scholarly journals Effect of Arm Eccentric Exercise on Muscle Damage of the Knee Flexors After High-Intensity Eccentric Exercise

2021 ◽  
Vol 12 ◽  
Author(s):  
Xin Ye ◽  
William M. Miller ◽  
Sunggun Jeon ◽  
Jun Seob Song ◽  
Tyler J. West
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
High Intensity ◽  
Elbow Flexion ◽  
Muscle Group ◽  
Isometric Strength ◽  
Exercise Time ◽  
Post Exercise ◽  
Non Local ◽  
Group 2

Repeated bout effect (RBE) describes a phenomenon that an initial unaccustomed eccentric exercise (ECC) bout can confer a protective effect against muscle damage from the subsequent same exercise. This protection has been observed in the same muscle, as well as the contralateral homologous (CL-RBE) muscle. But it is unknown whether the RBE is evident for non-local unrelated heterogonous muscles. The purpose of this study was to examine whether an initial elbow flexion (EF) muscle-damaging ECC could confer RBE against muscle damage from the subsequent ECC performed in the remote lower limb knee flexor (KF) muscle group. Twenty-seven young individuals were randomly assigned into the experimental (EXP: n = 15) and the control (CON: n = 12) groups. All participants performed a baseline unilateral KF ECC (six sets of 10 repetitions) on a randomly chosen leg. After a washout period (4 weeks), the EXP group performed 60 high-intensity unilateral EF ECC on a randomly chosen arm, followed by the same intensity exercise using the contralateral KF muscle group 2 weeks later. The CON group performed the same contralateral KF ECC, but with no prior EF ECC bout. Changes in the KF muscle damage indirect markers (muscle soreness, range of motion, and maximal isometric strength) after the ECC were compared between the baseline and second bouts for both groups with mixed factorial three-way (group × bout × time) ANOVA. Additionally, index of protection for each damage marker was calculated at 1 and 2 days after the ECC and compared between groups with independent t-tests. For both groups, the magnitude of the changes in the damage markers between the baseline and the second ECC bouts were not significantly different (all values of p > 0.05). As for the index of protection, relative to the CON, the EXP showed an exacerbating damaging effect on the KF isometric strength following the second ECC bout, particularly at the 1-day post-exercise time point (index of protection: EXP vs. CON mean ± SD = −29.36 ± 29.21 vs. 55.28 ± 23.83%, p = 0.040). Therefore, our results do not support the existence of non-local RBE.

scholarly journals Effect of Body Fat Percentage on Muscle Damage Induced by High-Intensity Eccentric Exercise

2020 ◽  
Vol 17 (10) ◽  
pp. 3476
Author(s):  
Eun-Jung Yoon ◽  
Jooyoung Kim
Keyword(s):  
Muscle Damage ◽  
Body Fat ◽  
Eccentric Exercise ◽  
High Intensity ◽  
Muscle Soreness ◽  
Isometric Strength ◽  
Significant Group ◽  
Time Interaction ◽  
Group Time ◽  
The Impact

This study aimed to investigate the impact of percent body fat (%BF) on muscle damage after high-intensity eccentric exercise. Thirty healthy male undergraduates (mean age: 22.0 ± 2 years, height: 176.9 ± 5 cm, weight: 75.8 ± 11.6 kg) participated in this study, and they were classified according to their %BF into a high %fat group (HFG, ≥20%, n = 15) and a low %fat group (LFG, ≤15%, n = 15). For eccentric exercise, two sets of 25 reps were performed on a modified preacher curl machine using the elbow flexor muscle. Maximal isometric strength, muscle soreness (passive and active), creatine kinase (CK), and myoglobin (Mb) were measured as indices of muscle damage. The data were analyzed with repeated measures ANOVA. The results show that there is a significant group–time interaction for both CK and Mb after eccentric exercise (p = 0.007, p = 0.015, respectively), with a greater increase in the HFG than in the LFG. However, there was no significant group–time interaction for maximal isometric strength and muscle soreness (passive and active) (p > 0.05). These results suggest that %BF is a factor that alters the muscle damage indices CK and Mb, which indicate membrane disruption, after eccentric exercise.

