scholarly journals Multiple Sclerosis in a Multi-Ethnic Population in Houston, Texas: A Retrospective Analysis

Biomedicines ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 534
Author(s):  
Vicki Mercado ◽  
Deepa Dongarwar ◽  
Kristen Fisher ◽  
Hamisu M. Salihu ◽  
George J. Hutton ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Atrophy ◽  
Clinical Encounter ◽  
Mri Findings ◽  
Disease Epidemiology ◽  
Treatment Regimens ◽  
Hispanic Patients ◽  
History Of ◽  
Different Populations ◽  
Disability Severity

Multiple Sclerosis (MS) is a progressive neurodegenerative disease that affects more than 2 million people worldwide. Increasing knowledge about MS in different populations has advanced our understanding of disease epidemiology and variation in the natural history of MS among White and minority populations. In addition to differences in incidence, African American (AA) and Hispanic patients have greater disease burden and disability in earlier stages of disease compared to White patients. To further characterize MS in AA and Hispanic populations, we conducted a retrospective chart analysis of 112 patients treated at an MS center in Houston, Texas. Here, we describe similarities and differences in clinical presentation, MRI findings, treatment regimens, disability progression, and relapse rate. While we found several similarities between the groups regarding mean age, disability severity, and degree of brain atrophy at diagnosis, we also describe a few divergences. Interestingly, we found that patients who were evaluated by a neurologist at symptom onset had significantly decreased odds of greater disability [defined as Expanded Disability Status Scale (EDSS) > 4.5] at last presentation compared to patients who were not evaluated by a neurologist (OR: 0.04, 95% CI: 0.16–0.9). We also found that active smokers had significantly increased odds of greater disability both at diagnosis and at last clinical encounter compared to nonsmokers (OR: 2.44, 95% CI: 1.10–7.10, OR= 2.44, 95% CI: 1.35–6.12, p = 0.01, respectively). Additionally, we observed significant differences in treatment adherence between groups. Assessment of the degree of brain atrophy and progression over time, along with an enumeration of T1, T2, and gadolinium-enhancing brain lesions, did not reveal differences across groups.

scholarly journals Multiple Sclerosis in a Multi-Ethnic Population in Houston, Texas: A Retrospective Analysis

2020 ◽  
Author(s):  
Vicki Mercado ◽  
Deepa Dongarwar ◽  
Kristen Fisher ◽  
Hamisu M. Salihu ◽  
George J. Hutton ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Burden ◽  
Clinical Encounter ◽  
Mri Findings ◽  
Disease Epidemiology ◽  
Treatment Regimens ◽  
Disability Status ◽  
Hispanic Patients ◽  
History Of ◽  
Different Populations

Multiple Sclerosis (MS) is a progressive neurodegenerative disease that affects more than 2 million people worldwide. Increasing knowledge about MS in different populations has advanced our understanding of disease epidemiology and variation in the natural history of MS among White and minority populations. In addition to differences in incidence, African American (AA) and Hispanic patients have greater disease burden and disability in earlier stages of disease compared to White patients. To further characterize MS in AA and Hispanic populations, we conducted a retrospective chart analysis of 112 patients treated at an MS center in Houston, Texas. Here, we describe differences in clinical presentation, MRI findings, treatment regimens, disability progression, and relapse rate. We found that patients who were evaluated by a neurologist at symptom onset had significantly decreased odds of greater disability [defined as Expanded Disability Status Scale (EDSS) > 4.5] at last presentation compared to patients who were not evaluated by a neurologist (OR: 0.04, 95% CI: 0.16-0.9). We also found that active smokers had significantly increased odds of greater disability both at diagnosis and at last clinical encounter compared to nonsmokers (OR: 2.44, 95% CI: 1.10-7.10, OR= 2.44, 95% CI: 1.35-6.12, p= 0.01, respectively). Assessment of the degree of brain atrophy and progression over time along with enumeration of T1, T2, and gadolinium-enhancing brain lesions did not reveal differences across groups.

