scholarly journals Calcium Spark Detection and Event-Based Classification of Single Cardiomyocyte Using Deep Learning

2021 ◽  
Vol 12 ◽  
Author(s):  
Shengqi Yang ◽  
Ran Li ◽  
Jiliang Chen ◽  
Zhen Li ◽  
Zhangqin Huang ◽  
...  
Keyword(s):  
Binary Classification ◽  
Detection Algorithm ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Detection Methods ◽  
Cardiac Pathology ◽  
Powerful Approach ◽  
Whole Heart ◽  
Event Based

Ca2+ sparks are the elementary Ca2+ release events in cardiomyocytes, altered properties of which lead to impaired Ca2+ handling and finally contribute to cardiac pathology under various diseases. Despite increasing use of machine-learning algorithms in deciphering the content of biological and medical data, Ca2+ spark images and data are yet to be deeply learnt and analyzed. In the present study, we developed a deep residual convolutional neural network method to detect Ca2+ sparks. Compared to traditional detection methods with arbitrarily defined thresholds to distinguish signals from noises, our new method detected more Ca2+ sparks with lower amplitudes but similar spatiotemporal distributions, thereby indicating that our new algorithm detected many very weak events that are usually omitted when using traditional detection methods. Furthermore, we proposed an event-based logistic regression and binary classification model to classify single cardiomyocytes using Ca2+ spark characteristics, which to date have generally been used only for simple statistical analyses and comparison between normal and diseased groups. Using this new detection algorithm and classification model, we succeeded in distinguishing wild type (WT) vs RyR2-R2474S± cardiomyocytes with 100% accuracy, and vehicle vs isoprenaline-insulted WT cardiomyocytes with 95.6% accuracy. The model can be extended to judge whether a small number of cardiomyocytes (and so the whole heart) are under a specific cardiac disease. Thus, this study provides a novel and powerful approach for the research and application of calcium signaling in cardiac diseases.

scholarly journals Machine Learning Models for Diagnosis of Cushing’s Syndrome Using Retrospective Data

2020 ◽  
Author(s):  
Senol Isci ◽  
Derya Sema Yaman Kalender ◽  
Firat Bayraktar ◽  
Alper Yaman
Keyword(s):  
Machine Learning ◽  
Cushing’S Syndrome ◽  
Binary Classification ◽  
Critical Role ◽  
Cushing's Syndrome ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Test Dataset ◽  
Class Comparison

ABSTRACTAccurate classification of Cushing’s Syndrome (CS) plays a critical role in providing early and correct diagnosis of CS that may facilitate treatment and improve patient outcomes. Diagnosis of CS is a complex process, which requires careful and concurrent interpretation of signs and symptoms, multiple biochemical test results, and findings of medical imaging by physicians with a high degree of specialty and knowledge to make correct judgments. In this article, we explore the state of the art machine learning algorithms to demonstrate their potential as a clinical decision support system to analyze and classify CS in order to facilitate the diagnosis, prognosis, and treatment of CS. Prominent algorithms are compared using nested cross-validation and various class comparison strategies including multiclass, one vs. all, and one vs. one binary classification. Our findings show that Random Forest (RF) algorithm is most suitable for the classification of CS. We demonstrate that the proposed approach can classify CS subjects with an average accuracy of 92% and an average F1 score of 91.5%, depending on the class comparison strategy and selected features. RF-based one vs. all binary classification model achieves sensitivity of 97.6%, precision of 91.1%, and specificity of 87.1% to discriminate CS from non-CS on the test dataset. RF-based multiclass classification model achieves average per class sensitivity of 91.8%, average per class specificity of 97.1%, and average per class precision of 92.1% to classify different subtypes of CS on the test dataset. Clinical performance evaluation suggests that the developed models can help improve physician’s judgment in diagnosing CS.

scholarly journals Attention-Guided Digital Adversarial Patches on Visual Detection

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Dapeng Lang ◽  
Deyun Chen ◽  
Ran Shi ◽  
Yongjun He
Keyword(s):  
Deep Learning ◽  
Learning Model ◽  
Detection Algorithm ◽  
Classification Model ◽  
Practical Application ◽  
Single Target ◽  
Attachment Mechanism ◽  
Human Eyes ◽  
Deep Learning Model

