scholarly journals A Novel Medical Blockchain Model for Drug Supply Chain Integrity Management in a Smart Hospital

Electronics ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 505 ◽  
Author(s):  
Faisal Jamil ◽  
Lei Hang ◽  
KyuHyung Kim ◽  
DoHyeun Kim
Keyword(s):  
Developing Countries ◽  
Supply Chain ◽  
Drug Supply ◽  
Counterfeit Drugs ◽  
Pharmaceutical Supply Chain ◽  
Blockchain Technology ◽  
Smart Healthcare ◽  
Drug Regulations ◽  
Pass Through ◽  
Drug Supply Chain

At present, in pharmacology one of the most serious problems is counterfeit drugs. The Health Research Funding organization reported that in developing countries, nearly 10–30% of the drugs are fake. Counterfeiting is not the main issue itself, but, rather, the fact that, as compared to traditional drugs, these counterfeit drugs produce different side effects to human health. According to WHO, around 30% of the total medicine sold in Africa, Asia, and Latin America is counterfeit. This is the major worldwide problem, and the situation is worse in developing countries, where one out of every 10 medicines are either fake or do not follow drug regulations. The rise of Internet pharmacies has made it more difficult to standardize drug safety. It is difficult to detect counterfeits because these drugs pass through different complex distributed networks, thus forming opportunities for counterfeits to enter the authentic supply chain. The safety of the pharmaceutical supply chain has become a major concern for public health, which is a collective process. In this paper, we propose a novel drug supply chain management using Hyperledger Fabric based on blockchain technology to handle secure drug supply chain records. The proposed system solves this problem by conducting drug record transactions on a blockchain to create a smart healthcare ecosystem with a drug supply chain. A smart contract is launched to give time-limited access to electronic drug records and also patient electronic health records. We also carried out a number of experiments in order to demonstrate the usability and efficiency of the designed platform. Finally, we used Hyperledger Caliper as a benchmarking tool to conduct the performance of the designed system in terms of transactions per second, transaction latency, and resource utilization.

scholarly journals Evaluation of Decentralized Verifiable Credentials to Authenticate Authorized Trading Partners and Verify Drug Provenance

2021 ◽  
Author(s):  
Ghada L. Ashkar ◽  
Kalpan s. Patel ◽  
Josenor De Jesus ◽  
Nikkhil Vinnakota ◽  
Natalie Helms ◽  
...  
Keyword(s):  
Supply Chain ◽  
Prescription Drugs ◽  
Single Point ◽  
Full Potential ◽  
Business Relationship ◽  
Counterfeit Drugs ◽  
Pharmaceutical Supply Chain ◽  
Pharmaceutical Manufacturers ◽  
Trading Partners ◽  
Drug Supply Chain

Summary: In 2013, the Drug Supply Chain Security Act (DSCSA) was signed into law to address the growing threat of counterfeit drugs and to ensure prescription drugs remain safe and effective for patients. As part of this law, US pharmaceutical supply chain stakeholders are required to confirm the authorized status of trading partners for transactions and information disclosures, even when there is no prior business relationship. While larger Authorized Trading Partners (ATPs) have connectivity solutions in place, newer and smaller ATPs have not traditionally participated, including tens of thousands of dispensers. To unlock the full potential of the interoperable system mandated by the DSCSA, the authors tested eXtended ATP (XATP), a blockchain-backed framework for ATP authentication and enhanced verification in a real-world pharmacy with genuine drug packages. The objective of this research study was to prove that electronic authentication and enhanced verification can be achieved between ATPs using a mobile-based solution. Moreover, we tested accurate reading of drug and associated electronic med guides, flagging of expired and recalled drugs, and correct generation of documentation to support saleable returns. Methods: This study involved two dispensers and three participating manufacturers. Dispensers were onboarded to a mobile application and used supporting documentation to authenticate their identities, and then scanned 2D drug barcodes to submit drug verification requests to manufacturers (including 11 additional, randomly selected manufacturers). Genuine and synthetic drug package barcodes were used to test workflows against genuine and synthetic manufacturer serialization data records. Manufacturers authenticated the identity of requesting dispensers with verifiable credentials and responded to verification requests. Results: Enhanced drug verification was achieved, with 100% of requests successfully delivered to participating manufacturers and 88% of requests being delivered to other manufacturers (based on the pharmacist selection of random packages from the pharmacy). Drug verification matching against synthetic serialization data records resulted in 86% accuracy, with the 14% error rate attributed to human factors. All barcodes were successfully scanned and provided package-accurate data, and 97% of randomly selected packages successfully generated drug package inserts. All synthetic recalls and expired drugs were successfully flagged. Four of the manufacturers contacted were among the top 15 pharmaceutical manufacturers globally; all four responded. Conclusions: The XATP framework provides a secure, reliable, and seamless remote method to conduct enhanced verification as required by law. Interoperability between manufacturers and dispensers with no prior business relationship can be achieved on ‘day zero’ using mobile devices that enable digital authentication and rapid barcode scanning. As users retain control of their own private keys, the framework also mitigates the single-point-of-attack risks associated with centrally managed systems.

