scholarly journals OXA-48 Carbapenemase-Producing Enterobacterales in Spanish Hospitals: An Updated Comprehensive Review on a Rising Antimicrobial Resistance

Antibiotics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 89
Author(s):  
Mario Rivera-Izquierdo ◽  
Antonio Jesús Láinez-Ramos-Bossini ◽  
Carlos Rivera-Izquierdo ◽  
Jairo López-Gómez ◽  
Nicolás Francisco Fernández-Martínez ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Prevention And Control ◽  
Preventive Measures ◽  
Resistance Mechanism ◽  
Hydrolytic Activity ◽  
Intrinsic Activity ◽  
Global Public Health ◽  
Comprehensive Review ◽  
Public Health Threat ◽  
And Control

Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins. CPEs have been classified by the WHO as high-priority pathogens given their association with morbidity and mortality and the scarce number of effective antibiotic treatments. In Spain, the frequency of OXA-48 CPE outbreaks is higher than in other European countries, representing the major resistance mechanism of CPEs. Horizontal transfer of plasmids and poor effective antibiotic treatment are additional threats to the correct prevention and control of these hospital outbreaks. One of the most important risk factors is antibiotic pressure, specifically carbapenem overuse. We explored the use of these antibiotics in Spain and analyzed the frequency, characteristics and prevention of CPE outbreaks. Future antibiotic stewardship programs along with specific preventive measures in hospitalized patients must be reinforced and updated in Spain.

scholarly journals Caregivers’ Perception and Practice of Infection Prevention and Control for COVID-19 at a Tertiary Centre, Southern Nigeria

2020 ◽  
pp. 280-288
Author(s):  
G. K. Eke ◽  
L. E. Yaguo-Ide
Keyword(s):  
Teaching Hospital ◽  
Prevention And Control ◽  
Preventive Measures ◽  
World Health ◽  
Infection Prevention And Control ◽  
Global Public Health ◽  
Port Harcourt ◽  
Significant Difference ◽  
The University ◽  
And Control

Introduction: The World Health Organization had recommended a multi-prong approach for the prevention and control of COVID-19, which has risen into a major global public health challenge. Government of nations are to disseminate information on these protective measures to the general public to mitigate the spread of the disease. However, people’s adherence to these preventive strategies is essential to guarantee success. Objective: To appraise the perception and practice of recommended measures for the prevention and control of COVID-19 by caregivers of children attending the University of Port Harcourt Teaching Hospital. Methodology: This descriptive cross-sectional study was done among parents/caregivers of children attending the Children’s Out Patient clinics, wards and emergency room of the Department of Paediatrics at the University of Port Harcourt Teaching Hospital, between August and September 2020. Information obtained using a structured investigator-administered questionnaire included bio data and perception about COVID-19 while practice of its preventive measures was observed. Data were analysed using SPSS version 25.  Results: All participants (161) have heard about COVID-19, mainly through the television and radio. The majority of them (n=141, 87.6%) knew that a combination of measures is needed for its prevention. More than half of participants (59%) washed their hands with water and soap provided, 89% of them had a facemask, a lesser proportion (58%) wore the mask and an even lesser proportion (28.6%) of them wore it properly. There was no significant difference between level of education or occupation of caregivers and proper wearing of the facemask. Conclusion: Though the awareness of COVID-19 was high, there was a gap between perception and practice of its preventive measures. Health education and innovative local strategies are recommended, to help improve the people’s acceptance of, and compliance to the stipulated multi-prong preventive measures.

scholarly journals Adapting to a Global Health Challenge: Managing Antimicrobial Resistance in the Nordics

2020 ◽  
Vol 8 (4) ◽  
pp. 53-64 ◽  
Author(s):  
Martin Stangborli Time ◽  
Frode Veggeland
Keyword(s):  
Antimicrobial Resistance ◽  
Prevention And Control ◽  
Expert Interviews ◽  
Global Public Health ◽  
Incremental Change ◽  
Existing Structures ◽  
Administrative Systems ◽  
Nordic Cooperation ◽  
And Control ◽  
Global Health Challenge

This article explores the adaptation of Norway and Sweden to one of the major challenges to global public health, antimicrobial resistance (AMR). Guided by assumptions derived from institutional theory, the article investigates whether, and, if so, how the AMR problem has affected the two Nordic countries’ administrative systems and frameworks for Nordic cooperation. The article builds on selected literature, expert interviews, and public documents. The findings suggest that the international impact on Norway and Sweden’s managerial adaptation to AMR is limited. Instead, adaptation takes place through incremental change within existing structures for disease prevention and control and follows traditional ways of organizing political and administrative systems.