Deep learning has been widely used in the field of image classification and image recognition and achieved positive practical results. However, in recent years, a number of studies have found that the accuracy of deep learning model based on classification greatly drops when making only subtle changes to the original examples, thus realizing the attack on the deep learning model. The main methods are as follows: adjust the pixels of attack examples invisible to human eyes and induce deep learning model to make the wrong classification; by adding an adversarial patch on the detection target, guide and deceive the classification model to make it misclassification. Therefore, these methods have strong randomness and are of very limited use in practical application. Different from the previous perturbation to traffic signs, our paper proposes a method that is able to successfully hide and misclassify vehicles in complex contexts. This method takes into account the complex real scenarios and can perturb with the pictures taken by a camera and mobile phone so that the detector based on deep learning model cannot detect the vehicle or misclassification. In order to improve the robustness, the position and size of the adversarial patch are adjusted according to different detection models by introducing the attachment mechanism. Through the test of different detectors, the patch generated in the single target detection algorithm can also attack other detectors and do well in transferability. Based on the experimental part of this paper, the proposed algorithm is able to significantly lower the accuracy of the detector. Affected by the real world, such as distance, light, angles, resolution, etc., the false classification of the target is realized by reducing the confidence level and background of the target, which greatly perturbs the detection results of the target detector. In COCO Dataset 2017, it reveals that the success rate of this algorithm reaches 88.7%.

An Algorithm of Edge Detection Based on FSVM

2013 ◽  
Vol 321-324 ◽  
pp. 1046-1050
Author(s):  
Ai Ping Cai
Keyword(s):  
Target Identification ◽  
Main Idea ◽  
Detection Algorithm ◽  
Training Data ◽  
Classification Model ◽  
Detection Methods ◽  
Support Vector ◽  
Classification Problems ◽  
Tracking Motion ◽  
Image Edge

The support vector machine (SVM) has been shown to be an efficient approach for a variety of classification problems. It has also been widely used in target identification and tracking, motion analysis, image segmentation technology. Traditional detection methods mostly exist pseudo-edge and poor anti-noise capability. Under these circumstances, developing an efficient method is necessary. In this paper, we propose a new detection algorithm based on FSVM, the main idea is to train classified sample and give all training data a degree of membership, increase punishment to the wrong sub-sample. Then training and testing the FSVM classification model. Finally, extract edge of the image by using FSVM classification model. Experimental results show that the new algorithm can detect a clear image edge and have a good anti-noise nature.

scholarly journals A Spectral Feature Based Convolutional Neural Network for Classification of Sea Surface Oil Spill

2019 ◽  
Vol 8 (4) ◽  
pp. 160 ◽  
Author(s):  
Bingxin Liu ◽  
Ying Li ◽  
Guannan Li ◽  
Anling Liu
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Convolutional Neural Network ◽  
Convolutional Neural Networks ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Support Vector ◽  
Oil Film ◽  
One Dimensional

Spectral characteristics play an important role in the classification of oil film, but the presence of too many bands can lead to information redundancy and reduced classification accuracy. In this study, a classification model that combines spectral indices-based band selection (SIs) and one-dimensional convolutional neural networks was proposed to realize automatic oil films classification using hyperspectral remote sensing images. Additionally, for comparison, the minimum Redundancy Maximum Relevance (mRMR) was tested for reducing the number of bands. The support vector machine (SVM), random forest (RF), and Hu’s convolutional neural networks (CNN) were trained and tested. The results show that the accuracy of classifications through the one dimensional convolutional neural network (1D CNN) models surpassed the accuracy of other machine learning algorithms such as SVM and RF. The model of SIs+1D CNN could produce a relatively higher accuracy oil film distribution map within less time than other models.

scholarly journals ELM and K-nn machine learning in classification of breath sounds signals

2020 ◽  
Vol 10 (4) ◽  
pp. 3528
Author(s):  
Z. Neili ◽  
M. Fezari ◽  
A. Redjati
Keyword(s):  
Machine Learning ◽  
Binary Classification ◽  
Machine Learning Algorithms ◽  
Permutation Entropy ◽  
Intrinsic Mode Functions ◽  
Electronic Stethoscope ◽  
Mode Decomposition ◽  
Breath Sounds ◽  
Learning Machine

The acquisition of Breath sounds (BS) signals from a human respiratory system with an electronic stethoscope, provide and offer prominent information which helps the doctors to diagnosis and classification of pulmonary diseases. Unfortunately, this BS signals with other biological signals have a non-stationary nature according to the variation of the lung volume, and this nature makes it difficult to analyze and classify between several diseases. In this study, we were focused on comparing the ability of the extreme learning machine (ELM) and k-nearest neighbour (K-nn) machine learning algorithms in the classification of adventitious and normal breath sounds. To do so, the empirical mode decomposition (EMD) was used in this work to analyze BS, this method is rarely used in the breath sounds analysis. After the EMD decomposition of the signals into Intrinsic Mode Functions (IMFs), the Hjorth descriptors (Activity) and Permutation Entropy (PE) features were extracted from each IMFs and combined for classification stage. The study has found that the combination of features (activity and PE) yielded an accuracy of 90.71%, 95% using ELM and K-nn respectively in binary classification (normal and abnormal breath sounds), and 83.57%, 86.42% in multiclass classification (five classes).

