scholarly journals Formation of Stable Lithium-Containing Ceramics Using Solid-Phase Synthesis Method

Crystals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1177
Author(s):  
Dmitriy I. Shlimas ◽  
Artem L. Kozlovskiy ◽  
Maxim V. Zdorovets
Keyword(s):  
Phase Composition ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Synthesis Method ◽  
X Ray Diffraction ◽  
Phase Synthesis ◽  
Practical Applications ◽  
Wide Range ◽  
Pure Phase ◽  
Temperature Dependences

Today, one of the most promising materials for a wide range of practical applications is lithium-containing ceramics based on Li2TiO3. At the same time, despite the high potential of their practical application, a number of questions remains related to the methods of their preparation, as well as the formation of a stable crystal structure and a pure-phase composition. To solve these issues, this paper proposes a method for obtaining stable Li2TiO3 ceramics, which is based on solid-phase synthesis combined with the high-temperature sintering of ceramics. During the studies carried out using X-ray diffraction methods, temperature dependences of phase transformations of the TiO2/Li2Ti6O13 → Li2TiO3 type were determined, according to which, at temperatures above 800 °C, the formation of a stable Li2TiO3 phase characterized by a high structural ordering degree of 89–91% is observed. The dependence of changes in structural, optical and ferroelectric characteristics on the conditions of synthesis and phase composition of ceramics was also determined.

scholarly journals Postsynthetic On-Column 2′ Functionalization of RNA by Convenient Versatile Method

2020 ◽  
Vol 21 (14) ◽  
pp. 5127
Author(s):  
Olga A. Krasheninina ◽  
Veniamin S. Fishman ◽  
Alexander A. Lomzov ◽  
Alexey V. Ustinov ◽  
Alya G. Venyaminova
Keyword(s):  
Chemical Synthesis ◽  
Physicochemical Properties ◽  
Functional Groups ◽  
Convenient Method ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Protecting Groups ◽  
Hydroxyl Group ◽  
Phase Synthesis ◽  
Wide Range

We report a universal straightforward strategy for the chemical synthesis of modified oligoribonucleotides containing functional groups of different structures at the 2′ position of ribose. The on-column synthetic concept is based on the incorporation of two types of commercial nucleotide phosphoramidites containing orthogonal 2′-O-protecting groups, namely 2′-O-thiomorpholine-carbothioate (TC, as “permanent”) and 2′-O-tert-butyl(dimethyl)silyl (tBDMS, as “temporary”), to RNA during solid-phase synthesis. Subsequently, the support-bound RNA undergoes selective deprotection and follows postsynthetic 2′ functionalization of the naked hydroxyl group. This convenient method to tailor RNA, utilizing the advantages of solid phase approaches, gives an opportunity to introduce site-specifically a wide range of linkers and functional groups. By this strategy, a series of RNAs containing diverse 2′ functionalities were synthesized and studied with respect to their physicochemical properties.

Combinatorial Synthesis of Exohedrally Modified Fullerene Derivatives

2003 ◽  
Vol 17 (08n09) ◽  
pp. 1910-1915 ◽  
Author(s):  
Yasuhiko Kawamura ◽  
Yasuyuki Akai ◽  
Masao Tsukayama
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Combinatorial Synthesis ◽  
Environmentally Benign ◽  
Azomethine Ylide ◽  
Dipolar Cycloaddition ◽  
Compound Library ◽  
Phase Synthesis ◽  
Fullerene Derivatives ◽  
Wide Range

Fulleropyrrolidines have been very welcomed in a community of a fullerene science. But sometimes the synthesis ends up with disappointing yields of the products. In order to overcome the problem and to explore more environmentally benign method for synthesizing fullerene derivatives having various attachment on the surface of the fullerenes, a solid-phase synthesis is examined. We found that the dipolar cycloaddition of an azomethine ylide, i.e., 2-phenyl-N-benzylideneglycine methyl ester, supported on a Wang resin, proceeded feasibly with C 60 and the objective fulleropyrrolidines were afforded in good yields (>75%). The method is expected to be utilized with wide range of application and it is therefore able to provide a compound library of modified fullerenes which is hard to obtain by other methods employed so far.

scholarly journals Структура и термодинамические свойства SmGaGe-=SUB=-2-=/SUB=-O-=SUB=-7-=/SUB=-

2020 ◽  
Vol 62 (2) ◽  
pp. 332
Author(s):  
Л.Т. Денисова ◽  
М.С. Молокеев ◽  
Л.А. Иртюго ◽  
В.В. Белецкий ◽  
Н.В. Белоусова ◽  
...  
Keyword(s):  
Differential Scanning Calorimetry ◽  
Heat Capacity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Phase Synthesis ◽  
High Temperature Heat Capacity ◽  
X Ray ◽  
Temperature Heat

