scholarly journals Inactivation by helium cold atmospheric pressure plasma for Escherichia coli and Staphylococcus aureus

2019 ◽  
Vol 14 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Khaled Lotfy ◽  
Sayed Mohammed Khalil ◽  
Hany Abd El-Raheem
Keyword(s):  
Flow Rate ◽  
Atmospheric Pressure ◽  
Plasma Temperature ◽  
Wavelength Region ◽  
Atmospheric Pressure Plasma ◽  
Optical Emission ◽  
Reactive Species ◽  
Pressure Plasma ◽  
Cold Atmospheric Pressure Plasma ◽  
The Impact

AbstractA helium cold atmospheric pressure plasma jet (HCAPPJ) driven by a commercial neon power supply was designed and utilized for inactivation bacteria. The generated reactive spices by HCAPPJ were investigated by optical emission spectroscopy. The reactive species of OH, OI, OI, N21+, N21+ and He were identified in the UV–Vis wavelength region. The reactive species was not detected between 200 nm and 300 nm, as the flow rate of helium gas increased that led to the plasma temperature reducing to a value near to the room temperature. In this work, we studied the impact of HCAPPJ on Gram-positive and Gram-negative bacteria. The survival amounts of the two types of bacteria were decreased vastly when the rate flow rate was equal to 10 L/min.

scholarly journals Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment

2020 ◽  
Vol 10 (19) ◽  
pp. 6898
Author(s):  
Lars Boeckmann ◽  
Mirijam Schäfer ◽  
Thoralf Bernhardt ◽  
Marie Luise Semmler ◽  
Ole Jung ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Reactive Species ◽  
Therapeutic Effects ◽  
Preclinical Research ◽  
Pressure Plasma ◽  
Cold Atmospheric Pressure Plasma

Plasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound healing and cancer treatment—two applications with entirely different goals. In wound healing, a tissue-stimulating effect is intended, whereas cancer therapy aims at killing malignant cells. In this review, we provide an overview of the latest clinical and some preclinical research on the efficacy of CAP in wound healing and cancer therapy. Furthermore, we discuss the current understanding of molecular signaling mechanisms triggered by CAP that grant CAP its antiseptic and tissue regenerating or anti-proliferative and cell death-inducing properties. For the efficacy of CAP in wound healing, already substantial evidence from clinical studies is available, while evidence for therapeutic effects of CAP in oncology is mainly from in vitro and in vivo animal studies. Efforts to elucidate the mode of action of CAP suggest that different components, such as ultraviolet (UV) radiation, electromagnetic fields, and reactive species, may act synergistically, with reactive species being regarded as the major effector by modulating complex and concentration-dependent redox signaling pathways.

scholarly journals Influence of Microwave Frequency and Gas Humidity on the In-Vitro Blood Coagulation in Cold Atmospheric Pressure Plasma

Processes ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1837
Author(s):  
Jie Yu ◽  
Li Wu ◽  
Kama Huang
Keyword(s):  
Blood Coagulation ◽  
Atmospheric Pressure ◽  
Blood Clotting ◽  
Atmospheric Pressure Plasma ◽  
Emission Spectra ◽  
Optical Emission ◽  
Microwave Frequency ◽  
Pressure Plasma ◽  
Cold Atmospheric Pressure Plasma

In this article, the effects of microwave frequency (2450 MHz and 5800 MHz) and gas humidity (1%, 2%, 3%, 4%, 6% and 8%) on in vitro blood coagulation with cold atmospheric pressure plasma (CAPP) were investigated. The generation of reactive oxygen species (ROS, OH, O) was measured by optical emission spectra. The exposure temperature on blood droplets under treatment was below 55 °C in all cases, to avoid the thermal effect of plasma on the blood clotting. Investigations showed that, with the increase of frequency, the doses of ROS increased, the blood sample presented a more serious collapse and its surface became drier. The humidity of ionized gas can also accelerate the generation of ROS and the process of blood clotting. Our results propose a method to accelerate in vitro blood coagulation in CAPP by adjusting microwave frequency and gas humidity, and suggest a clinical benefit for plasma treatment as a coagulation device in surgery.

scholarly journals Applications of Cold Atmospheric Pressure Plasma in Dentistry

2021 ◽  
Vol 11 (5) ◽  
pp. 1975
Author(s):  
Aline C. Borges ◽  
Konstantin G. Kostov ◽  
Rodrigo S. Pessoa ◽  
Geraldo M.A. de Abreu ◽  
Gabriela de M.G. Lima ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Biological Effects ◽  
Atmospheric Pressure Plasma ◽  
Reactive Species ◽  
Electrically Conducting ◽  
Pressure Plasma ◽  
Cold Plasmas ◽  
Cold Atmospheric Pressure Plasma ◽  
Ultraviolet Photons ◽  
Oral Oncology

Plasma is an electrically conducting medium that responds to electric and magnetic fields. It consists of large quantities of highly reactive species, such as ions, energetic electrons, exited atoms and molecules, ultraviolet photons, and metastable and active radicals. Non-thermal or cold plasmas are partially ionized gases whose electron temperatures usually exceed several tens of thousand degrees K, while the ions and neutrals have much lower temperatures. Due to the presence of reactive species at low temperature, the biological effects of non-thermal plasmas have been studied for application in the medical area with promising results. This review outlines the application of cold atmospheric pressure plasma (CAPP) in dentistry for the control of several pathogenic microorganisms, induction of anti-inflammatory, tissue repair effects and apoptosis of cancer cells, with low toxicity to healthy cells. Therefore, CAPP has potential to be applied in many areas of dentistry such as cariology, periodontology, endodontics and oral oncology.

scholarly journals The Effect of Oxygen Admixture with Argon Discharges on the Impact Parameters of Atmospheric Pressure Plasma Jet Characteristics

2021 ◽  
Vol 11 (15) ◽  
pp. 6870
Author(s):  
Atif H. Asghar ◽  
Ahmed Rida Galaly
Keyword(s):  
Flow Rate ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Emission Spectra ◽  
Optical Emission ◽  
Plasma Jet ◽  
Flow Rates ◽  
Jet Length ◽  
Pressure Plasma ◽  
Optical Emission Spectra

Dry argon (Ar) discharge and wet oxygen/argon (O2/Ar) admixture discharge for alternating current atmospheric pressure plasma jets (APPJs) were studied for Ar discharges with flow rates ranging from 0.2 to 4 slm and for O2/Ar discharges with different O2 ratios and flow rates ranging from 2.5 to 15 mslm. The voltage–current waveform signals of APPJ discharge, gas flow rate, photo-imaging of the plasma jet length and width, discharge plasma power, axial temperature distribution, optical emission spectra, and irradiance were investigated. Different behavior for varying oxygen content in the admixture discharge was observed. The temperature recognizably decreased, axially, far away from the nozzle of the jet as the flow rate of dry argon decreased. Similar behavior was observed for wet argon but with a lower temperature than for dry argon. The optical emission spectra and the dose rate of irradiance of a plasma jet discharge were investigated as a function of plasma jet length, for dry and wet Ar discharges, to determine the data compatible with the International Commission on Non-Ionizing Radiation Protection (ICNIRP) data for irradiance exposure limits of the skin, which are suitable for the disinfection of microbes on the skin without harmful effects, equivalent to 30 μJ/mm2.

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