The Role of Nutritional Habits and Moderate Red Wine Consumption in PON1 Status in Healthy Population

Paraoxonase 1 (PON1) plays a role as antioxidant on HDL. Including in diet additionally ingest of polyphenolic compounds can stimulate PON1 transcription and increase its activity. The aim of this study was to evaluate the effect of dietary intake, red wine consumption, and PON1 genotypes (Q192R, L55M and C-108T) on the specific activity of PON1 in a healthy population. A descriptive and analytical pilot study was conducted in Mexican volunteers clinically healthy (n = 45) aged from 21–59 years. Over 6 weeks, the study participants ingested 120 mL of red wine per day. PON1 concentration, PON1 activities, genetic polymorphisms and dietary intake were evaluated. The preliminary fingerprinting of the wine was determined to corroborate the presence of phenolic compounds such as tannins and gallotannins. Neither dietary intake nor PON1 genotypes showed an effect on the specific activity of PON1. However, a significant increase in specific AREase activity after red wine consumption period was observed in the study participants. Our data suggest that the moderate consumption of red wine has a beneficial effect on PON1 specific AREase activity in this healthy Mexican population.

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Wine: An Aspiring Agent in Promoting Longevity and Preventing Chronic Diseases

Diseases ◽

10.3390/diseases6030073 ◽

2018 ◽

Vol 6 (3) ◽

pp. 73 ◽

Cited By ~ 11

Author(s):

Eleni Pavlidou ◽

Maria Mantzorou ◽

Aristeidis Fasoulas ◽

Christina Tryfonos ◽

Dimitris Petridis ◽

...

Keyword(s):

Human Health ◽

Chronic Diseases ◽

Mediterranean Diet ◽

Red Wine ◽

White Wine ◽

Wine Consumption ◽

Beneficial Role ◽

Pubmed Database ◽

The Mediterranean

Introduction: Moderate wine consumption is a characteristic of the Mediterranean diet. Studies around the world have shown a beneficial effect of moderate alcohol intake, especially wine, on health. This review aims to critically summarise the most recent studies that investigate the beneficial effects of moderate wine intake on human health. Methods: The PubMed database was comprehensively searched to identify trials published from 2013 to 2018 that investigated the association between moderate wine consumption and health. Results: The most recent studies confirm the valuable role of moderate wine consumption, especially red wine, in the prevention and treatment of chronic diseases such as cardiovascular disease, metabolic syndrome, cognitive decline, depression, and cancer. In the meantime, recent studies also highlight the beneficial role of red wine against oxidative stress and in favour of desirable gut bacteria. The beneficial role of red wine has been attributed to its phytochemical compounds, as highlighted by clinical trials, where the effect of red wine has been compared to white wine, non-alcoholic wine, other alcoholic drinks, and water. Conclusions: Moderate wine intake, at 1–2 glasses per day as part of the Mediterranean diet, has been positively associated with human health promotion, disease prevention, and disease prognosis.

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Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice

The Journal of Nutritional Biochemistry ◽

10.1016/j.jnutbio.2008.06.002 ◽

2009 ◽

Vol 20 (8) ◽

pp. 586-596 ◽

Cited By ~ 40

Author(s):

Christophe Noll ◽

Julien Hamelet ◽

Ewelina Matulewicz ◽

Jean-Louis Paul ◽

Jean-Maurice Delabar ◽

...

Keyword(s):

Red Wine ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Polyphenolic Compounds ◽

Paraoxonase 1 ◽

Low Density ◽

Lipoprotein Receptor ◽

Oxidized Low Density Lipoprotein ◽

Low Density Lipoprotein Receptor ◽

Density Lipoprotein Receptor

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Impact of Red Wine Consumption on Cardiovascular Health

Current Medicinal Chemistry ◽

10.2174/0929867324666170518100606 ◽

2019 ◽

Vol 26 (19) ◽

pp. 3542-3566 ◽

Cited By ~ 10

Author(s):

Luca Liberale ◽

Aldo Bonaventura ◽

Fabrizio Montecucco ◽

Franco Dallegri ◽

Federico Carbone

Keyword(s):

Heart Failure ◽

Red Wine ◽

Randomized Clinical Trials ◽

Metabolic Diseases ◽

Current Knowledge ◽

Antioxidant Properties ◽

Narrative Review ◽

Wine Consumption

Background:The devastating effects of heavy alcohol drinking have been long time recognized. In the last decades, potential benefits of modest red wine drinking were suggested. In European countries in which red wide intake is not negligible (such as France), the association between cholesterol and cardiovascular (CV) risk was less evident, suggesting the action of some protective molecules in red wine or other foods and drinks.Methods:This narrative review is based on the material searched for and obtained via PubMed up to May 2016. The search terms we used were: “red wine, cardiovascular, alcohol” in combination with “polyphenols, heart failure, infarction”.Results:Epidemiological and mechanistic evidence of a J-shaped relationship between red wine intake and CV risk further supported the “French paradox”. Specific components of red wine both in vitro and in animal models were discovered. Polyphenols and especially resveratrol largely contribute to CV prevention mainly through antioxidant properties. They exert beneficial effects on endothelial dysfunction and hypertension, dyslipidemia, metabolic diseases, thus reducing the risk of adverse CV events such as myocardial infarction ischemic stroke and heart failure. Of interest, recent studies pointed out the role of ethanol itself as a potential cardioprotective agent, but a clear epidemiological evidence is still missing. The aim of this narrative review is to update current knowledge on the intracellular mechanism underlying the cardioprotective effects of polyphenols and ethanol. Furthermore, we summarized the results of epidemiological studies, emphasizing their methodological criticisms and the need for randomized clinical trials able to clarify the potential role of red wine consumption in reducing CV risk.Conclusion:Caution in avowing underestimation of the global burden of alcohol-related diseases was particularly used.

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You Are the One I Want to Communicate With!

Social Psychology ◽

10.1027/1864-9335/a000097 ◽

2013 ◽

Vol 44 (1) ◽

pp. 16-25 ◽

Cited By ~ 3

Author(s):

Sabrina Pierucci ◽

Olivier Klein ◽

Andrea Carnaghi

Keyword(s):

Memory Bias ◽

Shared Reality ◽

Communication Partner ◽

Shared Reality Theory ◽

The One ◽

Study Participants

This article investigates the role of relational motives in the saying-is-believing effect ( Higgins & Rholes, 1978 ). Building on shared reality theory, we expected this effect to be most likely when communicators were motivated to “get along” with the audience. In the current study, participants were asked to describe an ambiguous target to an audience who either liked or disliked the target. The audience had been previously evaluated as a desirable vs. undesirable communication partner. Only participants who communicated with a desirable audience tuned their messages to suit their audience’s attitude toward the target. In line with predictions, they also displayed an audience-congruent memory bias in later recall.

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