scholarly journals The Self and Its Right Insula—Differential Topography and Dynamic of Right vs. Left Insula

2021 ◽  
Vol 11 (10) ◽  
pp. 1312
Author(s):  
Andrea Scalabrini ◽  
Angelika Wolman ◽  
Georg Northoff
Keyword(s):  
Functional Connectivity ◽  
Neural Activity ◽  
Functional Integration ◽  
The Self ◽  
Special Role ◽  
Dynamic Features ◽  
Spatiotemporal Model ◽  
The Right ◽  
Left Insula

Various studies demonstrate a special role of the right compared to the left anterior insula in mediating our self. However, the neural features of the right insula that allow for its special role remain unclear. Presupposing a spatiotemporal model of self—“Basis model of self-specificity” (BMSS)—we here address the following question: what spatial-topographic and temporal-dynamic features render neural activity in the right insula to be more suitable in mediating self-specificity than the left insula? First, applying fMRI, we demonstrate that the right insula (i) exhibits higher degrees of centrality in rest, and (ii) higher context-dependent functional connectivity in a self-specific task among regions of distinct layers of self (intero-, extero-proprioceptive, and mental). Second, using EEG in rest and task, we show that the right insula shows longer autocorrelation window (ACW) in its neural activity than both left insula and other regions of the different layers of self. Together, we demonstrate special topographic, i.e., high functional connectivity, and dynamic, i.e., long ACW, neural features of the right insula compared to both left insula and other regions of the distinct layers of self. This suits neural activity in the right insula ideally for high functional integration and temporal continuity as key features of the self including its intero-, extero-proprioceptive, and mental layers.

Equity and the Right to Do Wrong

2020 ◽  
pp. 72-91
Author(s):  
Andrew S Gold
Keyword(s):  
The State ◽  
The Self ◽  
Role Of The State ◽  
The Right ◽  
The Relationship ◽  
Private Litigation ◽  
Better Than

This chapter discusses how the ‘stickler-enjoining’ account of equity has important limits. While many distinctive doctrines of equity can be understood to limit stickler behaviour, equity in fact often turns a blind eye to, and sometimes even enables, stickler behaviour. One can sort cases in which equity restrains sticklers from those in which it is indifferent to stickler behaviour if one attends to the role of the state in private litigation. Sometimes the state’s responsibilities require it to protect plaintiffs against sticklers. Other times, it requires it to protect the stickler, as a means, for example, of keeping as open as possible each person’s sphere of choices. Ultimately, the self-regarding account of equity sheds light on the question of the relationship between equity and justice: from the distinct perspective of the judgment, sometimes equitable justice is better than legal justice and sometimes legal justice is better than equitable justice.

scholarly journals Frequency-dependent circuits anchored in the dorsal and ventral left anterior insula

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yifeng Wang ◽  
Qijun Zou ◽  
Yujia Ao ◽  
Yang Liu ◽  
Yujie Ouyang ◽  
...  
Keyword(s):  
Functional Organization ◽  
Functional Integration ◽  
Anterior Insula ◽  
Frequency Effect ◽  
Frequency Dependent ◽  
Functional Connections ◽  
Human Connectome Project ◽  
Cognitive Neurosciences ◽  
The Right

Abstract The hub role of the right anterior insula (AI) has been emphasized in cognitive neurosciences and been demonstrated to be frequency-dependently organized. However, the functional organization of left AI (LAI) has not been systematically investigated. Here we used 100 unrelated datasets from the Human Connectome Project to study the frequency-dependent organization of LAI along slow 6 to slow 1 bands. The broadband functional connectivity of LAI was similar to previous findings. In slow 6-slow 3 bands, both dorsal and ventral seeds in LAI were correlated to the salience network (SN) and language network (LN) and anti-correlated to the default mode network (DMN). However, these seeds were only correlated to the LAI in slow 2-slow 1 bands. These findings indicate that broadband and narrow band functional connections reflect different functional organizations of the LAI. Furthermore, the dorsal seed had a stronger connection with the LN and anti-correlation with DMN while the ventral seed had a stronger connection within the SN in slow 6-slow 3 bands. In slow 2-slow 1 bands, both seeds had stronger connections with themselves. These observations indicate distinctive functional organizations for the two parts of LAI. Significant frequency effect and frequency by seed interaction were also found, suggesting different frequency characteristics of these two seeds. The functional integration and functional segregation of LDAI and LVAI were further supported by their cognitive associations. The frequency- and seed-dependent functional organizations of LAI may enlighten future clinical and cognitive investigations.

