scholarly journals Nutraceuticals and Herbs in Reducing the Risk and Improving the Treatment of COVID-19 by Targeting SARS-CoV-2

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1266
Author(s):  
Priti Tagde ◽  
Sandeep Tagde ◽  
Pooja Tagde ◽  
Tanima Bhattacharya ◽  
Shams Minhaz Monzur ◽  
...  
Keyword(s):  
Prescription Drugs ◽  
Food Additives ◽  
Specific Treatment ◽  
The Body ◽  
Natural Food ◽  
Risk Of Infection ◽  
Human Immune System ◽  
Affected Person ◽  
Coronavirus Infection ◽  
Human Immune

The worldwide transmission of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a deadly or devastating disease is known to affect thousands of people every day, many of them dying all over the planet. The main reason for the massive effect of COVID-19 on society is its unpredictable spread, which does not allow for proper planning or management of this disease. Antibiotics, antivirals, and other prescription drugs, necessary and used in therapy, obviously have side effects (minor or significant) on the affected person, there are still not clear enough studies to elucidate their combined effect in this specific treatment, and existing protocols are sometimes unclear and uncertain. In contrast, it has been found that nutraceuticals, supplements, and various herbs can be effective in reducing the chances of SARS-CoV-2 infection, but also in alleviating COVID-19 symptoms. However, not enough specific details are yet available, and precise scientific studies to validate the approved benefits of natural food additives, probiotics, herbs, and nutraceuticals will need to be standardized according to current regulations. These alternative treatments may not have a direct effect on the virus or reduce the risk of infection with it, but these products certainly stimulate the human immune system so that the body is better prepared to fight the disease. This paper aims at a specialized literary foray precisely in the field of these “cures” that can provide real revelations in the therapy of coronavirus infection

Experimental Study of Biological Material Preparation Based on Optical and Mechanical Dynamics

2014 ◽  
Vol 556-562 ◽  
pp. 366-370
Author(s):  
Jun Mei Wan ◽  
Ming Zhang Ao
Keyword(s):  
Konjac Glucomannan ◽  
The Body ◽  
Molar Ratio ◽  
Human Immune System ◽  
Scientific Analysis ◽  
Human Experiments ◽  
Data Statistics ◽  
Human Immune ◽  
Main Components ◽  
Mechanical Dynamics

The main components of Konjac glucomannan are glucose and glucomannan that are byڂ1-4 bond [ molar ratio is 1.6: (1~4) ] of high molecular weight non-ionic glucomannan, special glucose and mannose's ڂ-1-4chain structure isn't affected by the human digestive enzymes, and does not generate heat. According to the peculiar properties of konjac glucomannan, through the scientific experiment in the body of a rabbit to verify its unique immunological function, and then the human experiments after the effective experimental data statistics scientific analysis, finally the system can obtain the effect of konjac glucomannan on human immune system.

Immunization

2010 ◽  
pp. 460-464
Author(s):  
D. Goldblatt ◽  
M. Ramsay
Keyword(s):  
T Cells ◽  
Immune System ◽  
Infectious Diseases ◽  
Specific Antibody ◽  
The Body ◽  
Memory Cells ◽  
Human Immune System ◽  
Medical Interventions ◽  
Human Immune

Immunization is one of the most successful medical interventions ever developed: it prevents infectious diseases worldwide. Mechanism of effect—the basis for the success of immunization is that the human immune system is able to respond to vaccines by producing pathogen-specific antibody and memory cells (both B and T cells) which protect the body should the pathogen be encountered....

Immunization

2020 ◽  
pp. 706-712
Author(s):  
David Goldblatt ◽  
Mary Ramsay
Keyword(s):  
Infectious Diseases ◽  
The Body ◽  
World Health ◽  
Human Immune System ◽  
Edible Vaccines ◽  
Poor Countries ◽  
Medical Interventions ◽  
Human Immune ◽  
Set Up ◽  
Health Organization

Immunization is one of the most successful medical interventions ever developed: it prevents infectious diseases worldwide. The basis for its success is that the human immune system can respond to vaccines by producing pathogen-specific antibody and memory cells (both B and T cells) which protect the body should the pathogen be encountered. Most currently licensed vaccines contain live or killed bacterial or viral constituents, bacterial polysaccharides, or bacterial toxoids, while new types of vaccines are being developed that contain DNA. Most vaccines are delivered directly into skin or muscle via needles, or they are administered orally. New edible vaccines and vaccines delivered via the skin without the use of needles are being developed. The Expanded Programme on Immunization, set up by the World Health Organization to define which vaccines should be delivered in resource-poor countries, has done much to increase vaccination coverage among infants most at risk of infectious diseases.

scholarly journals The immune system as a biomonitor: explorations in innate and adaptive immunity

