scholarly journals Sulfated Polysaccharides from Marine Algae as a Basis of Modern Biotechnologies for Creating Wound Dressings: Current Achievements and Future Prospects

Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 301 ◽  
Author(s):  
Boris G. Andryukov ◽  
Natalya N. Besednova ◽  
Tatyana A. Kuznetsova ◽  
Tatyana S. Zaporozhets ◽  
Svetlana P. Ermakova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Trial Data ◽  
Biological Properties ◽  
Biologically Active ◽  
Wound Dressings ◽  
Sulfated Polysaccharides ◽  
Wound Treatment ◽  
Accelerate Wound Healing ◽  
Therapeutic Tools ◽  
Scar Mark

Wound healing involves a complex cascade of cellular, molecular, and biochemical responses and signaling processes. It consists of successive interrelated phases, the duration of which depends on a multitude of factors. Wound treatment is a major healthcare issue that can be resolved by the development of effective and affordable wound dressings based on natural materials and biologically active substances. The proper use of modern wound dressings can significantly accelerate wound healing with minimum scar mark. Sulfated polysaccharides from seaweeds, with their unique structures and biological properties, as well as with a high potential to be used in various wound treatment methods, now undoubtedly play a major role in innovative biotechnologies of modern natural interactive dressings. These natural biopolymers are a novel and promising biologically active source for designing wound dressings based on alginates, fucoidans, carrageenans, and ulvans, which serve as active and effective therapeutic tools. The goal of this review is to summarize available information about the modern wound dressing technologies based on seaweed-derived polysaccharides, including those successfully implemented in commercial products, with a focus on promising and innovative designs. Future perspectives for the use of marine-derived biopolymers necessitate summarizing and analyzing results of numerous experiments and clinical trial data, developing a scientifically substantiated approach to wound treatment, and suggesting relevant practical recommendations.

scholarly journals Sulfated Polysaccharides From Sea Algae as the Basis of Modern Biotechnologies for Creating Wound Coverings: Current Achievements and Coming Prospects

2020 ◽  
Author(s):  
Boris Andryukov ◽  
Natalya Besednova ◽  
Tatyana Kuznetsova ◽  
Tatyana Zaporozhets ◽  
Svetlana Ermakova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Trial Data ◽  
Biological Properties ◽  
Biologically Active ◽  
Wound Dressings ◽  
Sulfated Polysaccharides ◽  
Accelerate Wound Healing ◽  
In Vivo Experiments

Wound healing involves a complex cascade of cellular, molecular, and biochemical responses and signaling processes. It consists of successive interrelated phases, the duration of which depends on multifactorial processes. Wound treatment is a major healthcare issue that can be resolved by development of effective and affordable wound dressings based on natural materials and biologically active substances. Proper use of modern wound dressings can significantly accelerate wound healing with minimal cosmetic defects. The innovative biotechnologies for creating modern natural interactive dressings are based on sulfated polysaccharides from seaweeds with their unique structures and biological properties, the availability of their sources in the form of wild bushes, and in the form of aquaculture, as well as with a high potential for participation in process control wound healing. These natural biopolymers are a novel and promising biologically active source for designing wound dressings based on alginates, fucoidans, carrageenans, and ulvans, which serve as active and effective therapeutic tools. The aim of this review is to summarize available information about the modern wound dressing’s technologies based on seaweed-derived polysaccharides, including those successfully implemented in commercial products, with the emphasis on promising and innovative designs. The further prospect of using marine biopolymers is related to the need to analyze the results of numerous in vitro and in vivo experiments, summarize clinical trial data, develop a scientifically based approach and relevant practical recommendations for the treatment of wounds.

scholarly journals Development of Spanish Broom and Flax Dressings with Glycyrrhetinic Acid-Loaded Films for Wound Healing: Characterization and Evaluation of Biological Properties

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1192
Author(s):  
Angela Abruzzo ◽  
Concettina Cappadone ◽  
Valentina Sallustio ◽  
Giovanna Picone ◽  
Martina Rossi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Drug Loading ◽  
Healing Process ◽  
In Vitro Release ◽  
Sodium Hyaluronate ◽  
Biological Properties ◽  
Glycyrrhetinic Acid ◽  
Wound Dressings ◽  
Biological Studies