SYSTEM OF FORMATION OF PROFESSIONAL AND PERSONAL SELF-GOVERNMENT AMONG CADETS OF MILITARY INSTITUTES

2020 ◽  
Author(s):  
Andrey Lagutin ◽  
Tatyana Sidorina
Keyword(s):  
Self Control ◽  
Self Management ◽  
Optimal Decision ◽  
Professional Activity ◽  
Special Role ◽  
Professional Activities ◽  
Managerial Decisions ◽  
The Right ◽  
The Military

When carrying out professional activities, officers of the VNG of the Russian Federation are often in difficult, stressful, emotionally stressful situations associated with the use of weapons as a particularly dangerous means of destruction. The right to use a weapon by an officer makes him responsible for its use. And therefore requires the officer to make a balanced optimal decision, which is associated with the risk and transience of events, and in which no mistake can be made, since the price of it can be someone's life. It is at such a moment that it is important that the officer has stable skills in making a decision on the use of weapons, and this requires skills not only in managing subordinates or the situation,but in managing himself. The complication of the military-professional activity, manifested in the need to develop the ability to quickly and accurately make command decisions, exacerbating the problem of social responsibility of an officer who has the management of unit that leads to an understanding of his singular personal and professional responsibility, as the ability to govern themselves makes it possible to achieve a positive result of the Department for the DBA. This characterizes the need for a commander to have the ability to manage himself, as a "system" that manages others. Forming skills of self-control, patience, compassion, having mastered algorithms of making managerial decisions, the cycle of implementing managerial functions, etc., a person comes to the belief: "before effectively managing others, it is necessary to learn how to manage yourself." The required level of personal and professional maturity can be formed in a person as a result of purposeful self-management, which determines the special role of professional and personal self-management in the training of future officers.

scholarly journals On Dr. Stockmann’s Parrhesia: Ibsen’s An Enemy of the People in the Light of Foucault

2019 ◽  
Vol 26 (1) ◽  
pp. 27-48
Author(s):  
Mohammad-Javad Haj’jari ◽  
Noorbakhsh Hooti
Keyword(s):  
Political Philosophy ◽  
Self Care ◽  
Political Corruption ◽  
Well Being ◽  
The Self ◽  
Unique Position ◽  
The People ◽  
Final Failure ◽  
The Right

Abstract An honest intellectual dutifully standing with truth against lies and treacheries of his society is a parrhesiastic figure in Foucault’s terminology. Foucault takes parrhesia as the fearless and frank speech regarding the truth of something or a situation before truthmongering and public deception and he takes the parrhesiastic as the spokesperson for truth. In this light, Dr. Stockmann in Ibsen’s An Enemy of the People occupies a unique position within Ibsen’s political philosophy. Dutifully criticizing what the majority blindly take for granted from their liar leaders in the name of democracy, Dr. Stockmann fulfills the role of a parrhesiastic figure that stands against socio-political corruption. He enters a parrhesiastic game with both the majority and the officialdom to fulfill his democratic parrhesia as a truthful citizen before the duped community, while covertly preparing for his own philosophic parrhesia or self-care within the conformist community. However, his final failure lies in his confrontation with democracy itself, which wrongly gives the right of speaking even to the liars. This article thus aims at analyzing Ibsen’s play through a Foucauldian perspective regarding the concept of parrhesia and its relation to democracy. It is to reveal Ibsen’s satire on the fake ideology of democracy and highlight the necessity of humanity’s parrhesiastic self-care for the well-being of the self and the others.

scholarly journals Cortical and thalamic influences on striatal involvement in instructed, serial reversal learning; implications for the organisation of flexible behaviour.

