scholarly journals Peripheral Inflammatory Biomarkers of Methamphetamine Withdrawal Patients Based on the Neuro-Inflammation Hypothesis: The Possible Improvement Effect of Exercise

2021 ◽  
Vol 12 ◽  
Author(s):  
Jingsong Wang ◽  
Chunxia Lu ◽  
Lan Zheng ◽  
Jun Zhang
Keyword(s):  
Resistance Training ◽  
Drug Use ◽  
Exercise Group ◽  
Control Group ◽  
Peripheral Inflammation ◽  
Analog Scale ◽  
Withdrawal Time ◽  
Tnf Α ◽  
Improvement Effect ◽  
Neuro Inflammation

Methamphetamine (MA) induced addiction and neuroinflammation has been implicated. Based on the neuroinflammation hypothesis, this study aims to investigate how exercise influences the craving of patients in MA withdrawal, and explore the mechanism of peripheral inflammation. A total of 90 patients in MA withdrawal were recruited. No difference was noted in the number of years of drug use and the frequency of drug use among patients, and the withdrawal time was within 2 months. The subjects were grouped based on the degree of craving induced by the cues: non-craving control group (NCC group), craving control group (CC group), and craving exercise group (CE group). The CE group was subjected to aerobic combined resistance training. Then, the ELISA method was used to detect plasma IL-6, TNF-α, and IL-1β concentrations; Visual Analog Scale (VAS) measurement of cue-induced cravings under Virtual Reality (VR) exposure (VR-VAS) and the Desires for Drug Questionnaire (DDQ) were used to assess cravings. Consequently, plasma IL-6, TNF-α, IL-1β, levels, and the VR-VAS and DDQ scores of MA withdrawal patients were significantly reduced after exercise. This study confirmed that 8 weeks of incremental load aerobic combined with resistance training reduces peripheral inflammation and significantly reduces the level of craving for MA.

scholarly journals Peripheral inflammatory biomarkers of methamphetamine withdrawal based on the neuro-inflammation hypothesis: the possible improvement effect of exercise

2021 ◽  
Author(s):  
Jingsong Wang ◽  
Chunxia Lu ◽  
Lan Zheng ◽  
Jun Zhang
Keyword(s):  
Resistance Training ◽  
Analogue Scale ◽  
Plasma Concentrations ◽  
Exercise Group ◽  
Control Group ◽  
Peripheral Inflammation ◽  
Elisa Method ◽  
Tnf Α ◽  
Improvement Effect ◽  
Neuro Inflammation

Abstract Background Investigate how exercise affects the desire for methamphetamine (MA) withdrawal and to explore the mechanisms of peripheral inflammation. Methods Ninety methamphetamine withdrawal patients participated enrolled in the study. The subjects were grouped according to the degree of craving induced by the clues: non craving control group (NCC group), craving control group (CC group) and craving exercise group (CE group). The CE group performed aerobic combined resistance training. The ELISA method was then used to detect plasma IL-6, TNF-α and IL-1β concentrations, Visual Analogue Scale(VAS) measurement of cue-induced cravings under Virtual Reality(VR) exposure (VR-VAS) and the Desires for Drug Questionnaire (DDQ) were used to assess cravings. Results Plasma IL-6, TNF-α, IL-1β, levels as well as the VR-VAS and DDQ scores of methamphetamine withdrawal patients were significantly reduced after exercise; The scores of VR-VAS were positively correlated with the plasma concentrations of IL-6, TNF-α and IL-1β. Conclusions This study confirmed that plasma IL-6, TNF-α and IL-1β can be used as biomarkers of peripheral inflammation in methamphetamine withdrawal patients to predict the degree of craving. At the same time,eight weeks of incremental load aerobic combined with resistance training reduces peripheral inflammation, significantly reduces the level of craving for MA extraction.

scholarly journals PO-071 Effects of Resistance Training of Different Loads on Gastrocnemius Protein, IGF-I and TNF-α in Aging Rats

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Min Jia ◽  
Xiquan Weng ◽  
Sanhua Zhai ◽  
Wentao Lin
Keyword(s):  
Skeletal Muscle ◽  
Resistance Training ◽  
Resistance Exercise ◽  
Protein Content ◽  
Gastrocnemius Muscle ◽  
Load Resistance ◽  
Exercise Group ◽  
Control Group ◽  
Tnf Α ◽  
Igf I

