scholarly journals Impact of Race and Socioeconomics Disparities on Survival in Young-Onset Colorectal Adenocarcinoma—A SEER Registry Analysis

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3262
Author(s):  
Mark M. Aloysius ◽  
Hemant Goyal ◽  
Niraj J. Shah ◽  
Kumar Pallav ◽  
Nimy John ◽  
...  

Introduction: We aimed to assess the impact of socio-economic determinants of health (SEDH) on survival disparities within and between the ethnic groups of young-onset (<50 years age) colorectal adenocarcinoma patients. Patients and Methods: Surveillance, epidemiology, and end results (SEER) registry was used to identify colorectal adenocarcinoma patients aged between 25–49 years from 2012 and 2016. Survival analysis was performed using the Kaplan–Meir method. Cox proportional hazards model was used to determine the hazard effect of SEDH. American community survey (ACS) data 2012–2016 were used to analyze the impact of high school education, immigration status, poverty, household income, employment, marital status, and insurance type. Results: A total of 17,145 young-onset colorectal adenocarcinoma patients were studied. Hispanic (H) = 2874, Non-Hispanic American Indian/Alaskan Native (NHAIAN) = 164, Non-Hispanic Asian Pacific Islander (NHAPI) = 1676, Non-Hispanic black (NHB) = 2305, Non-Hispanic white (NHW) = 10,126. Overall cancer-specific survival was, at 5 years, 69 m. NHB (65.58 m) and NHAIAN (65.67 m) experienced worse survival compared with NHW (70.11 m), NHAPI (68.7), and H (68.31). High school education conferred improved cancer-specific survival significantly with NHAPI, NHB, and NHW but not with H and NHAIAN. Poverty lowered and high school education improved cancer-specific survival (CSS) in NHB, NHW, and NHAPI. Unemployment was associated with lowered CSS in H and NAPI. Lower income below the median negatively impacted survival among H, NHAPI NHB, and NHW. Recent immigration within the last 12 months lowered CSS survival in NHW. Commercial health insurance compared with government insurance conferred improved CSS in all groups. Conclusions: Survival disparities were found among all races with young-onset colorectal adenocarcinoma. The pattern of SEDH influencing survival was unique to each race. Overall higher income levels, high school education, private insurance, and marital status appeared to be independent factors conferring favorable survival found on multivariate analysis.

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1426-1426
Author(s):  
Kijoon Kim ◽  
Kyungho Ha ◽  
Junichi Sakaki ◽  
Hwayoung Noh ◽  
Ock Chun

Abstract Objectives Diets rich in flavonoids can reduce the risk of developing chronic diseases through their antioxidant and anti-inflammatory properties. While differences in flavonoid intake by race/ethnicity have been previously described, differences between race/ethnicity within categories sociodemographic characteristics have not been fully assessed. Therefore, the objective of this study was to estimate flavonoid intake and evaluate the disparities by race/ethnicity within categories of sociodemographic characteristics in US adults. Methods A total of 15,775 US adults aged 20 years and older in NHANES 2007–2014 were included in this cross-sectional study. Flavonoid intake was calculated by linking food consumption data from a 24-hour diet recall to a flavonoid database which has been expanded on by our research group using the USDA Databases for the Flavonoid (Release 3.3), and Isoflavone (Release 2.1) in addition to the USDA's Expanded Flavonoid Database for the Assessment of Dietary Intakes (Release 1.1). Mean (SE) flavonoid intakes by sociodemographic categories were compared with one-way ANOVA. Results Among US adults, mean (SE) total flavonoid intake was 227.6 (8.0) mg/day, and total flavonoid intake was highest in 40–59 year olds, non-Hispanic whites, those with a poverty-income ratio (PIR) ≥1.85, those with a college education or above, and those married or living with a partner. In most sociodemographic categories, Hispanics consistently had the lowest total flavonoid intakes compared to other races/ethnicities. Among Hispanic subgroups, total flavonoid intake was lowest in men, 20–39 years olds, PIR &lt; 1.3, less than high school education, and single marital status (men only). Ethnic disparities in flavonoid intake were more pronounced between certain sociodemographic subcategories including men, 40–59 year olds, PIR &lt; 1.3, less than high school education, and married marital status (men only). Conclusions These findings indicate that there are significant racial differences in flavonoid intake. Notably, Hispanics tended to have the lowest intake. Certain sociodemographic populations such as males, low income or low educated may be at an increased risk of flavonoid under-consumption. Funding Sources This research received no external funding.