The frequency and characteristics of MS misdiagnosis in patients referred to the multiple sclerosis centre of Catalonia

2021 ◽  
pp. 135245852098814 ◽  
Author(s):  
Luciana Midaglia ◽  
Jaume Sastre-Garriga ◽  
Agustín Pappolla ◽  
Laura Quibus ◽  
René Carvajal ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Low Frequency ◽  
White Matter Lesions ◽  
Final Diagnosis ◽  
Personal History ◽  
Contributing Factors ◽  
Mri Findings ◽  
History Of ◽  
A Prospective Study

Background: Multiple sclerosis (MS) misdiagnosis may cause physical and emotional damage to patients. Objectives: The objective of this study is to determine the frequency and characteristics of MS misdiagnosis in patients referred to the Multiple Sclerosis Centre of Catalonia. Methods: We designed a prospective study including all new consecutive patients referred to our centre between July 2017 and June 2018. Instances of misdiagnosis were identified, and referral diagnosis and final diagnosis were compared after 1 year of follow-up. Association of misdiagnosis with magnetic resonance imaging (MRI) findings, presence of comorbidities and family history of autoimmunity were assessed. Results: A total of 354 patients were referred to our centre within the study period, 112 (31.8%) with ‘established MS’. Misdiagnosis was identified in eight out of 112 cases (7.1%). MRI identified multifocal white matter lesions, deemed non-specific or not suggestive of MS in all misdiagnosed cases. Patients with MS misdiagnosis had more comorbidities in general than patients with MS ( p = 0.026) as well as a personal history of autoimmunity ( p < 0.001). Conclusion: A low frequency of MS misdiagnosis was found in our clinical setting. Multifocal non-specific white matter lesions in referral MRI examinations and the presence of comorbidities, including a personal history of autoimmunity, seem to be contributing factors to misdiagnosis.

scholarly journals Multiple sclerosis neuropathic arthropathy of elbow: Report of a rare case and literature review

2019 ◽  
Vol 26 (1) ◽  
pp. 52-55
Author(s):  
Mohammad Hassani ◽  
Mohammad Javad Shariyate ◽  
Bita Abbasi ◽  
Faezeh Nemati Karimooy
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Resonance Images ◽  
Joint Disease ◽  
Mri Findings ◽  
Neuropathic Arthropathy ◽  
Left Elbow ◽  
Clinical Presentations ◽  
History Of ◽  
Tumor Involvement ◽  
Underlying Diseases

Neuropathic arthropathy (NA) is a progressive degenerative and destructive joint disease associated with underlying chronic neurologic deficit. A 34-year-old woman was referred to our tumor clinic with swelling and destruction of her left elbow joint. Except for a 5-year history of multiple sclerosis (MS), she had no other underlying diseases. Suspected of tumor involvement, she had been undergone an open biopsy. The pathologic report was fibromatosis, which was not compatible with imaging studies and clinical presentations. Second surgical inspection and cellular study didn’t prove tumoral involvement. Magnetic resonance images (MRIs) showed multiple hyper signal plaques in her cervical spine. MRI findings, clinical features, surgical observations, and disproportionate painless elbow destruction all confirmed the MS NA diagnosis.

Periodic hyperthermia and abnormal circadian temperature rhythm in a patient with multiple sclerosis

2006 ◽  
Vol 12 (4) ◽  
pp. 515-517 ◽  
Author(s):  
J E Martinez-Rodriguez ◽  
E Munteis ◽  
J Roquer
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Presentation ◽  
Thermal Control ◽  
Mri Findings ◽  
Bilateral Involvement ◽  
Diffuse White Matter ◽  
Temperature Rhythm ◽  
Body Temperature Measurement ◽  
History Of ◽  
The Central Nervous System

Disturbances of the central thermoregulation in patients with multiple sclerosis (MS) are not often reported. We describe a 45-year old patient with a 13-year history of MS, who developed a clinical picture of recurrent hyperthermia. MRI showed a bilateral involvement of the hypothalamus in the setting of diffuse white matter disease. Serial body temperature measurement for five consecutive months disclosed an inversion of the circadian temperature rhythm. The clinical presentation and MRI findings suggested abnormalities of the central thermal control in relation to MS widespread involvement of the central nervous system (CNS).