2013 ◽  
Vol 3 (2) ◽  
pp. 20120099 ◽  
Author(s):  
Niclas Thomas ◽  
James Heather ◽  
Gabriel Pollara ◽  
Nandi Simpson ◽  
Theres Matjeka ◽  
...  
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Lymphoid Tissue ◽  
Tissue Injury ◽  
Great Sensitivity ◽  
The Body ◽  
Human Immune System ◽  
Ligand Interactions ◽  
Human Immune ◽  
Body Self

The human immune system has a highly complex, multi-layered structure which has evolved to detect and respond to changes in the internal microenvironment of the body. Recognition occurs at the molecular or submolecular scale, via classical reversible receptor–ligand interactions, and can lead to a response with great sensitivity and speed. Remarkably, recognition is coupled to memory, such that responses are modulated by events which occurred years or even decades before. Although the immune system in general responds differently and more vigorously to stimuli entering the body from the outside (e.g. infections), this is an emergent property of the system: many of the recognition molecules themselves have no inherent bias towards external stimuli (non-self) but also bind targets found within the body (self). It is quite clear that the immune response registers pathophysiological changes in general. Cancer, wounding and chronic tissue injury are some obvious examples. Against this background, the immune system ‘state’ tracks the internal processes of the body, and is likely to encode information regarding both current and past disease processes. Moreover, the distributed nature of most immune responses (e.g. typically involving lymphoid tissue, non-lymphoid tissue, bone marrow, blood, extracellular interstitial spaces, etc.) means that many of the changes associated with immune responses are manifested systemically, and specifically can be detected in blood. This provides a very convenient route to sampling immune cells. We consider two different and complementary ways of querying the human immune ‘state’ using high-dimensional genomic screening methodologies, and discuss the potentials of these approaches and some of the technological and computational challenges to be overcome.

scholarly journals Macro- and microenvironment, its impact on human health and longevity

2020 ◽  
pp. 9-13
Author(s):  
V. E. Kazmirchuk ◽  
V. F. Orlik
Keyword(s):  
Human Health ◽  
Pathological Process ◽  
The Body ◽  
Human Immune System ◽  
Source Of Infection ◽  
Healthy Longevity ◽  
The Family ◽  
Health And Illness ◽  
Pathogenetic Factor ◽  
Human Immune

Currently there is a revival of interest in the intestinal microflora and its influence on human health and illness. Well-tied food is the basis for vital activity not only the necessary microflora, and is a building material for the human immune system. Not an important meaning in human health has a macrobriety, the idea of ​​which is much more complicated. In the treatment of one of the family members, it is necessary to examine all members for the presence of this source of infection, without the elimination of which to achieve the effectiveness of treatment is not possible. Hormones, cytostatics, chemotherapy cannot eliminate the pathological process with a preserving pathogenetic factor. It should be striving to clarify the causes and factors that served as a breakdown of the immune response and the launch of the pathological process in the body. From the position of modern immunology, as well as the theories of micro and macrobractions, it is possible to achieve a healthy longevity.

Immune response by the human body to SARS-CoV 2 infection

2021 ◽  
Vol 6 (1) ◽  
pp. 30-31
Author(s):  
PD Gupta
Keyword(s):  
Immune System ◽  
Lymphatic System ◽  
The Body ◽  
Human Beings ◽  
Human Immune System ◽  
First Line ◽  
Organ Systems ◽  
Mucous Membranes ◽  
Human Immune ◽  
Lymphatic Organs

A new virus SARS-CoV2 is responsible for Covid-19. Many existing drugs were tried but failed to treat Covid-19 patients. To begin with our immune system also couldn’t cope with Covid-19, therefore within no time it became pandemic. It is a well-known fact that our body fights against all infections and inflammations through well-organized immune system. The human immune system is made up of individual cells (T and B cells) and proteins as well as entire organs and organ systems. The organs of the immune system include skin and mucous membranes, and the organs of the lymphatic system. The skin and mucous membranes are the first line of defense against germs entering from outside the body and once the infection enter in the organs and tissues lymphatic organs take over. Additionally, here we also described gut bacteria and food to build up immunity. In this way human beings are fight against the new virus SARS-CoV2 infections.

scholarly journals The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host

mBio ◽  
2012 ◽  
Vol 3 (4) ◽  
Author(s):  
John R. Perfect
Keyword(s):  
The Body ◽  
Past Century ◽  
Human Immune System ◽  
Separate Species ◽  
Content Type ◽  
The Past ◽  
The Status ◽  
Causative Agents ◽  
Life Threatening ◽  
Human Immune

