Data Collection for the Fourth Multicentre Confidential Enquiry into Perioperative Equine Fatalities (CEPEF4) Study: New Technology and Preliminary Results

It is almost 20 years since the largest observational, multicentre study evaluating the risks of mortality associated with general anaesthesia in horses. We proposed an internet-based method to collect data (cleaned and analysed with R) in a multicentre, cohort, observational, analytical, longitudinal and prospective study to evaluate peri-operative equine mortality. The objective was to report the usefulness of the method, illustrated with the preliminary data, including outcomes for horses seven days after undergoing general anaesthesia and certain procedures using standing sedation. Within six months, data from 6701 procedures under general anaesthesia and 1955 standing sedations from 69 centres were collected. The results showed (i) the utility of the method; also, that (ii) the overall mortality rate for general anaesthesia within the seven-day outcome period was 1.0%. In horses undergoing procedures other than exploratory laparotomy for colic (“noncolics”), the rate was lower, 0.6%, and in “colics” it was higher, at 3.4%. For standing sedations, the overall mortality rate was 0.2%. Finally, (iii) we present some descriptive data that demonstrate new developments since the previous CEPEF2. In conclusion, horses clearly still die unexpectedly when undergoing procedures under general anaesthesia or standing sedation. Our method is suitable for case collection for future studies.

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A Review of Non-Operative Treatment of Splenic Trauma

Tropical Doctor ◽

10.1177/004947559502500308 ◽

1995 ◽

Vol 25 (3) ◽

pp. 112-114 ◽

Cited By ~ 2

Author(s):

Isaac Alidria-Ezati

Keyword(s):

Mortality Rate ◽

Exploratory Laparotomy ◽

Splenic Trauma ◽

Close Monitoring ◽

Delayed Bleeding ◽

Blunt Splenic Trauma ◽

Spleen Trauma ◽

Splenic Repair ◽

Splenic Salvage ◽

Overall Mortality

From January 1984 to June 1992, a period of 8.5 years, 60 patients with splenic trauma were treated in Lacor Hospital. The spleen trauma was managed conservatively in 47 (78%) of the patients. Of these, 36 of the patients (60%) were not operated upon. Eleven (18%) were operated upon but nine (15%) patients had exploratory laparotomy only without spleen manipulation and in two (3%) splenic repair was performed. Thirteen (22%) patients had splenectomy. In the non-operative group, recurrent or rebleeding was detected in one patient (2%) and delayed bleeding occurred in five patients (8%). Overall mortality rate was five (8%); two (3%) occurring in splenic salvage and three (5%) in splenectomized patients. It is concluded that with availability of facilities and personnel, in selected cases of blunt splenic trauma, splenic conservation is safe but requires close monitoring.

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INTERNET-BASED PROJECT WORK// Social Sciences: Achievements and Prospects Journal 4(12), 2019/ OEAPS Inc.(Open European Academy of Public Sciences); Chief Editor Mark Freeman - Barcelona, Spain. 16.05.2019: OEAPS Inc., 2019. - pp. 34-40.

10.31219/osf.io/kjn7q ◽

2019 ◽

Author(s):

Zhanna Borisovna Erzhanova ◽

Zhanna Borisovna Erzhanova

Keyword(s):

Social Sciences ◽

New Technology ◽

Chief Editor ◽

Computer Users ◽

Project Work ◽

The Internet ◽

Digital Native ◽

Negative Attitudes ◽

New Developments ◽

European Academy

Some words about attitudes to technology: many people are afraid of new technology and, with the increasing presence of the Internet and computers, the term technophobe has appeared to refer to those of us who might be wary of these new developments. More recently, the term digital native has been coined to refer to someone who grows up using technology, and who thus feels comfortable and confident with it there is a tendency to call computer users either technophobes or technogeeks ( a term for a technology enthusiast) the truth is that most of us probably fall somewhere between the two extremes. A large part of the negative attitudes teachers have towards technology is usually the result of a lack of confidence, a lack of facilities or a lack of training, resulting in an inability to see the benefit of using technologies in the classroom. It is also often the case that teachers may not be fully in control of their work situations. A teacher may want to use more technology in their teaching, but the school may not have the facilities, or, on the other hand, a teacher may be instructed to start using technology for which they feel unprepared or untrained.

