scholarly journals Resveratrol Enhances the Cytotoxic Activity of Lymphocytes from Menopausal Women

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1914
Author(s):  
Andrea Di Credico ◽  
Giulia Gaggi ◽  
Pascal Izzicupo ◽  
Ines Bucci ◽  
Angela Di Baldassarre
Keyword(s):  
Cytotoxic Activity ◽  
Healthy Lifestyle ◽  
Immune Surveillance ◽  
Antioxidant Properties ◽  
Redox Balance ◽  
Noncommunicable Diseases ◽  
Positive Effects ◽  
Increased Risk ◽  
Menopausal Women ◽  
Total Antioxidant

Nutraceuticals and functional foods are the main sources of antioxidants and have positive effects on health through regulation of the redox balance. Accordingly, they represent a useful nutritional source for the prevention of noncommunicable diseases (NCDs). Menopausal women have an increased risk of developing NCDs due to hormonal dysregulation and the ongoing aging process. Accordingly, a healthy lifestyle and good nutritional habits are of utmost importance in this population. Resveratrol (RSV) is a natural polyphenol, and it is used as a nutraceutical given its estrogenic, anti-inflammatory, and antioxidant properties. The aim of this study was to analyze the effects of RSV on the lymphocyte cytotoxicity in menopausal women. Lymphocytes from 13 healthy menopausal women (56.18 ± 4.24 years) were isolated, and then cocultured with hTERT-HME1, a breast cell line with a precancerous phenotype. The results showed that, when treated with RSV, lymphocytes significantly increased the TNF-α production (p < 0.001), the formation of immune synapses (p = 0.009), and the target cell lysis (p = 0.002). No effects were detected in the lymphocyte total antioxidant capacity. In conclusion, RSV might enhance the immune surveillance in menopausal women by increasing the cytotoxic activity of lymphocytes.

Processed Tomato Products as a Source of Dietary Lycopene: Bioavailability and Antioxidant Properties

2004 ◽  
Vol 65 (4) ◽  
pp. 161-165 ◽  
Author(s):  
A. Venket Rao
Keyword(s):  
Oxidative Stress ◽  
Chronic Diseases ◽  
Human Subjects ◽  
Antioxidant Properties ◽  
Healthy Human ◽  
Increased Risk ◽  
Total Antioxidant ◽  
Trolox Equivalent ◽  
Tomato Products ◽  
Total Antioxidant Potential

Oxidative stress is one of the major contributors to increased risk of chronic diseases. A diet rich in tomatoes and tomato products containing lycopene, a carotenoid antioxidant, has been found to protect against these chronic diseases by mitigating oxidative damage. The study aim was to evaluate the effects of a long-term tomato-rich diet, consisting of various processed tomato products, on bioavailability and antioxidant properties of lycopene. Seventeen healthy human subjects (ten men, seven non-pregnant women) participated in the study. Following a two-week washout period during which subjects avoided foods containing lycopene, all subjects consumed test tomato products including tomato juice, tomato sauce, tomato paste, ketchup, spaghetti sauce, and ready-to-serve tomato soup providing 30 mg of lycopene a day for four weeks. At the end of treatment, serum lycopene level increased significantly (p <0.05), from 181.79 ± 31.25 to 684.7 ± 113.91 nmol/L. Similarly, total antioxidant potential increased significantly (p <0.05), from 2.26 ± 0.015 to 2.38 ± 0.17 mmol/L Trolox equivalent. Lipid and protein oxidation was reduced significantly (p <0.05). The results suggest that a tomato-rich diet containing different sources of lycopene can increase serum lycopene levels and reduce oxidative stress effectively.

scholarly journals Estrogen Receptors, ERK 1/2 Phosphorylation and Reactive Oxidizing Species in Red Blood Cells From Patients With Rheumatoid Arthritis

2021 ◽  
Author(s):  
Manuela Di Franco ◽  
Lucrezia Gambardella ◽  
Camilla Cittadini ◽  
Martina Favretti ◽  
Chiara Gioia ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Estrogen Receptor Alpha ◽  
Redox Balance ◽  
Das 28 ◽  
Increased Risk ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
Chronic Autoimmune Disease

Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with a significantly increased risk of cardiovascular mortality, mainly attributed to accelerated atherosclerosis. Methods: Thirty-two women (aged more than 18 years) with RA, and 25 age-matched healthy women were included in this study. Biomarkers of inflammation, red blood cells (RBCs) redox balance, estrogen receptor alpha (ER-&alpha;) expression as well as ERK 1/2 phosphorylation content were evaluated in RA patients at baseline and six months after treatment with disease modifying anti‐rheumatic drugs (DMARDs). Results: For the first times we demonstrated that in RA patients: i) disease activity score (DAS-28) positively correlated with RBC ER-&alpha; expression, and negatively with total antioxidant capacity of plasma; ii) RBC ER-&alpha; expression positively correlated with systemic inflammatory biomarkers and oxidative stress parameters as well as ERK 1/2 phosphorylation; and iii) DMARDs treatments improved the clinical condition measured by DAS-28 score decrease, although the RBCs appeared to be more prone to pro-oxidant status associated to the expression of survival molecules. Conclusion: Our data strongly suggest that RBCs could also participate in vascular homeostasis through fine modulation of an intracellular signal linked to the ER-&alpha;.

scholarly journals YOGA FOR MENOPAUSE

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Ms. Kumareswari Kandasamy Ms. Kumareswari Kandasamy ◽  
Ms. Kumareswari Kandasamy Ms. Kumareswari Kandasamy
Keyword(s):  
Healthy Lifestyle ◽  
Age Groups ◽  
Modern Society ◽  
Hatha Yoga ◽  
Hand Gestures ◽  
Natural Menopause ◽  
Positive Effects ◽  
Breathing Techniques ◽  
Menopausal Women ◽  
Resting Period

Yoga has recognized as a major role in modern society since it provides a healthy lifestyle for all age groups but it is more important for menopausal women. Natural menopause can occur between 45-55 years of women’s midlife and most women spend their life with symptoms after they reach menopause. Therapeutic yoga consists of breathing techniques (Pranayama), hand gestures (Mudra), vocal tones (Mandra), gentle movements (Asana) and different forms of meditation. Hatha yoga focuses on pranayama’s (breath-controlled exercises) which followed by a series of asanas (Yoga Postures), which end with savasana (a resting period). As many research has showed positive effects of yoga on menopausal symptoms. While therapeutic yoga can help to handle the women in stressful situations gracefully and adopt well to change and keep moving forward in their midlife after attain menopause.

scholarly journals Information communication texnolgy for monitoring of a prenosological state of the population health 

2020 ◽  
Author(s):  
Akhrorjon Abdumanonov ◽  
Muhammadjon Karabaev
Keyword(s):  
Risk Factors ◽  
Population Health ◽  
Information And Communication Technologies ◽  
Mobile Communications ◽  
Healthy Lifestyle ◽  
Medical Knowledge ◽  
Health Indicators ◽  
Dynamic Monitoring ◽  
Noncommunicable Diseases ◽  
Increased Risk

Abstract Background: The article describes the development of an uninterrupted functioning technology for remote automated monitoring of the prenosological level of individual health, which allows optimizing the medical non-invasive mass examination of the population. Methods:In order to provide their functioning by using information and communication technologies, mobile communications, automated remote exchange methods, accumulation, storage of information, as well as involving medical knowledge, mathematical models and algorithms for their intellectual analysis, the opportunities have been created for the development and implementation of preventive measures that are effective mechanisms to ensure a healthy lifestyle. Results: According to the stated goal, a comprehensive monitoring of the physical, functional and clinical-somatic status of population health indicators is carried out. It provides the implementation of the functions of a comprehensive prenosological examination of citizens and the results of the surveys assess the risk of developing certain diseases; assisting in the implementation of measures to form a healthy lifestyle and reduce the spread of risk factors for noncommunicable diseases among the attached population; dynamic monitoring of the contingent of individuals at increased risk of developing the disease. The practical use of this technology helps to conduct mass prenosological examinations of the population and improve the quality of targeted, personalized prevention of risk factors and improve their health.

Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia

2019 ◽  
Vol 70 (8) ◽  
pp. 2822-2825 ◽  
Author(s):  
Cornel Moisa ◽  
Mihnea Alexandru Gaman ◽  
Camelia Cristina Diaconu ◽  
Amelia Maria Gaman
Keyword(s):  
Oxidative Stress ◽  
Essential Thrombocythemia ◽  
Myeloproliferative Neoplasm ◽  
Oxygen Species ◽  
Mutational Status ◽  
Increased Risk ◽  
Stress Levels ◽  
Total Antioxidant ◽  
Thrombotic Complications ◽  
The Relationship

Essential thrombocythemia (ET) is a BCR-ABL1-negative myeloproliferative neoplasm associated with thrombotic and haemorrhagic complications. Reactive oxygen species (ROS) overexpression induces a growth advantage to JAK2V617F-positive clones and, in association with a higher number of immature platelets, leukocytosis, and additional cardiovascular risk factors, leads to an increased risk for thrombotic events. We evaluated oxidative stress by measuring ROS levels and the total antioxidant capacity (TAC) in 62 ET patients and investigated the relationship between oxidative stress, JAK2V617F mutational status and the development of thrombotic events. We found higher oxidative stress levels in JAK2V617F-positive vs. JAK2V617F-negative ET cases with no significant differences between homozygous and heterozygous genotypes. Increased ROS levels and thrombotic events were more frequent in ET patients with old age at diagnosis, higher haematocrit levels or leukocytosis.

scholarly journals The Beneficial Health Effects of Vegetables and Wild Edible Greens: The Case of the Mediterranean Diet and Its Sustainability

2020 ◽  
Vol 10 (24) ◽  
pp. 9144
Author(s):  
Elena Chatzopoulou ◽  
Márcio Carocho ◽  
Francesco Di Gioia ◽  
Spyridon A. Petropoulos
Keyword(s):  
Health Effects ◽  
Mediterranean Diet ◽  
Healthy Lifestyle ◽  
Scientific Interest ◽  
Mediterranean Populations ◽  
Cultural Aspects ◽  
Positive Effects ◽  
Healthy Diets ◽  
The World ◽  
The Mediterranean

The Mediterranean diet (MD) concept as currently known describes the dietary patterns that were followed in specific regions of the area in the 1950s and 1960s. The broad recognition of its positive effects on the longevity of Mediterranean populations also led to the adoption of this diet in other regions of the world, and scientific interest focused on revealing its health effects. MD is not only linked with eating specific nutritional food products but also with social, religious, environmental, and cultural aspects, thus representing a healthy lifestyle in general. However, modern lifestyles adhere to less healthy diets, alienating people from their heritage. Therefore, considering the increasing evidence of the beneficial health effects of adherence to the MD and the ongoing transitions in consumers’ behavior, the present review focuses on updating the scientific knowledge regarding this diet and its relevance to agrobiodiversity. In addition, it also considers a sustainable approach for new marketing opportunities and consumer trends of the MD.

scholarly journals Psychosocial interventions to support the mental health of informal caregivers of persons living with dementia – a systematic literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Henrik Wiegelmann ◽  
Sarah Speller ◽  
Lisa-Marie Verhaert ◽  
Liane Schirra-Weirich ◽  
Karin Wolf-Ostermann
Keyword(s):  
Mental Health ◽  
Informal Caregivers ◽  
Psychosocial Interventions ◽  
Health Interventions ◽  
Subjective Burden ◽  
Dementia Caregivers ◽  
Targeted Interventions ◽  
Positive Effects ◽  
Increased Risk ◽  
Mental Health Interventions

Abstract Background Informal caregivers of persons living with dementia have an increased risk of adverse mental health effects. It is therefore important to systematically summarize published literature in order to find out which mental health interventions generate effective support for informal caregivers of persons living with dementia. The objective of this study is to conduct a systematic review of intervention content, effectiveness and subgroup differentiation of mental health interventions for informal caregivers of persons with dementia living at home. Method We searched four electronic databases (PubMed, PsychINFO, Scopus and CINAHL) and included only methodically high-quality randomized controlled trials (RCTs), published in English or German language between 2009 and 2018. The intervention programmes focused on mental health of family caregivers. A narrative synthesis of the included studies is given. Results Forty-eight publications relating to 46 intervention programmes met the inclusion criteria. Burden, depression and quality of life (QoL) are the predominant parameters that were investigated. Twenty-five of forty-six interventions (54.3%) show positive effects on at least one of the outcomes examined. Most often, positive effects are reported for the outcome subjective burden (46.2%). Only six studies explicitly target on a certain subgroup of informal dementia caregivers (13%), whereas all other interventions (87%) target the group as a whole without differentiation. Conclusion The most beneficial results were found for cognitive behavioural approaches, especially concerning the reduction of depressive symptoms. Besides this, leisure and physical activity interventions show some good results in reducing subjective caregiver burden. In order to improve effectiveness, research and practice may focus on developing more targeted interventions for special dementia informal caregiver subgroups.