2021 ◽  
Author(s):  
Brendan Williams ◽  
Anastasia Christakou
Keyword(s):  
Functional Connectivity ◽  
Cognitive Flexibility ◽  
Reversal Learning ◽  
Orbitofrontal Cortex ◽  
Dorsal Striatum ◽  
Response Strategy ◽  
Flexible Control ◽  
The Right ◽  
Serial Reversal

Cognitive flexibility is essential for enabling an individual to respond adaptively to changes in their environment. Evidence from human and animal research suggests that the control of cognitive flexibility is dependent on an array of neural architecture. Cortico-basal ganglia circuits have long been implicated in cognitive flexibility. In particular, the role of the striatum is pivotal, acting as an integrative hub for inputs from the prefrontal cortex and thalamus, and modulation by dopamine and acetylcholine. Striatal cholinergic modulation has been implicated in the flexible control of behaviour, driven by input from the centromedian-parafascicular nuclei of the thalamus. However, the role of this system in humans is not clearly defined as much of the current literature is based on animal work. Here, we aim to investigate the roles corticostriatal and thalamostriatal connectivity in serial reversal learning. Functional connectivity between the left centromedian-parafascicular nuclei and the associative dorsal striatum was significantly increased for negative feedback compared to positive feedback. Similar differences in functional connectivity were observed for the right lateral orbitofrontal cortex, but these were localised to when participants switched to using an alternate response strategy following reversal. These findings suggest that connectivity between the centromedian-parafascicular nuclei and the striatum may be used to generally identify potential changes in context based on negative outcomes, and the effect of this signal on striatal output may be influenced by connectivity between the lateral orbitofrontal cortex and the striatum.

scholarly journals Disruption of Neural Activity and Functional Connectivity in Adolescents With Major Depressive Disorder Who Engage in Non-suicidal Self-Injury: A Resting-State fMRI Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Qian Huang ◽  
Muni Xiao ◽  
Ming Ai ◽  
Jianmei Chen ◽  
Wo Wang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Neural Activity ◽  
Resting State ◽  
Brain Regions ◽  
Major Depressive ◽  
Superior Frontal Gyrus ◽  
Self Injury ◽  
The Right

Background: Non-suicidal self-injury (NSSI), which commonly occurs during adolescence, often co-occurs with major depressive disorder (MDD). However, the underlying neurobiological mechanisms in adolescents with MDD who engage in NSSI remain unclear. The current study examined the aberrant local neural activity in certain areas of the visual regions and the default mode network (DMN) and the resting-state functional connectivity (rs-FC) in changed brain regions in adolescents with MDD who engage in NSSI and adolescents with MDD only.Methods: A total of 67 adolescents with MDD were divided into two groups based on their NSSI behavior: the NSSI group (n = 31) and an age-, gender-, and education-matched MDD group (n = 36). The Hamilton Depression Rating Scale (HAMD) was used to assess the severity of MDD. Amplitude of low-frequency fluctuation (ALFF) analysis was used to detect alterations in local neural activity. Brain regions with aberrant neural activity were considered regions of interest (ROI). ALFF-based rs-FC analysis was used to further explore the underlying changes in connectivity between ROI and other areas in the NSSI group. Correlation analyses were performed to examine the relationship between neural changes and clinical characteristics.Results: There was no significant difference in HAMD scores between the two groups. ALFF analysis revealed that, compared to adolescents with MDD only, adolescents with MDD who engaged in NSSI displayed significantly enhanced neural activity in the right fusiform gyrus (FFG. R) and the right median cingulate and paracingulate gyri (DCG. R). Significantly reduced rs-FC of the FFG. R-bilateral medial orbital of the superior frontal gyrus (ORBsupmed. L/R)/bilateral medial superior frontal gyrus (SFGmed. L/R), FFG. R-bilateral posterior cingulate gyrus (PCG. L/R), DCG. R-left pallidum (PAL. L), DCG. R-right superior temporal gyrus (STG. R), and DCG. R-right postcentral gyrus (PoCG. R)/right inferior parietal lobule (IPL. R) was found in adolescents with MDD who were engaged in NSSI. Additionally, no significant correlations were observed between ALFF or rs-FC values and the HAMD scores between the two groups.Limitations: Owing to the cross-sectional design, the alterations in ALFF and rs-FC values in the FFG. R and DCG. R could not demonstrate that it was a state or feature in adolescents with MDD who engaged in NSSI. Additionally, the sample size was relatively small.Conclusions: This study highlights changes in regional brain activity and remote connectivity in the FFG. R and DCG. R in adolescents with MDD who engage in NSSI. This could provide a new perspective for further studies on the neurobiological mechanism of NSSI behavior in adolescents with MDD.