The selection of an appropriate dressing for each type of wound is a very important procedure for a faster and more accurate healing process. So, the aim of this study was to develop innovative Spanish Broom and flax wound dressings, as alternatives to cotton used as control, with polymeric films containing glycyrrhetinic acid (GA) to promote wound-exudate absorption and the healing process. The different wound dressings were prepared by a solvent casting method, and characterized in terms of drug loading, water uptake, and in vitro release. Moreover, biological studies were performed to evaluate their biocompatibility and wound-healing efficacy. Comparing the developed wound dressings, Spanish Broom dressings with GA-loaded sodium hyaluronate film had the best functional properties, in terms of hydration ability and GA release. Moreover, they showed a good biocompatibility, determining a moderate induction of cell proliferation and no cytotoxicity. In addition, the wound-healing test revealed that the Spanish Broom dressings promoted cell migration, further facilitating the closure of the wound.

scholarly journals Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation

2019 ◽  
Author(s):  
Chen-Chen Zhao ◽  
Lian Zhu ◽  
Zheng Wu ◽  
Rui Yang ◽  
Na Xu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Damage Model ◽  
Skin Wound ◽  
Scar Formation ◽  
Wound Dressings ◽  
Skin Damage ◽  
Skin Wound Healing ◽  
Accelerate Wound Healing ◽  
Peptide Hydrogels

Abstract Scar formation seriously affects the repair of damaged skin especially in adults and the excessive inflammation has been considered as the reason. The self-assembled peptide-hydrogels are ideal biomaterials for skin wound healing due to their similar nanostructure to natural extracellular matrix, hydration environment and serving as drug delivery systems. In our study, resveratrol, a polyphenol compound with anti-inflammatory effect, is loaded into peptide-hydrogel (Fmoc-FFGGRGD) to form a wound dressing (Pep/RES). Resveratrol is slowly released from the hydrogel in situ, and the release amount is controlled by the loading amount. The in vitro cell experiments demonstrate that the Pep/RES has no cytotoxicity and can inhibit the production of pro-inflammatory cytokines of macrophages. The Pep/RES hydrogels are used as wound dressings in rat skin damage model. The results suggest that the Pep/RES dressing can accelerate wound healing rate, exhibit well-organized collagen deposition, reduce inflammation and eventually prevent scar formation. The Pep/RES hydrogels supply a potential product to develop new skin wound dressings for the therapy of skin damage.

Erfahrungen mit einer Hydrofaser in der Behandlung von chronischen Wunden, insbesondere beim diabetischen Fuss

VASA ◽  
2000 ◽  
Vol 29 (4) ◽  
pp. 253-257 ◽  
Author(s):  
Urs Brunner ◽  
Eberlein
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
General Medicine ◽  
Positive Influence ◽  
Wound Dressings ◽  
Treatment Result ◽  
Major Advance ◽  
Accelerate Wound Healing ◽  
Everyday Problem ◽  
Diabetic Wounds

Background: Chronic wounds are an everyday problem in general medicine. Likewise, their persistence, painfulness and frequency of relapse are everyday problems which strain the stamina of patients and doctors to the point of desperation. Over recent years, the moist therapy concept has proven to be a major advance in wound treatment. The introduction of innovative wound dressings in the 1990’s made it possible to substantially accelerate wound healing and couple it with a simultaneous alleviation of pain. Patients:In the scope of our team’s experience one such product is the hydrofibre. This paper offers information on the possibilities for using this material on the basis of 135 wound situations, 44% of which are within the context of diabetes mellitus. Results: There was a positive influence on wound healing in 92% of the cases. This treatment result is analysed in terms of causal, topographic and iconographic aspects. Conclusion: Given the main focal points of our group of patients, it may be stated that hydrofibres are suitable for diabetic wounds.

scholarly journals Antihypertensive and anticoagulant properties of glycosaminoglycans extracted from the sturgeon (Acipenser persicus) cartilage

