scholarly journals Animal Models of Hepatocellular Carcinoma Prevention

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1792 ◽  
Author(s):  
Ram C. Shankaraiah ◽  
Laura Gramantieri ◽  
Francesca Fornari ◽  
Silvia Sabbioni ◽  
Elisa Callegari ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Animal Models ◽  
Latency Period ◽  
Prevention Strategies ◽  
Long Latency ◽  
Genetic Mechanisms ◽  
Patient Prognosis ◽  
Therapeutic Prevention ◽  
Improve Patient ◽  
Insight Into

Hepatocellular carcinoma (HCC) is a deadly disease and therapeutic efficacy in advanced HCC is limited. Since progression of chronic liver disease to HCC involves a long latency period of a few decades, a significant window of therapeutic opportunities exists for prevention of HCC and improve patient prognosis. Nonetheless, there has been no clinical advancement in instituting HCC chemopreventive strategies. Some of the major challenges are heterogenous genetic aberrations of HCC, significant modulation of tumor microenvironment and incomplete understanding of HCC tumorigenesis. To this end, animal models of HCC are valuable tools to evaluate biology of tumor initiation and progression with specific insight into molecular and genetic mechanisms involved. In this review, we describe various animal models of HCC that facilitate effective ways to study therapeutic prevention strategies that have translational potential to be evaluated in a clinical context.

scholarly journals Peptides in Low Molecular Weight Fraction of Serum Associated with Hepatocellular Carcinoma

2010 ◽  
Vol 29 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Yanming An ◽  
Slavka Bekesova ◽  
Nathan Edwards ◽  
Radoslav Goldman
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mass Spectra ◽  
Coagulation Factor ◽  
Weight Fraction ◽  
The United States ◽  
Ionization Time ◽  
Maldi Tof Mass Spectra ◽  
Native Peptides ◽  
Patient Prognosis ◽  
Improve Patient

The incidence of hepatocellular carcinoma (HCC) in the United States is increasing and the increase is projected to continue for several decades. The overall survival of HCC patients is poor and treatments are not effective in part because most of the diagnoses come at a late stage. The development of new markers for detection of HCC would significantly improve patient prognosis. This paper describes identification of candidate markers previously reported in our serologic study of an Egyptian population by quantitative comparison of matrix assisted laser desorption ionization time of flight (MALDI-TOF) mass spectra. To identify these marker candidates, we performed LC-MS/MS sequencing that identified nine native peptides associated with HCC, including two reported previously. Four truncations of N terminus of complement C3f and a fibrinopeptide increased in control sera; two complement C4α peptides, a zyxin peptide, and a coagulation factor XIII peptide increased in cancer patient sera. We have also identified increased biliverdin diglucuronide in the sera of cancer patients. These peptides could potentially serve as markers of HCC following additional validation studies; however, association of similar peptides with other diseases and cancers dictates a very cautious approach.

scholarly journals Metastatic Extraskeletal Mesenchymal Chondrosarcoma of the Pancreas: Report of an Unusual Case with Review of Literature

2021 ◽  
Author(s):  
Saloni Naresh Shah ◽  
Ashok Parameswaran ◽  
Prasanna Kumar Reddy
Keyword(s):  
Unusual Case ◽  
English Literature ◽  
Latency Period ◽  
Sudden Onset ◽  
Mesenchymal Chondrosarcoma ◽  
Pancreatic Tumors ◽  
Good Survival ◽  
Review Of Literature ◽  
Long Latency ◽  
Extraskeletal Mesenchymal Chondrosarcoma

AbstractExtraskeletal mesenchymal chondrosarcoma (ESMC) metastasizing to the pancreas in isolation is a rare occurrence. We report a 49-year-old gentleman who had undergone excision of an ESMC of the thigh in 2009 and presented with sudden onset abdominal pain and icterus in 2019. Radiological imaging revealed calcified mass of the pancreas with multiple nodules with extension into the adipose tissue. Distal pancreatectomy was performed and the pathology revealed a bimorphic tumor composed of undifferentiated round blue cells with abrupt transition to hyaline cartilage, typical of mesenchymal chondrosarcoma. To the best of our knowledge, there are only seven prior cases of metastatic ESMC of the pancreas in the English literature. Surgical intervention appears to be the preferred modality of treatment for metastatic pancreatic tumors. These patients may have long latency period before metastasizing and seem to have a good survival period post excision.