scholarly journals Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder

2021 ◽  
Author(s):  
Marieke A. G. Martens ◽  
Nicola Filippini ◽  
Catherine J. Harmer ◽  
Beata R. Godlewska
Keyword(s):  
Functional Connectivity ◽  
Treatment Response ◽  
Resting State ◽  
Rating Scale ◽  
Antidepressant Treatment ◽  
Resting State Functional Connectivity ◽  
The Right ◽  
Treatment Responsivity ◽  
Response Biomarkers

Abstract Rational With no available response biomarkers, matching an appropriate antidepressant to an individual can be a lengthy process. Improving understanding of processes underlying treatment responsivity in depression is crucial for facilitating work on response biomarkers. Objectives To identify differences in patterns of pre-treatment resting-state functional connectivity (rsFC) that may underlie response to antidepressant treatment. Methods After a baseline MRI scan, thirty-four drug-free patients with depression were treated with an SSRI escitalopram 10 mg daily for 6 weeks; response was defined as ≥ 50% decrease in Hamilton Depression Rating Scale (HAMD) score. Thirty-one healthy controls had a baseline clinical assessment and scan. Healthy participants did not receive treatment. Results Twenty-one (62%) of patients responded to escitalopram. Treatment responsivity was associated with enhanced rsFC of the right fronto-parietal network (FPN)—with the posterior DMN, somatomotor network (SMN) and somatosensory association cortex. The lack of treatment response was characterized by reduced rsFC: of the bilateral FPN with the contralateral SMN, of the right FPN with the posterior DMN, and of the extended sensorimotor auditory area with the inferior parietal lobule (IPL) and posterior DMN. Reduced rsFC of the posterior DMN with IPL was seen in treatment responders, although only when compared with HC. Conclusions The study supports the role of resting-state networks in response to antidepressant treatment, and in particular the central role of the frontoparietal and default mode networks.

Impact of self-designed Ningxin Anshen Decoction on the resting-state network functional connectivity in patients with mild to moderate generalized anxiety disorders: a Clinical Trial (Preprint)

2020 ◽  
Author(s):  
Wenjing He ◽  
Hang Xiong ◽  
Jiangshan Fang ◽  
Hao Gu ◽  
Rongjuan Guo
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
The Self ◽  
Control Group ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity ◽  
Before And After ◽  
Generalized Anxiety Disorders ◽  
Hamilton Anxiety Scale ◽  
The Right

BACKGROUND Generalized anxiety disorder (GAD) is a persistent chronic excessive anxiety that is hard to control. Our previous study indicated that self-designed Ningxin Anshen Formula (NXAS) was effective to improve the symptoms and Hamilton anxiety scale (HAMA) of mild to moderate GAD patients. OBJECTIVE This study aimed to investigate the imapct of self-designed NXAS on the resting-state functional connectivity (RSFC) in patients with mild to moderate GAD and explore the potential mechanisms. METHODS A total of 61 patients diagnosed with mild to moderate GAD were recruited and divided into two groups: NXAS group (n=31) and placebo group (n=30). Before and after treatment, the RSFC was examined by resting-state functional MRI (rs-fMRI), the anxiety was assessed with HAMA, and the independent component analysis (ICA) was used to analyze the resting-state functional connectivity (RSFC). The correlation between HAMA score and abnormal RSFC was further evaluated. RESULTS The default mode network (DMN) showed evident RSFC interaction in the PCUN in both groups before and after therapy. The salience network (SN) showed obvious RSFC interaction in the bilateral gyrus frontalis inferiors and bilateral gyri temporalis superiors before and after therapy. In the NXAS group, the RSFC interction reduced significantly in the left gyrus frontalis inferior, but remained unchanged in the right gyrus frontalis inferior and bilateral gyri temporalis superiors after therapy. In the control group, the RSFC interaction increased dramatically after treatment. In addition, the abnormal RSFC had no relationship with HAMA score. CONCLUSIONS The self-designed NXAS can increase the RSFC in the PUCN on DMN and reduce RSFC in the orbIFG.L on SN to exert anti-anxiety effect. CLINICALTRIAL The study was registered on the Clinical Trials (NO. ChiCTR-OCC-12002329).

