Long-Term Trends in Unintentional Fall Mortality in China: A Population-Based Age-Period-Cohort Study

Background: Unintentional falls seriously threaten the life and health of people in China. This study aimed to assess the long-term trends of mortality from unintentional falls in China and to examine the age-, period-, and cohort-specific effects behind them.Methods: This population-based multiyear cross-sectional study of Chinese people aged 0–84 years was a secondary analysis of the mortality data of fall injuries from 1990 to 2019, derived from the Global Burden of Disease Study 2019. Age-standardized mortality rates of unintentional falls by year, sex, and age group were used as the main outcomes and were analyzed within the age-period-cohort framework.Results: Although the crude mortality rates of unintentional falls for men and women showed a significant upward trend, the age-standardized mortality rates for both sexes only increased slightly. The net drift of unintentional fall mortality was 0.13% (95% CI, −0.04 to 0.3%) per year for men and −0.71% (95% CI, −0.96 to −0.46%) per year for women. The local drift values for both sexes increased with age group. Significant age, cohort, and period effects were found behind the mortality trends of the unintentional falls for both sexes in China.Conclusions: Unintentional falls are still a major public health problem that disproportionately threatens the lives of men and women in China. Efforts should be put in place urgently to prevent the growing number of fall-related mortality for men over 40 years old and women over 70 years old. Gains observed in the recent period, relative risks (RRs), and cohort RRs may be related to improved healthcare and better education.

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Mortality Rates and Trends in Massachusetts Before 1860

The Journal of Economic History ◽

10.1017/s002205070007546x ◽

1972 ◽

Vol 32 (1) ◽

pp. 184-213 ◽

Cited By ~ 48

Author(s):

Maris A. Vinovskis

Keyword(s):

United States ◽

Nineteenth Century ◽

Mortality Rate ◽

The United States ◽

Mortality Rates ◽

Mortality Data ◽

Different Types ◽

Long Term Trends ◽

Different Sources

The study of mortality rates and trends in the United States before 1860 has been rather unsystematic to date. Most scholars have been content to estimate the mortality rate at some point in time and only a few serious efforts have been made to ascertain the long-term trends in mortality. Particularly lacking are efforts to relate estimates of mortality in the seventeenth and eighteenth centuries to those of the nineteenth century. In addition, the few studies that have attempted to discuss long-term trends in American mortality have been forced to rely on estimates of mortality gathered from different sources and based on different techniques of analysis. Unfortunately, almost no efforts have been made to estimate possible biases introduced when comparing mortality data from different types of records.

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PMS11 LONG-TERM MORTALITY RATES AFTER INCIDENT FRACTURES IN A POPULATION-BASED COHORT OF MEN AND WOMEN

Value in Health ◽

10.1016/s1098-3015(10)75151-2 ◽

2009 ◽

Vol 12 (7) ◽

pp. A435

Author(s):

S Morin ◽

M Azimaee ◽

L Lix ◽

C Metge ◽

P Caetano ◽

...

Keyword(s):

Mortality Rates ◽

Population Based ◽

Men And Women ◽

Long Term Mortality

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Abstract P265: Physical Activity is Inversely Associated with Multimorbidity in Men: Results from the Population-Based KORA-Age Augsburg Study

Circulation ◽

10.1161/circ.125.suppl_10.ap265 ◽

2012 ◽

Vol 125 (suppl_10) ◽

Author(s):

Christine S Autenrieth ◽

Inge Kirchberger ◽

Margit Heier ◽

Anja Zimmermann ◽

Annette Peters ◽

...

Keyword(s):