scholarly journals CLASSIFICATION MODEL FOR LEARNING DISABILITIES IN ELEMENTARY SCHOOL PUPILS

2019 ◽  
Vol 17 (1) ◽  
pp. 9-20
Author(s):  
I. O. AWOYELU ◽  
I. A. AGBOOLA
Keyword(s):  
Learning Disabilities ◽  
Learning Disability ◽  
Primary Schools ◽  
Binary Classification ◽  
Back Propagation ◽  
Principal Component ◽  
General Term ◽  
Classification Model ◽  
Back Propagation Algorithm

Learning disability is a general term that describes specific kinds of learning problems.  Although, Learning Disability cannot be cured medically, there exist several methods for detecting learning disabilities in a child. Existing methods of classification of learning disabilities in children are binary classification – either a child is normal or learning disabled. The focus of this paper is to extend the binary classification to multi-label classification of learning disabilities. This paper formulated and simulated a classification model for learning disabilities in primary school pupils. Information containing the symptoms of learning disabilities in pupils were elicited by administering five hundred (500) questionnaire to teachers of Primary One to Four pupils in fifteen government owned elementary schools within Ife Central Local Government Area, Ile-Ife of Osun State. The classification model was formulated using Principal Component Analysis, rule based system and back propagation algorithm. The formulated model was simulated using Waikatto Environment for Knowledge Analysis (WEKA) version 3.7.2. The performance of the model was evaluated using precision and accuracy. The classification model of primary one, primary two, primary three and primary four yielded precision rate of 95%, 91.18%, 93.10% and 93.60% respectively while the accuracy results were 95.00%, 91.18%, 93.10% and 93.60% respectively. The results obtained showed that the developed model proved to be accurate and precise in classifying pupils with learning disabilities in primary schools. The model can be adopted for the management of pupils with learning disabilities.  

Intrusion detection algorithm based on image enhanced convolutional neural network

2021 ◽  
pp. 1-12
Author(s):  
Qian Wang ◽  
Wenfang Zhao ◽  
Jiadong Ren
Keyword(s):  
Neural Network ◽  
Intrusion Detection ◽  
Convolutional Neural Network ◽  
Detection System ◽  
Binary Classification ◽  
Original Data ◽  
Detection Algorithm ◽  
Machine Learning Algorithms ◽  
Data Set ◽  
Softmax Classifier

Intrusion Detection System (IDS) can reduce the losses caused by intrusion behaviors and protect users’ information security. The effectiveness of IDS depends on the performance of the algorithm used in identifying intrusions. And traditional machine learning algorithms are limited to deal with the intrusion data with the characteristics of high-dimensionality, nonlinearity and imbalance. Therefore, this paper proposes an Intrusion Detection algorithm based on Image Enhanced Convolutional Neural Network (ID-IE-CNN). Firstly, based on the image processing technology of deep learning, oversampling method is used to increase the amount of original data to achieve data balance. Secondly, the one-dimensional data is converted into two-dimensional image data, the convolutional layer and the pooling layer are used to extract the main features of the image to reduce the data dimensionality. Third, the Tanh function is introduced as an activation function to fit nonlinear data, a fully connected layer is used to integrate local information, and the generalization ability of the prediction model is improved by the Dropout method. Finally, the Softmax classifier is used to predict the behavior of intrusion detection. This paper uses the KDDCup99 data set and compares with other competitive algorithms. Both in the performance of binary classification and multi-classification, ID-IE-CNN is better than the compared algorithms, which verifies its superiority.

scholarly journals Design of Accurate Classification of COVID-19 Disease in X-Ray Images Using Deep Learning Approach

2021 ◽  
Vol 2 (2) ◽  
pp. 132-148
Author(s):  
Joy Iong-Zong Chen
Keyword(s):  
Transfer Learning ◽  
Research Work ◽  
Well Being ◽  
Classification Model ◽  
Classification Method ◽  
World Health ◽  
Detection Methods ◽  
X Rays ◽  
X Ray

COVID-19 appears to be having a devastating influence on world health and well-being. Moreover, the COVID-19 confirmed cases have recently increased to over 10 million worldwide. As the number of verified cases increase, it is more important to monitor and classify healthy and infected people in a timely and accurate manner. Many existing detection methods have failed to detect viral patterns. Henceforth, by using COVID-19 thoracic x-rays and the histogram-oriented gradients (HOG) feature extraction methodology; this research work has created an accurate classification method for performing a reliable detection of COVID-19 viral patterns. Further, the proposed classification model provides good results by leveraging accurate classification of COVID-19 disease based on the medical images. Besides, the performance of our proposed CNN classification method for medical imaging has been assessed based on different edge-based neural networks. Whenever there is an increasing number of a class in the training network, the accuracy of tertiary classification with CNN will be decreasing. Moreover, the analysis of 10 fold cross-validation with confusion metrics can also take place in our research work to detect various diseases caused due to lung infection such as Pneumonia corona virus-positive or negative. The proposed CNN model has been trained and tested with a public X-ray dataset, which is recently published for tertiary and normal classification purposes. For the instance transfer learning, the proposed model has achieved 85% accuracy of tertiary classification that includes normal, COVID-19 positive and Pneumonia. The proposed algorithm obtains good classification accuracy during binary classification procedure integrated with the transfer learning method.