scholarly journals Evaluation and Classification Risks of Implementing Blockchain in the Drug Supply Chain with a New Hybrid Sorting Method

2021 ◽  
Vol 13 (20) ◽  
pp. 11466
Author(s):  
Parisa Sabbagh ◽  
Rana Pourmohamad ◽  
Marischa Elveny ◽  
Mohammadali Beheshti ◽  
Afshin Davarpanah ◽  
...  
Keyword(s):  
Supply Chain ◽  
Literature Review ◽  
Technology Implementation ◽  
Integrated System ◽  
Drug Supply ◽  
Point Of Sale ◽  
Blockchain Technology ◽  
Medical Supplies ◽  
Wide Range ◽  
Drug Supply Chain

In blockchain technology, all registered information, from the place of production of the product to its point of sale, is recorded as permanent and unchangeable, and no intermediary has the ability to change the data of other members and even the data registered by them without public consensus. In this way, users can trust the accuracy of the data. Blockchain systems have a wide range of applications in the medical and health sectors, from creating an integrated system for recording and tracking patients’ medical records to creating transparency in the drug supply chain and medical supplies. However, implementing blockchain technology in the supply chain has limitations and sometimes has risks. In this study, BWM methods and VIKORSort have been used to classify the risks of implementing blockchain in the drug supply chain. The results show that cyberattacks, double spending, and immutability are very dangerous risks for implementation of blockchain technology in the drug supply chain. Therefore, the risks of blockchain technology implementation in the drug supply chain have been classified based on a literature review and opinions of the experts. The risks of blockchain technology implementation in the supply chain were determined from the literature review.

scholarly journals Securing Pharmaceutical Supply Chain using Blockchain Technology

2021 ◽  
Vol 37 ◽  
pp. 01013
Author(s):  
Vishwesh Lingayat ◽  
Isha Pardikar ◽  
Shubham Yewalekar ◽  
Shyamal Khachane ◽  
Sachin Pande
Keyword(s):  
Supply Chain ◽  
Pharmaceutical Products ◽  
Management Systems ◽  
Smart Contracts ◽  
Counterfeit Drugs ◽  
Supply Chain System ◽  
Pharmaceutical Supply Chain ◽  
Manual Operation ◽  
Blockchain Technology ◽  
Production And Distribution

The production and distribution of counterfeit drugs is an urgent and increasingly critical worldwide issue, especially in pandemics. The imperfect supply chain system in the pharmaceutical industry is one of the reasons for drug counterfeiting. Drugs ownership changes from manufacturers to wholesaler, distributor, and then pharmacist before it reaches the customer thus making it difficult to keep track of it. In this paper, we have compared the existing proposed architectures of blockchain and IoT based supply chain management systems. The system implemented using hyper ledger fabric ensures sharing, storing, transparency, and traceability of data in each link of the supply chain. On the other hand, Ethereum architecture utilized the features of smart contracts to manage the interactions between sender and receiver. Finally, the study mainly focuses on increasing the safety of pharmaceutical products and reducing the manual operation of the supply chain with the most efficient architecture.

scholarly journals Block Chain Based Supply Chain Management for Counterfeit Drugs in Pharmaceutical Industry

2021 ◽  
pp. 100-108
Author(s):  
Lokesh M R ◽  
Suhail Ahmed M N ◽  
Saifulla Khan
Keyword(s):  
Supply Chain ◽  
Supply Chain Management ◽  
Pharmaceutical Industry ◽  
Chain Process ◽  
Drug Supply ◽  
Counterfeit Drugs ◽  
Chain Management ◽  
Supply Chain Process ◽  
Block Chain ◽  
Drug Supply Chain

This paper provides a detailed overview of the block chain technology and how it can be used to build a foolproof system in eliminating counterfeit products in pharmaceutical industries. From the last decade, pharmaceutical companies are facing difficulties in tracking their products during the supply chain process, allowing the counterfeiters to add their fake medicines into the market. Counterfeit drugs are analysed as a very big challenge for the pharmaceutical industry worldwide. As indicated by the statistics, yearly business loss of around $200 billion is reported by US pharmaceutical companies due to these counterfeit drugs. These drugs may not help the patients to recover the disease but have many other dangerous side effects. According to the World Health Organization (WHO) survey report, in under-developed countries every 10th drug use by the consumers is counterfeit and has low quality. Hence, a system that can trace and track drug delivery at every phase is needed to solve the counterfeiting problem. The block chain has the full potential to handle and track the supply chain process very efficiently. In this paper, we have proposed and implemented a block chain based drug supply chain management. Our proposed system block chain-based drug supply chain management for consumers. In this drug supply chain management the system is deployed using Hyper ledger fabrics which is capable of continuously monitor and track the drug delivery process in the smart pharmaceutical industry. Finally, we also perform several tests to check the efficiency and usability of our proposed system.

