scholarly journals The Impact of the FKBP5 Gene Polymorphisms on the Relationship between Traumatic Life Events and Psychotic-Like Experiences in Non-Clinical Adults

2021 ◽  
Vol 11 (5) ◽  
pp. 561
Author(s):  
Filip Stramecki ◽  
Dorota Frydecka ◽  
Łukasz Gawęda ◽  
Katarzyna Prochwicz ◽  
Joanna Kłosowska ◽  
...  
Keyword(s):  
Physical Abuse ◽  
Life Events ◽  
Psychotic Disorders ◽  
Traumatic Events ◽  
Psychosis Proneness ◽  
Traumatic Life Events ◽  
History Of ◽  
The Impact ◽  
The Relationship ◽  
Pituitary Adrenal Axis

Common variations of the FKBP5 gene are implicated in psychotic disorders, by modulating the hypothalamic–pituitary–adrenal axis reactivity to stress. It has been demonstrated that some of them might moderate the effects of childhood trauma on psychosis proneness. However, these associations have not been investigated with respect to traumatic life events (TLEs). Therefore, we aimed to explore whether the FKBP5 polymorphisms moderate the effects of TLEs on the level of psychotic-like experiences (PLEs). A total of 535 non-clinical adults were approached for participation, and genotyping of six FKBP5 polymorphisms (rs3800373, rs9470080, rs4713902, rs737054, rs1360780 and rs9296158) was performed. The Prodromal Questionnaire-16 (PQ-16) and the Traumatic Events Checklist (TEC) were administered to assess PLEs and TLEs, respectively. Among the rs1360780 CC homozygotes, a history of physical abuse was associated with significantly higher PQ-16 scores. This difference was not significant in the rs1360780 T allele carriers. Similarly, a history of physical abuse was associated with significantly higher PQ-16 scores in the rs9296158 GG homozygotes but not in the rs9296158 A allele carriers. Finally, emotional neglect was related to significantly higher PQ-16 scores in the rs737054 T allele carriers but not in the rs737054 CC homozygotes. The present study indicates that variation in the FKBP5 gene might moderate the effects of lifetime traumatic events on psychosis proneness.

scholarly journals Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness: Results from a cross-sectional study in a nonclinical sample

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Dorota Frydecka ◽  
Kamila Kotowicz ◽  
Łukasz Gawęda ◽  
Katarzyna Prochwicz ◽  
Joanna Kłosowska ◽  
...  
Keyword(s):  
Life Events ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Dopaminergic Neurotransmission ◽  
Psychosis Proneness ◽  
Traumatic Life Events ◽  
Gene Environment ◽  
History Of

Abstract Background There is a growing number of studies showing interactions between genetic polymorphisms associated with dopaminergic neurotransmission and traumatic life events (TLEs) on a risk of psychotic-like experiences (PLEs). Anomalous self-experiences (ASEs) have been associated both with TLEs as well as with PLEs. However, it remains unknown what is the role of ASEs in the complexity of gene–environment interactions on the emergence of PLEs. Patients and methods We included 445 young adults—university students from three big cities in Poland. We used the Traumatic Events Checklist to assess TLEs, the Inventory of Psychotic-Like anomalous self-experiences in order to measure ASEs, and the Prodromal Questionnaire (PQ16) to record the level of PLEs. The following gene polymorphisms, related to dopaminergic neurotransmission, were determined: the catechol-O-methyltransferase (COMT) rs4680 polymorphism, the dopamine D2 receptor (DRD2) rs6277 polymorphism, and the dopamine transporter 1 (DAT1) rs28363170 polymorphism. Results There was a significant effect of the interaction between the DAT1 polymorphism, a severity of ASEs, and a history of TLEs on the level of PLEs. Among the DAT1 10R/10R homozygotes with low level of ASEs, a severity of PLEs was significantly higher in individuals with a history of any TLEs. Higher scores of the PQ16 were associated with a greater severity of ASEs both in the DAT1 9R allele carriers and the DAT1 10R/10R homozygotes. Conclusion Our findings imply that genetic liability related to aberrant dopamine transport might impact the association between TLEs and PLEs in subjects with high levels of ASEs.