Cytokinesis regulators as potential diagnostic and therapeutic biomarkers for human hepatocellular carcinoma

2021 ◽  
pp. 153537022110083
Author(s):  
Yiting Qiao ◽  
Yunxin Pei ◽  
Miao Luo ◽  
Muthukumar Rajasekaran ◽  
Kam M Hui ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
High Frequency ◽  
Genetic Instability ◽  
Dna Ploidy ◽  
Human Hepatocellular Carcinoma ◽  
Signaling Networks ◽  
Preclinical Studies ◽  
Dna Ploidy Pattern ◽  
Ploidy Pattern ◽  
Patient Prognosis

Cytokinesis, the final step of mitosis, is critical for maintaining the ploidy level of cells. Cytokinesis is a complex, highly regulated process and its failure can lead to genetic instability and apoptosis, contributing to the development of cancer. Human hepatocellular carcinoma is often accompanied by a high frequency of aneuploidy and the DNA ploidy pattern observed in human hepatocellular carcinoma results mostly from impairments in cytokinesis. Many key regulators of cytokinesis are abnormally expressed in human hepatocellular carcinoma, and their expression levels are often correlated with patient prognosis. Moreover, preclinical studies have demonstrated that the inhibition of key cytokinesis regulators can suppress the growth of human hepatocellular carcinoma. Here, we provide an overview of the current understanding of the signaling networks regulating cytokinesis, the key cytokinesis regulators involved in the initiation and development of human hepatocellular carcinoma, and their applications as potential diagnostic and therapeutic biomarkers.

scholarly journals Paracoccidioidomycosis Diagnosed in Europe—A Systematic Literature Review

2021 ◽  
Vol 7 (2) ◽  
pp. 157
Author(s):  
Gernot Wagner ◽  
Deddo Moertl ◽  
Anna Glechner ◽  
Verena Mayr ◽  
Irma Klerings ◽  
...  
Keyword(s):  
Latency Period ◽  
European Countries ◽  
Systemic Mycosis ◽  
Endemic Region ◽  
Travel History ◽  
Long Latency ◽  
Geographical Regions ◽  
The World ◽  
First Occurrence ◽  
Full Text Screening

Paracoccidioidomycosis is a systemic mycosis that is endemic in geographical regions of Central and South America. Cases that occur in nonendemic regions of the world are imported through migration and travel. Due to the limited number of cases in Europe, most physicians are not familiar with paracoccidioidomycosis and its close clinical and histopathological resemblance to other infectious and noninfectious disease. To increase awareness of this insidious mycosis, we conducted a systematic review to summarize the evidence on cases diagnosed and reported in Europe. We searched PubMed and Embase to identify cases of paracoccidioidomycosis diagnosed in European countries. In addition, we used Scopus for citation tracking and manually screened bibliographies of relevant articles. We conducted dual abstract and full-text screening of references yielded by our searches. To identify publications published prior to 1985, we used the previously published review by Ajello et al. Overall, we identified 83 cases of paracoccidioidomycosis diagnosed in 11 European countries, published in 68 articles. Age of patients ranged from 24 to 77 years; the majority were male. Time from leaving the endemic region and first occurrence of symptoms considerably varied. Our review illustrates the challenges of considering systemic mycosis in the differential diagnosis of people returning or immigrating to Europe from endemic areas. Travel history is important for diagnostic-workup, though it might be difficult to obtain due to possible long latency period of the disease.

scholarly journals Trust in science increases conservative support for social distancing

2021 ◽  
Vol 24 (4) ◽  
pp. 680-697
Author(s):  
Jonah Koetke ◽  
Karina Schumann ◽  
Tenelle Porter
Keyword(s):  
Public Health ◽  
Government Official ◽  
Prevention Strategies ◽  
Social Distancing ◽  
Scientific Consensus ◽  
Ideological Differences ◽  
Moderating Role ◽  
Insight Into

The COVID-19 pandemic necessitates adherence to scientifically supported prevention strategies, such as social distancing. Although most Americans support social distancing, a subset of conservatives reject the scientific consensus on this matter. We explored why some conservatives reject social distancing, focusing on how trust in science contributes to ideological differences in social distancing intentions. In two studies, we replicated recent research demonstrating that conservatives report lower support for social distancing compared to liberals. However, in Study 1 we found support for a moderating role of trust in science, such that conservatives reported stronger intentions to socially distance when they had high trust in science. In Study 2, we enhanced trust in messaging about social distancing – and in turn, social distancing intentions among conservatives – by having the messages come from a Republican (vs. unidentified) government official. These studies provide insight into how we can increase adherence to public health recommendations regarding COVID-19.

scholarly journals Revisiting an Aspergillus flavus Strain Isolated from an Egyptian Sugarcane Field in 1930