Clinical Features of Patients With Familiar Multiple Sclerosis in Lithuania

2019 ◽  
Author(s):  
Denas Andrijauskis ◽  
Renata Balnyte ◽  
Ieva Keturkaite ◽  
Antanas Vaitkus
Keyword(s):  
Multiple Sclerosis ◽  
Family History ◽  
Acute Onset ◽  
Control Group ◽  
Study Group ◽  
Conversion Table ◽  
History Of ◽  
Severity Of The Disease ◽  
Mri Changes ◽  
Disability Severity

Abstract Background. Most multiple sclerosis (MS) cases are sporadic, however about 20 percent are hereditary [2]. It is still unclear whether heredity affects the progression and severity of the disease. The aim of this study is to assess the effect of heredity on the development of multiple sclerosis and on the course of disease by analyzing the results of disability, severity scales and clinical studies, and comparing them with sporadic cases. Methods. Our study included 104 patients with MS. The study group was comprised of 38 patients with family history of MS; the control group consisted of 66 patients with no family history. The survey included questions about demographic and clinical characteristics. Diagnostic results were evaluated retrospectively from medical records. Disability assessment was made according to EDSS. MSSS score was calculated using conversion table. Results. Patients with a family history tend to have slower onset of the disease, while control group is more likely to have an acute onset (p <0.001). Study group more often complained of symptoms related to pyramidal (74 % vs. 50 %) and brainstem (68 % vs. 20 %), cognitive dysfunction (47 % vs. 20 %), headache (37 % vs. 9 %), back pain (32 % vs. 9 %) than those in control group, p <0.05. EDSS and MSSS scores were higher in familiar cases (p <0.05). The number of exacerbations per year was also higher in study group (1.4 vs. 0.8; p <0.05). Patients with a family history have a higher incidence of MRI changes in brainstem (74% vs. 30%) and cerebellum (58% vs. 30%) than the control group (p <0.01). Conclusions. Patients with a family history tend to have slower onset of the disease, while control group is more likely to have an acute onset. Patients with a family history of MS more often complained of brainstem and cortical dysfunction, and pain in head or back. Both EDSS and MSSS scores were higher in familiar cases. They also have a higher number of exacerbations per year. Patients with a family history have a higher incidence of MRI changes in brainstem and cerebellum.

Computed Tomography and Magnetic Resonance Imaging-aided Diagnosis of Primary Essential Cutis Verticis Gyrata: A Case Report with 5-year Follow-up and Review of the Literature

2019 ◽  
Vol 15 (9) ◽  
pp. 906-910
Author(s):  
Hongzhang Zhu ◽  
Shi-Ting Feng ◽  
Xingqi Zhang ◽  
Zunfu Ke ◽  
Ruixi Zeng ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Three Dimensional ◽  
Stable Condition ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Cutis Verticis Gyrata ◽  
Essential Form ◽  
History Of ◽  
Magnetic Resonance Imaging Mri

Background: Cutis Verticis Gyrata (CVG) is a rare skin disease caused by overgrowth of the scalp, presenting as cerebriform folds and wrinkles. CVG can be classified into two forms: primary (essential and non-essential) and secondary. The primary non-essential form is often associated with neurological and ophthalmological abnormalities, while the primary essential form occurs without associated comorbidities. Discussion: We report on a rare case of primary essential CVG with a 4-year history of normal-colored scalp skin mass in the parietal-occipital region without symptom in a 34-year-old male patient, retrospectively summarizing his pathological and Computer Tomography (CT) and magnetic resonance imaging (MRI) findings. The major clinical observations on the CT and MR sectional images include a thickened dermis and excessive growth of the scalp, forming the characteristic scalp folds. With the help of CT and MRI Three-dimensional (3D) reconstruction techniques, the characteristic skin changes could be displayed intuitively, providing more evidence for a diagnosis of CVG. At the 5-year followup, there were no obvious changes in the lesion. Conclusion: Based on our observations, we propose that not all patients with primary essential CVG need surgical intervention, and continuous clinical observation should be an appropriate therapy for those in stable condition.

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