scholarly journals From Nanosystems to a Biosensing Prototype for an Efficient Diagnostic: A Special Issue in Honor of Professor Bansi D. Malhotra

Biosensors ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 359
Author(s):  
Ajeet Kaushik ◽  
Raju Khan ◽  
Pratima Solanki ◽  
Sonu Gandhi ◽  
Hardik Gohel ◽  
...  
Keyword(s):  
Bioinformatics Analysis ◽  
Predictive Analysis ◽  
Management Approach ◽  
Biomarker Detection ◽  
Special Issue ◽  
Patient Health ◽  
Internet Of Medical Things ◽  
Micro Technology ◽  
Diagnostics System ◽  
Made In

It has been proven that rapid bioinformatics analysis according to patient health profiles, in addition to biomarker detection at a low level, is emerging as essential to design an analytical diagnostics system to manage health intelligently in a personalized manner. Such objectives need an optimized combination of a nano-enabled sensing prototype, artificial intelligence (AI)-supported predictive analysis, and Internet of Medical Things (IoMT)-based bioinformatics analysis. Such a developed system began with a prototype demonstration of efficient diseases diagnostics performance is the future diseases management approach. To explore these aspects, the Special Issue planned for the nano-and micro-technology section of MDPI’s Biosensors journal will honor and acknowledge the contributions of Prof. B.D. Malhotra, Ph.D., FNA, FNASc has made in the field of biosensors.

scholarly journals Special Issue on Computational Intelligence for Healthcare

Electronics ◽  
2021 ◽  
Vol 10 (15) ◽  
pp. 1841
Author(s):  
Gabriella Casalino ◽  
Giovanna Castellano
Keyword(s):  
Computational Intelligence ◽  
Health Data ◽  
Special Issue ◽  
Patient Health

The number of patient health data has been estimated to have reached 2314 exabytes by 2020 [...]

scholarly journals Identification and Validation of New Cancer Stem Cell-Related Genes and Their Regulatory microRNAs in Colorectal Cancerogenesis

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 179
Author(s):  
Kristian Urh ◽  
Margareta Žlajpah ◽  
Nina Zidar ◽  
Emanuela Boštjančič
Keyword(s):  
Experimental Validation ◽  
Target Gene ◽  
Bioinformatics Analysis ◽  
Early Carcinoma ◽  
Significant Progress ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Node Metastases ◽  
Formalin Fixed ◽  
Made In

Significant progress has been made in the last decade in our understanding of the pathogenetic mechanisms of colorectal cancer (CRC). Cancer stem cells (CSC) have gained much attention and are now believed to play a crucial role in the pathogenesis of various cancers, including CRC. In the current study, we validated gene expression of four genes related to CSC, L1TD1, SLITRK6, ST6GALNAC1 and TCEA3, identified in a previous bioinformatics analysis. Using bioinformatics, potential miRNA-target gene correlations were prioritized. In total, 70 formalin-fixed paraffin-embedded biopsy samples from 47 patients with adenoma, adenoma with early carcinoma and CRC without and with lymph node metastases were included. The expression of selected genes and microRNAs (miRNAs) was evaluated using quantitative PCR. Differential expression of all investigated genes and four of six prioritized miRNAs (hsa-miR-199a-3p, hsa-miR-335-5p, hsa-miR-425-5p, hsa-miR-1225-3p, hsa-miR-1233-3p and hsa-miR-1303) was found in at least one group of CRC cancerogenesis. L1TD1, SLITRK6, miR-1233-3p and miR-1225-3p were correlated to the level of malignancy. A negative correlation between miR-199a-3p and its predicted target SLITRK6 was observed, showing potential for further experimental validation in CRC. Our results provide further evidence that CSC-related genes and their regulatory miRNAs are involved in CRC development and progression and suggest that some them, particularly miR-199a-3p and its SLITRK6 target gene, are promising for further validation in CRC.

scholarly journals Many faces of acute bowel ischemia: overview of radiologic staging

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Amir H. Davarpanah ◽  
Afshar Ghamari Khameneh ◽  
Bardia Khosravi ◽  
Ali Mir ◽  
Hiva Saffar ◽  
...  
Keyword(s):  
Wide Spectrum ◽  
Bowel Ischemia ◽  
Management Approach ◽  
Final Decision ◽  
Imaging Findings ◽  
Life Threatening ◽  
Imaging Signs ◽  
Late Stages ◽  
Underlying Pathophysiology ◽  
Made In

