scholarly journals A Prospective, Randomised, Controlled, Split-Face Clinical Trial to Assess the Safety and the Efficacy of Cold Atmospheric Plasma in the Treatment of Acne Vulgaris

2021 ◽  
Vol 11 (23) ◽  
pp. 11181
Author(s):  
Sigrid Karrer ◽  
Mark Berneburg ◽  
Florian Zeman ◽  
Michael Koller ◽  
Karolina Müller
Keyword(s):  
Acne Vulgaris ◽  
Atmospheric Plasma ◽  
Serious Adverse Events ◽  
Inflammatory Lesions ◽  
Cold Atmospheric Plasma ◽  
Moderate Reduction ◽  
The Face ◽  
Randomised Controlled ◽  
Split Face

The increase in antibiotic resistance requires effective non-antibiotic therapies for acne. Cold atmospheric plasma (CAP) inactivates bacteria and improves wound healing, but its effect on acne has not been investigated. The objective of this controlled split-face study was to assess safety and efficacy of CAP in moderate acne. One side of the face received 8–10 treatments with cold helium plasma within 4–6 weeks; follow-up was two and four weeks thereafter. Acne lesions were counted, followed by global acne severity ratings. Of the 34 patients included, 29 completed the study. No serious adverse events occurred. The two facial sides did not significantly differ in the number of inflammatory and non-inflammatory lesions. An interaction effect of number and type of treatment was found for inflammatory lesions. Lesion reduction after 10 treatments was significantly higher on the treated than on the untreated side. Percentage of patients reporting improved aesthetics was higher for the treated than for the untreated side after treatment completion (79% vs. 45%) and at the two- (72% vs. 45%) and four-week follow-up (79% vs. 52%). In conclusion, CAP was safe with excellent tolerability, showed moderate reduction in acne lesions and led to higher patient-based ratings of aesthetics than non-treatment.

scholarly journals FRI0460 SAFETY OF BIOLOGICAL AGENTS IN JUVENILE IDIOPATHIC ARTHRITIS: A META-ANALYSIS OF OBSERVATIONAL STUDIES

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 827.2-827
Author(s):  
N. Cabrera ◽  
G. Avila ◽  
A. Belot ◽  
J. P. Larbre ◽  
G. Cattivelli ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Clinical Practice ◽  
Incidence Rate ◽  
Observational Studies ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Serious Adverse Events ◽  
Serious Infections ◽  
Randomised Controlled

Background:Follow-up cohorts (observational studies) were initiated consecutively or simultaneously to the development of randomised controlled trials (RCTs) in JIA patients(1,2). They help to identify many complications observed only in clinical practice related to off label use, coadministration of treatments, drug misuse, and occurrence of rare or unexpected event. In addition, observational studies include a higher number of patients with a longer duration of follow-up compared to randomised trials. Hence, they have a higher power to capture the occurrence of serious adverse events (SAE) in daily clinical practice3.Objectives:To estimate the incidence of serious adverse events (SAEs) including serious infections, malignancies, and death in patients with juvenile idiopathic arthritis (JIA) treated with biological agents (BAs) in daily clinical practice, using meta-analysis techniques.Methods:We systematically searched, up to May 2019, Medline and Embase databases for observational studies performed in JIA disease under BAs treatment. Outcomes were SAEs, serious infections, malignancies and all-cause mortality. Complementary, the incidence of SAEs in randomised controlled trials (RCTs) with withdrawal and parallel designs was performed by meta-analysis.Results:A total of 31 observational studies were included (6811 patients totalizing 17530 patients-years [PY] of follow-up). The incidence rate of SAEs was similar in observational cohorts and withdrawal RCTs (4.46 events per 100 PY, 95% CI 2.85- 6.38, I2= 95%) and 3.71 events per 100 PY (95%CI 0.0-13.34), I2= 56%, respectively). The incidence of SAE was lower in parallel RCT. The incidence rate of serious infections, malignancies and death in observational cohorts was estimated at 0.74 events per 100 PY (95%CI 0.32-1.30, I2=83%), 0.10 events per 100 PY (95% CI 0.06-0.16, I2=0%) and 0.09 events per 100 PY (95% CI 0.05-0.14, I2=0%), respectively. Infections were the known cause of death in 8 of the 14 deaths. In meta-regression and subgroup analysis, variation of serious infections rates were partially explained by follow-up time (R2= 30.3%, p= 0.0008), JIA categories (all JIA versus polyarticular versus systemic JIA categories, p= 0.001) and cohort quality (Newcastle-Ottawa score ≥ to 6 versus ≤ to 5 stars, p= 0.0025).Conclusion:Our results suggest that the incidence rate of SAEs related to BAs in JIA disease is similar to those observed in randomised withdrawal trials. The overall incidence remained low. However, unsatisfactory description of SAEs prevents analysis of hospitalisation causes. Infection and, to a lesser extent, cancer and death, explain only part of burden of BAs.References:[1]Berard RA, Laxer RM. Learning the hard way: clinical trials in juvenile idiopathic arthritis. Ann Rheum Dis. 2018;77(1):1–2.[2]Swart J, Giancane G, Horneff G, Magnusson B, Hofer M, Alexeeva Е, et al. Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from Pharmachild and national registries. Arthritis Res Ther. 2018 27;20(1):285.[3]Monti S, Grosso V, Todoerti M, Caporali R. Randomized controlled trials and real-world data: differences and similarities to untangle literature data. Rheumatol Oxf Engl. 2018 01;57(57 Suppl 7):vii54–Disclosure of Interests:None declared

