtesy to read Al-Quran in the book At-Tibyan, (2) How does the relevance of courtesy to read the Qur'an in the book of At-Tibyan in contemporary times? The research methods use library research. This study is conducted using data collection techniques by conducting observations on certain sources, seeking, studying books, articles, journals, theses or others related to this study. Data collection is divided into two sources, namely primary and secondary data. Then the data are analyzed using descriptive and contextual methods. The results show that courtesy reading the Quran in the book of At-Tibyan fi Adabi Hamalatil Quran includes: Solemn, sincere, ethical, clean and holy State, facing the Qibla, start with Ta'awudz. While the relevance of courtesy reading the Quran in the book of At-Tibyan fi Adabi Hamalatil Quran with the context of contemporary can be a solution in improving the manners of interacting with the Quran, especially in the face of today's characteristics or contemporary.

Did They Mind the Gap? Voter/Party Ideological Proximity between the BQ, the NDP and Quebec Voters, 2006–2011

2016 ◽  
Vol 49 (2) ◽  
pp. 289-310 ◽  
Author(s):  
Jean-Philippe Gauvin ◽  
Chris Chhim ◽  
Mike Medeiros
Keyword(s):  
Political Party ◽  
Three Dimensional ◽  
Election Study ◽  
Federal Election ◽  
Party Manifestos ◽  
Longitudinal Approach ◽  
The Face ◽  
Election Results ◽  
Using Data ◽  
Over Time

AbstractThe 2011 Canadian federal election results changed the face of federal politics in Quebec. In a sudden and spectacular reversal of electoral fortunes, BQ support crumbled while that of the NDP surged. While most commentators focused exclusively on the 2011 election itself to explain what had happened, we offer an interpretation that takes a longitudinal approach. Using data from the Canadian Election Study and political party manifestos from 2006 to 2011, we propose a three-dimensional proximity model of voter/party congruence to explore the evolution of the ideological stances of Quebec voters and parties. Empirical results suggest these ideological distances between the NDP and Quebec voters decreased over time, whereas the BQ has distanced itself from voters. Furthermore, ideological distances between party and voters are a significant predictor of vote.

scholarly journals Are Artificial Intelligence (AI) And Machine Learning (ML) Having An Effective Role In Helping Humanity Address The New Coronavirus Pandemic?

2020 ◽  
Vol 17 ◽  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Disease Outbreaks ◽  
Hospital Capacity ◽  
Data Engineering ◽  
Clinical Presentations ◽  
The Face ◽  
Effective Role ◽  
Using Data ◽  
The Right

COVID-19 has become a pandemic affecting the most of countries in the world. One of the most difficult decisions doctors face during the Covid-19 epidemic is determining which patients will stay in hospital, and which are safe to recover at home. In the face of overcrowded hospital capacity and an entirely new disease with little data-based evidence for diagnosis and treatment, the old rules for determining which patients should be admitted have proven ineffective. But machine learning can help make the right decision early, save lives and lower healthcare costs. So, there is therefore an urgent and imperative need to collect data describing clinical presentations, risks, epidemiology and outcomes. On the other side, artificial intelligence(AI) and machine learning(ML) are considered a strong firewall against outbreaks of diseases and epidemics due to its ability to quickly detect, examine and diagnose these diseases and epidemics.AI is being used as a tool to support the fight against the epidemic that swept the entire world since the beginning of 2020.. This paper presents the potential for using data engineering, ML and AI to confront the Coronavirus, predict the evolution of disease outbreaks, and conduct research in order to develop a vaccine or effective treatment that protects humanity from these deadly diseases.

scholarly journals Common Starling Sturnus vulgaris expansion in South Africa

2018 ◽  
Vol 9 ◽  
Author(s):  
Ielyzaveta M. Ivanova ◽  
Craig T. Symes
Keyword(s):  
South Africa ◽  
Sturnus Vulgaris ◽  
Anthropogenic Change ◽  
Gauteng Province ◽  
The Past ◽  
Entire Country ◽  
The Face ◽  
The Common ◽  
Potential Impact ◽  
Using Data

The Common Starling Sturnus vulgaris has progressively expanded its range in South Africa since its introduction into Cape Town in the late 19th century. In the past few decades it has extended this range into Gauteng province. Using data from the Southern African Bird Atlas Project 2, this paper examines the spread and relative abundance changes for the species across South Africa over the past 10 years, with a detailed look at the recently-colonised Gauteng. Across South Africa, the Common Starling's distribution has shifted, and grown. As it spreads north along the coastline and northwards inland, some of the former range has been lost. In Gauteng, the species has shown a range and abundance expansion over the same period. If the observed trends are to continue, this species is likely to eventually become a prominent species across the entire country, and further north into the sub-region. However, the potential impact that this species has on indigenous avifauna is unknown and, in the face of rapid anthropogenic change, remains to be investigated.