scholarly journals Muscle Damage Indicated by Maximal Voluntary Contraction Strength Changes From Immediately to 1 Day After Eccentric Exercise of the Knee Extensors

2021 ◽  
Vol 12 ◽  
Author(s):  
Mikio Shoji ◽  
Ryoichi Ema ◽  
Kazunori Nosaka ◽  
Akihiro Kanda ◽  
Kosuke Hirata ◽  
...  
Keyword(s):  
Shear Modulus ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Recovery Rate ◽  
Muscle Soreness ◽  
Knee Extensors ◽  
Significant Group ◽  
Post Exercise ◽  
Significant Difference ◽  
Recovery Group

The present study examined if the magnitude of changes in indirect muscle damage markers could be predicted by maximal voluntary isometric contraction (MVIC) torque changes from immediately to 1 day after eccentric exercise. Twenty-eight young men performed 100 maximal isokinetic (60°/s) eccentric contractions of the knee extensors. MVIC torque, potentiated doublet torque, voluntary activation (VA) during MVIC, shear modulus of rectus femoris (RF), vastus medialis and lateralis, and muscle soreness of these muscles were measured before, immediately after, and 1–3 days post-exercise. Based on the recovery rate of the MVIC torque from immediately to 1-day post-exercise, the participants were placed to a recovery group that showed an increase in the MVIC torque (11.3–79.9%, n = 15) or a no-recovery group that showed no recovery (−71.9 to 0%, n = 13). No significant difference in MVIC torque decrease immediately post-exercise was found between the recovery (−33 ± 12%) and no-recovery (−32 ± 9%) groups. At 1–3 days, changes in MVIC torque (−40 to −26% vs. −22 to −12%), potentiated doublet torque (−37 to −22% vs. −20 to −9%), and proximal RF shear modulus (29–34% vs. 8–15%) were greater (p < 0.05) for the no-recovery than recovery group. No significant group differences were found for muscle soreness. The recovery rate of MVIC torque was correlated (p < 0.05) with the change in MVIC torque from baseline to 2 (r = 0.624) or 3 days post-exercise (r = 0.526), or peak change in potentiated doublet torque at 1–3 days post-exercise from baseline (r = 0.691), but not correlated with the changes in other dependent variables. These results suggest that the recovery rate of MVIC torque predicts changes in neuromuscular function but not muscle soreness and stiffness following eccentric exercise of the knee extensors.

Is isometric strength loss immediately after eccentric exercise related to changes in indirect markers of muscle damage?

2006 ◽  
Vol 31 (3) ◽  
pp. 313-319 ◽  
Author(s):  
Kazunori Nosaka ◽  
Dale Chapman ◽  
Mike Newton ◽  
Paul Sacco
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Elbow Joint ◽  
Muscle Soreness ◽  
Correlation Coefficients ◽  
Strength Loss ◽  
Isometric Strength ◽  
Joint Angles ◽  
Arm Circumference ◽  
Strong Correlate

This study tested the hypothesis that the magnitude of maximal isometric strength (MVC) loss immediately following eccentric exercise (MVC-post) would relate to changes in other indirect markers of muscle damage following exercise. Eighty-nine men were recruited from the same student population and performed 24 maximal eccentric actions of the elbow flexors. Commonly used markers of muscle damage such as relaxed and flexed elbow joint angles, range of motion (ROM), upper-arm circumference, muscle soreness, and plasma creatine kinase (CK) activity were measured before, immediately after, and 1-4 d after exercise. Pearson's product-moment correlation coefficients (r) between change in MVC-post and other markers of muscle damage, as well as MVC during recovery days, were calculated. Changes in MVC-post ranged from -72.8% to -17.6%, and correlated significantly (p < 0.01) with MVC at 1 (r = 0.59), 2 (0.63), 3 (0.61), and 4 (0.62) d after exercise. Reduction in MVC-post also correlated significantly (p < 0.05) with changes in relaxed (r = 0.50) and flexed elbow joint angles (-0.40), ROM (0.55), arm circumference (-0.45), peak palpation (-0.34) and extension muscle soreness (-0.48), and peak CK activity (-0.59). However, the r values were not necessarily high, and MVC-post poorly reflected the distribution of some measures, such as peak CK activity (124 - 50 440 IU·L-1). These results suggest that MVC-post is not a strong correlate of the changes in markers of muscle damage following eccentric exercise of the elbow flexors.Key words: maximal isometric strength, plasma CK activity, ROM, swelling, muscle soreness.