scholarly journals ROLE OF JALUKAVACHARAN AND MAHAMANJISHTADI KWATH IN THE MANAGEMENT OF MUKHADUSHIKA W.S.R TO ACNE VULGARIS- A CASE STUDY

2018 ◽  
Vol 6 (8) ◽  
pp. 25-32
Author(s):  
Dhalpe Suchita Jayant ◽  
Vivek S. Chandurkar
Keyword(s):  
Acne Vulgaris ◽  
Burning Sensation ◽  
Inflammatory Lesions ◽  
The Face ◽  
Sebum Production ◽  
Major Factors

Acne vulgaris is a disease of the pilosebaceous follicle characterized by noninflammatory (open and closed comedowns) and inflammatory lesions (papules, pustules, and nodules). There are four major factors involved in the disease production viz. increased sebum production, cornification of pilosebaceous ducts, microbial involvement and inflammation. This condition is found commonly in puberty. In Ayurveda, it is termed as Mukhadushika In Ayurveda Mukhadushika is described under the heading of Kshudrarogas. The Shalmali thorn like eruption on the face due to vitiation of Kapha, Vata and Rakta which are found on the face of adolescent are called as Mukhadushika or YuvanPidika. Although vata, kapha and rakta are mentioned as dosha-duṣya involved in the pathogenesis of the disease, pittaja symptoms are also found in the disease like daha and paka.  Patient was suffering from Acne over face (Pidika), Burning sensation over face (Daha), Itching over face (Kandu), and Discolouration of skin (Vaivarnya) since 6 months. Patient was treated with jalukavacharan and mahamanjishtadi kwath.

scholarly journals A CONCEPTUAL STUDY ON ETIOLOGY AND AYURVEDIC MANAGEMENT OF MUKHADUSHIKA W.S. R TO ACNE VULGARIS: A REVIEW

2021 ◽  
Vol 9 (7) ◽  
pp. 1538-1543
Author(s):  
Gupta Deepak ◽  
Asthana Alok
Keyword(s):  
Acne Vulgaris ◽  
Treatment Modalities ◽  
Clinical Approach ◽  
Healthy Life ◽  
Inflammatory Lesions ◽  
Causative Factors ◽  
The Face ◽  
Sebum Production ◽  
Conceptual Study ◽  
Major Factors

Ayurveda is considered an ancient healthcare system of India which is based on the eternal principle of healthy life. The whole clinical approach of Ayurveda is based on the preventive, promotive & curative aspects that aim of Ayurveda. Now a days, the whole world is gradually turning towards Ayurveda for a safe and complete cure of diseases, especially in the field of skin problems, Ayurveda can contribute remarkably. Skin is known as the larg- est organ of the human body, which performs many functions like thermoregulation, vitamin D synthesis, sensory perception, immunological function etc. But besides this, it also seems an important symbol of beauty. Acne vul- garis is the most common problem affecting the normal texture of skin bothering teenagers today. This skin con- dition lights the mankind and caricature of youth. Acne vulgaris is known as a disease of the pilosebaceous folli- cle characterized by non-inflammatory (open and closed comedones) and inflammatory lesions (papules, pustules, and nodules). Four major factors involved in the disease production are inflammation, rise in sebum production, cornification of pilosebaceous ducts and microbial involvement. In Ayurveda, Shalmali thorn-like eruptions on the face of a youth caused by Kapha, Vata and Rakta are known as Yuvanpidika. They are also known as Mukha- dushika.1The painful eruptions packed with Meda, similar to the thorns of Shalmali having their site on the face of adults are known as Yuvanpidika2. This article describes the Ayurvedic review of Mukhadushika with Nidan, Pur-varoop, Roop, Samprapti and Chikitsa along with its modern counterpart of Acne with its definition, causative factors, and types of acne, complications and treatment modalities. Keywords: Mukhadushika, Ksudrarogas, Yuvanpidika, Acne vulgaris, Shalmali

scholarly journals 577-nm high-power optically pumped semiconductor laser is safe and effective in the treatment of inflammatory acne: a prospective, single-center, split-face comparative study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
E. M. Mohamed ◽  
K. M. Tawfik ◽  
I. B. Elsayed ◽  
E. Bölke ◽  
P. A. Gerber
Keyword(s):  
Semiconductor Laser ◽  
High Power ◽  
Acne Vulgaris ◽  
Optically Pumped ◽  
Control Side ◽  
Significant Difference ◽  
The Face ◽  
The Mean ◽  
Split Face ◽  
Single Lesion

