scholarly journals Photo-Based Nanomedicines Using Polymeric Systems in the Field of Cancer Imaging and Therapy

Biomedicines ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 618
Author(s):  
Patihul Husni ◽  
Yuseon Shin ◽  
Jae Chang Kim ◽  
Kioh Kang ◽  
Eun Seong Lee ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Optical Imaging ◽  
Photothermal Therapy ◽  
Cancer Imaging ◽  
Polymeric Systems ◽  
Therapeutic Applications ◽  
Shed Light

The use of photo-based nanomedicine in imaging and therapy has grown rapidly. The property of light in converting its energy into different forms has been exploited in the fields of optical imaging (OI) and phototherapy (PT) for diagnostic and therapeutic applications. The development of nanotechnology offers numerous advantages to overcome the challenges of OI and PT. Accordingly, in this review, we shed light on common photosensitive agents (PSAs) used in OI and PT; these include fluorescent and bioluminescent PSAs for OI or PT agents for photodynamic therapy (PDT) and photothermal therapy (PTT). We also describe photo-based nanotechnology systems that can be used in photo-based diagnostics and therapies by using various polymeric systems.

High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticles

2005 ◽  
Vol 10 (4) ◽  
pp. 041203 ◽  
Author(s):  
Hui Li ◽  
Diane E. Marotta ◽  
Soungkyoo Kim ◽  
Theresa M. Busch ◽  
E. Paul Wileyto ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Optical Imaging ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
High Payload

Porphyrin-lipid nanovesicles (Porphysomes) are effective photosensitizers for photodynamic therapy

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Keegan Guidolin ◽  
Lili Ding ◽  
Juan Chen ◽  
Brian C. Wilson ◽  
Gang Zheng
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Intrinsic Structure ◽  
Therapeutic Applications ◽  
Positron Emission ◽  
Theranostic Agents ◽  
Negative Controls ◽  
And Control ◽  
Complete Tumor

Abstract Porphysomes (PS) are liposome-like nanoparticles comprising pyropheophorbide-conjugated phospholipids that have demonstrated potential as multimodal theranostic agents for applications that include phototherapies, targeted drug delivery and in vivo fluorescence, photoacoustic, magnetic resonance or positron emission imaging. Previous therapeutic applications focused primarily on photothermal therapy (PTT) and suggested that PSs require target-triggered activation for use as photodynamic therapy (PDT) sensitizers. Here, athymic nude mice bearing subcutaneous A549 human lung tumors were randomized into treatment and control groups: PS-PDT at various doses, PS-only and no treatment negative controls, as well as positive controls using the clinical photosensitizer Photofrin. Animals were followed for 30 days post-treatment. PS-PDT at all doses demonstrated a significant tumor ablative effect, with the greatest effect seen with 10 mg/kg PS at a drug-light interval of 24 h. By comparison, negative controls (PS-only, Photofrin-only, and no treatment) showed uncontrolled tumor growth. PDT with Photofrin at 5 mg/kg and PS at 10 mg/kg demonstrated similar tumor growth suppression and complete tumor response rates (15 vs. 25%, p = 0.52). Hence, porphysome nanoparticles are an effective PDT agent and have the additional advantages of multimodal diagnostic and therapeutic applications arising from their intrinsic structure. Porphysomes may also be the first single all-organic agent capable of concurrent PDT and PTT.

scholarly journals New Insights into the Therapeutic Applications of CRISPR/Cas9 Genome Editing in Breast Cancer

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 723
Author(s):  
Munazza Ahmed ◽  
Grace Hope Daoud ◽  
Asmaa Mohamed ◽  
Rania Harati
Keyword(s):  
Breast Cancer ◽  
Dna Sequence ◽  
Gene Editing ◽  
Causes Of Death ◽  
Breast Cancer Treatment ◽  
Delivery Methods ◽  
Therapeutic Applications ◽  
Tumorigenic Potential ◽  
Its Gene ◽  
Shed Light

Breast cancer is one of the most prevalent forms of cancer globally and is among the leading causes of death in women. Its heterogenic nature is a result of the involvement of numerous aberrant genes that contribute to the multi-step pathway of tumorigenesis. Despite the fact that several disease-causing mutations have been identified, therapy is often aimed at alleviating symptoms rather than rectifying the mutation in the DNA sequence. The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 is a groundbreaking tool that is being utilized for the identification and validation of genomic targets bearing tumorigenic potential. CRISPR/Cas9 supersedes its gene-editing predecessors through its unparalleled simplicity, efficiency and affordability. In this review, we provide an overview of the CRISPR/Cas9 mechanism and discuss genes that were edited using this system for the treatment of breast cancer. In addition, we shed light on the delivery methods—both viral and non-viral—that may be used to deliver the system and the barriers associated with each. Overall, the present review provides new insights into the potential therapeutic applications of CRISPR/Cas9 for the advancement of breast cancer treatment.