2020 ◽  
Vol 8 (11) ◽  
pp. 1633
Author(s):  
Mohamed F. Abdallah ◽  
Kris Audenaert ◽  
Sarah De Saeger ◽  
Jos Houbraken
Keyword(s):  
Aspergillus Flavus ◽  
Short Communication ◽  
Aflatoxin Contamination ◽  
Type B ◽  
Prevention Strategies ◽  
Sugarcane Field ◽  
Host Pathogen Interaction ◽  
Sugarcane Crop ◽  
Insight Into ◽  
Shed Light

The aflatoxin type B and G producer Aspergillus novoparasiticus was described in 2012 and was firstly reported from sputum, hospital air (Brazil), and soil (Colombia). Later, several survey studies reported the occurrence of this species in different foods and other agricultural commodities from several countries worldwide. This short communication reports on an old fungal strain (CBS 108.30), isolated from Pseudococcus sacchari (grey sugarcane mealybug) from an Egyptian sugarcane field in (or before) 1930. This strain was initially identified as Aspergillus flavus; however, using the latest taxonomy schemes, the strain is, in fact, A. novoparasiticus. These data and previous reports indicate that A. novoparasiticus is strongly associated with sugarcane, and pre-harvest biocontrol approaches with non-toxigenic A. novoparasiticus strains are likely to be more successful than those using non-toxigenic A. flavus strains. Further studies on the association between A. novoparasiticus and Pseudococcus sacchari might shed light on the distribution (and aflatoxin contamination) of this species in sugarcane. Additionally, the interaction between A. novoparasiticus, Pseudococcus sacchari, and sugarcane crop under different scenarios of climate change will be critical in order to get more insight into the host–pathogen interaction and host resistance and propose appropriate prevention strategies to decrease mycotoxin contamination and crop loss due to A. novoparasiticus attack.

“Re-Emergence” of Silicosis and Coal Workers Pneumoconiosis in Australia

2020 ◽  
Vol 119 (1) ◽  
pp. 65-92
Author(s):  
Beris Penrose
Keyword(s):  
Data Collection ◽  
Coal Mining ◽  
Disease Onset ◽  
Latency Period ◽  
Dust Exposure ◽  
Long Latency ◽  
History Of ◽  
Coal Workers Pneumoconiosis ◽  
Coal Workers

Some reporters, politicians, and doctors have described current cases as a “re-emergence” of these diseases, based on the notion that they had been eliminated. However, silicosis persisted in centuries-old industries like sandblasting and stonemasonry and coal workers pneumoconiosis (CWP) continued in coal mining. Until recently, their presence was obscured by a combination of factors such as misdiagnosis, especially if there was a history of smoking; the failure to follow up workers thought to have silicosis or CWP; the long latency period between dust exposure and disease onset that can conceal the link between the two; and the lack of data collection that may have revealed their presence. As the recent Queensland government inquiry into CWP noted, current cases are more accurately a reidentification.

Purinoceptor expression in hepatocellular virus (HCV)-induced and non-HCV hepatocellular carcinoma: an insight into the proviral role of the P2X4 receptor

2018 ◽  
Vol 45 (6) ◽  
pp. 2625-2630 ◽  
Author(s):  
Madiha Khalid ◽  
Sobia Manzoor ◽  
Hassam Ahmad ◽  
Arun Asif ◽  
Tariq Ali Bangash ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
P2x4 Receptor ◽  
Insight Into

scholarly journals Medication Errors: Scope and prevention strategies

2012 ◽  
Vol 1 (2) ◽  
pp. 54 ◽  
Author(s):  
Luigi Brunetti ◽  
Dong-Churl Suh
Keyword(s):  
Medication Error ◽  
Medication Errors ◽  
Health Concern ◽  
Prevention Strategies ◽  
Error Prevention ◽  
Integration Of Technology ◽  
Significant Public Health Concern ◽  
Significant Public Health ◽  
Safety Systems ◽  
Improve Patient

Background: Medication errors are a significant public health concern.  Although significant advances have been made, errors are still relatively common and represent an opportunity for healthcare improvement.Methodology/Principal Findings: Since the publication of To Err is Human, medication errors have been under tremendous scrutiny.  Organizations have moved towards a non-punitive approach to evaluating errors.  This approach to medication errors has aided in identifying common pathways to medication errors and improving understanding regarding the anatomy of a medication error.  As a result, prevention strategies have been developed to target common themes contributing to errors.  Error prevention strategies may target common contributors of medication errors, broadly grouped as performance lapses, lack of knowledge, and lack or failure of safety systems.  Strategies to thwart medication errors range from process improvement to integration of technology in the health care environment.Conclusions/Significance:  Organizations should devote resources to address medication error prevention strategies in an effort to improve patient outcomes and decrease morbidity and mortality associated with medication errors.

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