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Prospective cohort study of mortality in very low birthweight infants in a single centre in the Eastern Cape province, South Africa

BMJ Paediatrics Open ◽

10.1136/bmjpo-2020-000918 ◽

2021 ◽

Vol 5 (1) ◽

pp. e000918

Author(s):

Isabel A Michaelis ◽

Ingeborg Krägeloh-Mann ◽

Ncomeka Manyisane ◽

Mikateko C Mazinu ◽

Esme R Jordaan

Keyword(s):

South Africa ◽

Cohort Study ◽

Birth Weight ◽

Mortality Rate ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Low Birthweight ◽

Eastern Cape Province ◽

Eastern Cape ◽

Overall Mortality

BackgroundNeonatal mortality is a major contributor worldwide to the number of deaths in children under 5 years of age. The primary objective of this study was to assess the overall mortality rate of babies with a birth weight equal or below 1500 g in a neonatal unit at a tertiary hospital in the Eastern Cape Province, South Africa. Furthermore, different maternal-related and infant-related factors for higher mortality were analysed.MethodsThis is a prospective cohort study which included infants admitted to the neonatal wards of the hospital within their first 24 hours of life and with a birth weight equal to or below 1500 g. Mothers who consented answered a questionnaire to identify factors for mortality.Results173 very low birth weight (VLBW) infants were recruited in the neonatal department between November 2017 and December 2018, of whom 55 died (overall mortality rate 32.0%). Twenty-three of the 44 infants (53,5%) with a birth weight below 1000 g died during the admission. One hundred and sixty-one mothers completed the questionnaire and 45 of their babies died.Main factors associated with mortality were lower gestational age and lower birth weight. Need for ventilator support and sepsis were associated with higher mortality, as were maternal factors such as HIV infection and age below 20 years.ConclusionThis prospective study looked at survival of VLBW babies in an underprivileged part of the Eastern Cape of South Africa. Compared with other public urban hospitals in the country, the survival rate remains unacceptably low. Further research is required to find the associated causes and appropriate ways to address these.

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All-cause mortality and location of death in patients with established cardiovascular disease before, during, and after the COVID-19 lockdown: a Danish Nationwide Cohort Study

European Heart Journal ◽

10.1093/eurheartj/ehab028 ◽

2021 ◽

Cited By ~ 1

Author(s):

Jawad H Butt ◽

Emil L Fosbøl ◽

Thomas A Gerds ◽

Charlotte Andersson ◽

Kristian Kragholm ◽

...

Keyword(s):

Cardiovascular Disease ◽

Mortality Rate ◽

Hospital Mortality ◽

Location Of Death ◽

All Cause Mortality ◽

History Of ◽

Adjusted Incidence Rate ◽

Artery Disease ◽

Adjusted Incidence ◽

Overall Mortality

Abstract Background On 13 March 2020, the Danish authorities imposed extensive nationwide lockdown measures to prevent the spread of the coronavirus disease 2019 (COVID-19) and reallocated limited healthcare resources. We investigated mortality rates, overall and according to location, in patients with established cardiovascular disease before, during, and after these lockdown measures. Methods and results Using Danish nationwide registries, we identified a dynamic cohort comprising all Danish citizens with cardiovascular disease (i.e. a history of ischaemic heart disease, ischaemic stroke, heart failure, atrial fibrillation, or peripheral artery disease) alive on 2 January 2019 and 2020. The cohort was followed from 2 January 2019/2020 until death or 16/15 October 2019/2020. The cohort comprised 340 392 and 347 136 patients with cardiovascular disease in 2019 and 2020, respectively. The overall, in-hospital, and out-of-hospital mortality rate in 2020 before lockdown was significantly lower compared with the same period in 2019 [adjusted incidence rate ratio (IRR) 0.91, 95% confidence interval (CI) CI 0.87–0.95; IRR 0.95, 95% CI 0.89–1.02; and IRR 0.87, 95% CI 0.83–0.93, respectively]. The overall mortality rate during and after lockdown was not significantly different compared with the same period in 2019 (IRR 0.99, 95% CI 0.97–1.02). However, the in-hospital mortality rate was lower and out-of-hospital mortality rate higher during and after lockdown compared with the same period in 2019 (in-hospital, IRR 0.92, 95% CI 0.88–0.96; out-of-hospital, IRR 1.04, 95% CI1.01–1.08). These trends were consistent irrespective of sex and age. Conclusions Among patients with established cardiovascular disease, the in-hospital mortality rate was lower and out-of-hospital mortality rate higher during lockdown compared with the same period in the preceding year, irrespective of age and sex.