Power loss is attenuated following a second bout of high intensity eccentric contractions due to the repeated bout effect’s protection of rate of torque and velocity development

2020 ◽  
Author(s):  
Avery Hinks ◽  
Adam Hess ◽  
Mathew I. B. Debenham ◽  
Jackey Chen ◽  
Nicole Mazara ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
High Intensity ◽  
Power Loss ◽  
Peak Power ◽  
Eccentric Contractions ◽  
Peak Power Output ◽  
Repeated Bout Effect ◽  
Maximum Voluntary Isometric Contraction ◽  
Repeated Bout

High intensity unaccustomed eccentric contractions result in weakness and power loss due to fatigue and muscle damage. Through the repeated bout effect (RBE), adaptations occur, then damage and weakness are attenuated following a subsequent bout. However, it is unclear whether the RBE protects peak power output. We investigated the influence of the RBE on power production and estimated fatigue- and damage-induced neuromuscular impairments following repeated high-intensity eccentric contractions. Twelve healthy adult males performed 5 sets of 30 maximal eccentric elbow flexions and repeated an identical bout 4 weeks later. Recovery was tracked over 7 days following both bouts. Reduced maximum voluntary isometric contraction torque, and increased serum creatine kinase and self-reported soreness indirectly inferred muscle damage. Peak isotonic power, time-dependent measures—rate of velocity development (RVD) and rate of torque development (RTD)—and several electrophysiological indices of neuromuscular function were assessed. The RBE protected peak power, with a protective index of 66% 24 hours after the second eccentric exercise bout. The protection of power also related to preserved RVD (R2=0.61, P<0.01) and RTD (R2=0.39, P<0.01). Furthermore, the RBE’s protection against muscle damage permitted the estimation of fatigue-associated neuromuscular performance decrements following eccentric exercise. Novelty Bullets • The repeated bout effect protects peak isotonic power. • Protection of peak power relates to preserved rates of torque and velocity development, but more so rate of velocity development. • The repeated bout effect has little influence on indices of neuromuscular fatigue.

Serial assessment of local peripheral vascular function after eccentric exercise

2013 ◽  
Vol 38 (12) ◽  
pp. 1181-1186 ◽  
Author(s):  
Mitchel R. Stacy ◽  
Kallie J. Bladon ◽  
Jennifer L. Lawrence ◽  
Sarah A. McGlinchy ◽  
Barry W. Scheuermann
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Vascular Function ◽  
Muscle Blood Flow ◽  
Isometric Strength ◽  
Flow Mediated Dilation ◽  
Vascular Responses ◽  
Study Results

Muscle damage is a common response to unaccustomed eccentric exercise; however, the effects of skeletal muscle damage on local vascular function and blood flow are poorly understood. This study examined serial local vascular responses to flow-mediated (endothelial-dependent) and nitroglycerin-mediated (endothelial-independent) dilation in the brachial artery after strenuous eccentric exercise and serially assessed resting blood flow. Ten healthy males performed 50 maximal eccentric unilateral arm contractions to induce muscle damage to the biceps brachii. Changes in maximal isometric strength and vascular responses were assessed 1, 24, 48, and 96 h after exercise. Mean blood velocities and arterial diameters, measured with Doppler ultrasound, were used to calculate blood flow and shear stress (expressed as area under the curve). Eccentric exercise resulted in impaired maximal isometric strength for up to 96 h (p < 0.001). Reductions in flow-mediated dilation (before exercise, 9.4% ± 2.6%; 1 h after exercise, 5.1% ± 2.2%) and nitroglycerin responses (before exercise, 26.3% ± 6.5%; 1 h after exercise, 20.7% ± 4.7%) were observed in the 1 h after exercise and remained lower for 96 h (p < 0.05). The shear stress response was attenuated immediately after exercise and remained impaired for 48 h (p < 0.05). Resting blood pressure and muscle blood flow remained similar throughout the study. Results suggest that muscle damage from eccentric exercise leads to impaired local endothelial and vascular smooth muscle function. Lower shear stress after exercise might contribute to the observed reduction in flow-mediated dilation responses, but the mechanism responsible for the attenuated endothelial-independent vasodilation remains unclear.