2020 ◽  
Vol 4 (2) ◽  
pp. 9
Author(s):  
Hartati Hartati ◽  
Destriana Destriana ◽  
Marlina Marlina ◽  
Muslimin Muslimin

Anemia is a condition when the body lacks blood cells that contain hemoglobin to spread oxygen to all organs of the body. The impact of anemia for elementary school-age children is that it can cause problems of child growth and development. This study aims to determine the factors that influence anemia in SD Gedung Batin, Negara Inner sub-district, Way Kanan Regency, Lampung Province. This research uses descriptive analytic that is describing and explaining the factors that influence anemia status in 6th grade students at Batin Building, Negara Batin Subdistrict, Way Kanan Regency, Lampung Province. The population in this study were all elementary school students in Batin Building, Batin Negara District, Way Kanan Regency, Lampung Province, totaling 50 students. The sample in this study amounted to 17 students. Research instruments include questionnaires, data collected in the form of primary data and secondary data based on the results of research and data analysis with cross sectional. The analysis shows that the nutritional status based on body mass index BMI there are 5 normal nutrition students, 4 students are fat nutritional status and 8 students are classified as underweight nutritional status. According to normal weight 40%, and low 60%. normal height 53% and low 47%. The majority are 60% and 40% are minority. Parents' income is high as much as 47% and less 53%. 65% of junior high / high school education and 35% of senior high school / elementary / junior high school education. The implication in this research is finding factors that influence anemia, one of which is related to nutritional problems.


2018 ◽  
Vol 8 (6) ◽  
pp. 96
Author(s):  
Egemen Hanımoğlu

Technology in secondary school is of great importance to students and teachers. School management teams focus onensuring that learners have access to computers during the high school years. The existence of the internet has led toan increase in the drive to promote the availability of computers to all high school scholars. For instance, wiring theinstitutions and classrooms is a measure adopted to improve access to quality education facilitated by internet use.Through technology, various concepts related to learning can be shared easily. Integration of IT in learning processrequires practical skills and access to technological tools for teachers. Therefore, many academic institutions havesignificantly invested in the purchase of equipment. The current study analyses various literature focusing on theroles that technology has played on high school education over the years. The critical area to focus on includestechnology and interaction of teachers, students, benefits of the technology, as well as possible drawbacks.Accordingly, integrating online learning and teaching activities plays a crucial role in accommodating student'sdiverse learning styles. In addition, such strategies can assist leaner's to work before or after school, unlike inconditions where only classroom learning occurs.


2020 ◽  
Vol 74 (3) ◽  
pp. 219-224 ◽  
Author(s):  
John A Kaufman ◽  
Leslie K Salas-Hernández ◽  
Kelli A Komro ◽  
Melvin D Livingston

BackgroundSocial welfare policies such as the minimum wage can affect population health, though the impact may differ by the level of unemployment experienced by society at a given time.MethodsWe ran difference-in-differences models using monthly data from all 50 states and Washington, DC from 1990 to 2015. We used educational attainment to define treatment and control groups. The exposure was the difference between state and federal minimum wage in US$2015, defined both by the date the state law became effective and lagged by 1 year. Models included state and year fixed effects, and additional state-level covariates to account for state-specific time-varying confounding. We assessed effect modification by the state-level unemployment rate, and estimated predicted suicide counts under different minimum wage scenarios.ResultsThe effect of a US$1 increase in the minimum wage ranged from a 3.4% decrease (95% CI 0.4 to 6.4) to a 5.9% decrease (95% CI 1.4 to 10.2) in the suicide rate among adults aged 18–64 years with a high school education or less. We detected significant effect modification by unemployment rate, with the largest effects of minimum wage on reducing suicides observed at higher unemployment levels.ConclusionMinimum wage increases appear to reduce the suicide rate among those with a high school education or less, and may reduce disparities between socioeconomic groups. Effects appear greatest during periods of high unemployment.