Epidemiology, Pathogenesis, Genoserotyping, Antimicrobial Resistance, and Prevention and Control of Non-Typhoidal Salmonella Serovars

2017 ◽  
Vol 4 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Gitanjali Arya ◽  
Robert Holtslander ◽  
James Robertson ◽  
Catherine Yoshida ◽  
Janet Harris ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Prevention And Control ◽  
Salmonella Serovars ◽  
And Control

AMR: effective infection prevention and control measures

2019 ◽  
Vol 30 (8) ◽  
pp. 390-395
Author(s):  
Naomi Fleming
Keyword(s):  
Antimicrobial Resistance ◽  
Prevention And Control ◽  
Infection Prevention ◽  
Control Measures ◽  
Infection Prevention And Control ◽  
Drug Resistant ◽  
Practice Nurses ◽  
Prevention And Control Measures ◽  
Spread Of Infection ◽  
And Control

Antimicrobial resistance is on the rise. As more infections are becoming resistant to antibiotic treatment, it would benefit practice nurses to be aware of the effective measures they can use to prevent the spread of infection, explains Naomi Fleming When micro-organisms are exposed to an antimicrobial, more susceptible organisms succumb, leaving behind those resistant to the antimicrobial. They can then pass on resistance to their offspring. The use and misuse of antimicrobials has increased the number and types of resistant organisms. As a result, standard treatments become ineffective and infections persist and may spread. Infection prevention and control (IPC) is key to reducing demand for antimicrobial use and reducing the acquisition of antimicrobial resistance. Poor IPC can increase the spread of drug-resistant infections. Interventions such as effective hand hygiene and vaccination have significant potential to limit opportunities for drug-resistant strains to emerge. Effective leadership is vital and nurses are central to promoting IPC, leading on IPC compliance and ensuring uptake of vaccination in primary care.

Critical Control Points of Street-Vended Foods in the Dominican Republic

1988 ◽  
Vol 51 (5) ◽  
pp. 373-383 ◽  
Author(s):  
FRANK L. BRYAN ◽  
SILVIA C. MICHANIE ◽  
PERSIA ALVAREZ ◽  
AURELIO PANIAGUA
Keyword(s):  
Dominican Republic ◽  
Prevention And Control ◽  
Preventive Measures ◽  
Control Points ◽  
Street Vending ◽  
Ambient Temperatures ◽  
Critical Control Points ◽  
Rice Samples ◽  
And Control ◽  
Time Periodic

Hazard analyses were conducted at four street-vending stands in the Dominican Republic. Temperatures of foods were measured during cooking, display (holding), and reheating (when done). Samples were taken at each step of the operation and at 5 to 6-h intervals during display. Foods usually attained temperatures that exceeded 90°C at the geometric center during cooking and reheating. At three of the stands, foods (e.g., fish, chickens, pork pieces) were fried and held until sold. Leftovers were held overnight at ambient temperatures in the home of the vendor or in a locked compartment of the stand. They were usually reheated early in the morning and displayed until sold. During the interval of holding, aerobic mesophilic counts progressively increased with time from about 103 after cooking to between 105 to 109/g. The higher counts were usually associated with holding overnight. Escherichia coli (in water, milk and cheese samples), Bacillus cereus (in bean and rice samples), and Clostridium perfringens (in meat, chicken and bean samples) were isolated, but usually in numbers less than 103/g. At the other stand, foods (e.g. beans, rice, meat and chicken) were cooked just before serving as complete meals. There were no leftovers. This operation was less hazardous, although there were many sanitary deficiencies. Recommendations for prevention and control of microbial hazards (mainly reducing holding time, periodic reheating and requesting reheating just before purchasing) are given. The need and suggestions for implementing educational activities to alert and inform those concerned about hazards and preventive measures are presented.

scholarly journals Antibiotic Use in Low and Middle-Income Countries and the Challenges of Antimicrobial Resistance in Surgery

Antibiotics ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 497
Author(s):  
Massimo Sartelli ◽  
Timothy C. Hardcastle ◽  
Fausto Catena ◽  
Alain Chichom-Mefire ◽  
Federico Coccolini ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Prevention And Control ◽  
Infection Prevention ◽  
Infection Prevention And Control ◽  
Antibiotic Prescribing ◽  
Prescribing Practices ◽  
Middle Income ◽  
Middle Income Countries ◽  
And Control ◽  
Low And Middle Income