Objective To observe the effects of different load resistance training on skeletal muscle dystrophy in aging rats by observing the expression of protein and protein of IGF-I and TNF-α in aging rats after 8 weeks of different load resistance training. The resistance training delays the theoretical basis for anti-skeletal muscle aging. Methods 40 aging SD rats (18 months old) were randomly divided into a quiet control group, a non-weight-bearing exercise group, 30% of the largest negative recombination, 50% of the largest negative recombination, and 70% of the largest negative recombination. The sports group carried the treadmill movement with the tail load, the slope was 35°, the running speed was 15m/min, the rest was 30s every 15s, the rest was 3min after four cycles, and the three groups were one cycle. The cycle was intermittent for 10 minutes, and the exercise frequency was the next day for 8 weeks. After 8 weeks, the rat gastrocnemius muscle was taken. The protein content of the gastrocnemius muscle was determined by Coomassie brilliant blue method. The contents of IGF-I and TNF-α in the gastrocnemius muscle were determined by enzyme-linked immunosorbent assay. Results After 1.8 weeks of different load resistance exercise, compared with the quiet control group, the skeletal muscle protein content of each exercise group increased, among which 50% of the largest negative recombination and 70% of the largest negative recombination was the most significant (P<0.01). Compared with 70% of the largest negative recombination, the 50% maximum negative recombination content was relatively high (P<0.05); After 8 weeks of different load resistance exercise, compared with the quiet control group, the content of IGF-I in the gastrocnemius of each exercise group was higher than that of the quiet control group, and there was a very significant difference (P<0.01), and 50%. The highest negative recombination and 70% of the largest negative recombination content is the highest; After 8 weeks of different load resistance exercise, compared with the quiet control group, the TNF-α content in the gastrocnemius muscle of the rats in each resistance exercise group increased slightly, and the increase of only 50% of the largest negative recombination was statistically significant (P<0.05), although there were differences between the exercise groups, there was no statistical significance (P>0.05). Conclusions 50% of the maximum weight-bearing resistance training can effectively increase the skeletal muscle muscle protein content of aging SD rats, and it is related to up-regulation of IGF-I factor and down-regulation of TNF-α factor expression by resistance training.

scholarly journals The effects of an individualized exercise intervention on body composition in breast cancer patients undergoing treatment

2007 ◽  
Vol 125 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Claudio Battaglini ◽  
Martim Bottaro ◽  
Carolyn Dennehy ◽  
Logan Rae ◽  
Edgar Shields ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Composition ◽  
Resistance Training ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Exercise Group ◽  
Moderate Intensity ◽  
Control Group ◽  
Breast Cancer Patients

CONTEXT AND OBJECTIVE: Changes in metabolism have been reported in the majority of patients undergoing cancer treatment, and these are usually characterized by progressive change in body composition. The effects of aerobic exercise programs to combat the cancer and cancer treatment-related side effects, which include the negative changes in body composition, have been extensively reported in the literature. However, few resistance exercise intervention studies have hypothesized that breast cancer patients might benefit from this type of exercise. The purpose of this study was to determine whether exercise protocols that emphasize resistance training would change body composition and strength in breast cancer patients undergoing treatment. DESIGN AND SETTING: Randomized controlled trial, at the Campus Recreation Center and Rocky Mountain Cancer Rehabilitation Institute of the University of Northern Colorado, and the North Colorado Medical Center. METHODS: Twenty inactive breast cancer patients were randomly assigned to a 21-week exercise group (n = 10) or a control group (n = 10). The exercise group trained at low to moderate intensity for 60 minutes on two days/week. The primary outcome measurements included body composition (skinfold method) and muscle strength (one repetition maximum). RESULTS: Significant differences in lean body mass, body fat and strength (p = 0.004, p = 0.004, p = 0.025, respectively) were observed between the groups at the end of the study. CONCLUSION: The results suggest that exercise emphasizing resistance training promotes positive changes in body composition and strength in breast cancer patients undergoing treatment.

scholarly journals The Resistance Training Reverses Insulin Resistance in Rats with Periodontitis

2021 ◽  
Vol 25 (273) ◽  
pp. 97-113
Author(s):  
Max Sander de Oliveira da Mota ◽  
Maria Sara de Lima Coutinho Mattera ◽  
Thaís Verônica Saori Tsosura ◽  
Fernando Yamamoto Chiba ◽  
Renato Felipe Pereira ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Resistance Training ◽  
Periodontal Disease ◽  
Control Group ◽  
Disease Group ◽  
Western Blot Method ◽  
Tnf Α ◽  
Significant Difference ◽  
Male Wistar Rats