ABSTRACT Cryptococcosis is the leading invasive fungal infection in the world today. Over the past century, the causative agents, Cryptococcus neoformans and Cryptococcus gattii, have risen from the status of medical curiosities to common but life-threatening central nervous system pathogens. In an elegant experimental pathobiology study of these two organisms carried out by Ngamskulrungroj et al., there are three matters that merit further discussion. First is the question of whether there is a variable specific pathobiology for each yeast strain. Does it make biological and clinical sense to designate C. neoformans and C. gattii as two separate species? Second is the matter of how the organisms differ pathologically at the site of infection. Finally, there is the possibility that the human immune system responds differently to each species. Although no single study can provide definitive mechanistic answers to the important questions, this experimental pathology study and its discussion clearly frame the issues to be dissected.

scholarly journals Photocatalytic water purification from dioxins (fragments of theory)

2020 ◽  
Vol 2020 (3) ◽  
pp. 111-120
Author(s):  
A. Roysen ◽  
T Musienko
Keyword(s):  
Drinking Water ◽  
Water Purification ◽  
Physicochemical Process ◽  
Local Source ◽  
Practical Implementation ◽  
Human Immune System ◽  
Coronavirus Infection ◽  
Human Immune ◽  
Drinking Water Purification ◽  
The Impact

Contamination of all natural sources of drinking water by human activities has become a matter of extreme concern to all who understand this problem as a threat to civilization. Dioxins and dioxin-like substances have been classified as particularly dangerous pollutants in the last thirty years. The authors provide generalized information about the danger of environmental pollution with dioxins and dioxin-like toxicants. It is suggested that the total weakening of the immunity of the world's population due to the presence of dioxins in the environment, which are hormone-like superecotoxicants. The factor of mass exposure of the population to coronavirus infection (COVID 19) is not excluded, as a result of the impact of dioxins and dioxin-like substances on the human immune system. The authors consider the most promising method of drinking water purification to be the photocatalysis method implemented directly in a local source (domestic consumption, production of bottled water). The physicochemical process of photocatalytic water purification using TiO2 activated by artificial ultraviolet radiation as a catalyst is considered. It is reported about the work aimed at the practical implementation of measures for the purification of drinking water.

scholarly journals Docking and Homology Modelling of Human T-Helper Cells for Various SCFV Fragments Domains to Block the Access of GP120

2019 ◽  
Vol 8 (9S3) ◽  
pp. 720-723
Keyword(s):  
T Helper Cells ◽  
Homology Modelling ◽  
The Body ◽  
T Helper ◽  
Cd4 Cells ◽  
Human Immune System ◽  
Immunodeficiency Virus ◽  
Human Immune ◽  
Hiv Gp120 ◽  
Cd4 Lymphocytes

HIV (Human Immunodeficiency Virus) is a virus which directly attacks human immune system as well as certain body organs such as brain kidneys and heart. The resistant framework is comprised of unique cells, which are associated with shielding the body from contaminations and a few tumors. The essential cells assaulted by HIV are the CD4+ lymphocytes, which help direct invulnerable capacity in the body. Since CD4+ cells are required for appropriate resistant framework work, when enough CD4+ lymphocytes have been devastated by HIV, the safe framework scarcely works. A considerable lot of the issues experienced by individuals contaminated with HIV result from a disappointment of the resistant framework to shield them from certain artful diseases (OIs) and tumors. This situation is utilized in a reasonable universe of bioinformatics in order to shape conceivable structure of the HIV gp120 which is reason for T cell contamination and a structure of the cd4+, to think about the coupling example of the gp120 and cd4+ through the docking procedure.

Application of mesenchymal stem cells in kidney and urinary tract diseases: literature review and own experience

MedAlliance ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 34-43
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Direct Action ◽  
Superparamagnetic Iron Oxide ◽  
Mechanisms Of Action ◽  
The Body ◽  
Target Cells ◽  
Human Immune System ◽  
Human Immune ◽  
Magnetic Response Imaging

SummaryIn recent years, cell therapy of diseases of various or-gans and tissues is gaining popularity, including the use of mesenchymal stem cells (MSCs). Many studies have confirmed the presence of pronounced immunoregula-tory properties in this type of cells, which are mediated both by direct action on target cells and by signaling mo-lecules and cytokines. This review is devoted to the pos-sibilities of using MSCs in urological pathology, including a description of the mechanisms of action on the human immune system and the prospects for using this type of cells in experimental and clinical practice. The article presents our own experience in studying the distribution of mesenchymal stem cells in various tissues and organs on a model of kidney tuberculosis in rabbits. Material and methods. The study involved 18 rabbits with kid-ney tuberculosis, which were injected intravenously with mesenchymal stem cells labeled with superparamagnetic iron oxide nanoparticles (SPION), followed by highly sen-sitive nonlinear longitudinal magnetic response imaging (NLR-M2). Results. 48 hours after the injection, MSCs ac-cumulated in the lungs, spleen, liver, paratracheal lymph nodes, and kidneys. Conclusion. The NLR-M2 method allows detecting SPION-labeled cells in various organs and tissues, giving an idea of the mesenchymal stem cells movement in the body.

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