AbstractAcute bowel ischemia (ABI) can be life threatening with high mortality rate. In spite of the advances made in diagnosis and treatment of ABI, no significant change has occurred in the mortality over the past decade. ABI is potentially reversible with prompt diagnosis. The radiologist plays a central role in the initial diagnosis and preventing progression to irreversible intestinal ischemic injury or bowel necrosis. The most single imaging findings described in the literature are either non-specific or only present in the late stages of ABI, urging the use of a constellation of features to reach a more confident diagnosis. While ABI has been traditionally categorized based on the etiology with a wide spectrum of imaging findings overlapped with each other, the final decision for patient’s management is usually made on the stage of the ABI with respect to the underlying pathophysiology. In this review, we first discuss the pathologic stages of ischemia and then summarize the various imaging signs and causes of ABI. We also emphasize on the correlation of imaging findings and pathological staging of the disease. Finally, a management approach is proposed using combined clinical and radiological findings to determine whether the patient may benefit from surgery or not.

Lessons learned in intellectual capital management in Germany between 2000 and 2020 – History, applications, outlook

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Manfred Bornemann ◽  
Kay Alwert ◽  
Markus Will
Keyword(s):  
Development Strategy ◽  
Intellectual Capital ◽  
Business Models ◽  
Business Processes ◽  
Lessons Learned ◽  
Strategy Development ◽  
Management Approach ◽  
Content Type ◽  
Over Time ◽  
Made In

PurposeThis article reports on the background, the conceptual ideas and the lessons learned from over more than 20 years of IC Statements and Management with a country focus on Germany and some international developments. It calls for an integrated management approach for IC and offers case study evidence on how to accomplish this quest.Design/methodology/approachReport on the German initiative “Intellectual Capital Statement made in Germany” (ICS m.i.G.). A brief review of the literature describes the background and theoretical foundation of the German IC method. A short description of the method is followed by four detailed case studies to illustrate long-term impact of IC management in very different organizations. A discussion of Lessons Learned from more than 200 implementations and an outlook on current and future developments finalizes the article.FindingsIC Statements made in Germany (ICS m.i.G.) was successful in providing a framework to systematically identify IC, evaluate the status quo of IC relative to the strategic requirements, visualize interdependencies of IC, business processes and business results as well as to connect IC reporting with internal management routines and external communication. However, ICS is not an insulated method but delivers the maximum benefit when integrated with strategy development, strategy implementation, business process optimization accompanied by change management routines. Strong ties to human resource management, information technology departments, quality management, research and development teams as well as business operations as the core of an organization help to yield the most for ICS m.i.G. Over time, the focus of managing IC changes and maturity leads to deutero learning.Practical implicationsICS m.i.G. proved easy to apply, cost efficient for SMEs, larger corporations and networks. It helps to better accomplish their objectives and to adjust their business models. The guidelines in German and English as well as a software application released were downloaded more than 100,000 times. A certification process based on a three-tier training module is available and was successfully completed by more than 400 practitioners. ICS m.i.G. is supporting current standards of knowledge management, such as ISO 9001, ISO 30401 or DIN SPEC PAS 91443 and therefore will most likely have a continuing impact on knowledge-based value creation.Originality/valueThis paper reports lessons learned from the country-wide IC initiative in Germany over the last 20 years initiated and supported by the authors. Several elements of the method have been published over time, but so far no comprehensive view on Lessons Learned had been published.

scholarly journals Lassa Fever: Viral Replication, Disease Pathogenesis, and Host Immune Modulations

Pathogens ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 437
Author(s):  
Hinh Ly
Keyword(s):  
Lassa Fever ◽  
West African ◽  
Host Factors ◽  
Current Status ◽  
Special Issue ◽  
African Countries ◽  
Disease Pathogenesis ◽  
Virus Life Cycle ◽  
Key Issues ◽  
Made In

