scholarly journals Complex Roles of Neutrophils during Arboviral Infections

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1324
Author(s):  
Abenaya Muralidharan ◽  
St Patrick Reid
Keyword(s):  
Viral Replication ◽  
Large Scale ◽  
Viral Pathogenesis ◽  
Complex Nature ◽  
Effective Protection ◽  
Wide Range ◽  
The World ◽  
Underlying Mechanisms ◽  
A Site

Arboviruses are known to cause large-scale epidemics in many parts of the world. These arthropod-borne viruses are a large group consisting of viruses from a wide range of families. The ability of their vector to enhance viral pathogenesis and transmission makes the development of treatments against these viruses challenging. Neutrophils are generally the first leukocytes to be recruited to a site of infection, playing a major role in regulating inflammation and, as a result, viral replication and dissemination. However, the underlying mechanisms through which neutrophils control the progression of inflammation and disease remain to be fully understood. In this review, we highlight the major findings from recent years regarding the role of neutrophils during arboviral infections. We discuss the complex nature of neutrophils in mediating not only protection, but also augmenting disease pathology. Better understanding of neutrophil pathways involved in effective protection against arboviral infections can help identify potential targets for therapeutics.

Educational Cluster as a Tool for Implementation Education for Sustainable Development

2018 ◽  
Vol 89 (1) ◽  
pp. 110-119
Author(s):  
V. Mykhailenko ◽  
M. Blyzniuk
Keyword(s):  
Sustainable Development ◽  
Civil Society ◽  
Education Reform ◽  
Cluster Model ◽  
Education For Sustainable Development ◽  
Economic Education ◽  
Complex Nature ◽  
Wide Range ◽  
The World

The world experience on educational clusters proves their applicability and efficiency. An example is the formation of educational clusters for economic education and business schools. Formation of educational clusters has become an important part of the state personnel policy of many countries of the world. Multidimensional notion of "sustainable development" in combination with a wide range of age-old target audiences requires new methodological approaches for building an open dialogue between a student and a teacher. Taking into account the complex nature of the research subject that combines social, economic and environmental dimensions of human activity, authors propose a scientific and educational cluster as an innovative form of implementation of cross-cutting education for sustainable development (ESD) in Ukraine. The role of the core formation of an educational cluster is best suited for universities that are open to innovation and new educational technologies. The new educational model is illustrated by ad hoc activity of Carpathian School held in Kosiv, Ivano-Frankivsk region. Target audience represented Master students of natural sciences, secondary school students, biologists and geography teachers together with civil society activists. The school organizers were "Centre for Civic Initiatives", Kosiv and Faculty of Geography of Taras Shevchenko National University of Kyiv supported by two National Natural Parks “Hutsulshchyna” and “Vyzhnytsky”. The lecturers’ team included university professors, experts of The Regional Environmental Centre for CEE countries (REC), Hungary, the National Ecological Centre of Ukraine (NECU), leading experts of the Ministry of Natural Resources of Ukraine, employees of local museums and cultural institutions. The main goal of the School is to consider the role of civil society, local activists, entrepreneurs and authorities in building sustainable communities, to achieve the UN Sustainable Development Goals. The cluster model was tested for obtaining a professional orientation of the lyceum graduates with a strong TOT component in view of education reform "New Ukrainian School". The students were acquainted with educational materials and methodical guides of the REC multimedia toolkits "Green Package" and "Step by Step", adapted to Ukrainian needs by local experts. These materials are easily perceived by young people, Master students and senior pupils. Interactive games and dilemmas were suitable for the formation of ecologically oriented thinking and social competence of youth. The guides were also highly praised by elderly participants and recommended for training and retraining of school teachers. Interviews with the school attendees and lecturers, interviews and publications in the local mass-media showed the benefits of cluster model in comparison with traditional forms of education. The school also identified the opportunities for professional guidance, training and retraining of teachers' staff.