SmGaGe2O7 has been prepared by solid-phase synthesis in air at temperatures from 1273 to 1473 K using the Sm2O3, Ga2O3, and GeO2 oxides as starting materials. The structure of the studied germanate was determined by X-ray diffraction (space group P2_1 / c; a = 7.18610(9) Angstrem, b = 6.57935(8) Angstrem, c = 12.7932(2) Angstrem). Its high-temperature heat capacity has been measured by differential scanning calorimetry. The obtained experimental dependence C_p = f (T) has been used to evaluate the thermodynamic properties of the compound.

scholarly journals Solid Phase Syntheses of Ferulic Acid Derivatives Acetyl Feruloyl Tyrosine and Acetyl Feruloyl Valyl Tyrosine

2015 ◽  
Vol 9 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Dongxin Zhao ◽  
Li Ma ◽  
Kui Lu ◽  
Juan He
Keyword(s):  
Ferulic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Acid Amide ◽  
Synthesis Method ◽  
Amide Bond ◽  
Peptide Transporter ◽  
Phase Synthesis ◽  
Amide Derivatives ◽  
Fmoc Solid Phase Synthesis

Ferulic acid was used as a common drug for cardia-cerebrovascular disease and leukopenia, but the application of ferulic acid was inhibited by the poor absorption and stability. The improvement of these defects can be realized by modifying ferulic acid by amino acids, because the amido bond can increase the bioavailability and therapeutic effect of some drugs based on the peptide transporter system of mammalian which can transport the peptidyl drugs. The peptidyl derivatives of ferulic acid, namely acetyl feruloyl tyrosine and acetyl feruloyl valyl tyrosine, were synthesized using Fmoc solid-phase synthesis method. The synthesized ferulic acid amide derivatives were purified by RP-HPLC, and characterized by IR, HNMR and ESI-MS. The results indicated that Fmoc solid phase synthesis was a convenient method for the amide bond modification of ferulic acid and the further property research on ferulic acid derivatives.

scholarly journals Solid-Phase Preparation of Al-TiO2 for Efficient Separation of Bioderived Product Danshensu

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Fei Chang ◽  
Zhong Bing He ◽  
Quan Zhou
Keyword(s):  
Solid Phase Synthesis ◽  
Ph Value ◽  
Solid Phase ◽  
Synthesis Method ◽  
Uv Spectrophotometry ◽  
Elution Volume ◽  
Phase Synthesis ◽  
Adsorption Time ◽  
Sample Concentration ◽  
Efficient Separation

Four kinds of Al-TiO2 solid samples with different Ti/Al ratios of 1 : 0.1, 1 : 0.09, 1 : 0.07, and 1 : 0.05 were synthesized via a solid-phase synthesis method and characterized by XRD, SEM, EDS, BET, and other techniques. The prepared solids were used for separation of the bioderived product danshensu, the content of which was determined by UV spectrophotometry. Moreover, the effects of extract concentration, PH value, adsorption time, and ethanol elution volume were investigated. The results showed that these Al-TiO2 samples had good adsorption and desorption ability. Especially, the solid Al-TiO2 with a Ti/Al ratio of 1 : 0.05 is more suitable for the separation of danshensu, exhibiting a higher adsorption (77.70%) under 2 h adsorption time and pH = 3; meanwhile, the high desorption rate (70.29%）was received under 80% ethanol and the sample concentration of 3.0 mg/mL.

Thermal Stability of Aluminum Titanate Ceramics

2016 ◽  
Vol 680 ◽  
pp. 137-140 ◽  
Author(s):  
Hai Jian Li ◽  
Xiao Shuang Shao ◽  
Kai Li ◽  
Zhen Hua Geng ◽  
Ping Wu
Keyword(s):  
Thermal Stability ◽  
Solid Phase ◽  
Synthesis Method ◽  
Electron Back Scatter Diffraction ◽  
Aluminum Titanate ◽  
X Ray Diffraction ◽  
Phase Synthesis ◽  
X Ray ◽  
Titanate Ceramics ◽  
Thermal Stability Of

The thermal stability of aluminum titanate (AT) ceramics is the main problem that restricted its extensive applications in many fields. In this paper, AT ceramics doped with single or composite additives of MgO, SiO2, mullite were fabricated by solid phase synthesis method. The thermal stability was tested by heated for 50h at 1100°C, and the phases of the samples were tested by X-ray diffraction (XRD) , and the microstructure were tested by SEM. The mechanism of the thermal stability of AT with additive was discussed based on DSC/TGA and electron back scatter diffraction pattern (EBSP). The results show that the adding of composite additives can improve the thermal stability of AT ceramics.