scholarly journals Towards Urban Environment Familiarity Prediction

2019 ◽  
Vol 2 ◽  
pp. 1-8
Author(s):  
Lukas Gokl ◽  
Marvin Mc Cutchan ◽  
Bartosz Mazurkiewicz ◽  
Paolo Fogliaroni ◽  
Ioannis Giannopoulos
Keyword(s):  
Machine Learning ◽  
Information Exchange ◽  
Municipal Government ◽  
Binary Classification ◽  
Ground Truth ◽  
Machine Learning Algorithms ◽  
Location Based Services ◽  
Ground Truth Data ◽  
Level Of Details

Abstract. Location Based Services (LBS) are definitely very helpful for people that interact within an unfamiliar environment, but also for those that already possess a certain level of familiarity with it. In order to avoid overwhelming familiar users with unnecessary information, the level of details offered by the LBS shall be adapted to the level of familiarity with the environment: providing more details to unfamiliar users and a lighter amount of information (that would be superfluous, if not even misleading) to the users that are more familiar with the current environment. Currently, the information exchange between the service and its users is not taking into account familiarity. Within this work, we investigate the potential of machine learning for a binary classification of environment familiarity (i.e., familiar vs unfamiliar) with the surrounding environment. For this purpose, a 3D virtual environment based on a part of Vienna, Austria was designed using datasets from the municipal government. During a navigation experiment with 22 participants we collected ground truth data in order to train four machine learning algorithms. The captured data included motion and orientation of the users as well as visual interaction with the surrounding buildings during navigation. This work demonstrates the potential of machine learning for predicting the state of familiarity as an enabling step for the implementation of LBS better tailored to the user.

scholarly journals BCDnet: Parallel heterogeneous eight-class classification model of breast pathology

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0253764
Author(s):  
Qingfang He ◽  
Guang Cheng ◽  
Huimin Ju
Keyword(s):  
Binary Classification ◽  
Recognition Rate ◽  
Image Features ◽  
Fine Tuning ◽  
Classification Model ◽  
Tubular Adenoma ◽  
Breast Pathology ◽  
Data Set ◽  
Pathological Tissues

Breast cancer is the cancer with the highest incidence of malignant tumors in women, which seriously endangers women’s health. With the help of computer vision technology, it has important application value to automatically classify pathological tissue images to assist doctors in rapid and accurate diagnosis. Breast pathological tissue images have complex and diverse characteristics, and the medical data set of breast pathological tissue images is small, which makes it difficult to automatically classify breast pathological tissues. In recent years, most of the researches have focused on the simple binary classification of benign and malignant, which cannot meet the actual needs for classification of pathological tissues. Therefore, based on deep convolutional neural network, model ensembleing, transfer learning, feature fusion technology, this paper designs an eight-class classification breast pathology diagnosis model BCDnet. A user inputs the patient’s breast pathological tissue image, and the model can automatically determine what the disease is (Adenosis, Fibroadenoma, Tubular Adenoma, Phyllodes Tumor, Ductal Carcinoma, Lobular Carcinoma, Mucinous Carcinoma or Papillary Carcinoma). The model uses the VGG16 convolution base and Resnet50 convolution base as the parallel convolution base of the model. Two convolutional bases (VGG16 convolutional base and Resnet50 convolutional base) obtain breast tissue image features from different fields of view. After the information output by the fully connected layer of the two convolutional bases is fused, it is classified and output by the SoftMax function. The model experiment uses the publicly available BreaKHis data set. The number of samples of each class in the data set is extremely unevenly distributed. Compared with the binary classification, the number of samples in each class of the eight-class classification is also smaller. Therefore, the image segmentation method is used to expand the data set and the non-repeated random cropping method is used to balance the data set. Based on the balanced data set and the unbalanced data set, the BCDnet model, the pre-trained model Resnet50+ fine-tuning, and the pre-trained model VGG16+ fine-tuning are used for multiple comparison experiments. In the comparison experiment, the BCDnet model performed outstandingly, and the correct recognition rate of the eight-class classification model is higher than 98%. The results show that the model proposed in this paper and the method of improving the data set are reasonable and effective.

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