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Characteristics and Outcomes of Critically Ill Patients with COVID-19 Disease in Jordan

10.47363/jsar/2020(1)112 ◽

2020 ◽

pp. 1-3

Author(s):

Hasan Ibrahim Al-Balas ◽

Keyword(s):

Health Care ◽

Mortality Rate ◽

Critically Ill ◽

Critically Ill Patients ◽

Tertiary Hospital ◽

Published Data ◽

First Case ◽

Global Health Care ◽

Novel Coronavirus ◽

Overall Mortality

Introduction: Coronavirus disease 2019 (COVID-19) is an emerging global health care threat that is caused by a novel coronavirus named 2019-nCoV (SARS-CoV-2). The first case of diagnosed COVID-19 patient was declared in Jordan in early March 2020. As of June 8, Jordan had confirmed 831 cases, with 9 deaths, with an overall mortality rate of 1.08%. As there is no published data about critically ill patients in Jordan, we aimed to describe the characteristics and outcomes of critically ill COVID-19 patients in a tertiary hospital in Jordan.

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DECREASING PREVALENCE OF THE ACUTE/SUBACUTE CLINICAL FORM OF PARACOCCIDIOIDOMYCOSIS IN MATO GROSSO DO SUL STATE, BRAZIL

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652014000200006 ◽

2014 ◽

Vol 56 (2) ◽

pp. 121-125 ◽

Cited By ~ 10

Author(s):

Larissa Rodrigues Fabris ◽

Úrsulla Vilella Andrade ◽

Aline Ferreira Dos Santos ◽

Ana Paula da Costa Marques ◽

Sandra Maria do Valle Leone de Oliveira ◽

...

Keyword(s):

Mortality Rate ◽

Age Distribution ◽

Epidemiological Data ◽

Infection Prevalence ◽

Age Group ◽

Clinical Form ◽

Mato Grosso ◽

Co Morbidity ◽

Mato Grosso Do Sul ◽

Overall Mortality

With the objective to evaluate the behavior of paracoccidioidomycosis in the last three decades, clinical and epidemiological data of 595 patients admitted to clinical services of the Federal University of Mato Grosso do Sul from 1980 to 2009 were investigated. Gender, age distribution, clinical form, comorbidity with tuberculosis or AIDS, and mortality were compared by decades of clinical admission. It was shown that during the three decades there was a decrease in women percentage, and the same manner occurred a reduction in participants in the age group of 20 to 39 years. Moreover, the acute/subacute forms have been diminished in the period. These fluctuations are closely related and can be simultaneously analyzed. Increased AIDS co-infection prevalence from the first to the second decade was also revealed, coinciding with the appearance of the retroviral epidemic and stabilizing during the third decade. No change in the tuberculosis co-infection rate was observed (overall = 6.9%). It reinforces the importance of this co-morbidity. The overall mortality rate remained steady at 6.7%, not varying significantly from one decade to another. The persistent mortality rate calls attention to the importance of this neglected disease.

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The Effects of Adjuvant Immunoglobulin M-Enriched Immunoglobulin Therapy on Mortality Rate and Renal Function in Sepsis-Induced Multiple Organ Dysfunction Syndrome: Retrospective Analysis of Intensive Care Unit Patients

Journal of International Medical Research ◽

10.1177/147323001204000337 ◽

2012 ◽

Vol 40 (3) ◽

pp. 1166-1174 ◽

Cited By ~ 11

Author(s):

L Yavuz ◽

G Aynali ◽

A Aynali ◽

A Alaca ◽

S Kutuk ◽

...

Keyword(s):

Intensive Care Unit ◽

Renal Function ◽

Intensive Care ◽

Mortality Rate ◽

Organ Dysfunction ◽

Multiple Organ ◽

Apache Ii ◽

Control Group ◽

Multiple Organ Dysfunction ◽

Overall Mortality

OBJECTIVE: To determine the effect of immunoglobulin (Ig)M-enriched Ig therapy on mortality rate and renal function in sepsis-induced multiple organ dysfunction syndrome (MODS), using the Acute Physiology and Chronic Health Evaluation II (APACHE II) score. METHODS: Retrospective study of patients with sepsis-induced MODS treated with standard antibiotic plus supportive therapy (control group) or IgM-enriched Ig therapy adjuvant to control group therapy (IVIg group). Total length of stay in the intensive care unit (ICU), overall mortality rate and 28-day case fatality rate (CFR), as well as APACHE II scores and renal function parameters at day 1 and day 4 of therapy, were recorded. RESULTS: A total of 118 patients were included (control group, n = 62; IVIg group, n = 56). In both groups, day 4 APACHE II scores decreased significantly compared with day 1 scores; the effect of treatment on renal function was minimal. Length of ICU stay, overall mortality rate and 28-day CFR were significantly lower in the IVIg group compared with the control group. CONCLUSIONS: Adding IgM-enriched Ig therapy to standard therapy for MODS improved general clinical conditions and significantly reduced APACHE II scores, overall mortality rate and 28-day CFR, although effects on renal function were minimal.