2018 ◽  
Vol 31 (4) ◽  
pp. 163-169
Author(s):  
Katayoon Karimzadeh
Keyword(s):  
Anticoagulant Activity ◽  
Cetylpyridinium Chloride ◽  
Dry Weight ◽  
Biological Properties ◽  
Biologically Active ◽  
Sulfated Polysaccharides ◽  
Chloride Salt ◽  
Thrombin Time ◽  
Acipenser Persicus ◽  
Ace Inhibitory

Abstract Large amounts of valuable waste are produced during sea food processing. This has a great potential for conversion to biologically active proteins and polysaccharides. Among these compounds, sulfated polysaccharides have been considered due to their many biological properties. The present work was conducted to study anticoagulant activities and angiotensin-I converting enzyme (ACE) inhibitory effects of glycosaminoglycans (GAGs) extracted from the cartilage of sturgeon (Acipenser persicus). The enzymatic extraction of sturgeon cartilage was performed in the presence of cetylpyridinium chloride salt. The structure was characterized via electron microscope and Fourier transform infrared spectroscopy (FTIR) analysis. Herein, ACE inhibitory and anticoagulant properties of extracted GAGs were determined. The amount of GAGs was 6.8±1.3% of cartilage dry weight. GAGs showed good activity in ACE inhibitory – with a highest level of 85.7%. The derived anticoagulant activity indexes, APPT (activated partial thromboplastin time) and TT (Thrombin time) of the extracted polysaccharide showed a prolonging of clotting time, compare to control. The results of this study revealed that the cartilage extracted GAGs possess promising ACE inhibitory properties and anticoagulant effects. Thus, the product can be substituted for blood reducing drugs and antithrombotic agents at least in laboratory conditions.

scholarly journals Wound healing effect of “Prolidoxid” and “Dexpanthenol with ceramides”: a сomparative study based on the model of chemical burns with expressed alterative skin processes

2021 ◽  
pp. 26-32
Author(s):  
Yaroslava Butko ◽  
Oksana Tkachova ◽  
Tetyana Tishakova ◽  
Anatoly Gordienko ◽  
Yevhen Bondariev
Keyword(s):  
Wound Healing ◽  
Hematological Parameters ◽  
Wound Treatment ◽  
Chemical Burn ◽  
Therapeutic Action ◽  
Medicinal Products ◽  
Chemical Burns ◽  
Accelerate Wound Healing ◽  
Healing Effect ◽  
Wound Healing Effect

Pharmacotherapy of chemical skin injuries remains an urgent issue today due to its serious health consequences and possible development of complications. Topical treatment is one of the most effective methods of wound treatment using hydrophilic ointments and creams. For now, range of hydrophilic medicinal products with a broad spectrum of action is limited. That is why a search and development of new hydrophilic ointments and creams remains an urgent challenge. The aim. The aim of this research was to study effectiveness of ointment “Prolidoxid” and cream “Dexpanthenol with ceramides” on the experimental chemical burn model in rats. Materials and methods. Wound healing effect of ointment “Prolidoxid” and cream “Dexpanthenol with ceramides” was proved by the study of planimetric and hematological parameters on the model of acetic acid burns in rats. Results. Using animal model of chemical burns it was found that ointment “Prolidoxid” and cream “Dexpanthenol with ceramides” accelerate wound healing on Day 5 and Day 6, consequently, compared to untreated control animals, but in comparison with the action of reference medicine wounds were healed two days faster. Hematological parameters showed that studied medicines inhibit inflammation and reactivate blood rheological properties. Conclusions. The results suggest that effectiveness of cream “Dexpanthenol with ceramides” is higher than for one-component cream “Dexpanthenol”, but ointment “Prolidoxid” exceeds therapeutic action of ointment “Wundahyl” as reported by hematological and planimetric parameters

scholarly journals Human Mesenchymal Stromal Cell-Derived Exosomes Promote In Vitro Wound Healing by Modulating the Biological Properties of Skin Keratinocytes and Fibroblasts and Stimulating Angiogenesis

2021 ◽  
Vol 22 (12) ◽  
pp. 6239
Author(s):  
Raluca Tutuianu ◽  
Ana-Maria Rosca ◽  
Daniela Madalina Iacomi ◽  
Maya Simionescu ◽  
Irina Titorencu
Keyword(s):  
Wound Healing ◽  
Smooth Muscle Actin ◽  
Cell Types ◽  
Biological Properties ◽  
Dermal Fibroblasts ◽  
Type I ◽  
Accelerate Wound Healing ◽  
Skin Keratinocytes ◽  
And Migration