scholarly journals Organic dots (O-dots) for theranostic applications: preparation and surface engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2253-2291
Author(s):  
Amin Shiralizadeh Dezfuli ◽  
Elmira Kohan ◽  
Sepand Tehrani Fateh ◽  
Neda Alimirzaei ◽  
Hamidreza Arzaghi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Surface Engineering ◽  
Graphene Quantum Dots ◽  
Carbon Quantum Dots ◽  
Cargo Delivery ◽  
Bio Imaging ◽  
Theranostic Applications

Organic dots is a term used to represent materials including graphene quantum dots and carbon quantum dots because they rely on the presence of other atoms (O, H, and N) for their photoluminescence or fluorescence properties. Cargo delivery, bio-imaging, photodynamic therapy and photothermal therapy are major biomedical applications of organic dots.

Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

2021 ◽  
Author(s):  
Zhaoguo Han ◽  
xianshuang tu ◽  
Lina Qiao ◽  
Yige Sun ◽  
Zibo Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Multimodal Imaging

Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT) possesses unique characteristics of non-invasiveness and minimal side effects in cancer treatment, compared with conventional therapies. However, the ubiquitous tumor...

Porphyrin-related photosensitizers for cancer imaging and therapeutic applications

2005 ◽  
Vol 218 (2) ◽  
pp. 133-147 ◽  
Author(s):  
K. BERG ◽  
P. K. SELBO ◽  
A. WEYERGANG ◽  
A. DIETZE ◽  
L. PRASMICKAITE ◽  
...  
Keyword(s):  
Cancer Imaging ◽  
Therapeutic Applications

scholarly journals A COF-based nanoplatform for highly efficient cancer diagnosis, photodynamic therapy and prognosis

2020 ◽  
Vol 11 (26) ◽  
pp. 6882-6888 ◽  
Author(s):  
Peng Gao ◽  
Mengzhen Wang ◽  
Yuanyuan Chen ◽  
Wei Pan ◽  
Ping Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Diagnosis ◽  
Cancer Imaging ◽  
Covalent Organic Framework ◽  
Highly Efficient ◽  
Organic Framework

A covalent organic framework-based nanoplatform has been developed for cancer imaging, photodynamic therapy, and prognosis.

scholarly journals Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics

2018 ◽  
Vol 6 (4) ◽  
pp. 746-765 ◽  
Author(s):  
Houjuan Zhu ◽  
Penghui Cheng ◽  
Peng Chen ◽  
Kanyi Pu
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Spatial Resolution ◽  
Photothermal Therapy ◽  
Normal Tissue ◽  
Recent Progress ◽  
Near Infrared ◽  
Tumor Ablation ◽  
Ablation Efficiency ◽  
Excellent Spatial Resolution

Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue.

Recent advances in combinatorial cancer therapy via multifunctionalized gold nanoparticles

Nanomedicine ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. 1221-1237
Author(s):  
Touqeer Ahmad ◽  
Rizwana Sarwar ◽  
Ayesha Iqbal ◽  
Uzma Bashir ◽  
Umar Farooq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Therapeutic Implications ◽  
Therapeutic Applications ◽  
Diagnosis Of Cancer ◽  
Targeted Drug ◽  
Cancerous Cells

The diverse behavior of nanogold in the therapeutic field is related to its unique size and shape. Nanogold offers improvements in modern diagnostic and therapeutic implications, increases disease specificity and targeted drug delivery, and is relatively economical compared with other chemotherapeutic protocols. The diagnosis of cancer and photothermal therapy improve drastically with the implementation of nanotechnology. Different types of nanoparticles, that is, gold silica nanoshells, nanorods and nanospheres of diverse shapes and geometries, are used widely in the photothermal therapy of cancerous cells and nodules. Numerous reviews have been published on the therapeutic applications of gold nanoparticles, but studies on combinatorial applications of nanogold in cancer therapy are limited. This review focuses on the combinatorial cancer therapy using optical properties of nanogold with different shapes and geometries, and their therapeutic applications in cancer diagnosis, photothermal therapy, cancer imaging and targeted drug delivery.

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