The present study, aimed to evaluate the effects of resistance training (RT) on glycemia, insulinemia, insulin sensitivity, insulin signaling (IS), and tumor necrosis factor-α (TNF-α) levels in rats with periodontitis. 40 male Wistar rats were distributed into 4 groups: sedentary control group (SCN), exercised control group (ExCN), sedentary ligature-induced periodontal disease group (SPD), and exercised ligature-induced periodontal disease group (ExPD). 28 days after inducing periodontitis the RT started (14-week). Glycemia, insulin, TNF-α levels, and insulin sensitivity were analyzed using various methods. IS was evaluated by measuring tyrosine phosphorylated pp185 in insulin-sensitive tissues (western blot method). Higher levels of insulin, HOMA-IR, and TNF-α, and a decrease in insulin sensitivity were observed in the SPD group, which also had decreased levels of insulin-stimulated tyrosine phosphorylated pp185 in muscle and adipose tissue, when compared to the other groups. The ExPD group had increased levels of insulin-stimulated tyrosine phosphorylated pp185 compared to the SPD group, but showed no significant difference when compared to the SCN and ExCN groups. RT reversed both the insulin resistance (IR) and the IS alterations in rats with induced periodontitis, and decreased the insulin and TNF-α levels. Therefore, the results of show the importance of RT in preventing or reversing IR in rats with periodontitis.

Assessing differential responders and mean changes in muscle size, strength, and the crossover effect to 2 distinct resistance training protocols

2020 ◽  
Vol 45 (5) ◽  
pp. 463-470 ◽  
Author(s):  
Scott J. Dankel ◽  
Zachary W. Bell ◽  
Robert W. Spitz ◽  
Vickie Wong ◽  
Ricardo B. Viana ◽  
...  
Keyword(s):  
Resistance Training ◽  
Random Error ◽  
Muscle Hypertrophy ◽  
Muscle Thickness ◽  
Exercise Group ◽  
Muscle Size ◽  
Control Group ◽  
Crossover Effect ◽  
Traditional Group ◽  
Training Protocols

The objective of this study was to determine differences in 2 distinct resistance training protocols and if true variability can be detected after accounting for random error. Individuals (n = 151) were randomly assigned to 1 of 3 groups: (i) a traditional exercise group performing 4 sets to failure; (ii) a group performing a 1-repetition maximum (1RM) test; and (iii) a time-matched nonexercise control group. Both exercise groups performed 18 sessions of elbow flexion exercise over 6 weeks. While both training groups increased 1RM strength similarly (∼2.4 kg), true variability was only present in the traditional exercise group (true variability = 1.80 kg). Only the 1RM group increased untrained arm 1RM strength (1.5 kg), while only the traditional group increased ultrasound measured muscle thickness (∼0.23 cm). Despite these mean increases, no true variability was present for untrained arm strength or muscle hypertrophy in either training group. In conclusion, these findings demonstrate the importance of taking into consideration the magnitude of random error when classifying differential responders, as many studies may be classifying high and low responders as those who have the greatest amount of random error present. Additionally, our mean results demonstrate that strength is largely driven by task specificity, and the crossover effect of strength may be load dependent. Novelty Many studies examining differential responders to exercise do not account for random error. True variability was present in 1RM strength gains, but the variability in muscle hypertrophy and isokinetic strength changes could not be distinguished from random error. The crossover effect of strength may differ based on the protocol employed.

Muscle fiber size increases following resistance training in multiple sclerosis

2010 ◽  
Vol 16 (11) ◽  
pp. 1367-1376 ◽  
Author(s):  
U Dalgas ◽  
E Stenager ◽  
J Jakobsen ◽  
T Petersen ◽  
K Overgaard ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Resistance Training ◽  
Muscle Fiber ◽  
Muscle Fibers ◽  
Exercise Group ◽  
Control Group ◽  
Fiber Types ◽  
Lower Body ◽  
Progressive Resistance Training ◽  
Fiber Size