Bone marrow-derived mesenchymal stromal cells (MSCs) are major players in regenerative therapies for wound healing via their paracrine activity, mediated partially by exosomes. Our purpose was to test if MSC-derived exosomes could accelerate wound healing by enhancing the biological properties of the main cell types involved in the key phases of this process. Thus, the effects of exosomes on (i) macrophage activation, (ii) angiogenesis, (iii) keratinocytes and dermal fibroblasts proliferation and migration, and (iv) the capacity of myofibroblasts to regulate the turnover of the extracellular matrix were evaluated. The results showed that, although exosomes did not exhibit anti-inflammatory properties, they stimulated angiogenesis. Exposure of keratinocytes and dermal (myo)fibroblasts to exosomes enhanced their proliferation and migratory capacity. Additionally, exosomes prevented the upregulation of gene expression for type I and III collagen, α-smooth muscle actin, and MMP2 and 14, and they increased MMP13 expression during the fibroblast–myofibroblast transition. The regenerative properties of exosomes were validated using a wound healing skin organotypic model, which exhibited full re-epithelialization upon exosomes exposure. In summary, these data indicate that exosomes enhance the biological properties of keratinocytes, fibroblasts, and endothelial cells, thus providing a reliable therapeutic tool for skin regeneration.

One-pot, self-catalyzed synthesis of self-adherent hydrogels for photo-thermal, antimicrobial wound treatment

2021 ◽  
Vol 9 (1) ◽  
pp. 159-169
Author(s):  
Pengfei Li ◽  
Wenqi She ◽  
Yadong Luo ◽  
Dengfeng He ◽  
Jiali Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressings ◽  
Wound Treatment ◽  
One Pot

Self-adhering hydrogels are promising materials to be employed as wound dressings, because they can be used for wound healing without the necessity of additional stitching.

Enzyme-catalyzed in situ forming gelatin hydrogels as bioactive wound dressings: effects of fibroblast delivery on wound healing efficacy

2014 ◽  
Vol 2 (44) ◽  
pp. 7712-7718 ◽  
Author(s):  
Yunki Lee ◽  
Jin Woo Bae ◽  
Jin Woo Lee ◽  
Wonhee Suh ◽  
Ki Dong Park
Keyword(s):  
Wound Healing ◽  
Wound Dressings ◽  
Wound Treatment ◽  
In Situ Forming

Wound treatment using injectable or sprayable fibroblast-encapsulated GH-hydrogels.

scholarly journals Effective spatio-temporal regimes for wound treatment by way of macrophage polarization: A mathematical model

2021 ◽  
Author(s):  
Ksenia Zlobina ◽  
Jiahao Xue ◽  
Marcella Gomez
Keyword(s):  
Mathematical Model ◽  
Wound Healing ◽  
Treatment Effectiveness ◽  
Macrophage Polarization ◽  
Healing Time ◽  
Wound Treatment ◽  
Optimal Regime ◽  
Macrophage Activity ◽  
Accelerate Wound Healing ◽  
Spatio Temporal

Wound healing consists of a sequence of biological processes often grouped into different stages. Interventions applied to accelerate normal wound healing must take into consideration timing with respect to wound healing stages in order to maximize treatment effectiveness. Macrophage polarization from M1 to M2 represents a transition from the inflammatory to proliferation stage of wound healing. Accelerating this transition may be an effective way to accelerate wound healing; however, it must be induced at the appropriate time. We search for an optimal spatio-temporal regime to apply wound healing treatment in a mathematical model of wound healing. In this work we show that to maximize effectiveness, treatment must not be applied too early or too late. We also show that effective spatial distribution of treatment depends on the heterogenity of the wound surface. In conclusion, this research provides a possible optimal regime of therapy that focuses on macrophage activity and a hypothesis of treatment outcome to be tested experimentally in future. Finding best regimes for treatment application is a first step towards development of intelligent algorithms of wound treatment that minimize healing time.

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