Physical Activity ◽

Chronic Diseases ◽

Large Population ◽

Public Health Problem ◽

The Elderly ◽

Population Based ◽

P Value ◽

Major Public Health Problem ◽

Inverse Association ◽

Men And Women

Background: The co-occurrence of two or more chronic diseases in one individual, commonly known as multimorbidity, has become a major public health problem among the elderly. Physical activity has proven to be an essential means to mitigate chronic morbidity and disability. Therefore, we hypothesized that physical activity was inversely associated with multimorbidity. Currently, epidemiological studies addressing this research question are lacking. Methods: Using data from 1,007 men and women aged 65–94 years who participated in the population-based KORA-Age project conducted in Augsburg/Germany and two adjacent counties in 2009, thirteen chronic conditions were identified through a standardized telephone interview and a self-administered questionnaire. Physical activity scores were calculated based on the self-reported physical activity scale for the elderly (PASE), comprised of occupational, household and leisure activity items. Sex-specific logistic regression adjusted for age, BMI, education, and nutritional status was applied to determine the relation of the continuous physical activity score and multimorbidity (yes/no). Results: Multimorbidity was prevalent in 62.3% and 68.5% for men and women, respectively. Physical activity (mean PASE score ± SD) was higher in men (125.1 ± 59.2) than in women (112.2 ± 49.2). Among men, the OR for multimorbidity was 0.57 (95% CI: 0.41–0.78) for a 100-unit increase in the PASE score. No significant results could be observed for women (OR: 1.17; 95% CI: 0.73–1.89) (p-value for sex interaction=0.271). Additional analyses of physical activity quartiles showed that the effect among men were mainly observed in the highest quartile versus the lower ones (Figure 1). Conclusion: Our data suggest an inverse association between physical activity and multimorbidity in men, but not in women. Physical activity may counteract the development or progression of chronic diseases in men; further large population-based studies are needed to explore the possible sex-differences.

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Secular Trends of Suicide in the City of São Paulo, 1904–2017

Crisis ◽

10.1027/0227-5910/a000816 ◽

2021 ◽

Author(s):

Daniel Hideki Bando ◽

Maria Helena Prado de Mello Jorge ◽

Eliseu Alves Waldman ◽

Fernando Madalena Volpe ◽

David Lester

Keyword(s):

Sao Paulo ◽

Mortality Data ◽

Age Group ◽

São Paulo ◽

Upward Trend ◽

Public Health Agencies ◽

Suicide Rates ◽

Health Agencies ◽

Long Term Trends

Abstract. Background: Few reports from developing countries have described long-term trends in suicide. Aims: To investigate the age-, sex-, and method-specific trends in suicide over the period 1904–2017 in São Paulo. Method: Mortality data were obtained from SEADE, DATASUS, and PRO-AIM. Results: Suicide peaked in the mid-1910s and mid-1950s, being higher among men. There was an upward trend from the 1920s for men and from the 1930s for women. Suicide rates have declined since the mid-1950s, reaching lower rates in the past 40 years. Men aged 60+ had higher rates at the beginning and a decreasing trend. Suicide rates among men aged 20–39 and 40–59 peaked in the mid-1950s and declined until the late 1970s, thereafter remaining stable. Women aged 20–39 years had the highest rates with decreasing trends from the mid-1950s. No trends were detected for the age group 40–59, and women aged 60+ presented a decreasing trend. Rates among women aged 0–19 declined after the late 1970s. Suicide by poisoning peaked in the 1950s, and there was a downward trend for firearms and an upward trend for hanging. Conclusion: Suicide trends vary by sex, age group, and method. Accurate monitoring of these trends is an important task for suicide prevention and public health agencies and personnel.

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GAMBARAN KEJADIAN TUBERKULOSIS DI KABUPATEN PATI

Jurnal Litbang Media Informasi Penelitian Pengembangan dan IPTEK ◽

10.33658/jl.v13i2.100 ◽

2017 ◽

Vol 13 (2) ◽

pp. 115-126

Author(s):

Dwi Murtono

Keyword(s):