Antimicrobial resistance (AMR) is a phenomenon resulting from the natural evolution of microbes. Nonetheless, human activities accelerate the pace at which microorganisms develop and spread resistance. AMR is a complex and multidimensional problem, threatening not only human and animal health, but also regional, national, and global security, and the economy. Inappropriate use of antibiotics, and poor infection prevention and control strategies are contributing to the emergence and dissemination of AMR. All healthcare providers play an important role in preventing the occurrence and spread of AMR. The organization of healthcare systems, availability of diagnostic testing and appropriate antibiotics, infection prevention and control practices, along with prescribing practices (such as over-the-counter availability of antibiotics) differs markedly between high-income countries and low and middle-income countries (LMICs). These differences may affect the implementation of antibiotic prescribing practices in these settings. The strategy to reduce the global burden of AMR includes, among other aspects, an in-depth modification of the use of existing and future antibiotics in all aspects of medical practice. The Global Alliance for Infections in Surgery has instituted an interdisciplinary working group including healthcare professionals from different countries with different backgrounds to assess the need for implementing education and increasing awareness about correct antibiotic prescribing practices across the surgical pathways. This article discusses aspects specific to LMICs, where pre-existing factors make surgeons’ compliance with best practices even more important.

scholarly journals Strategies for prevention and control of COVID-19 in Nepal

2020 ◽  
Vol 7 (1) ◽  
pp. 85-88 ◽  
Author(s):  
Kiran Sapkota ◽  
Ganesh Dangal ◽  
Madhu Koirala ◽  
Kalyan Sapkota ◽  
Asmita Poudel ◽  
...  
Keyword(s):  
World Health Organization ◽  
Prevention And Control ◽  
Preventive Measures ◽  
Large Population ◽  
World Health ◽  
The World ◽  
Community Transmission ◽  
The Government ◽  
Health Organization ◽  
And Control

Coronavirus disease (COVID-19) outbreak, caused by the most recently discovered coronavirus, is currently affecting a large population across the globe. World health organization (WHO) has already declared COVID-19, a pandemic, and the world is fighting to contain the COVID-19 outbreak. Nepal has taken several preventive measures to control the coronavirus outbreak. However, some additional steps are needed to prevent community transmission of the disease. This brief communication discusses the government of Nepal actions and provides recommendations for the prevention and control of COVID-19 infection in Nepal.

scholarly journals Moving from rhetoric to action: how Africa can use scientific evidence to halt the COVID-19 pandemic

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Olushayo Oluseun Olu ◽  
Joy Luba Lomole Waya ◽  
Sylvester Maleghemi ◽  
John Rumunu ◽  
David Ameh ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Preventive Measures ◽  
Negative Impact ◽  
Control Strategies ◽  
Scientific Evidence ◽  
Scale Up ◽  
High Impact ◽  
The Social ◽  
And Control

Abstract The ongoing pandemic of the coronavirus disease 2019 has spread rapidly to all countries of the world. Africa is particularly predisposed to an escalation of the pandemic and its negative impact given its weak economy and health systems. In addition, inadequate access to the social determinants of health such as water and sanitation and socio-cultural attributes may constrain the implementation of critical preventive measures such as hand washing and social distancing on the continent. Given these facts, the continent needs to focus on targeted and high impact prevention and control strategies and interventions which could break the chain of transmission quickly. We conclude that the available body of scientific evidence on the coronavirus disease 2019 holds the key to the development of such strategies and interventions. Going forward, we recommend that the African research community should scale up research to provide scientific evidence for a better characterization of the epidemiology, transmission dynamics, prevention and control of the virus on the continent.

scholarly journals Overcoming the Pandemic: Analysing the Ongoing Challenges in the Prevention of COVID-19 in India

2020 ◽  
Vol 22 (4) ◽  
pp. 630-652
Author(s):  
Puneeta Ajmera ◽  
Jaseela Majeed ◽  
Ramesh K. Goyal ◽  
Sheetal Yadav ◽  
Debraj Mukhopadhyay
Keyword(s):  
Prevention And Control ◽  
Public Health Emergency ◽  
Decision Makers ◽  
World Health ◽  
Family Welfare ◽  
Published Data ◽  
Global Public Health ◽  
Recent Outbreak ◽  
Health Organization ◽  
And Control

World Health Organization (WHO) has declared the recent outbreak of coronavirus disease (COVID-19) a Pandemic and a global public health emergency. The eventual scope and consequences of this outbreak are uncertain at present as the condition is swiftly evolving. The purpose of this article is to cumulate existing published data and researches, identify the challenges with reference to India and develop a comprehensive preventive plan to prevent the spread of this deadly pandemic. The authors explored WHO situation dashboards, the web portal of Ministry of Health and Family Welfare of India and press reports of different countries, published literature on coronavirus transmission, textbooks, scientific and medical journals and several other sources to identify ongoing challenges in the fight against COVID-19 in India. After an exhaustive literature search, 15 ongoing challenges in the fight against novel COVID-19 especially with reference to India have been identified. After a thorough analysis of all these challenges along with the lessons from the International community, a preventive plan has been established to be devised by different agencies from our personal perspectives to overcome the challenges which may assist decision-makers in the prevention and control of COVID-19 in India.

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