Abstract Objective This study aimed to appraise the efficacy of a 577-nm high-power optically pumped semiconductor laser (HOPSL) for the treatment of inflammatory acne. Methods The study included 50 patients with acne vulgaris (inflammatory type), 14 men, and 36 women; patient ages ranged from 16 to 35 years. The left side of the face was treated with a single pass of a 577-nm high-power optically pumped semiconductor laser (HOPSL) every 2 weeks for 3 sessions. The severity of acne examined prior to the first session and 4 weeks after the last session (Investigator's Global Assessment of acne severity, IGA; single lesion count). Results At baseline, no statistically significant difference in the severity of inflammatory acne lesions between both sides was observed. One month after the final session, a significant improvement (IGA reduction of > 50%) of the overall severity of acne was observed in 49 patients (98%) on the laser-treated side versus 41 (82%) the control side of the face (P < .05). Hence, we found a significant reduction in the mean percentage of inflammatory papules, pustules, and nodules on the laser-treated versus the control side (79.33 vs 56.92, 78.04 vs 43.33, 64.85 vs 21.93%, respectively) (P < 0.05). Side effects in the form of erythema and irritation during sessions were transient and tolerated by the patients. Conclusion The 577-nm high-power optically pumped semiconductor laser is effective and safe for the treatment of inflammatory lesions (papules, pustules, and nodules) in acne patients.

Clinical Trial of Topical Erythromycin in Inflammatory Acne

1981 ◽  
Vol 15 (5) ◽  
pp. 372-376 ◽  
Author(s):  
Randall A. Prince ◽  
Douglas A. Busch ◽  
Charles D. Hepler ◽  
Harley G. Feldick
Keyword(s):  
Inflammatory Lesion ◽  
Double Blind ◽  
Inflammatory Lesions ◽  
Erythromycin Base ◽  
Significant Difference ◽  
The Face ◽  
The Difference ◽  
Clinically Significant ◽  
Split Face ◽  
Paired T Test

Sixty-nine informed subjects participated in a split-face, double-blind trial of topical erythromycin base 2% in Vehicle/N® versus Vehicle/N® alone. All subjects had grades II or III acne as described by Pillsbury. Study solutions were assigned to a randomly selected side of the subject's face. Solutions were applied twice daily. Inflammatory lesion counts were performed by the same investigator during the eight weeks of study at biweekly intervals. The difference in inflammatory lesion counts from beginning to end of study for each side of the face was compared utilizing Student's paired t-test There was not a statistically significant difference in mean inflammatory lesions at the end of eight weeks (D̅ = 1.46, t = 1.36, df 68). There was, however, a significant difference at two and six weeks (D̅ = 2.59, t = 3.72, df 68; D̅ = 1.41, t = 2.03, df 68). Observed differences in lesion counts were not considered to be clinically significant.

scholarly journals MEDICINAL LEECH FOR THE TREATMENT OF ACNE VULGARIS W.S.R. TO MUKHADUSHIKA: A RANDOMISED CLINICAL STUDY

AYUSHDHARA ◽  
2021 ◽  
pp. 3064-3070
Author(s):  
Gupta Sudesh ◽  
Sharma Sakshi ◽  
Prasher Aarushi ◽  
Sharma Kumar Arun ◽  
Manhas Raman
Keyword(s):  
Acne Vulgaris ◽  
Signs And Symptoms ◽  
Medicinal Leech ◽  
Inflammatory Disorder ◽  
Age Group ◽  
Time Saving ◽  
Chronic Inflammatory Disorder ◽  
Effective Time ◽  
The Face