Public Health ◽

Descriptive Analysis ◽

Public Health Problem ◽

Secondary Data ◽

Major Public Health Problem ◽

Age Group ◽

Men And Women ◽

Group 4 ◽

The World ◽

Positive Smear

ENGLISHTuberculosis is one of the long-known diseases and still becomes the leading cause of death in the world. The TB incidence needs a serious attention because it is a major public health problem. The objective of the study was to describe the TB incidence in Pati Regency in the period 2014-2016. It used quantitative and descriptive approaches. Secondary data sourced from Integrated Tuberculosis Information System (SITT) period 2014-2016 at Health Service of Pati Regency. Data were classified based on sex, TB classification, and age. Data were tested using descriptive analysis. The results of the study were: (1) The TB incidence showed an increase, (2) The increase of TB incidence was found both in men and women, but the number of TB cases was higher in men compared to the counterparts. (3) The number of TB cases increased in all TB classification groups, which the highest was found in positive smear pulmonary group. (4) The number of TB cases rose along with the increase of age, which the majority cases occurred in the productive age group. INDONESIATuberkulosis (TB) merupakan salah satu penyakit yang telah lama dikenal dan sampai saat ini masih menjadi penyebab utama kematian di dunia. Kejadian TB perlu mendapat perhatian serius karena TB merupakan masalah kesehatan publik mayor. Tujuan penelitian ini adalah untuk memberikan gambaran kejadian TB di Kabupaten Pati dalam kurun waktu tahun 2014-2016. Penelitian ini menggunakan pendekatan deskriptif kuantitatif. Data sekunder berasal dari Sistem Informasi Tuberculosis Terpadu (SITT) Kabupaten Pati tahun 2014-2016 dari Dinas Kesehatan Kabupaten Pati. Data diolah berdasarkan jenis kelamin, klasifikasi TB dan umur penderita TB. Analisis data dilakukan secara deskriptif. Hasil penelitian adalah (1) angka kejadian TB menunjukkan adanya peningkatan; (2) angka kejadian TB berdasarkan klasifikasi jenis kelamin lebih banyak ditemukan pada jenis kelamin laki-laki dan menunjukkan terjadi peningkatan kejadian TB baik untuk laki-laki maupun perempuan; (3) angka kejadian TB berdasarkan klasifikasi TB secara umum menunjukkan terjadi peningkatan dan mayoritas kejadian adalah TB paru BTA positif; (4) kejadian TB mengalami peningkatan seiring dengan bertambahnya umur. Secara umum, kejadian TB paling besar terjadi pada usia produktif.

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Childhood cancer incidence and survival trends in Estonia (1970–2016): a nationwide population-based study

BMC Cancer ◽

10.1186/s12885-019-6510-7 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Keiu Paapsi ◽

Aleksei Baburin ◽

Sirje Mikkel ◽

Margit Mägi ◽

Kadri Saks ◽

...

Keyword(s):

Health Care ◽

Childhood Cancer ◽

Cancer Incidence ◽

Population Based ◽

Major Public Health Problem ◽

Population Based Study ◽

Incidence Trends ◽

Depth Analysis ◽

Long Term Trends

Abstract Background Childhood cancers represent a small proportion of all cancers but are still a major public health problem. The study analysed long-term trends in childhood cancer incidence and survival in Estonia in relation to societal and health care transition. Methods Data on all malignant tumours, diagnosed in children aged 0–14 during 1970–2016, were derived from the Estonian Cancer Registry. Age-standardised (World standard) incidence rates were calculated by ICCC-3 site groups and joinpoint regression was used to estimate annual percentage change (APC) for incidence trends. Cohort and period approach were used to estimate 5-year survival. Internal age standardisation was applied. Results A total of 1628 incident cancer cases were diagnosed during the study period and overall incidence increased significantly at a rate of 0.5% per year. Significant increases were seen for neuroblastoma and germ cell tumours, for lymphoid leukemias and some CNS sub-sites. At the same time, decline in incidence was seen in almost all subgroups of unspecified neoplasms. The overall 5-year survival improved from 24% in 1970–1979 to 73% in 2010–2016, with the largest changes occurring in the 1990s and 2000s. For many sites, survival increase thereafter has been marginal. Conclusion In this first comprehensive population-based study of childhood cancer incidence and survival in Estonia, long-term trends are shown in the context of societal and health care changes. Even though the increasing incidence of some sites may, at least partially, be explained by improved diagnostics reflected in the decreased incidence of unspecified neoplasms, the overall cancer incidence in children seems to be rising. Rapid progress in diagnosis and care have improved childhood cancer survival immensely, but deficit in Estonia persists compared to other European countries. Results of the study accentuate the need for a more in-depth analysis of clinical data, but also for the prioritization of childhood cancer in Estonia, to ensure access to standard care and innovative treatments.

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Childhood cancer incidence and survival trends in Estonia (1970–2016): a nationwide population-based study

10.21203/rs.2.19883/v1 ◽

2020 ◽

Author(s):

Keiu Paapsi ◽

Aleksei Baburin ◽

Sirje Mikkel ◽

Margit Mägi ◽

Kadri Saks ◽

...