scholarly journals A Blockchain and Machine Learning-Based Drug Supply Chain Management and Recommendation System for Smart Pharmaceutical Industry

Electronics ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 852 ◽  
Author(s):  
Khizar Abbas ◽  
Muhammad Afaq ◽  
Talha Ahmed Khan ◽  
Wang-Cheol Song
Keyword(s):  
Machine Learning ◽  
Supply Chain ◽  
Supply Chain Management ◽  
Pharmaceutical Industry ◽  
Recommendation System ◽  
Chain Process ◽  
Drug Supply ◽  
Counterfeit Drugs ◽  
Chain Management ◽  
Drug Supply Chain

From the last decade, pharmaceutical companies are facing difficulties in tracking their products during the supply chain process, allowing the counterfeiters to add their fake medicines into the market. Counterfeit drugs are analyzed as a very big challenge for the pharmaceutical industry worldwide. As indicated by the statistics, yearly business loss of around $200 billion is reported by US pharmaceutical companies due to these counterfeit drugs. These drugs may not help the patients to recover the disease but have many other dangerous side effects. According to the World Health Organization (WHO) survey report, in under-developed countries every 10th drug use by the consumers is counterfeit and has low quality. Hence, a system that can trace and track drug delivery at every phase is needed to solve the counterfeiting problem. The blockchain has the full potential to handle and track the supply chain process very efficiently. In this paper, we have proposed and implemented a novel blockchain and machine learning-based drug supply chain management and recommendation system (DSCMR). Our proposed system consists of two main modules: blockchain-based drug supply chain management and machine learning-based drug recommendation system for consumers. In the first module, the drug supply chain management system is deployed using Hyperledger fabrics which is capable of continuously monitor and track the drug delivery process in the smart pharmaceutical industry. On the other hand, the N-gram, LightGBM models are used in the machine learning module to recommend the top-rated or best medicines to the customers of the pharmaceutical industry. These models have trained on well known publicly available drug reviews dataset provided by the UCI: an open-source machine learning repository. Moreover, the machine learning module is integrated with this blockchain system with the help of the REST API. Finally, we also perform several tests to check the efficiency and usability of our proposed system.

scholarly journals Blockchain technology in the pharmaceutical supply chain: researching a business model based on Hyperledger Fabric

2019 ◽  
pp. 134-140
Author(s):  
S R Bryatov ◽  
A A Borodinov
Keyword(s):  
Supply Chain ◽  
Control System ◽  
Pharmaceutical Products ◽  
Pharmaceutical Companies ◽  
Counterfeit Drugs ◽  
Development Environment ◽  
Pharmaceutical Supply Chain ◽  
Russian Market ◽  
Medical Products ◽  
Blockchain Technology

Pharmaceutical companies that manufacture, ship and supply products face difficulties in tracking their products, allowing counterfeiters to inject counterfeit drugs into the system. This situation is observed, in particular, in the Russian market of turnover of pharmaceutical products, although the problem has long been global. The ability of blockchain systems to pinpoint the origin of data makes them particularly suitable for pharmaceutical supply chain applications. The data stored in the blockchain distributed register on the identification of drugs produced by the plant, as well as records of their movements throughout the supply chain, can accurately determine the authenticity of pharmaceutical products lying on the shelves of pharmacies. The development and implementation of such a system can be a big step towards winning the exhausting fight against the easy availability of counterfeit drugs and medical products. In the first part of this work, the main characteristics and features of the functioning of blockchain systems will be studied. In the second and final part, the designed concept of the pharmaceutical turnover control system based on the blockchain technology Hyperledger Fabric using the Hyperledger Composer development environment will be investigated.

scholarly journals Blockchain technology for digitalization of the pharmaceutical sector of the Russian Federation

2021 ◽  
Vol 291 ◽  
pp. 02028
Author(s):  
Ahad Qodirov
Keyword(s):  
Supply Chain ◽  
Pharmaceutical Products ◽  
Drug Supply ◽  
Technological Solution ◽  
Decentralized System ◽  
Blockchain Technology ◽  
Transportation Process ◽  
The Russian Federation ◽  
Drug Supply Chain

