scholarly journals Regulation of Swine Growth by Backfat Tissue during Growing and Finishing Stages

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3511
Author(s):  
Young-Jun Seo ◽  
Byeonghwi Lim ◽  
Do-Young Kim ◽  
Kyu-Sang Lim ◽  
Jun-Mo Kim
Keyword(s):  
Lipid Metabolism ◽  
Sequencing Analysis ◽  
Hormonal Changes ◽  
Fat Tissue ◽  
Biological Mechanisms ◽  
Gene Network Analysis ◽  
Yorkshire Pigs ◽  
Korean Native Pigs ◽  
Native Pigs ◽  
Core Genes

Recently, interest in the function of pig backfat (BF) has increased in the field of livestock animals, and many transcriptome-based studies using commercial pig breeds have been conducted. However, there is a lack of comprehensive studies regarding the biological mechanisms of Korean native pigs (KNPs) and Yorkshire pig crossbreeds. In this study, therefore, BF samples of F1 crossbreeds of KNPs and Yorkshire pigs were investigated to identify differentially expressed genes (DEGs) and their related terms using RNA-sequencing analysis. DEG analysis identified 611 DEGs, of which 182 were up-regulated and 429 were down-regulated. Lipid metabolism was identified in the up-regulated genes, whereas growth and maturation-related terminologies were identified in the down-regulated genes. LEP and ACTC1 were identified as highly connected core genes during functional gene network analysis. Fat tissue was observed to affect lipid metabolism and organ development due to hormonal changes driven by transcriptional alteration. This study provides a comprehensive understanding of BF contribution to crossbreeds of KNPs and Yorkshire pigs during growth periods.

scholarly journals Sequence-based characterization of the eight SLA loci in Korean native pigs

2008 ◽  
Vol 35 (4-5) ◽  
pp. 333-334 ◽  
Author(s):  
Y. J. Lee ◽  
K. H. Cho ◽  
M. J. Kim ◽  
D. M. Smith ◽  
C. S. Ho ◽  
...  
Keyword(s):  
Korean Native Pigs ◽  
Native Pigs

Establishment of a resource population of SLA haplotype-defined Korean native pigs

2010 ◽  
Vol 29 (5) ◽  
pp. 493-499 ◽  
Author(s):  
Han-Ok Cho ◽  
Chak-Sum Ho ◽  
Yu-Joo Lee ◽  
In-Cheol Cho ◽  
Sung-Soo Lee ◽  
...  
Keyword(s):  
Resource Population ◽  
Korean Native Pigs ◽  
Native Pigs

scholarly journals The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nicholas J. Carruthers ◽  
Clarissa Strieder-Barboza ◽  
Joseph A. Caruso ◽  
Carmen G. Flesher ◽  
Nicki A. Baker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Visceral Adipose Tissue ◽  
Sequencing Analysis ◽  
Complement Factor ◽  
Endothelial Protein C Receptor ◽  
Visceral Adipose

AbstractDysfunctional visceral adipose tissue (VAT) in obesity is associated with type 2 diabetes (DM) but underlying mechanisms remain unclear. Our objective in this discovery analysis was to identify genes and proteins regulated by DM to elucidate aberrant cellular metabolic and signaling mediators. We performed label-free proteomics and RNA-sequencing analysis of VAT from female bariatric surgery subjects with DM and without DM (NDM). We quantified 1965 protein groups, 23 proteins, and 372 genes that were differently abundant in DM vs. NDM VAT. Proteins downregulated in DM were related to fatty acid synthesis and mitochondrial function (fatty acid synthase, FASN; dihydrolipoyl dehydrogenase, mitochondrial, E3 component, DLD; succinate dehydrogenase-α, SDHA) while proteins upregulated in DM were associated with innate immunity and transcriptional regulation (vitronectin, VTN; endothelial protein C receptor, EPCR; signal transducer and activator of transcription 5B, STAT5B). Transcriptome indicated defects in innate inflammation, lipid metabolism, and extracellular matrix (ECM) function, and components of complement classical and alternative cascades. The VAT proteome and transcriptome shared 13 biological processes impacted by DM, related to complement activation, cell proliferation and migration, ECM organization, lipid metabolism, and gluconeogenesis. Our data revealed a marked effect of DM in downregulating FASN. We also demonstrate enrichment of complement factor B (CFB), coagulation factor XIII A chain (F13A1), thrombospondin 1 (THBS1), and integrins at mRNA and protein levels, albeit with lower q-values and lack of Western blot or PCR confirmation. Our findings suggest putative mechanisms of VAT dysfunction in DM.

HYSTERECTOMY IS ASSOCIATED WITH POSTMENOPAUSAL BODY COMPOSITION CHARACTERISTICS

2000 ◽  
Vol 32 (1) ◽  
pp. 37-46 ◽  
Author(s):  
SYLVIA KIRCHENGAST ◽  
DORIS GRUBER ◽  
MICHAEL SATOR ◽  
JOHANNES HUBER
Keyword(s):  
Body Composition ◽  
Weight Gain ◽  
Bone Mass ◽  
Psychological Stress ◽  
Stress Factors ◽  
Hormonal Changes ◽  
Fat Tissue ◽  
Abdominal Region ◽  
The Impact ◽  
Composition Characteristics

The impact of hysterectomy without oophorectomy and with no malignant purpose on body composition and postmenopausal weight gain was tested in 184 Viennese females aged between 47 and 57 years (mean 52·9). Hysterectomized women were significantly heavier than those who experienced a spontaneous menopause (controls). The amount of fat tissue, especially in the abdominal region, was significantly higher in hysterectomized women. Furthermore, they were reported to have experienced a significantly higher weight gain since menopause (9·1 versus 6·0 kg). No significant differences in bone mass were found. Psychological stress factors and hormonal changes following hysterectomy are discussed as possible causes of these differences.

scholarly journals Genome-wide QTL analysis of meat quality-related traits in a large F2 intercross between Landrace and Korean native pigs

2015 ◽  
Vol 47 (1) ◽  
pp. 7 ◽  
Author(s):  
In-Cheol Cho ◽  
Chae-Kyoung Yoo ◽  
Jae-Bong Lee ◽  
Eun-Ji Jung ◽  
Sang-Hyun Han ◽  
...  
Keyword(s):  
Meat Quality ◽  
Qtl Analysis ◽  
Genome Wide ◽  
Korean Native Pigs ◽  
Native Pigs
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