Comparison of Carbohydrate and Milk-Based Beverages on Muscle Damage and Glycogen Following Exercise

2001 ◽  
Vol 11 (4) ◽  
pp. 406-419 ◽  
Author(s):  
Janet R. Wojcik ◽  
Janet Walberg-Rankin ◽  
Lucille L. Smith ◽  
F.C. Gwazdauskas
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Muscle Glycogen ◽  
Muscle Function ◽  
Muscle Protein ◽  
Serum Insulin ◽  
Peak Torque ◽  
Group Differences ◽  
Protein Breakdown ◽  
Post Exercise

This study examined effects of carbohydrate (CHO), milk-based carbohydrate-protein (CHO-PRO), or placebo (P) beverages on glycogen resynthesis, muscle damage, inflammation, and muscle function following eccentric resistance exercise. Untrained males performed a cycling exercise to reduce muscle glycogen 12 hours prior to performance of 100 eccentric quadriceps contractions at 120% of 1-RM (day 1) and drank CHO (n = 8), CHO-PRO (n = 9; 5 kcal/kg), or P (n = 9) immediately and 2 hours post-exercise. At 3 hours post-eccentric exercise, serum insulin was four times higher for CHO-PRO and CHO than P (p < .05). Serum creatine kinase (CK) increased for all groups in the 6 hours post-eccentric exercise (p < .01), with the increase tending to be lowest for CHO-PRO (p < .08) during this period. Glycogen was low post-exercise (33 ± 3.7 mmol/kg ww), increased 225% at 24 hours, and tripled by 72 hours, with no group differences. The eccentric exercise increased muscle protein breakdown as indicated by urinary 3-methylhistidine and increased IL-6 with no effect of beverage. Quadriceps isokinetic peak torque was depressed similarly for all groups by 24% 24 hours post-exercise and remained 21 % lower at 72 hours (p < .01). In summary, there were no influences of any post-exercise beverage on muscle glycogen replacement, inflammation, or muscle function.

Short-Term β-Hydroxy-β-Methylbutyrate Supplementation Does Not Reduce Symptoms of Eccentric Muscle Damage

2001 ◽  
Vol 11 (4) ◽  
pp. 442-450 ◽  
Author(s):  
Douglas Paddon-Jones ◽  
Andrew Keech ◽  
David Jenkins
Keyword(s):  
Body Weight ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Muscle Soreness ◽  
Exercise Bout ◽  
Similar Amount ◽  
Short Term ◽  
Placebo Condition ◽  
Post Exercise ◽  
Eccentric Muscle Damage

Purpose:We examined the effects of short-term β-hydroxy-β-methylbutyrate (HMB) supplementation on symptoms of muscle damage following an acute bout of eccentric exercise.Methods:Non-resistance trained subjects were randomly assigned to a HMB supplement group (HMB, 40mg/kg body weight/day, n = 8) or placebo group (CON, n = 9). Supplementation commenced 6 days prior to a bout of 24 maximal isokinetic eccentric contractions of the elbow flexors and continued throughout post-testing. Muscle soreness, upper arm girth, and torque measures were assessed pre-exercise, 15 min post-exercise, and 1,2,3, 4,7, and 10 days post-exercise.Results:No pre-test differences between HMB and CON groups were identified, and both performed a similar amount of eccentric work during the main eccentric exercise bout (p > .05). HMB supplementation had no effect on swelling, muscle soreness, or torque following the damaging eccentric exercise bout (p > .05).Conclusion:Compared to a placebo condition, short-term supplementation with 40mg/kg body weight/day of HMB had no beneficial effect on a range of symptoms associated with eccentric muscle damage. If HMB can produce an ergogenic response, a longer pre-exercise supplementation period may be necessary.