scholarly journals The Comparison of Physical Activity, Sedentary Behavior, and Mental Health between Early Menopausal Women and Age-Matched General Middle-Aged Women

2021 ◽  
Vol 18 (14) ◽  
pp. 7256
Author(s):  
Ji-Su Kim ◽  
Ju-Pil Choe ◽  
Jeong-Hui Park ◽  
Eunhye Yoo ◽  
Jung-Min Lee
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Sedentary Behavior ◽  
Healthy Lifestyle ◽  
Multinomial Logistic Regression ◽  
Middle Aged ◽  
General Group ◽  
Menopausal Women ◽  
Global Physical Activity Questionnaire ◽  
Causes Of Mortality

The current study is to examine the differences in physical activity (PA), sedentary behavior (SB), and mental health (i.e., stress, depression, and suicidal behaviors) between early menopausal women and age-matched general middle-aged women. Among 1348 participants in South Korea, 674 participants who experienced menopause before the age of 45 were defined as the early menopausal group, and 674 women who experienced menopause from 45 years to 55 years were classified as the general group by matching age based on early menopausal women. PA, SB, and mental health were evaluated by using the Global Physical Activity Questionnaire (GPAQ). An independent t-test was used to compare the associations of PA, SB, and mental health between the two groups. To demonstrate the predictors of early menopause, variables in the study were analyzed by multinomial logistic regression. The main findings were that moderate-to-vigorous PA (MVPA) and light PA (LPA) had significant differences between the two groups, but SB had no significant differences. In mental health, only perceived stress had significant differences in this study. The moderate level of stress in the early menopausal group was twice as high as that of the general group, and the severe level of stress was even 2.6 times higher than the general group. PA plays an essential role in mitigating the causes of mortality and the risk of various chronic diseases and improving quality of life; thus, the main findings of this study could be important to provide insights on the corresponding impact between early menopausal women and PA to encourage their healthy lifestyle. Further longitudinal studies are needed to examine the mechanisms underlying the effects of PA, SB, and mental health on early menopausal women.

scholarly journals Climate Change, Weather, Housing Precarity, and Homelessness: A Systematic Review of Reviews

2021 ◽  
Vol 18 (11) ◽  
pp. 5812
Author(s):  
Mariya Bezgrebelna ◽  
Kwame McKenzie ◽  
Samantha Wells ◽  
Arun Ravindran ◽  
Michael Kral ◽  
...  
Keyword(s):  
Climate Change ◽  
Systematic Review ◽  
Natural Disasters ◽  
Green Infrastructure ◽  
Temperature Extremes ◽  
Weather Extremes ◽  
Positive Effects ◽  
Increased Risk ◽  
Review Of Reviews ◽  
The Impact

This systematic review of reviews was conducted to examine housing precarity and homelessness in relation to climate change and weather extremes internationally. In a thematic analysis of 15 reviews (5 systematic and 10 non-systematic), the following themes emerged: risk factors for homelessness/housing precarity, temperature extremes, health concerns, structural factors, natural disasters, and housing. First, an increased risk of homelessness has been found for people who are vulnerably housed and populations in lower socio-economic positions due to energy insecurity and climate change-induced natural hazards. Second, homeless/vulnerably-housed populations are disproportionately exposed to climatic events (temperature extremes and natural disasters). Third, the physical and mental health of homeless/vulnerably-housed populations is projected to be impacted by weather extremes and climate change. Fourth, while green infrastructure may have positive effects for homeless/vulnerably-housed populations, housing remains a major concern in urban environments. Finally, structural changes must be implemented. Recommendations for addressing the impact of climate change on homelessness and housing precarity were generated, including interventions focusing on homelessness/housing precarity and reducing the effects of weather extremes, improved housing and urban planning, and further research on homelessness/housing precarity and climate change. To further enhance the impact of these initiatives, we suggest employing the Human Rights-Based Approach (HRBA).

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