The role of self-disturbances and cognitive biases in the relationship between traumatic life events and psychosis proneness in a non-clinical sample

2018 ◽  
Vol 193 ◽  
pp. 218-224 ◽  
Author(s):  
Łukasz Gawęda ◽  
Katarzyna Prochwicz ◽  
Przemysław Adamczyk ◽  
Dorota Frydecka ◽  
Błażej Misiak ◽  
...  
Keyword(s):  
Life Events ◽  
Cognitive Biases ◽  
Clinical Sample ◽  
Psychosis Proneness ◽  
Traumatic Life Events ◽  
The Relationship

scholarly journals Intergeneration Transmission of Violence in Forensic Patients With a Diagnosis of Schizophrenia and Psychosis: Was Parental Alcoholic Abuse a Significant Factor?

2021 ◽  
Vol 12 ◽  
Author(s):  
Milena Petrovic ◽  
Lidija Injac Stevovic
Keyword(s):  
Mental Illness ◽  
Family History ◽  
Alcohol Abuse ◽  
Childhood Trauma ◽  
Psychotic Disorders ◽  
Violent Behavior ◽  
Traumatic Events ◽  
History Of ◽  
The Impact ◽  
Parental Alcohol

Background: Child abuse during childhood and the presence of parental alcohol abuse increase the risk of developing mental illness in children, as well as the risk of violent behavior in adulthood. The association of these factors has not been sufficiently investigated when it comes to forensic mental patients. In this study, we examined the impact of traumatic events in childhood and the presence of mental illness and alcohol abuse of parents in subjects with psychosis and schizophrenia who committed serious crimes.Methods: One-hundred and forty-three respondents were included in the current study. Information on childhood abuse was collected by Childhood Trauma Questionnaire (CTQ). The sample included participants diagnosed with psychotic disorders and schizophrenia with a history of violent behavior (PSCH-V, n = 20), patients diagnosed with psychotic disorders and schizophrenia without a history of violent behavior (Non-V-PSCH, n = 51), and healthy control patients (HC, n = 72). Participants were diagnosed according to the ICD 10 classification system. MINI and CAINS scales were used to confirm the diagnosis. Data on sociodemographic and clinical characteristics were collected. Differences between groups in terms of traumatic events in childhood as well as parental alcohol abuse are presented and analyzed, using descriptive statistical values and nonparametric techniques of inferential statistics.Results: Statistically significant differences were obtained for total scores (χ2 = 28.522, p < 0.001) as well as for (1) major upheaval between the parents (χ2 = 20.739, p < 0.001), (2) being victim of violence—other than sexual (χ2 = 12.701, p < 0.01), and (3) other major upheaval that may have shaped life or personality significantly (χ2 = 30.920, p < 0.001). PSCH-V, compared to HC, had greater exposure to all of the three domains of childhood trauma (U = 396.500, 436.500, and 376.000, respectively; p < 0.001). Similar results were obtained when Non V-PSCH were compared with HC (U = 1,223.000, 1,535.000, and 999.000, respectively; p < 0.001). The results indicated statistically insignificant differences between PSCH-V and Non-V-PSCH in having a family history of mental illness. On the other hand, family history of mental illness was less present in HC compared to PSCH-V (χ2 = 24.238, p < 0.001) and Non V-PSCH (χ2 = 14.456, p < 0.001). The presence of parental alcohol abuse was predominantly present in the PSCH-V group (60%) while a significantly lower presence was found in the Non-V PSCH group (35%) and HC (5.5%).Conclusion: Both PSCH-V and Non-V-PSCH groups had a high degree of exposure to traumatic events in childhood compared to the HC. In PSCH-V, the presence of parental alcohol abuse compared to Non-V-PSCH was dominant. Mental illness coupled with a history of violent behavior represents a factor of polyvictimization, which may increase the likelihood of violent behavior of offspring.