scholarly journals Effects of Whey and Pea Protein Supplementation on Post-Eccentric Exercise Muscle Damage: A Randomized Trial

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2382
Author(s):  
David C. Nieman ◽  
Kevin A. Zwetsloot ◽  
Andrew J. Simonson ◽  
Andrew T. Hoyle ◽  
Xintang Wang ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Muscle Damage ◽  
Whey Protein ◽  
Eccentric Exercise ◽  
Protein Supplementation ◽  
Post Exercise ◽  
Pea Protein ◽  
Cohen’S D ◽  
Cohen's D ◽  
Water Supplementation

This randomized trial compared pea protein, whey protein, and water-only supplementation on muscle damage, inflammation, delayed onset of muscle soreness (DOMS), and physical fitness test performance during a 5-day period after a 90-min eccentric exercise bout in non-athletic non-obese males (n = 92, ages 18–55 years). The two protein sources (0.9 g protein/kg divided into three doses/day) were administered under double blind procedures. The eccentric exercise protocol induced significant muscle damage and soreness, and reduced bench press and 30-s Wingate performance. Whey protein supplementation significantly attenuated post-exercise blood levels for biomarkers of muscle damage compared to water-only, with large effect sizes for creatine kinase and myoglobin during the fourth and fifth days of recovery (Cohen’s d > 0.80); pea protein versus water supplementation had an intermediate non-significant effect (Cohen’s d < 0.50); and no significant differences between whey and pea protein were found. Whey and pea protein compared to water supplementation had no significant effects on post-exercise DOMS and the fitness tests. In conclusion, high intake of whey protein for 5 days after intensive eccentric exercise mitigated the efflux of muscle damage biomarkers, with the intake of pea protein having an intermediate effect.

scholarly journals Comparison between old and young men for changes in makers of muscle damage following voluntary eccentric exercise of the elbow flexors

2006 ◽  
Vol 31 (3) ◽  
pp. 218-225 ◽  
Author(s):  
Andrew P Lavender ◽  
Kazunori Nosaka
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Repeated Measures ◽  
Muscle Soreness ◽  
Young Men ◽  
Young Group ◽  
Creatine Kinase Activity ◽  
Isometric Strength ◽  
Elbow Flexors

This study aimed to investigate if old men were more susceptible than young men to muscle damage induced by exercise consisting of repeated-lengthening muscle actions. The responses to a bout of eccentric exercise were compared between 10 young (mean age ± SEM = 19.4 ± 0.4 y) and 10 old (70.5 ± 1.5 y) men. All subjects performed 6 sets of 5 lengthening actions of the left elbow flexors at a range of 90° from an elbow flexed (90°) to an extended (180°) position in 5 s using a dumbbell massed at 40% maximal isometric strength (MVC) at an elbow joint angle of 90°. Changes in MVC, range of motion (ROM), upper arm circumference (CIR), muscle soreness (DOMS), plasma creatine kinase activity (CK), and myoglobin (Mb) concentration over 7-10 d following exercise were compared between groups by 2-way repeated measures analysis of variance (ANOVA). Significant differences between groups were evident at baseline for ROM (significantly smaller for the older group) and CIR (significantly larger for the older group), but not for MVC and other measures. Contrary to the hypothesis, the young group showed significantly larger decreases in MVC and ROM and larger increases in circumference, DOMS, CK activity, and Mb con centration than those of the old group. These results suggest that muscle damage is not necessarily greater in old versus young men following voluntary eccentric exercise. It may be that physiological changes that occur with ageing, including a decrease in ROM, reduce damaging stress to muscles during lengthening muscle actions.Key words: ageing, maximal isometric strength, muscle soreness, creatine kinase, myoglobin.

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