scholarly journals Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study

Biology ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 244
Author(s):  
Samy M. Abdel-Halim ◽  
Ashraf Al Madhoun ◽  
Rasheeba Nizam ◽  
Motasem Melhem ◽  
Preethi Cherian ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Levels ◽  
Energy Homeostasis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Camp Levels ◽  
Circulating Levels

Adenylate cyclases (ADCYs) catalyze the conversion of ATP to cAMP, an important co-factor in energy homeostasis. Giving ADCYs role in obesity, diabetes and inflammation, we questioned whether calcium-stimulated ADCY isoforms may be variably detectable in human plasma. We report the results of a cross-sectional study assessing circulating levels of functional ADCY1, −3 and −8 in patients with T2D vs. non-diabetic (ND) controls in association with obesity. ADCY1 levels exhibited no significant change between ND and T2D groups. ADCY3 levels were lower in obese individuals, albeit not statistically significantly. In contrast, ADCY8 plasma levels were significantly higher in obese and T2D patients compared to controls (p = 0.001) and patients with T2D only (p = 0.039). ADCY8 levels correlated positively with body mass index and Hb1Ac levels. Parallel to the increased ADCY8 levels, significantly higher cAMP levels were observed in patients with T2D compared with ND controls, and further elevated in obese individuals, irrespective of T2D status. Additionally, cAMP levels positively correlated with fasting plasma glucose levels. In conclusion, the current cross-sectional study demonstrated elevated levels of circulating plasma ADCY8 and cAMP in obesity and T2D.

scholarly journals Gambaran Status Gingiva Pada Penderita Diabetes Melitus Tipe 2 Di Rumah Sakit Umum GMIM Pancaran Kasih Manado

e-GIGI ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Olyvia Octaviany Monoarfa ◽  
Karel Pandelaki ◽  
Christy N. Mintjelungan
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Age Range ◽  
Diabetes Melitus

Abstract: Diabetes Mellitus (DM) is a metabolic disease group with the characteristic blood glucose levels than normal (hyperglycemia) that occurs because abnormalities in insulin secretion, insulin recognized when payable disorders, or combination of both. Regular blood glucose levels cause patients uncontrolled type 2 diabetes are at greater risk for experiencing problems of oral health, including gingivitis. Purpose of this research was to know the description of gingival status in patients of type 2 diabetes at RSU GMIM Pancaran Kasih Manado. This research is an observational descriptive with cross sectional study approach. The research population is all patients of type 2 diabetes outpatient clinic Interna RSU GMIM Pancaran Kasih Manado in September 2014. The research method is by using a Consecutive sampling with a sample of 100 people. The result of this research showed that the gingival status in patients of type 2 diabetes calculated based gingival index that most occur severe gingivitis was 45 respondents (45%). The gingival status that showed the severe gingivitis in patients of type 2 diabetes based on age 17 respondents (48,6%) in the age range of 51-60 years old, based on gender that most occur in women 27 respondents (49,1%), based on duration of suffering 25 respondents (55,6%) in the age range >10 years, and based on blood glucose control (HbA1c) that most numerous in patients with poor blood glucose 30 respondents (60%). Conclusion: The gingival status in patients of type 2 diabetes most occur severe gingivitis, and recommended in patients of type 2 diabetes to improve their healthy lifestyle in order to normalize blood glucose levels so as to reduce the occurrence of diabetes, more attention and maintain oral hygiene, especially the gingival health.Keywords: gingival status, patients of type 2 diabetes.Abstrak: Diabetes Melitus (DM) adalah suatu kelompok penyakit metabolik dengan karakteristik kadar glukosa darah yang melebihi normal (hiperglikemia) yang terjadi karena kelainan sekresi insulin, gangguan kerja insulin, ataupun kombinasi dari keduanya. Kadar gula darah yang tidak terkontrol menyebabkan penderita DM tipe 2 beresiko lebih tinggi mengalami masalah kesehatan mulut, termasuk gingivitis. Penelitian ini bertujuan untuk mengetahui gambaran status gingiva pada penderita Diabetes Melitus tipe 2 di Rumah Sakit Umum GMIM Pancaran Kasih Manado. Penelitian ini merupakan penelitian deskriptif observasional dengan pendekatan cross sectional study. Populasi penelitian yaitu seluruh pasien DM tipe 2 rawat jalan di Poliklinik Interna Rumah Sakit Umum GMIM Pancaran Kasih Manado pada bulan September 2014. Metode penelitian yaitu Consecutive sampling dengan sampel penelitian berjumlah 100 orang. Hasil penelitian menunjukkan bahwa status gingiva yang dihitung berdasarkan indeks gingiva paling banyak menunjukkan gingivitis berat 45 subjek penelitian (45%). Status Gingiva berdasarkan umur paling banyak 17 subjek penelitian (48,6%) pada rentang umur 51–60 tahun, berdasarkan jenis kelamin paling banyak pada perempuan 27 subjek penelitian (49,1%), berdasarkan lamanya menderita paling banyak selama >10 tahun 25 subjek penelitian (55,6%), dan berdasarkan kontrol gula darah (HbA1c) paling banyak pada pasien dengan kontrol gula darah buruk (>9%) 30 subjek penelitian (60%). Simpulan: Penderita DM tipe 2 di Rumah Sakit Umum GMIM Pancaran Kasih Manado paling banyak mengalami gingivitis berat, serta disarankan bagi penderita agar lebih meningkatkan pola hidup sehat guna menormalkan kadar glukosa darah sehingga dapat mengurangi terjadinya diabetes, lebih memperhatikan dan menjaga kebersihan gigi dan mulut, terutama kesehatan gingivanya.Kata kunci: status gingiva, penderita diabetes melitus tipe 2