Inflammatory Biomarkers in Atrial Fibrillation

2019 ◽  
Vol 26 (5) ◽  
pp. 837-854 ◽  
Author(s):  
Effimia Zacharia ◽  
Nikolaos Papageorgiou ◽  
Adam Ioannou ◽  
Gerasimos Siasos ◽  
Spyridon Papaioannou ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Plasma Levels ◽  
Large Scale ◽  
Inflammatory Biomarkers ◽  
Inflammatory Pathways ◽  
Inflammatory State ◽  
Anti Inflammatory ◽  
Underlying Mechanisms

During the last few years, a significant number of studies have attempted to clarify the underlying mechanisms that lead to the presentation of atrial fibrillation (AF). Inflammation is a key component of the pathophysiological processes that lead to the development of AF; the amplification of inflammatory pathways triggers AF, and, in tandem, AF increases the inflammatory state. Indeed, the plasma levels of several inflammatory biomarkers are elevated in patients with AF. In addition, the levels of specific inflammatory biomarkers may provide information regarding to the AF duration. Several small studies have assessed the role of anti-inflammatory treatment in atrial fibrillation but the results have been contradictory. Large-scale studies are needed to evaluate the role of inflammation in AF and whether anti-inflammatory medications should be routinely administered to patients with AF.

scholarly journals A Large-Scale COVID-19 Twitter Chatter Dataset for Open Scientific Research—An International Collaboration

Epidemiologia ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 315-324
Author(s):  
Juan M. Banda ◽  
Ramya Tekumalla ◽  
Guanyu Wang ◽  
Jingyuan Yu ◽  
Tuo Liu ◽  
...  
Keyword(s):  
Large Scale ◽  
Social Dynamics ◽  
Additional Data ◽  
Open Data ◽  
Data Sources ◽  
Research Projects ◽  
Research Groups ◽  
The World ◽  
Data Source

As the COVID-19 pandemic continues to spread worldwide, an unprecedented amount of open data is being generated for medical, genetics, and epidemiological research. The unparalleled rate at which many research groups around the world are releasing data and publications on the ongoing pandemic is allowing other scientists to learn from local experiences and data generated on the front lines of the COVID-19 pandemic. However, there is a need to integrate additional data sources that map and measure the role of social dynamics of such a unique worldwide event in biomedical, biological, and epidemiological analyses. For this purpose, we present a large-scale curated dataset of over 1.12 billion tweets, growing daily, related to COVID-19 chatter generated from 1 January 2020 to 27 June 2021 at the time of writing. This data source provides a freely available additional data source for researchers worldwide to conduct a wide and diverse number of research projects, such as epidemiological analyses, emotional and mental responses to social distancing measures, the identification of sources of misinformation, stratified measurement of sentiment towards the pandemic in near real time, among many others.

Haemorheological Effects on Thrombocyte Adhesion and Aggregation Found Under Controlled Flow Conditions

1979 ◽  
Author(s):  
P.D. Richardson
Keyword(s):  
Rate Of Change ◽  
Continuous Observation ◽  
Flow Conditions ◽  
Wide Range ◽  
Stream Migration ◽  
Local Shear ◽  
Videotape Recording ◽  
Controlled Flow ◽  
A Site

Thrombocyte adhesion and aggregation in a vessel or on a chamber wall can be measured most readily if the flow is controlled and steady, and continuous observation is used. Videotape recording is very helpful for subsequent quantification of the dynamics. The adhesion of each thrombocyte can occur for a finite time interval:this interval has been observed to have a wide range. Platelets which escape often leave open a site which attracts other platelets preferentially. The rate of change of adhesion density (platelets/mm2) is affected by the local shear rate and the shear history upstream. Aggregation is affected similarly, and also proceeds with some platelet turnover. The role of erythrocytes in facilitating cross-stream migration of thrombocytes (which can enhance the growth rate of large thrombi) appears due in part to convective flow fields induced by the motion of erythrocytes in a shear flow, which can be demonstrated theoretically and experimentally. Observations of the phenomenlogy of adhesion and aggregation under controlled flow conditions and comparison with fLu id-dynamically based theory allows representation in terras of a small number of parameters with prospects of prediction of behaviour over a wide range of haemodynamic conditions; biochemical changes lead to changes in values of the parameters, so that activating agents and inhibiting agents modify values in different directions.

