Neuro-Psychiatric Disorders: From Diagnosis to Care

Abstract Background Patients with adrenal insufficiency (AI) are treated with glucocorticoid replacement therapy (GRT). Although current glucocorticoid regimens aim to mimic the physiological circadian rhythm of cortisol secretion, temporary phases of hypo- and hypercortisolism are common undesired effects which lead to a variety of consequences like increased cardiovascular risk and premature mortality. Additionally, poor quality of life (QoL) and impaired sleep have been reported. However, little is known about these topics regarding the effects of daily dosage, duration of therapy, and patients with different forms of AI (primary, PAI, and secondary, SAI). Methods In this study, 40 adults with AI substituted with hydrocortisone (HC) and 20 matched healthy controls completed questionnaires evaluating depressive symptoms, subjective health status, quality of sleep and daytime sleepiness. Furthermore, demographic data, dosage of HC, duration of therapy and co-medication were evaluated. Patients were compared in different groups. Results Patients assessed general health significantly worse than controls; likewise, daytime sleepiness was reported significantly more often. Depressive symptoms differed significantly in the two groups but did not reach clinically relevant scores. There was no difference between patients with PAI and SAI. High dosage of hydrocortisone had negative impact on mental health but not on sleep quality or daytime sleepiness. Conclusions The present data highlight that poor QoL and impaired sleep are still severe and underrated issues in current GRT and might be additional factors for premature mortality in patients with AI. Some AI patients reach normal or near-normal self-assessed QoL and sleep, even despite unphysiological replacement.

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Rational Approach to Children with Drug-Resistant Epilepsy

Journal of the International Child Neurology Association ◽

10.17724/jicna.2021.191 ◽

2021 ◽

Vol 1 (1) ◽

Author(s):

Elaine Wirrell

Keyword(s):

Quality Of Life ◽

Psychiatric Disorders ◽

Neurological Disorders ◽

Poor Quality ◽

Rational Approach ◽

Drug Resistant ◽

Unexpected Death ◽

Increased Risk ◽

Drug Resistant Epilepsy

Epilepsy is one of the most common neurological disorders to affect children, and has its highest incidence in infancy. Approximately one-quarter of children have seizures which are drug-resistant, and place the child at increased risk of cognitive delays, attention, behavior and psychiatric disorders, injury, sudden unexpected death and poor quality of life. This article presents a rational approach to the investigation and management of children with drug-resistant epilepsy.

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A Clinical Study of Psychiatric Morbidity and Quality of Life among Suicide Attempted Patients

International Journal of Indian Psychology ◽

10.25215/0401.063 ◽

2016 ◽

Vol 4 (1) ◽

Author(s):

Dr. Challa Venkata Suresh

Keyword(s):

Quality Of Life ◽

Psychiatric Disorders ◽

Psychotic Disorders ◽

Rating Scale ◽

Psychiatric Morbidity ◽

Poor Quality ◽

Control Group ◽

Suicide Attempters ◽

Suicide Attempted

Risk of suicide is more common in patients with psychiatric disorders and poor quality of life. The aim of this study was to find out the prevalence of psychiatric morbidity and its relationship with suicide attempters. Materials and Method- The cross sectional study was carried out in Psychiatric department of MNR Medical College and Hospital. A total 70 cases of first suicide attempts were included in this study. Psychiatric morbidity and quality of life were analysed by Schedule for clinical assessment in neuropsychiatric (SCAN), Montgomery Asberg’s depression rating scale (MADRS), Hamilton anxiety rating scale (HAM-A) and WHOQOL-BREF version. Statistical analysis was done by SPSS 20.0 software. Result- Among 70 cases, 92.85% of the suicide attempters had one or more psychiatric disorders compared to 21.43% among the controls. Major psychotic disorder was mood disorder (56.92%), followed by Neurotic and somatoform disorders (36.92%) and substance related disorders (32.3%). Schizophrenia and other psychotic disorders were diagnosed in 7.69% of cases. Quality of life score was assessed by WHOQOL-BREF questionnaire. The mean of total score in suicide attempters was 57.44 and in control group was 73.67. Conclusion- In the present study suicide attempters had higher psychotic morbidity and poor quality of life in comparison to the control groups.

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KUALITAS HIDUP PASIEN STROKE DI POLIKLINIK RAWAT JALAN RUMAH SAKIT SWASTA YOGYAKARTA

Media Ilmu Kesehatan ◽

10.30989/mik.v7i3.274 ◽

2019 ◽

Vol 7 (3) ◽

pp. 232-237

Author(s):

Hana Larasati ◽

Theresia Titin Marlina

Keyword(s):

Quality Of Life ◽

Social Relations ◽

Hemorrhagic Stroke ◽

Poor Quality ◽

Social Dimension ◽

Stroke Patients ◽

Sampling System ◽

Post Stroke ◽

Psychological Dimension

Background: stroke is a disorder of nervous system function that occurs suddenly and is caused by brain bleeding disorders that can affect the quality of life physical dimensions, social dimensions, psychological dimensions, environmental dimensions. Based on the result of Lumbu study (2015) the number of samples were 71 people collected data using the (WHOQOL-BREF). There were 56 people (78,9%) had the poor quality of life of post stroke. The mean of post-stroke quality of life domain was physical domain (45,27%), psychological domain (49,87%), social relations domain (48,15%) and environmental domain (50.01%). Objective: the purpose of the study was know the quality of life of the stroke patients in Outpatient Polyclinic of Private Hospital in Yogyakarta. Methods: used descriptive quantitative by using questionnaire test of purposive sampling system based on patients who have been affected of ischemic or hemorrhagic stroke before, number 30 respondents. Result: quality of life of stroke patient of medium physical dimension (67%), psychological dimension (71%), social dimension (67%), dimension good environment (63%). Conclusion: the quality of life of stroke patients of physical dimension, psychological dimension, and moderate social dimension, while the quality of life of stroke patients were good environmental dimension. Keywords: Hemorrhagic stroke, ischemic stroke, quality of life