Large-Scale Cross-Sectional Study of the Problem Areas in Diabetes Survey among Japanese Patients with Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2393-PUB
Author(s):  
KENICHIRO TAKAHASHI ◽  
MINORI SHINODA ◽  
RIKA SAKAMOTO ◽  
JUN SUZUKI ◽  
TADASHI YAMAKAWA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Large Scale ◽  
Japanese Patients ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetes Survey

scholarly journals Associations between multimorbidity and glycaemia (HbA1c) in people with type 2 diabetes: cross-sectional study in Australian general practice

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e039625
Author(s):  
Jason I Chiang ◽  
John Furler ◽  
Frances Mair ◽  
Bhautesh D Jani ◽  
Barbara I Nicholl ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
General Practice ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Linear Regression Models ◽  
Sectional Study ◽  
Cross Sectional ◽  
Long Term Conditions ◽  
Australian General Practice

ObjectivesTo explore the prevalence of multimorbidity as well as individual and combinations of long-term conditions (LTCs) in people with type 2 diabetes (T2D) attending Australian general practice, using electronic health record (EHR) data. We also examine the association between multimorbidity condition count (total/concordant(T2D related)/discordant(unrelated)) and glycaemia (glycated haemoglobin, HbA1c).DesignCross-sectional study.SettingAustralian general practice.Participants69 718 people with T2D with a general practice encounter between 2013 and 2015 captured in the MedicineInsight database (EHR Data from 557 general practices and >3.8 million Australian patients).Primary and secondary outcome measuresPrevalence of multimorbidity, individual and combinations of LTCs. Multivariable linear regression models used to examine associations between multimorbidity counts and HbA1c (%).ResultsMean (SD) age 66.42 (12.70) years, 46.1% female and mean (SD) HbA1c 7.1 (1.4)%. More than 90% of participants with T2D were living with multimorbidity. Discordant conditions were more prevalent (83.4%) than concordant conditions (69.9 %). The three most prevalent discordant conditions were: painful conditions (55.4%), dyspepsia (31.6%) and depression (22.8%). The three most prevalent concordant conditions were hypertension (61.4%), coronary heart disease (17.1%) and chronic kidney disease (8.5%). The three most common combinations of conditions were: painful conditions and hypertension (38.8%), painful conditions and dyspepsia (23.1%) and hypertension and dyspepsia (22.7%). We found no associations between any multimorbidity counts (total, concordant and discordant) or combinations and HbA1c.ConclusionsMultimorbidity was common in our cohort of people with T2D attending Australian general practice, but was not associated with glycaemia. Although we did not explore mortality in this study, our results suggest that the increased mortality in those with multimorbidity and T2D observed in other studies may not be linked to glycaemia. Interestingly, discordant conditions were more prevalent than concordant conditions with painful conditions being the second most common comorbidity. Better understanding of the implications of different patterns of multimorbidity in people with T2D will allow more effective tailored care.

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