scholarly journals Maladaptive alterations of resting state cortical network in Tinnitus: A directed functional connectivity analysis of a larger MEG data set

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Evangelos Paraskevopoulos ◽  
Christian Dobel ◽  
Andreas Wollbrink ◽  
Vasiliki Salvari ◽  
Panagiotis D. Bamidis ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Emotional Processing ◽  
Phase Transfer ◽  
Superior Temporal Gyrus ◽  
Cortical Networks ◽  
Data Set ◽  
Tinnitus Distress ◽  
The Right

Abstract The present study used resting state MEG whole-head recordings to identify how chronic tonal tinnitus relates to altered functional connectivity of brain’s intrinsic cortical networks. Resting state MEG activity of 40 chronic tinnitus patients and 40 matched human controls was compared identifying significant alterations in intrinsic networks of the tinnitus population. Directed functional connectivity of the resting brain, at a whole cortex level, was estimated by means of a statistical comparison of the estimated phase Transfer Entropy (pTE) between the time-series of cortical activations, as reconstructed by LORETA. As pTE identifies the direction of the information flow, a detailed analysis of the connectivity differences between tinnitus patients and controls was possible. Results indicate that the group of tinnitus patients show increased connectivity from right dorsal prefrontal to right medial temporal areas. Our results go beyond previous findings by indicating that the role of the left para-hippocampal area is dictated by a modulation from dmPFC; a region that is part of the dorsal attention network (DAN), as well as implicated in the regulation of emotional processing. Additionally, this whole cortex analysis showed a crucial role of the left inferior parietal cortex, which modulated the activity of the right superior temporal gyrus, providing new hypotheses for the role of this area within the context of current tinnitus models. Overall, these maladaptive alterations of the structure of intrinsic cortical networks show a decrease in efficiency and small worldness of the resting state network of tinnitus patients, which is correlated to tinnitus distress.

scholarly journals Reorganization of hippocampal functional connectivity with transition to chronic back pain

2014 ◽  
Vol 111 (5) ◽  
pp. 1065-1076 ◽  
Author(s):  
Amelia A. Mutso ◽  
Bogdan Petre ◽  
Lejian Huang ◽  
Marwan N. Baliki ◽  
Souraya Torbey ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Back Pain ◽  
Functional Connectivity ◽  
Neural Activity ◽  
Chronic Back Pain ◽  
Rodent Models ◽  
Attention Task ◽  
Pain Chronification

The hippocampus has been shown to undergo significant changes in rodent models of neuropathic pain; however, the role of the hippocampus in human chronic pain and its contribution to pain chronification have remained unexplored. Here we examine hippocampal processing during a simple visual attention task. We used functional MRI to identify intrinsic and extrinsic hippocampal functional connectivity (synchronous neural activity), comparing subacute back pain (SBP, back pain 1–4 mo) and chronic back pain (CBP, back pain >10 yr) patients to control (CON) subjects. Both groups showed more extensive hippocampal connectivity than CON subjects. We then examined the evolution of hippocampal connectivity longitudinally in SBP patients who recovered (SBPr, back pain decreased >20% in 1 yr) and those with persistent pain (SBPp). We found that SBPp and SBPr subjects have distinct changes in hippocampal-cortical connectivity over 1 yr; specifically, SBPp subjects showed large decreases in hippocampal connectivity with medial prefrontal cortex (HG-mPFC). Furthermore, in SBP patients the strength of HG-mPFC reflected variations in back pain over the year. These relationships were replicated when examined in a different task performed by SBP patients (rating fluctuations of back pain), indicating that functional connectivity of the hippocampus changes robustly in subacute pain and the nature of these changes depends on whether or not patients recover from SBP. The observed reorganization of processing within the hippocampus and between the hippocampus and the cortex seems to contribute to the transition from subacute to chronic pain and may also underlie learning and emotional abnormalities associated with chronic pain.

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