Events in Northern Africa and Middle East: Causes and Consequences

2011 ◽  
pp. 11-25
Author(s):  
I. Labinskaya
Keyword(s):  
Middle East ◽  
North Africa ◽  
Large Scale ◽  
Arab Countries ◽  
Northern Africa ◽  
External Factors ◽  
Wide Range ◽  
The Usa ◽  
Oriental Studies

Political developments in North Africa and the Middle East that have begun in January 2011 are gaining strength and involve an increasing number of Arab countries. The participants of the Roundtable – experts from IMEMO, Institute of Oriental Studies (RAS), Institute of the USA and Canada (RAS) and Mrs. E. Suponina from “Moscow News” newspaper analyzed a wide range of issues associated with these events. Among them are: 1) the reasons for such a large-scale explosion, 2) the nature of the discussed developments (revolutions, riots?) and who are the subjects of the current “Arab drama”, 3) the role of Islam and political Islamism, 4) the role of external factors.

Investment in the agricultural sector as a way to solve food security problems in developing countries: the example of investment activity of the US agribusiness

2021 ◽  
Author(s):  
Elena Stepanovna Ustinovich ◽  
Tatyana Petrovna Boldyreva
Keyword(s):  
Developing Countries ◽  
Large Scale ◽  
Agricultural Sector ◽  
International Investment ◽  
Investment Activity ◽  
Agricultural Investment ◽  
Wide Range ◽  
The Us ◽  
The World ◽  
Potential Benefits

It is clear to everyone that investment in the agricultural sector in developing countries is one of the most effective ways to reduce poverty and hunger in the world. Agricultural investment can generate a wide range of development opportunities. However, these benefi ts cannot be expected to arise automatically. Some forms of large-scale investment pose significant risks to investor states. It should be noted, however, that, despite discussions about the potential benefits and risks of international investment, there is still no evidence of negative actual consequences for the countries receiving investments. This article examines the issues of investment activity in relation to developing countries using the example of US agribusiness entities.

scholarly journals Addressing the Haze: The Role of Local Traditional Cultures and Islamic Teachings

ICR Journal ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 97-100
Author(s):  
Shahino Mah Abdullah
Keyword(s):  
Growth Rate ◽  
Forest Fires ◽  
Large Scale ◽  
Land Use Changes ◽  
Airborne Particles ◽  
Health Economy ◽  
Crop Growth Rate ◽  
The World ◽  
Related Mortality

The most frequent transboundary haze in the world takes place in Southeast Asia. It is usually caused by land-use changes, open burning, peat combustion, wildfires, and other farming activities. Serious haze occurred in 1983, 1997, 2005, 2006, 2009, 2010, 2013, 2015 and 2016, originating from large-scale forest fires in western Sumatra and southern Kalimantan, Indonesia. It caused adverse effects to locals as well as neighbouring countries, affecting their health, economy, agriculture, and biodiversity. Among the serious effects of haze are increased respiratory-related mortality due to toxic airborne particles, jet crashs and ship collisions due to restricted visibility, reduction of crop growth rate due to limited solar radiation, and extinction of endangered primates due to habitat loss. Neighbouring countries like Malaysia and Singapore sometimes have to close schools to prevent people from being exposed to air pollution, and its consequent respiratory ailments.  

scholarly journals Cycling Pathways

2021 ◽  
Author(s):  
Henk-Jan Dekker
Keyword(s):  
Climate Change ◽  
The Netherlands ◽  
Political Struggle ◽  
The Road ◽  
Wide Range ◽  
The World ◽  
Road Space ◽  
History Of ◽  
On The Road