Dynamic interplay between life events and course of psychotic disorders: 10-year longitudinal study following first admission

2020 ◽  
pp. 1-8
Author(s):  
Kayla R. Donaldson ◽  
Katherine G. Jonas ◽  
Yuan Tian ◽  
Emmett M. Larsen ◽  
Daniel N. Klein ◽  
...  
Keyword(s):  
Life Events ◽  
Negative Symptoms ◽  
Psychotic Disorders ◽  
Negative Events ◽  
First Onset ◽  
Specific Symptoms ◽  
The Impact ◽  
The Relationship ◽  
Reality Distortion ◽  
First Admission

Abstract Background Life events (LEs) are a risk factor for first onset and relapse of psychotic disorders. However, the impact of LEs on specific symptoms – namely reality distortion, disorganization, negative symptoms, depression, and mania – remains unclear. Moreover, the differential effects of negative v. positive LEs are poorly understood. Methods The present study utilizes an epidemiologic cohort of patients (N = 428) ascertained at first-admission for psychosis and followed for a decade thereafter. Symptoms were assessed at 6-, 24-, 48-, and 120-month follow-ups. Results We examined symptom change within-person and found that negative events in the previous 6 months predicted an increase in reality distortion (β = 0.07), disorganized (β = 0.07), manic (β = 0.08), and depressive symptoms (β = 0.06), and a decrease in negative symptoms (β = −0.08). Conversely, positive LEs predicted fewer reality distortion (β = −0.04), disorganized (β = −0.04), and negative (β = −0.13) symptoms, and were unrelated to mood symptoms. A between-person approach to the same hypotheses confirmed that negative LEs predicted change in all symptoms, while positive LEs predicted change only in negative symptoms. In contrast, symptoms rarely predicted future LEs. Conclusions These findings confirm that LEs have an effect on symptoms, and thus contribute to the burden of psychotic disorders. That LEs increase positive symptoms and decrease negative symptoms suggest at least two different mechanisms underlying the relationship between LEs and symptoms. Our findings underscore the need for increased symptom monitoring following negative LEs, as symptoms may worsen during that time.

Investigating the Relationship Between Self-Esteem and Stigma Among Young Adults With History of Suicide Attempts

Crisis ◽  
2016 ◽  
Vol 37 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Meshan Lehmann ◽  
Matthew R. Hilimire ◽  
Lawrence H. Yang ◽  
Bruce G. Link ◽  
Jordan E. DeVylder
Keyword(s):  
Young Adults ◽  
Suicide Attempts ◽  
Self Esteem ◽  
High Risk Population ◽  
High Functioning ◽  
People With Mental Illness ◽  
History Of ◽  
The Individual ◽  
The Impact ◽  
The Relationship

Abstract. Background: Self-esteem is a major contributor to risk for repeated suicide attempts. Prior research has shown that awareness of stigma is associated with reduced self-esteem among people with mental illness. No prior studies have examined the association between self-esteem and stereotype awareness among individuals with past suicide attempts. Aims: To understand the relationship between stereotype awareness and self-esteem among young adults who have and have not attempted suicide. Method: Computerized surveys were administered to college students (N = 637). Linear regression analyses were used to test associations between self-esteem and stereotype awareness, attempt history, and their interaction. Results: There was a significant stereotype awareness by attempt interaction (β = –.74, p = .006) in the regression analysis. The interaction was explained by a stronger negative association between stereotype awareness and self-esteem among individuals with past suicide attempts (β = –.50, p = .013) compared with those without attempts (β = –.09, p = .037). Conclusion: Stigma is associated with lower self-esteem within this high-functioning sample of young adults with histories of suicide attempts. Alleviating the impact of stigma at the individual (clinical) or community (public health) levels may improve self-esteem among this high-risk population, which could potentially influence subsequent suicide risk.

Dependency in Africa: Stages of African Political Economy

1983 ◽  
Vol 9 (2) ◽  
pp. 229-247 ◽  
Author(s):  
Amechi Okolo
Keyword(s):  
Political Economy ◽  
International System ◽  
Raw Material ◽  
The West ◽  
Cheap Labour ◽  
History Of ◽  
The Common ◽  
First Contact ◽  
The Impact ◽  
The Relationship

This paper traces the history of the relationship between Africa and the West since their first contact brought about by the outward thrust of the West, under the impetus of rising capitalism, in search of cheap labour and cheap raw material for its industries and expanding markets for its industrial products, both of which could be better ensured through domination and exploitation. The paper identifies five successive stages that African political economy has passed through under the impact of this relationship, each phase qualitatively different from the other but all having the common characteristic of domination-dependence syndrome, and each phase having been dictated by the dynamics of capitalism in different eras and by the dominant forces in the changing international system. Its finding is that the way to the latest stage, the dependency phase, was paved by the progressive proletarianization of the African peoples and the maintenance of an international peonage system. It ends by indicating the direction in which Africa can make a beginning to break out of dependency and achieve liberation.