Aging Properties of Yttria-Stabilized Zirconia Ceramics

2012 ◽  
Vol 512-515 ◽  
pp. 435-438
Author(s):  
Chang Tian Huan ◽  
Jin Feng Xia ◽  
Dan Yu Jiang ◽  
Qiang Li
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Synthesis Method ◽  
Phase Changes ◽  
Synthesis Methods ◽  
Weight Changes ◽  
Zirconia Ceramics ◽  
Phase Synthesis ◽  
Aging Properties ◽  
Aging Performance

This paper compares the low-temperature aging performance of 5Y-TZP and 8Y-TZP by coprecipitation and solid-phase synthesis methods in the steam. Analysis the weight changes of samples using analytical balance, and the sample surface microstructure and phase changes with SEM, XRD. The results show that the content of Y2O3 and synthesis method all affect the aging properties of zirconia ceramics; solid-phase synthesis of 8Y-TZP has the best anti-aging performance.

Study on Multi-Doped Ceria-Based Solid Electrolytes

2012 ◽  
Vol 519 ◽  
pp. 28-31
Author(s):  
Yong Li Yao ◽  
Yan Gai Liu ◽  
Zhao Hui Huang ◽  
Ming Hao Fang
Keyword(s):  
Electron Microscopy ◽  
Solid Electrolytes ◽  
Solid Phase ◽  
Synthesis Method ◽  
Fluorite Structure ◽  
Doped Ceria ◽  
X Ray Diffraction ◽  
Phase Synthesis ◽  
Transmission Electron ◽  
Trivalent Cations

Doped ceria-based (Gd0.2Ce0.8O1.9, GDC) solid electrolytes were prepared by Solid-phase synthesis method. The effect of doping bismuth oxide and samarium oxide on the phase and microstructure of GDC was investigated. The phase composition was analyzed by the X-ray diffraction (XRD).The single cubic fluorite structure was observed after doping these oxides. Appearance and microstructure of doped ceria-based solid electrolytes were analyzed by the scanning electron microscopy (SEM) and the transmission electron microscopy (TEM). The results showed that the doped trivalent cations had entered into the ceria structure uniformly. The density, porosity rate and water absorption of GDC were measured by Archimedes principle. It indicated that the density of doped GDC solid electrolyte increased with the rising of sintering temperature.

Microwave assisted solid-phase synthesis of substituted tetraazaporphyrins and a phthalocyanine-peptide conjugate

2010 ◽  
Vol 14 (10) ◽  
pp. 891-903 ◽  
Author(s):  
Mercy Mudyiwa ◽  
Margaret W. Ndinguri ◽  
Steven A. Soper ◽  
Robert P. Hammer
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Synthesis Method ◽  
Reaction Times ◽  
Solid Support ◽  
Phase Synthesis ◽  
Covalently Bonded ◽  
Poly Ethylene ◽  
High Degree ◽  
Acid Labile

Various asymmetrically substituted phthalocyanines (Pcs) and porphyrazines (Pzs) have been synthesized in good yields using a solid-phase synthesis method with a poly(ethylene glycol) (PEG) resin attached to an indole linker as the solid support. These compounds are formed by cross condensation of maleonitrile or phthalonitrile with another phthalonitrile covalently bonded to the solid support with an amino linking group. The polymer bound Pc or Pz is separated by filtration, and washing the symmetrical Pc or Pz by-product. The amine Pc -appended to polyethylene glycol resin is further reacted to yield azide whilst still on the solid support. Cleavage of the Pc or Pz off the solid support results in 3:1 asymmetric Pz or Pz with high degree of purity, requiring minimal further purification. The use of hydrophilic PEG-based resin allows the symmetrical compound to be removed completely by washing whereas the acid labile indole linker makes it easier to cleave the product under mild conditions. The conjugation abilities of these compounds have been demonstrated by the successful conjugation of one of the azide Pcs with a peptide elaborated with an alkyne function. Use of microwave for the synthesis of these compounds results in shorter reaction times, higher yields and higher degree of purity.

scholarly journals Solid-Phase Synthesis and Circular Dichroism Study of β-ABpeptoids

Molecules ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 178 ◽  
Author(s):  
Ganesh A. Sable ◽  
Kang Ju Lee ◽  
Hyun-Suk Lim
Keyword(s):  
Circular Dichroism ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Nmr Studies ◽  
Phase Synthesis ◽  
Methyl Group ◽  
Wide Range ◽  
Material Sciences ◽  
Folded Structures ◽  
Circular Dichroïsm

The development of peptidomimetic foldamers that can form well-defined folded structures is highly desirable yet challenging. We previously reported on α-ABpeptoids, oligomers of N-alkylated β2-homoalanines and found that due to the presence of chiral methyl groups at α-positions, α-ABpeptoids were shown to adopt folding conformations. Here, we report β-ABpeptoids having chiral methyl group at β-positions rather than α-positions as a different class of peptoids with backbone chirality. We developed a facile solid-phase synthetic route that enables the synthesis of β-ABpeptoid oligomers ranging from 2-mer to 8-mer in excellent yields. These oligomers were shown to adopt ordered folding conformations based on circular dichroism (CD) and NMR studies. Overall, these results suggest that β-ABpeptoids represent a novel class of peptidomimetic foldamers that will find a wide range of applications in biomedical and material sciences.

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