Keyword(s):

Health Care ◽

Childhood Cancer ◽

Cancer Incidence ◽

Population Based ◽

Major Public Health Problem ◽

Population Based Study ◽

Incidence Trends ◽

Depth Analysis ◽

Long Term Trends

Abstract Background: Childhood cancers represent a small proportion of all cancers but are still a major public health problem. The study analysed long-term trends in childhood cancer incidence and survival in Estonia in relation to societal and health care transition. Methods: Data on all malignant tumours, diagnosed in children aged 0–14 during 1970–2016, were derived from the Estonian Cancer Registry. Age-standardised (World standard) incidence rates were calculated by ICCC-3 site groups and joinpoint regression was used to estimate annual percentage change (APC) for incidence trends. Cohort and period approach were used to estimate 5-year survival. Internal age standardisation was applied. Results: A total of 1628 incident cancer cases were diagnosed during the study period and overall incidence increased significantly at a rate of 0.5% per year. Significant increases were seen for neuroblastoma and germ cell tumours, for lymphoid leukemias and some CNS sub-sites. At the same time, decline in incidence was seen in almost all subgroups of unspecified neoplasms. The overall 5-year survival improved from 24% in 1970–1979 to 73% in 2010–2016, with the largest changes occurring in the 1990s and 2000s. For many sites, survival increase thereafter has been marginal. Conclusion: In this first comprehensive population-based study of childhood cancer incidence and survival in Estonia, long-term trends are shown in the context of societal and health care changes. Even though the increasing incidence of some sites may, at least partially, be explained by improved diagnostics reflected in the decreased incidence of unspecified neoplasms, the overall cancer incidence in children seems to be rising. Rapid progress in diagnosis and care have improved childhood cancer survival immensely, but deficit in Estonia persists compared to other European countries. Results of the study accentuate the need for a more in-depth analysis of clinical data, but also for the prioritization of childhood cancer in Estonia, to ensure access to standard care and innovative treatments.

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Haematological profile of children with malaria in Sorong, West Papua, Indonesia

Malaria Journal ◽

10.1186/s12936-021-03638-w ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Syilvia Jiero ◽

Ayodhia Pitaloka Pasaribu

Keyword(s):

Malaria Infection ◽

Clinical Symptoms ◽

Public Health Problem ◽

Malaria Diagnosis ◽

White Blood Count ◽

P Value ◽

Major Public Health Problem ◽

Age Group ◽

Haematological Profile ◽

West Papua

Abstract Background Malaria remains a major public health problem in Indonesian Papua, with children under five years of age being the most affected group. Haematological changes, such as cytopenia that occur during malaria infection have been suggested as potential predictors and can aid in the diagnosis of malaria. This study aimed to assess the haematological alterations associated with malaria infection in children presenting with signs and symptoms of malaria. Methods A retrospective study was performed by collecting data from the medical records of malaria patients at Sorong Regional General Hospital, Sorong, West Papua, Indonesia, both from outpatient and inpatient clinics, from January 2014 until December 2017. The laboratory profile of children suffering from malaria was evaluated. Results One hundred and eighty-two children aged 1 month to 18 years old were enrolled. The subjects were mostly male (112, 61.5%) with a mean age of 6.45 years (SD = 4.3 years). Children below 5 years of age suffered the most from malaria in this study (77, 42.3%). One hundred two subjects (56%) were infected with Plasmodium falciparum. Half of the enrolled subjects (50%) had haemoglobin level (Hb) between 5.1 and 10 gr/dL. A total of 41 children (53.2%) less than 5 years old suffered from P. falciparum infection. In the age group of 5–10 years, there were 34 children (57.6%) who suffered from P. falciparum, and in the age group > 10 years, 27 children (58.7%) suffered from P. falciparum infection. Only 4 subjects (5.2%) in the less than 5 years old age group had mixed malaria infection. Among eight predictors of the haematological profile, there were five predictors that were significantly associated with the diagnostic criteria, namely haemoglobin, haematocrit, leukocytes, platelets and monocytes (p < 0.05). Generally, clinical symptoms are not significantly associated with a malaria diagnosis, and only one variable showed a significant relationship, pale, with a P value of 0.001. Conclusions Children with malaria had changes in some haematological markers, with anaemia, low platelet count, white blood count, and lymphocyte count being the most important predictors of malaria infection in the study area. These markers could be used to raise suspicion of malaria in children living in high endemic areas, such as West Papua.