2016 ◽  
Vol 9 (3) ◽  
pp. 13
Author(s):  
Patricia A. Metcalf ◽  
Michelle L. Meyer ◽  
Chirayath M. Suchindran ◽  
Gerardo Heiss

<p><strong>BACKGROUND: </strong>Evaluation of cause-specific mortality for public health research depends on accurate death certificates and vital records. However, ill-defined causes of death (termed garbage codes), such as heart failure, are often listed as the underlying cause of death. We examined a regression method proposed by Ahern and colleagues for redistributing deaths attributed to heart failure and compared it to a simulation of the regression method by bootstrapping. </p><p><strong>METHODS: </strong>Deaths attributed to heart failure in four U.S. states (Maryland, Minnesota, Mississippi and North Carolina) were redistributed to a set of underlying causes of death using regression models that identified the proportion of deaths for each target code within a given state-age-sex-education group using ICD-10 mortality data. The results were compared with 3,000 bootstrapped samples with replacement regression.</p><p><strong>RESULTS: </strong>The odds of death from heart failure in the population studied increased with age, was higher in whites and lower in decedents with greater than a high school education compared to those with less than high school education. There were 18 (29.0%) subgroups that showed no significant redistribution targets for the Ahern regression method and 28 (45.2%) for the bootstrapped regression method. Ischemic heart disease was a distribution target for 28 (45.2%) of the Ahern regression subgroups and 22 (35.5%) of the bootstrapped regression subgroups. The Ahern regression method and bootstrapped regression methods were discordant in 19 (30.6%) out of the 62 subgroups examined.</p><p><strong>CONCLUSION: </strong>The Ahern regression method tended to redistribute deaths attributed to heart failure to more target groups compared with the bootstrapped regression method. Both the Ahern regression and the bootstrap regression methods were computationally intensive and inefficient, and results appeared to be influenced by the choices of sex-age-education group strata. Other methods such as coarsened exact matching and improvements to the Ahern approach are desirable additions to the tools available to mitigate the impact of garbage codes on the accuracy of death certification.</p>


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
J Kalubi ◽  
Z Tchouaga ◽  
A Ghenadenik ◽  
J O'Loughlin ◽  
K L Frohlich

Abstract Background Tobacco use accounts for half the difference in life expectancy across groups of low and high socioeconomic status. The objective was to assess whether social inequalities in smoking in Canada-born young adults are also apparent among same-age immigrants, a group often viewed as disadvantaged and vulnerable to multiple health issues. Methods Data were drawn from the Interdisciplinary Study of Inequalities in Smoking, a longitudinal investigation of social inequalities in smoking in Montreal, Canada. The sample included 2,077 young adults age 18-25 (56.6% female; 18.9% immigrants). Immigrants had been in Canada 11.6 (SD 6.4) years on average. The association between level of education and current smoking was examined separately in immigrants and non-immigrants in multivariate logistic regression analyses controlling for covariates. Results Twenty percent of immigrants were current smokers compared to 24% of non-immigrants. In immigrants, relative to those who were university-educated, the adjusted odds ratio (OR) (95% confidence interval) for current smoking was 1.2 (0.6, 2.3) among those with pre-university or vocational training, and 1.5 (0.7, 2.9) among those with high school education only. In non-immigrants, the adjusted ORs were 1.9 (1.4, 2.5) among those with pre-university or vocational training and 4.0 (2.9, 5.5) among those with high school education. Conclusions Despite a mean of over 10 years in Canada, young adults who immigrated to Canada did not manifest the strong social gradient in smoking apparent in non-immigrants. Identification of factors that protect immigrants from manifesting marked social inequalities in smoking could inform the development of smoking preventive intervention sensitive to social inequalities in smoking. Key messages A social gradient in smoking apparent in Canada-born young adults was not observed in same-age immigrants. Factors that protect immigrants against social inequalities in smoking should be identified.


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