Objective: To test the hypothesis that lower body progressive resistance training (PRT) leads to an increase of the muscle fiber cross-sectional area (CSA) and a shift in the proportion of fiber types in patients with multiple sclerosis (MS). Methods: The present study was a two-arm, randomized controlled trial (RCT). Thirty-eight MS patients (Expanded Disability Status Scale (EDSS) 3—5.5) were randomized to a PRT group (Exercise, n = 19) or a control group (Control, n = 19). The Exercise group performed a biweekly 12-week lower body PRT program [five exercises progressing from 15RM (Repetition Maximum) towards 8RM], whereas the Control group maintained their usual daily activity level during the trial period. Muscle biopsies from vastus lateralis were taken before (pre) and after the trial (post). Thigh volume (TV) was estimated from anthropometric measurements. Isokinetic muscle strength of the knee extensors (KE) and flexors (KF) were evaluated at slow (90°/s) and fast (180°/s) angular velocities. Results: In the Exercise group the mean CSA of all muscle fibers (7.9 ± 15.4% vs. -3.5 ± 9.0%, p = 0.03) and of type II muscle fibers (14.0 ± 19.4% vs. -2.6 ± 15.5%, p = 0.02) increased in comparison with the Control group. No changes occurred in the proportion of fiber types in the Exercise group. Neither was there any change in total TV. Isokinetic strength at KE180, KF90 and KF180 improved significantly after PRT when compared with the control group (10.2—21.3%, p ≤ 0.02). Conclusions: We conclude that progressive resistance training induces a compensatory increase of muscle fiber size in patients with the central nervous system disorder, multiple sclerosis.

scholarly journals What Happens to Adipokines and Cytokine in Overweight and Obese Girls with Central Precocious Puberty When They Exercise and Stop Exercising? A randomized Controlled Trial

2021 ◽  
Author(s):  
Elnaz Shokri ◽  
Ali Heidarian pour ◽  
Zahra Razavi
Keyword(s):  
Precocious Puberty ◽  
Training Session ◽  
Exercise Group ◽  
Trial Registration ◽  
Control Group ◽  
Blood Samples ◽  
Combined Exercise ◽  
Tnf Α ◽  
Significant Difference ◽  
And Control

Abstract Background we investigate the levels of adiponectin, resistin, tumor necrosis factor-alpha (TNF-α) and signs of puberty progression after 12-weeks of combined exercise and 4-weeks of detraining. Methods Thirty overweight and obese girls (age7-9) with precocious puberty who injected Differlin were randomly divided into two groups (exercise and control). At the beginning, blood samples were obtained from all subjects and serum levels of adiponectin, resistin and TNF-α were measured. Exercise group performed 60minutes of combined (aerobic and resistance) exercises 3 times a week for 12-weeks.Control group did not receive any exercise. 48 hours after the last training session and after four weeks of detraining, blood samples were collected in the second and third stage, respectively. Blood samples were collected from the control group in both steps. BMI, cholesterol, triglyceride, signs of puberty progression (bone age, uterine lengths, ovarian volumes), luteinising hormone (LH) and follicle-stimulating hormone (FSH) were measured on all three occasions. Results In the exercise group, adiponectin significantly increased and resistin significantly decreased after 12-weeks. After 4-weeks of detraining, adiponectin significantly decreased and resistin significantly increased. TNF-α levels did not change significantly during the study. There was no significant difference in all of the factors in the control group. Throughout the 16-week study period, the rate of puberty and LH significantly decreased in both exercise and control groups but FSH and LH/FSH significantly decreased in exercise group, alone. Conclusion Combined exercise increased adiponectin and decreased resistin and rate of puberty. After 4-weeks of detraining, these effects diminished but did not disappear. Trial registration: Trial registration: ISRCTN, ISRCTN39938. Registered 24 may 2021 - Retrospectively registered, https://www.isrctn.com/trialist

scholarly journals Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Elnaz Shokri ◽  
Ali Heidarianpour ◽  
Zahra Razavi
Keyword(s):  
Precocious Puberty ◽  
Repeated Measures ◽  
Training Session ◽  
User Profile ◽  
Exercise Group ◽  
Control Group ◽  
Ovarian Volume ◽  
Combined Exercise ◽  
Tnf Α ◽  
Significant Difference

Abstract Background The prevalence of precocious puberty is increasing. Obesity has been demonstrated to be associated with changes in the adipokine profile and incidence of early puberty in girls. This study assessed the pubertal signs, the levels of adiponectin, resistin, and tumor necrosis factor-alpha (TNF-α) after 12 weeks of combined exercise and 4 weeks of detraining in overweight and obese girls with precocious puberty. Methods Thirty overweight and obese girls (aged 7–9) with precocious puberty, who had received Triptorelin, were randomly divided into two groups (15 exercise and 15 control). Initially, serum levels of adiponectin, resistin, TNF-α, luteinising hormone (LH), and follicle-stimulating hormone (FSH) and the signs of puberty progression (bone age, uterine length, and ovarian volume) were measured. The exercise group performed 60 min of combined (aerobic and resistance) exercise three times/week for 12 weeks. The control group did not receive any exercise. 48 h after the last training session and after 4 weeks of detraining, all research variables were measured (also in the control group). The statistical method used for data analysis was repeated measures ANOVA. Results In the exercise group, adiponectin significantly increased and resistin significantly decreased after 12 weeks. After 4 weeks of detraining, adiponectin significantly decreased, but resistin significantly increased. TNF-α levels did not change significantly during the study. There was no significant difference in all of the factors in the control group. Throughout the 16-week study period, the rate of puberty and LH significantly decreased in both exercise and control groups, but FSH, LH/FSH and ovarian volume significantly decreased in the exercise group alone (P<0.05). Conclusions Combined exercise increased adiponectin and decreased resistin and the rate of puberty. However, after 4 weeks of detraining, these effects diminished but did not disappear. Trial registration IRCT, IRCT56471. Registered 25 may 2021 - Retrospectively registered, https://fa.irct.ir/user/profile