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Mortality beyond emergency threshold in a silent crisis– results from a population-based mortality survey in Ouaka prefecture, Central African Republic, 2020

Conflict and Health ◽

10.1186/s13031-021-00385-2 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Eve Robinson ◽

Lawrence Lee ◽

Leslie F. Roberts ◽

Aurelie Poelhekke ◽

Xavier Charles ◽

...

Keyword(s):

Central African Republic ◽

Causes Of Death ◽

Maternal Mortality Ratio ◽

Mortality Rates ◽

Population Based ◽

Access To Healthcare ◽

Mortality Data ◽

Humanitarian Emergency ◽

The World ◽

Mortality Survey

Abstract Background The Central African Republic (CAR) suffers a protracted conflict and has the second lowest human development index in the world. Available mortality estimates vary and differ in methodology. We undertook a retrospective mortality study in the Ouaka prefecture to obtain reliable mortality data. Methods We conducted a population-based two-stage cluster survey from 9 March to 9 April, 2020 in Ouaka prefecture. We aimed to include 64 clusters of 12 households for a required sample size of 3636 persons. We assigned clusters to communes proportional to population size and then used systematic random sampling to identify cluster starting points from a dataset of buildings in each commune. In addition to the mortality survey questions, we included an open question on challenges faced by the household. Results We completed 50 clusters with 591 participating households including 4000 household members on the interview day. The median household size was 7 (interquartile range (IQR): 4—9). The median age was 12 (IQR: 5—27). The birth rate was 59.0/1000 population (95% confidence interval (95%-CI): 51.7—67.4). The crude and under-five mortality rates (CMR & U5MR) were 1.33 (95%-CI: 1.09—1.61) and 1.87 (95%-CI: 1.37–2.54) deaths/10,000 persons/day, respectively. The most common specified causes of death were malaria/fever (16.0%; 95%-CI: 11.0–22.7), violence (13.2%; 95%-CI: 6.3–25.5), diarrhoea/vomiting (10.6%; 95%-CI: 6.2–17.5), and respiratory infections (8.4%; 95%-CI: 4.6–14.8). The maternal mortality ratio (MMR) was 2525/100,000 live births (95%-CI: 825—5794). Challenges reported by households included health problems and access to healthcare, high number of deaths, lack of potable water, insufficient means of subsistence, food insecurity and violence. Conclusions The CMR, U5MR and MMR exceed previous estimates, and the CMR exceeds the humanitarian emergency threshold. Violence is a major threat to life, and to physical and mental wellbeing. Other causes of death speak to poor living conditions and poor access to healthcare and preventive measures, corroborated by the challenges reported by households. Many areas of CAR face similar challenges to Ouaka. If these results were generalisable across CAR, the country would suffer one of the highest mortality rates in the world, a reminder that the longstanding “silent crisis” continues.

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Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm10051082 ◽

2021 ◽

Vol 10 (5) ◽

pp. 1082

Author(s):

Maria-José Montoya-García ◽

Mercè Giner ◽

Rodrigo Marcos ◽

David García-Romero ◽

Francisco-Jesús Olmo-Montes ◽

...

Keyword(s):

Cohort Study ◽

Incidence Rate ◽

Public Health Problem ◽

Osteoporotic Fractures ◽

Fragility Fractures ◽

Population Based ◽

High Morbidity ◽

Major Public Health Problem ◽

Skeletal Site ◽

Mortality Incidence

Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk of a subsequent fracture and mortality. This is a retrospective population-based cohort study (n = 1369) with a fragility fracture. We estimated the incidence rate of index fragility fractures and obtained information on the subsequent fractures and death during a follow-up of up to three years. We assessed the effect of age, sex, and skeletal site of index fracture as independent risk factors of further fractures and mortality. Incidence rate of index fragility fractures was 86.9/10,000 person-years, with highest rates for hip fractures in women aged ≥80 years. The risk of fracture was higher in subjects with a recent fracture (Relative Risk(RR), 1.80; p < 0.01). Higher age was an independent risk factor for further fracture events. Significant excess mortality was found in subjects aged ≥80 years and with a previous hip fracture (hazard ratio, 3.43 and 2.48, respectively). It is the first study in Spain to evaluate the incidence of major osteoporotic fractures, not only of the hip, and the rate of imminent fracture. Our results provide further evidence highlighting the need for early treatment.

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