scholarly journals Representational drift in the mouse visual cortex

2020 ◽  
Author(s):  
Daniel Deitch ◽  
Alon Rubin ◽  
Yaniv Ziv
Keyword(s):  
Large Scale ◽  
Activity Patterns ◽  
Population Level ◽  
Population Activity ◽  
Cortical Areas ◽  
Electrophysiological Recordings ◽  
The Face ◽  
Visual Cortical ◽  
Mouse Visual Cortex ◽  
Over Time

AbstractNeuronal representations in the hippocampus and related structures gradually change over time despite no changes in the environment or behavior. The extent to which such ‘representational drift’ occurs in sensory cortical areas and whether the hierarchy of information flow across areas affects neural-code stability have remained elusive. Here, we address these questions by analyzing large-scale optical and electrophysiological recordings from six visual cortical areas in behaving mice that were repeatedly presented with the same natural movies. We found representational drift over timescales spanning minutes to days across multiple visual areas. The drift was driven mostly by changes in individual cells’ activity rates, while their tuning changed to a lesser extent. Despite these changes, the structure of relationships between the population activity patterns remained stable and stereotypic, allowing robust maintenance of information over time. Such population-level organization may underlie stable visual perception in the face of continuous changes in neuronal responses.

scholarly journals Thrombocytopenia with Tedizolid and Linezolid

2017 ◽  
Vol 62 (1) ◽  
Author(s):  
Erica Yookyung Lee ◽  
Aisling R. Caffrey
Keyword(s):  
Adverse Event ◽  
Confidence Interval ◽  
Drug Administration ◽  
Odds Ratio ◽  
Reporting System ◽  
Adverse Event Reporting System ◽  
Adverse Event Reporting ◽  
Reporting Odds Ratio ◽  
Event Reporting ◽  
Using Data

ABSTRACT Several studies have suggested the risk of thrombocytopenia with tedizolid, a second-in-class oxazolidinone antibiotic (approved June 2014), is less than that observed with linezolid (first-in-class oxazolidinone). Using data from the Food and Drug Administration adverse event reporting system (July 2014 through December 2016), we observed significantly increased risks of thrombocytopenia of similar magnitudes with both antibiotics: linezolid reporting odds ratio [ROR], 37.9 (95% confidence interval [CI], 20.78 to 69.17); tedizolid ROR, 34.0 (95% CI, 4.67 to 247.30).

scholarly journals Relative toxicity of benzodiazepines and hypnotics commonly used for self-poisoning: An epidemiological study of fatal toxicity and case fatality

2018 ◽  
Vol 32 (6) ◽  
pp. 654-662 ◽  
Author(s):  
Galit Geulayov ◽  
Anne Ferrey ◽  
Deborah Casey ◽  
Claudia Wells ◽  
Alice Fuller ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Case Fatality ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Relative Toxicity ◽  
Reference Drug ◽  
Alcohol Involvement ◽  
Self Harm ◽  
Hypnotic Drugs ◽  
Using Data

The relative toxicity of anxiolytic and hypnotic drugs commonly used for self-poisoning was assessed using data on suicides, prescriptions and non-fatal self-poisonings in England, 2005–2012. Data on suicide by self-poisoning were obtained from the Office for National Statistics, information on intentional non-fatal self-poisoning was derived from the Multicentre Study of Self-harm in England and data on prescriptions in general practice from the Clinical Practice Research Datalink. We used two indices of relative toxicity: fatal toxicity (the number of fatal self-poisonings relative to the number of individuals prescribed each drug) and case fatality (the number of fatal relative to non-fatal self-poisonings). Diazepam was the reference drug in all analyses. Temazepam was 10 times (95% confidence interval 5.48–18.99) and zopiclone/zolpidem nine times (95% confidence interval 5.01–16.65) more toxic in overdose than diazepam (fatal-toxicity index). Temazepam and zopiclone/zolpidem were 13 (95% confidence interval 6.97–24.41) and 12 (95% confidence interval 6.62–22.17) times more toxic than diazepam, respectively (case-fatality index). Differences in alcohol involvement between the drugs were unlikely to account for the findings. Overdoses of temazepam and zopiclone/zolpidem are considerably more likely to result in death than overdoses of diazepam. Practitioners need to exercise caution when prescribing these drugs, especially for individuals who may be at risk of self-harm, and also consider non-pharmacological options.

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