scholarly journals PO-241 Effects of Aerobic Exercise on Activation of Neuroglia Cell and Expression of Inflammatory Factors in Aging Rats

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Yaya Xiong ◽  
Jia Jia ◽  
Xuanming Hao
Keyword(s):  
Aerobic Exercise ◽  
Exercise Intervention ◽  
Exercise Group ◽  
Inflammatory Factors ◽  
Control Group ◽  
Sprague Dawley ◽  
Tnf Α ◽  
Significant Difference ◽  
Group A ◽  
Aging Models

Objective In recent years, aerobic exercise has been considered as a method of anti-aging. The aging mechanism in nervous system is closely related to increased activation of neuroglia cells and progressing neuroinflammation with aging.This study tried to shed some light on relationship between chronic inflammation accumulation and aerobic exercise so as to understand how exercise intervened nervous aging through inflammation. In this study, we used D- galactose aging models, applying two intervention ways: aerobic exercise during aging process, after that, to explore the changes of astrocytes, microglia and TNF-α expression. This study aims to provide certain evidence that sport plays a role in anti-aging. Methods Fifty male Sprague-Dawley rats at age of eight weeks, are randomly divided into five groups: control group(A), Aging group(S), Aging while exercising group(YS), After aging Quiet group(SA), After aging exercise group(SY). The aging groups were subcutaneously injected with D- galactose 150mg / kg / d for six weeks. Group YS do swimming exercise three times a week,once 60 minutes in the first six weeks. SY had same exercise intervention in the 7-12 week after injection. We took the hippocampus of rats in A, S, YS at the end of the sixth week, and of those in SA, SY at the end of twelfth week. tested the expression of GFAP, CD11b and TNF-α by immunohistochemical staining. Results 1.GFAP immunohistochemistry: Compared with group A,The expression of GFAP in group S, YS, SA and SY was significantly increased (P<0.01). Compared with group S, The expression of GFAP in group YS significantly decreased by 20.5% (P<0.01). There is no significant difference between group SA and SY(P > 0.05). 2.CD11b immunohistochemistry: Compared with group A, The expression of CD11b in group S, YS, SA and SY was significantly increased (P<0.01). Compared with group S, The expression of CD11b in group YS decreased by 18.4% (P < 0.05).There is no significant difference between group SA and SY(P > 0.05). 3.TNF-α Immunohistochemistry: Compared with group A,The expression of TNF-α in group S, YS, SA and SY was significantly increased (P<0.01). Compared with group S, The expression of TNF-α in group YS decreased by 30.1% (P < 0.01).There is no significant difference between group SA and SY(P > 0.05). Conclusions Exercise could effectively delay aging progression through improving neuroinflammation, but hard to reverse it, so the earlier in age to exercise, the better to delay aging.  

scholarly journals Exercise preserves muscle mass and force in a prostate cancer mouse model

2019 ◽  
Vol 29 (4) ◽  
Author(s):  
Darpan I. Patel ◽  
Kira Abuchowski ◽  
Bilal Sheikh ◽  
Paul Rivas ◽  
Nicolas Musi ◽  
...  
Keyword(s):  
Grip Strength ◽  
Muscle Mass ◽  
Wheel Running ◽  
Exercise Group ◽  
Control Group ◽  
Mouse Prostate ◽  
Tnf Α ◽  
Significant Difference ◽  
Treatment Naïve ◽  
Gastrocnemius Muscles

The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04). Myostatin was significantly lower in the exercise group compared to controls (p=0.01). Exercise mice maintained forelimb grip force while control mice had a significaint decrease (p=0.01). No significant difference was observed in pre-post all limb grip strength. Further, forelimb and all limb grip strength was negatively associated with tumor mass (p<0.01).

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