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Faculty Opinions recommendation of Factors associated with poor quality of life among cervical cancer survivors: implications for clinical care and clinical trials.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718634930.793502075 ◽

2014 ◽

Author(s):

David Kushner ◽

Laura Huffman

Keyword(s):

Quality Of Life ◽

Cervical Cancer ◽

Clinical Trials ◽

Cancer Survivors ◽

Clinical Care ◽

Poor Quality ◽

Factors Associated

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Psychiatric disorders, peer-victimization, and quality of life in girls with central precocious puberty

Journal of Psychosomatic Research ◽

10.1016/j.jpsychores.2021.110401 ◽

2021 ◽

Vol 143 ◽

pp. 110401

Author(s):

Özge Gizli Çoban ◽

Aynur Bedel ◽

Arif Önder ◽

Aslı Sürer Adanır ◽

Hale Tuhan ◽

...

Keyword(s):

Quality Of Life ◽

Psychiatric Disorders ◽

Peer Victimization ◽

Precocious Puberty ◽

Central Precocious Puberty

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Survey of Quality of Life and Related Risk Factors for a Taiwanese Village Population 3 Years Post-Earthquake

Australian & New Zealand Journal of Psychiatry ◽

10.1080/j.1440-1614.2006.01802.x ◽

2006 ◽

Vol 40 (4) ◽

pp. 355-361 ◽

Cited By ~ 72

Author(s):

Hung-Chi Wu ◽

Pesus Chou ◽

Frank Huang-Chih Chou ◽

Chao-Yueh Su ◽

Kuan-Yi Tsai ◽

...

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Psychiatric Disorders ◽

Short Form ◽

Social Activity ◽

Economic Problems ◽

Related Risk ◽

Sf 36 ◽

Earthquake Survivors

Objective: To investigate quality of life (QOL) and related risk factors in Taiwanese earthquake survivors diagnosed with different psychiatric disorders 3 years after the 1999 Chi-Chi earthquake. Method: This study was a population survey. Trained assistants used the Medical Outcomes Study Short Form-36 (MOS SF-36) and questionnaires to interview 405 respondents (189 men and 216 women) aged 16 years or older, who had been exposed to the earthquake. Psychiatrists interviewed the same respondents using the Mini-International Neuropsychiatric Interview, with an adjusted response rate of 70.2%. Results: The prevalence range for psychiatric disorders in the earthquake survivors was 0.2–7.2% 3 years after the Chi-Chi earthquake, with rates for major depression (MD) and posttraumatic stress disorder (PTSD) of 6.4% and 4.4%, respectively. The QOL scores for the PTSD/MD group were lower than for the other two diagnostic groups, as determined by assessment of physical and mental aspects of functional integrity from MOS SF-36 scores. The predictors for poor QOL were age, female gender, economic problems, physical illness, subjective assessment of memory and social-activity decline and diagnosis of PTSD or MD. Conclusion: The QOL for earthquake survivors with psychiatric disorders, especially PTSD or MD, was inferior compared with the mentally healthy analogues, with contemporaneous decreases in mental and physical function scores across the QOL subscales. The persistence of long-term economic problems was one of many important factors affecting QOL.

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Hyperhidrosis: prevalence and impact on quality of life

Jornal Brasileiro de Pneumologia ◽

10.1590/s1806-37562017000000379 ◽

2018 ◽

Vol 44 (4) ◽

pp. 292-298 ◽

Cited By ~ 5

Author(s):

Erica Nishida Hasimoto ◽

Daniele Cristina Cataneo ◽

Tarcísio Albertin dos Reis ◽

Antonio José Maria Cataneo

Keyword(s):

Quality Of Life ◽

Poor Quality ◽

Cluster Sampling ◽

Excessive Sweating ◽

Medical Evaluation ◽

Primary Hyperhidrosis ◽

Systematic Cluster ◽

The City ◽

Impaired Quality

ABSTRACT Objective: To determine the prevalence of primary hyperhidrosis in the city of Botucatu, Brazil, and to evaluate how this disorder affects the quality of life in those suffering from it. Methods: A population survey was conducted in order to identify cases of hyperhidrosis among residents in the urban area of the city, selected by systematic cluster sampling. In accordance with the census maps of the city, the sample size should be at least 4,033 participants. Ten interviewers applied a questionnaire that evaluated the presence of excessive sweating and invited the subjects who reported hyperhidrosis to be evaluated by a physician in order to confirm the diagnosis. Results: A total of 4,133 residents, in 1,351 households, were surveyed. Excessive sweating was reported by 85 residents (prevalence = 2.07%), of whom 51 (60%) were female. Of those 85 respondents, 51 (60%) agreed to undergo medical evaluation to confirm the diagnosis and only 23 (45%) were diagnosed with primary hyperhidrosis (prevalence = 0.93%). Of the 23 subjects diagnosed with primary hyperhidrosis, 11 (48%) reported poor or very poor quality of life. Conclusions: Although the prevalence of self-reported excessive sweating was greater than 2%, the actual prevalence of primary hyperhidrosis in our sample was 0.93% and nearly 50% of the respondents with primary hyperhidrosis reported impaired quality of life.

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