Acne vulgaris is a chronic inflammatory disorder of the pilo-sebaceous follicles characterised by comedones, papules, pustules, nodules and often scars mainly seen on cheeks, chin, nose, forehead and upper trunk during adolescence. The symptoms of Acne vulgaris resemble Mukhadushika as per Ayurvedic classics. Acharya Sushruta has mentioned Mukhadushika as one of the Kshudra Rogas. In Mukhadushika, there are Shalmali kantak like eruptions on the face which are impregnated with Meda caused due to vitiation of Kaphadosha, Vatadosha and Raktadhatu which destroy the beauty of the face and makes the appearance ugly. The disease almost take place in adolescent and young age group prominently therefore is also known as Yuvanapidika. Acharya Sushruta stated Jalaukavacharana is the preferred method of bloodletting in Sukumara. Aim: To evaluate the efficacy of Jalaukavacharana in the management of Acne vulgaris w.s.r. to Mukhadushika. Methodology: Fourteen patients of age group 15-30 years having signs and symptoms of Mukhadushika were selected and four sittings of Jalaukavacharana on a seven day interval were given. Apart from treatment duration of 28 days, a follow-up was also done after 30 days. Results: Intervention was found to be highly significant (p<0.001) in Vedana, Kandu, Daha, number of Pidika, size of Pidika, Pidika ghanata, Shotha, Vaivarnyata. However, significant effect (p<0.05) was found in Vranavastu and non-significant result (p>0.05) was found in Srava. Conclusion: The results are satisfactory. Jalaukavacharana is proved to be an effective, time saving, affordable and acceptable treatment in Mukhadushika without causing any adverse effect.

scholarly journals Efficacy of Acupuncture in Improving Symptoms and Quality of Life of Patients With Acne Vulgaris: a Randomized Sham Acupuncture-controlled Trial

2021 ◽  
Author(s):  
Ruimin Jiao ◽  
Xu Zhai ◽  
Xuecheng Zhang ◽  
Zhiyi Xiong ◽  
Zhishun Liu
Keyword(s):  
Primary Outcome ◽  
Controlled Trial ◽  
Acne Vulgaris ◽  
Inflammatory Lesion ◽  
Sham Acupuncture ◽  
Lesion Count ◽  
Serious Adverse Events ◽  
Scale Total Score ◽  
Secondary Outcomes

Abstract Objective: The aim of this study was to examine the effectiveness of acupuncture in treating the symptoms and QoL of patients with moderate or severe AV. Methods: Participants were randomly assigned (1:1) to receive 12 treatment sessions of acupuncture or sham acupuncture over 4 weeks with 24 weeks of follow-up. The primary outcome was the change from baseline in the Skindex-16 scale total score at treatment completion. Secondary outcomes included Skindex-16 subscale score, Dermatology Life Quality Index scale total score, total lesion count and inflammatory lesion count, and visual analogue scale scores for itch and pain evaluation. Results: There is no statistically significant between-group difference for the primary outcome and any secondary outcomes after 4 weeks of treatment and at 16 weeks and 28 weeks of follow-up, except for the Skindex-16 subscale (the emotions of participants with AV) at week 4 (P = 0.026). No serious adverse events occurred in two group. Conclusion: Acupuncture and sham acupuncture might both relieve the symptoms of patients with moderate or severe AV, reduce the number and degree of inflammatory lesion counts, and improve QoL. Trial registration number: ChiCTR-1900023649 Chinese Clinical Trial Registry

scholarly journals Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Common Vulgaris Acne in Vietnamese Patients

2019 ◽  
Vol 7 (2) ◽  
pp. 217-220
Author(s):  
Thuong Nguyen Van ◽  
Lan Duong Thi ◽  
Hao Nguyen Trong ◽  
Tro Chau Van ◽  
Trang Trinh Minh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Treatment Time ◽  
Acne Vulgaris ◽  
Control Group ◽  
Inflammatory Lesions ◽  
Comparative Clinical Trial ◽  
Oral Isotretinoin ◽  
The Mean

AIM: To evaluate the efficacy of oral isotretinoin used alone and in combination with desloratadine in the treatment of moderate acne vulgaris. METHODS: A comparative clinical trial was undertaken to evaluate the efficacy of oral isotretinoin alone and in combination with desloratadine in the treatment of 62 moderate acne vulgaris patients. Patients were randomised into two groups with 31 patients in each group. Each studied group's patient took 20 mg isotretinoin and 5 mg desloratadine per day. In the control group, patients took only 20 mg isotretinoin per day. The treatment time was 16 weeks. The evaluation and follow-up were done at week 2, 4, 8, 12 and 16 of the treatment. RESULTS: The studied group had a better curative rate than the control group (45.2% versus 22.6%). The average number of inflammatory lesions in the studied group was significantly lower than the control group (0.19 versus 0.94). The mean GAGS score of the studied group was significantly lower than the control group (3.71 versus 6.52). Acne outbreaks rate of the studied group was lower than the control group (in week 2: 22.6% versus 45.2% and in week 4: 16.1% versus 38.7%, respectively). The rate of itchy was lower in the studied group. CONCLUSION: In the treatment of moderate acne vulgaris, oral isotretinoin in combination with desloratadine is more effective and has fewer side effects than using isotretinoin alone.

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