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The outcome of severe closed head injury

Journal of Neurosurgery ◽

10.3171/sup.1991.75.1s.0s28 ◽

1991 ◽

Vol 75 (Supplement) ◽

pp. S28-S36 ◽

Cited By ~ 355

Author(s):

Lawrence F. Marshall ◽

Theresa Gautille ◽

Melville R. Klauber ◽

Howard M. Eisenberg ◽

John A. Jane ◽

...

Keyword(s):

Head Injury ◽

Mortality Rate ◽

Severe Head Injury ◽

Closed Head Injury ◽

Data Bank ◽

Content Type ◽

Severity Of Injury ◽

Gcs Score ◽

Fine Print ◽

Overall Mortality

✓ The outcome of severe head injury was prospectively studied in patients enrolled in the Traumatic Coma Data Bank (TCDB) during the 45-month period from January 1, 1984, through September 30, 1987. Data were collected on 1030 consecutive patients admitted with severe head injury (defined as a Glasgow Coma Scale (GCS) score of 8 or less following nonsurgical resuscitation). Of these, 284 either were brain-dead on admission or had a gunshot wound to the brain. Patients in these two groups were excluded, leaving 746 patients available for this analysis. The overall mortality rate for the 746 patients was 36%, determined at 6 months postinjury. As expected, the mortality rate progressively decreased from 76% in patients with a postresuscitation GCS score of 3 to approximately 18% for patients with a GCS score of 6, 7, or 8. Among the patients with nonsurgical lesions (overall mortality rate, 31%), the mortality rate was higher in those having an increased likelihood of elevated intracranial pressure as assessed by a new classification of head injury based on the computerized tomography findings. In the 276 patients undergoing craniotomy, the mortality rate was 39%. Half of the patients with acute subdural hematomas died — a substantial improvement over results in previous reports. Outcome differences between the four TCDB centers were small and were, in part, explicable by differences in patient age and the type and severity of injury. This study describes head injury outcome in four selected head-injury centers. It indicates that a mortality rate of approximately 35% is to be expected in such patients admitted to experienced neurosurgical units.

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The effects of general anaesthesia on oxygen consumption: A meta-analysis guiding future studies on perioperative oxygen transport

Acta Anaesthesiologica Scandinavica ◽

10.1111/aas.13265 ◽

2018 ◽

Vol 63 (2) ◽

pp. 144-153 ◽

Cited By ~ 2

Author(s):

Julia Jakobsson ◽

Sofia Vadman ◽

Eva Hagel ◽

Sigridur Kalman ◽

Erzsébet Bartha

Keyword(s):

Oxygen Consumption ◽

General Anaesthesia ◽

Oxygen Transport ◽

Meta Analysis ◽

Future Studies

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Getting around the gut: a unique management challenge of thyroid storm precipitated by amphetamine-associated duodenal ischaemia leading to compromised enteric absorption

BMJ Case Reports ◽

10.1136/bcr-2020-238889 ◽

2021 ◽

Vol 14 (8) ◽

pp. e238889

Author(s):

Jin Sol Gene Lee ◽

Ian Elliott Brown ◽

Alison M Semrad ◽

Amir A Zeki

Keyword(s):

Mortality Rate ◽

Exploratory Laparotomy ◽

Thyroid Storm ◽

Critically Ill Patient ◽

Duodenal Perforation ◽

Mesenteric Ischaemia ◽

Biochemical Control ◽

Clinical Criteria ◽

Life Threatening ◽

Management Challenge

Thyroid storm is a rare, life-threatening endocrine emergency with a high mortality rate of up to 30%. We present a unique management challenge of a critically ill patient who developed thyroid storm in the setting of a duodenal perforation from amphetamine-associated non-occlusive mesenteric ischaemia. The diagnosis of ‘thyroid storm’ was made based on clinical criteria and a Burch-Wartofsky score of 100. During emergent exploratory laparotomy, a 1 cm duodenal perforation with surrounding friable tissue was found and repaired. Intraoperatively, a nasogastric tube was guided distal to the area of perforation to allow for enteric administration of medications, which was critical in the setting of thyroid storm. Therapeutic plasma exchange achieved biochemical control of our patient’s thyroid storm but ultimately did not prevent in-hospital mortality.

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