scholarly journals Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216

2021 ◽  
Vol 12 ◽  
Author(s):  
Kristina R. Gopcevic ◽  
Eugenia Gkaliagkousi ◽  
János Nemcsik ◽  
Ömür Acet ◽  
M. Rosa Bernal-Lopez ◽  
...  

Impairment of the arteries is a product of sustained exposure to various deleterious factors and progresses with time; a phenomenon inherent to vascular aging. Oxidative stress, inflammation, the accumulation of harmful agents in high cardiovascular risk conditions, changes to the extracellular matrix, and/or alterations of the epigenetic modification of molecules, are all vital pathophysiological processes proven to contribute to vascular aging, and also lead to changes in levels of associated circulating molecules. Many of these molecules are consequently recognized as markers of vascular impairment and accelerated vascular aging in clinical and research settings, however, for these molecules to be classified as biomarkers of vascular aging, further criteria must be met. In this paper, we conducted a scoping literature review identifying thirty of the most important, and eight less important, biomarkers of vascular aging. Herein, we overview a selection of the most important molecules connected with the above-mentioned pathological conditions and study their usefulness as circulating biomarkers of vascular aging.

2012 ◽  
Vol 40 (3) ◽  
Author(s):  
Richard van der Wurff

Climate change as a challenge for journalism: a review of the literature Climate change as a challenge for journalism: a review of the literature This literature review synthesizes 35 years of research on climate change reporting in industrialized countries. It focuses on the production and content of climate change news. Starting from the notion of the mediatisation of politics, the study shows that news values and media logic shape the selection of climate change related newsworthy events, while political actors and their logics determine the political framing of the issue. Next, implications for public opinion and mediated public debate are briefly assessed. Overall, the findings suggest that reporting focuses on threats and conflicts, favours national rather than transnational angles, reinforces ideological cleavages, downplays deliberative arguments, and disengages citizens. In conclusion, four lines of research are proposed that can help us better understand the role media might play in engaging citizens in a more deliberative mediated debate on climate change as important ecological and political challenge.


2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Luiz Anselmo Menezes Santos ◽  
Antônio Hamilton Dos Santos ◽  
Viviane Novaes de Souza ◽  
Hudson Leonardo Cordeiro de Moura

This study aimed to identify and analyze scientific publications related to training that address professional development. It was based on the selection of articles from the CAPES Journal Portal database, in which 12 references were analyzed. Among the main authors that supported this work, choose: (Garcia, 1999), (André, 2017), (Alarcão, 2014), (Gatti & Barreto, 2009) who have a great contribution in research on teacher professional development. The methodology used, according to (Morosini & Fernandes, 2014), stands out as a review of the literature, of the state of knowledge type. The results show that it is necessary for the teacher to develop professionally, always renewing his knowledge, overcoming the difficulties present in the school context, introducing new instruments and mechanisms so that the classes have more meanings and senses and consequently a solidification in relation to the - students' learning, thus contributing to the existence of comprehensive training.


2021 ◽  
Vol 100 (5) ◽  
pp. 76-82
Author(s):  
A.V. Mostovoy ◽  
◽  
S.S. Mezhinsky ◽  
A.L. Karpova ◽  
A.N. Nikolishin ◽  
...  

The review presents and systematizes the current provisions on artificial lung ventilation (ALV) with a guaranteed or target tidal volume as the most effective and safe mode of ALV in neonatal practice. The application of this method of respiratory support is described. The authors present the main provisions on the optimal selection of the target tidal volume in various pathological conditions. The use of various modes of ALV in combination with a guaranteed tidal volume makes it possible to prevent or reduce the harmful impact of ALV in patients with acute and chronic lung pathology, in newborns and children in the first year of life.


Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1476 ◽  
Author(s):  
Kenichiro Takano ◽  
Junko Tatebe ◽  
Naohiro Washizawa ◽  
Toshisuke Morita

Inhibiting the onset of arteriosclerotic disease, which has been increasing due to the westernized diet and aging, is a significant social challenge. Curcumin, a type of polyphenol, has anti-oxidative effects and anti-inflammatory action and is expected to treat and to have prophylactic effects on different diseases. In this study, we examined the effects of long-term administration of curcumin on vascular aging and chronic inflammation—the causes of arteriosclerotic disease. Eight-week-old C57BL/6J mice were fed with high fat diet (HFD) or 0.1% curcumin-mixed HFD (HFD + Cu) until 80 weeks old (n = 20 for each group). After the breeding, we examined the expression of antioxidant enzymes, heme oxygenase-1 (HO-1), oxidative stress, vascular aging, and inflammatory changes in the aorta. In the HFD group, oxidative stress increased with decreased sirt1 expression in the aorta followed by increased senescent cells and enhanced inflammation. Whereas in the HFD + Cu group, HO-1 was induced in the aorta with the suppression of oxidative stress. Additionally, it was shown that sirt1 expression in the aorta in the HFD + Cu group remained at a level comparable to that of the 8-week-old mice with suppression of increased senescent cells and enhanced inflammation. Consequently, disorders associated with HFD were resolved. These results suggest that curcumin might be a food with a prophylactic function against arteriosclerotic disease.


Biology Open ◽  
2021 ◽  
Vol 10 (12) ◽  

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Natalí Delorme and Leonardo Zamora are co-first authors on ‘ A new method to localise and quantify oxidative stress in live juvenile mussels’, published in BiO. They are both researchers in the laboratory of Serean Adams at the Cawthron Institute, Nelson, New Zealand. Natalí's research interests centre around ecophysiology of marine invertebrates, particularly on the organisms' stress response. Leonardo is investigating the biology of commercially, ecologically and culturally relevant marine invertebrates throughout their life cycle.


2021 ◽  
Vol 27 (2) ◽  
pp. 133-145
Author(s):  
E. N. Dudinskaya ◽  
L. V. Matchekhina ◽  
K. A. Eruslanova ◽  
O. A. Dogotar ◽  
L. P. Ryltseva ◽  
...  

The review summarizes the data of past two decades on the effect of hypertension on vascular aging and considers the effect of chronic inflammation and oxidative stress patterns on the remodeling of cardiovascular system. Clinical studies on the effect of various classes of antihypertensive drugs on age-associated parameters of vascular aging are discussed. These include endothelial dysfunction and arterial assessed by endothelium-dependent vasodilation, pulse wave velocity, augmentation index, cardiovascular index, thickness of the intima-media complex, and so on.


Author(s):  
Jom’ehToloo Riazi

This paper aims to analyze a weekly magazine called Ketab-e-Jom’eh (Friday’s Book) and the reflection of Latin American’s revolutionary movements in it. Ketab-e-Jom’eh, published from July 26, 1979, to May 22, 1980, was supervised by a number of the most legendary Iranian authors and poets, such as Ahmad Shamloo1 and Gholam Hossein Saedi. I focus on the way a particular perspective on Latin American movements is constructed and perpetuated among Ketab-e-Jom’eh’s lectors. With a symbolic approach, I analyze those texts through their symbolic representation in the Iranian society, which requires me to study those symbols and their concomitant relevance in Iran. Eventually, I will use an interpretative approach to examine this magazine’s ideologically motivated articles in the broader context of the Iranian society with its particular traits. The dialectic relationship between literature and society helps us understand literature as the product of social conditions and influential factors in society. The position that I develop here echoes Louis de Bonald’s belief that “through a careful reading of any nation’s literature ‘one could tell what this people had been’” (as cited in Hall, 1979, p. 13). I employ such an expansive horizon to scrutinize the selection of literature on Latin American guerillas. I shall unfold the magazine’s ideological orientation from the angle of the context in which it is used. I aim to show that the historical context of the Iranian society at the moment gives those articles specific meanings. In pursuit of my goals, I will recontextualize the articles to determine their primary significance in the Iran of the 1970s and 1980s.


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