Religion and Politics in Contemporary Turkey

2021 ◽  
Author(s):  
Ateş Altınordu
Keyword(s):  
Religion And Politics ◽  
Political Incorporation ◽  
Turkish Politics ◽  
Primary Means ◽  
History Of ◽  
The Republic ◽  
Turkish State ◽  
Islamic Parties ◽  
The Impact ◽  
The Relationship

Religion and secularism have been central threads in Turkish politics throughout the history of the republic. This chapter focuses on three important aspects of the relationship between religion and politics in contemporary Turkey. First, it explores the political functions of the Directorate of Religious Affairs (Diyanet), a government agency that has served as the primary means for the implementation of the religious policies of the Turkish state. Second, it investigates the relations between Islamic communities, political parties, and the state and argues that the distinction between official and unofficial Islam that has informed much of the work on the Turkish religious field must be strongly qualified. Finally, the author focuses on the trajectory of political Islam in Turkey, critically reviewing the literature on the rise, political incorporation, and authoritarian turn of Islamic parties. The conclusion emphasizes the need for studies investigating the impact of politics on religiosity in Turkish society.

scholarly journals Dissociative Experiences Mediate the Relationship Between Traumatic Life Events and Types of Skin Picking. Findings From Non-clinical Sample

2021 ◽  
Vol 12 ◽  
Author(s):  
Joanna Kłosowska ◽  
Rachela Antosz-Rekucka ◽  
Alina Kałużna-Wielobób ◽  
Katarzyna Prochwicz
Keyword(s):  
Life Events ◽  
Clinical Sample ◽  
Self Report ◽  
Skin Picking ◽  
Mediation Analyses ◽  
Dissociative Experiences ◽  
Traumatic Life Events ◽  
Path Analyses ◽  
Excoriation Disorder ◽  
The Relationship

Aim: Skin-picking (excoriation) disorder is considered as a form of maladaptive coping methods used by individuals who have difficulties in applying more adaptive strategies. Skin-picking development has been suggested to be preceded by traumatic life events. Dissociative symptoms have been reported as experienced by skin-picking sufferers during picking episodes. The purpose of the study was to examine whether the link between trauma and automatic type of skin-picking is mediated by the frequency of dissociative experiences, and whether the COVID-19 pandemic conditions have changed this relationship in any way.Methods: The study sample consisted of 594 adults (76% women) aged from 18 to 60. Traumatic life events, dissociative experiences, and types of skin-picking (focused vs. automatic) were assessed with self-report questionnaires. Mediation analyses and multigroup path analyses were carried out.Results: Dissociative experiences partially mediated the link between traumatic events and both types of skin-picking. The model was robust considering the conditions in which survey was filled out (pre-pandemic vs. pandemic).Conclusions: Traumatic life events and dissociative experiences are associated with both automatic and focused skin-picking regardless of pandemic conditions. Further studies are needed to understand mechanisms underlying the relationship between dissociation and skin-picking styles.

scholarly journals Substance use disorders and psychological trauma

2009 ◽  
Vol 33 (7) ◽  
pp. 257-260
Author(s):  
Shaheen Shora ◽  
Elizabeth Stone ◽  
Keron Fletcher
Keyword(s):  
Substance Use ◽  
Alcohol Dependence ◽  
Life Events ◽  
Substance Use Disorders ◽  
Best Practice ◽  
Clinical Course ◽  
Traumatic Events ◽  
Psychological Trauma ◽  
Clinical Implications ◽  
The Impact

Aims and MethodThe Impact of Events Scale was administered to 104 in-patients detoxing from alcohol or opiates to determine the prevalence of psychological trauma, the severity of its symptoms and the types of trauma responsible for symptoms.ResultsOut of the 104 in-patients undergoing detoxification, 75 had symptoms of psychological trauma; in 60 patients the symptoms were in the treatable range. Patients with alcohol-dependence were more severely affected. ‘Life events’ traumatised a higher proportion of individuals than ‘traumatic events’.Clinical ImplicationsPsychological trauma requiring treatment is commonly found in substance misusers. This is rarely addressed despite the cormorbid disorder running a complicated clinical course. There are conflicting opinions about best practice, but consideration should be given to providing patients with accessible treatments for psychological trauma.

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