In an effort to fight climate change, many cities try to boost their cycling levels. They often look towards the Dutch for guidance. However, historians have only begun to uncover how and why the Netherlands became the premier cycling country of the world. Why were Dutch cyclists so successful in their fight for a place on the road? Cycling Pathways: The Politics and Governance of Dutch Cycling Infrastructure, 1920-2020 explores the long political struggle that culminated in today’s high cycling levels. Delving into the archives, it uncovers the important role of social movements and shows in detail how these interacted with national, provincial, and urban engineers and policymakers to govern the distribution of road space and construction of cycling infrastructure. It discusses a wide range of topics, ranging from activists to engineering committees, from urban commuters to recreational cyclists and from the early 1900s to today in order to uncover the long and all-but-forgotten history of Dutch cycling governance.

scholarly journals The role of airborne volcanic ash for the surface ocean biogeochemical iron-cycle: a review

2009 ◽  
Vol 6 (4) ◽  
pp. 6441-6489 ◽  
Author(s):  
S. Duggen ◽  
N. Olgun ◽  
P. Croot ◽  
L. Hoffmann ◽  
H. Dietze ◽  
...  
Keyword(s):  
Large Scale ◽  
Volcanic Ash ◽  
Volcanic Eruptions ◽  
Research Field ◽  
Ash Deposition ◽  
Future Directions ◽  
Iron Cycle ◽  
Surface Ocean ◽  
Wide Range

Abstract. Iron is a key micronutrient for phytoplankton growth in the surface ocean. Yet the significance of volcanism for the marine biogeochemical iron-cycle is poorly constrained. Recent studies, however, suggest that offshore deposition of airborne ash from volcanic eruptions is a way to inject significant amounts of bio-available iron into the surface ocean. Volcanic ash may be transported up to several tens of kilometres high into the atmosphere during large-scale eruptions and fine ash may encircle the globe for years, thereby reaching even the remotest and most iron-starved oceanic areas. Scientific ocean drilling demonstrates that volcanic ash layers and dispersed ash particles are frequently found in marine sediments and that therefore volcanic ash deposition and iron-injection into the oceans took place throughout much of the Earth's history. The data from geochemical and biological experiments, natural evidence and satellite techniques now available suggest that volcanic ash is a so far underestimated source for iron in the surface ocean, possibly of similar importance as aeolian dust. Here we summarise the development of and the knowledge in this fairly young research field. The paper covers a wide range of chemical and biological issues and we make recommendations for future directions in these areas. The review paper may thus be helpful to improve our understanding of the role of volcanic ash for the marine biogeochemical iron-cycle, marine primary productivity and the ocean-atmosphere exchange of CO2 and other gases relevant for climate throughout the Earth's history.

scholarly journals Рукописное наследие татарских ученых в фондах Института востоковедения Академии Наук Республики Узбекистан

Islamology ◽  
2019 ◽  
Vol 9 (1-2) ◽  
pp. 195
Author(s):  
Saidakbar Mukhammadaminov
Keyword(s):  
Wide Range ◽  
The World ◽  
The Creation ◽  
Oriental Studies ◽  
Academy Of Sciences

The article is dedicated to the manuscript heritage of Tatar scholars held in Abu Rayhan Beruni Institute of Oriental Studies of the Academy of Sciences of Uzbekistan, one of the richest manuscript repositories in the world. Works of manuscripts of Tatar theologians such as Abdurahim Utyz-Imyani, Abu al-Nasr Qursawi, Shihabaddin Mardjani, and Hisam al-Din b. Sharaf al- Din al-Bulgari, Kamal al-Din b. Siraj al-Din al-Uribfori al-Kazani, ̒Ayn al-Din b. Jalal al-Din al-Kazani, Abu al-Sharaf Husain b. Abu Umar al- Bulgari, Muhammad Latif b. Abdulislam al-Bulgari are analyzed. Based on a review of the manuscripts, it is established that some of them have not yet been catalogued. It is argued that the works of Tatar scholars were mainly devoted to religious subjects. The role of Tatar scholars in the creation of commentaries and works on legal, medical and Sufi terms is analyzed in order to make the works accessible to a wide range of people seeking knowledge.

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