Despite major discoveries made in the last few decades about Lassa fever, there are still many unresolved key issues that hamper the development of effective vaccines and therapies against this deadly disease that is endemic in several West African countries. Some of these issues include the lack of a detailed understanding of the viral and participating host factors in completing the virus life cycle, in mediating disease pathogenesis or protection from disease, and in activating or suppressing host innate and cellular immunity against virus infection, as well as of the animal models required for testing vaccines and therapeutics. This Special Issue is devoted to understanding some of these important issues and to exploring the current status of the research and development in combating Lassa fever.

scholarly journals Insect Physical Control: Electric Field-Based Pest Management Approach

Insects ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 480
Author(s):  
Hideyoshi Toyoda
Keyword(s):  
Electric Field ◽  
Pest Management ◽  
Electric Fields ◽  
Research Field ◽  
Management Approach ◽  
Special Issue ◽  
Future Directions ◽  
Physical Control ◽  
New Research ◽  
Electric Field Generation

The Special Issue ‘Insect physical control: electric field-based pest management approach’ was launched to showcase valuable new research on pest control using applied electrostatic engineering. Some phenomena generated in static and dynamic electric fields can be used to build new devices to capture or kill target insects using an attractive force or a force striking insects entering an electric field. This research field is new, and there are few researchers currently working within it. Consequently, this editorial introduces the history and general principles of electric field generation. I then discuss future directions for this field.

Fall Prevention and Management App Prototype for the Elderly and Their Caregivers

2020 ◽  
Vol 2 (1) ◽  
pp. 48-67
Author(s):  
Eseohen Imoukhome ◽  
Lori E. Weeks ◽  
Samina Abidi
Keyword(s):  
Management Practices ◽  
Point Of Care ◽  
Frailty Index ◽  
The Elderly ◽  
Mobile App ◽  
Management Approach ◽  
End User ◽  
Educational Materials ◽  
Patient Health ◽  
Potential Improvement

The objective of this article is to develop a validated mobile app prototype to empower the elderly and caregivers to manage falls that provides personalized and actionable educational materials at the point of care and improves the engagement of the elderly and caregiver in adopting validated fall management practices; To determine the usefulness and suitability of a fall management mobile app to the elderly and caregivers. The method used is a knowledge management approach is used to implement the app based on 2 validated models: Patient Health Engagement Model and Rockwood frailty index. A mixed method evaluation including a cognitive walk through is used to collect end-user feedback from the elderly and caregivers, on the usability, usefulness, and suitability of the app. The app was deemed easy to use, informative and understandable. Potential improvement areas include: larger print; less wordy interfaces; better navigation features; data sharing functionalities; and voice readers. These suggestions will be incorporated in the future. The conclusion of this article is that smartphones have vast potential in providing relevant and creditable fall management information to elderly and caregivers.

scholarly journals Editorial of Special Issue “Nanostructured Light-Emitters”

Micromachines ◽  
2020 ◽  
Vol 11 (6) ◽  
pp. 601
Author(s):  
Hieu P. T. Nguyen
Keyword(s):  
Nanostructured Materials ◽  
Light Emitting Diodes ◽  
Laser Diodes ◽  
Optoelectronic Devices ◽  
Special Issue ◽  
Significant Progress ◽  
Light Emitters ◽  
Light Emitting ◽  
Nanophotonic Devices ◽  
Made In

Significant progress has been made in the development of nanophotonic devices and the use of nanostructured materials for optoelectronic devices, including light-emitting diodes (LEDs) and laser diodes, has recently attracted tremendous attention due to the fact of their unique geometry [...]

scholarly journals Foreword: special issue on coalgebraic logic

2016 ◽  
Vol 27 (7) ◽  
pp. 1108-1110
Author(s):  
ERNST-ERICH DOBERKAT ◽  
ALEXANDER KURZ
Keyword(s):  
Computer Science ◽  
Special Issue ◽  
Mathematical Structures ◽  
Coalgebraic Logic ◽  
Made In

The second Dagstuhl seminar on coalgebraic logics took place from October 7–12, 2012, in the Leibniz Forschungszentrum Schloss Dagstuhl, following a successful earlier one in December 2009. From the 44 researchers who attended and the 30 talks presented, this collection highlights some of the progress that has been made in the field. We are grateful to Giuseppe Longo and his interest in a special issue in Mathematical Structures in Computer Science.

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