One of the main priorities of the modern healthcare system is the transportation of pharmaceutical products. The drug supply chain consists of many participants. These are drug manufacturers, intermediary organizations, and end users. The biggest problems associated with this transportation are temperature monitoring and the quality of the offered products. This is because many drugs and vaccines remain viable within a certain temperature range. As soon as the temperature regime during transportation is violated, the quality of the medicine decreases sharply. In this article, the author proposes the use of Blockchain technology to solve these problems and focuses on improving the transportation process. In his opinion, a decentralized system based on Blockchain technology is the best technological solution. In addition, the author is developing a concept for the application of Blockchain technologies to create a functioning medical ecosystem.

scholarly journals Requirements Identification for a Blockchain-Based Traceability Model for Animal-Based Medicines

2021 ◽  
Vol 9 (1) ◽  
pp. 11
Author(s):  
Rodrigo S. Aranda ◽  
Roberto F. Silva ◽  
Carlos E. Cugnasca
Keyword(s):  
Supply Chain ◽  
Raw Materials ◽  
Current Situation ◽  
Drug Supply ◽  
Traceability System ◽  
Blockchain Technology ◽  
Approval Time ◽  
Drug Supply Chain ◽  
Requirements Identification

In this paper, the traceability of heparin medicine will be studied. Currently, the registration of traceability data is conducted in a decentralized manner. With blockchain implementation, the traceability systems that use this data could become semi-automated, increasing the quality, security, and confidence of the information generated in the supply chain. This paper presents the essential requirements and activities wherein information must be collected within the heparin drug supply chain, focusing on the animal raw materials production link and its requirements. Blockchain technology is proposed to increase traceability and reliability in relation to the current situation. It also fulfills all the requirements identified if used as part of a traceability system. These requirements are: the existence of a consensus mechanism; anonymity; protocol, efficiency, and consumption; immutability; ownership and management; and approval time. We conclude the paper by presenting the mapping of requirements and entities and critical activities for adopting blockchain technology to support the traceability of raw materials from animals used in heparin production.

scholarly journals Combating Substandard and Counterfeit Medicines by Securing the Pharmaceutical Supply Chain:

2018 ◽  
Vol 9 (2) ◽  
pp. 13
Author(s):  
Phuong Chi Nam Sophie Le ◽  
Laurie Grund ◽  
John Marwa ◽  
John Otts ◽  
Wuraola Ojo ◽  
...  
Keyword(s):  
Supply Chain ◽  
Counterfeit Drugs ◽  
President Obama ◽  
Implementation Framework ◽  
Pharmaceutical Supply Chain ◽  
Potential Effectiveness ◽  
Current State ◽  
Future State ◽  
Drug Supply Chain ◽  
The U.S

On November 27, 2013, President Obama signed into law the Drug Quality Security Act (DQSA). Title II of the DQSA, the Drug Supply Chain Security Act (DSCSA), replaces all existing or future state-wide drug track or trace systems with a new federal drug tracing program that uses pedigrees and product identifiers for verification of the drugs being accepted by the buyer. While the full implementation of the DSCSA is projected to take about ten years from its enactment, both the implementation framework and milestones of the new federal tracing program have been carefully laid out. In this essay, we will explore the current state of the U.S. pharmaceutical supply chain and the imperatives behind the DSCSA. At the crux of this essay is an analysis of the DSCSA implementation plan, its challenges according to feedback from stakeholders, and its potential effectiveness against the entrance of substandard and counterfeit drugs into the U.S. pharmaceutical supply chain.   Topic: Student Project      

scholarly journals The Nigerian Pharmaceutical Supply Chain: Blockchain Adoption, Counterfeit Drugs and Successful Deployment of COVID-19 Vaccine in Nigeria

2021 ◽  
pp. 20-36
Author(s):  
Muhammad Jameel Labaran ◽  
Mansur Hamma-Adama
Keyword(s):  
Supply Chain ◽  
Distribution System ◽  
Drug Distribution ◽  
Primary Data ◽  
Regulatory Agencies ◽  
Counterfeit Drugs ◽  
Pharmaceutical Supply Chain ◽  
Blockchain Technology ◽  
Drug Regulatory Agencies ◽  
High Level

Aim: Critically investigating the possibility of adopting blockchain technology within the Nigerian pharmaceutical supply chain to curb the supply of counterfeit drugs. Study Design: The study is qualitative in nature and the primary data were fetched through interviews. Place and Duration of the Study: Conducted within Nigeria for a period of 3 months. Methodology: A qualitative method of data collection was adopted in the study, where some stakeholders were interviewed. The interviews were conducted with employees from different pharmaceutical companies and some drug regulatory agencies in Nigeria. Result: Firstly, this study has ascertained the current prevalence of counterfeit drugs and the reasons for that. The study discovers a very high level of counterfeit drugs and some reasons behind that. Secondly, this study has also found some barriers to blockchain adoption, including the fact that the level of awareness of blockchain technology among stakeholders within the Nigerian pharmaceutical supply chain and the regulatory agencies is very low. Conclusion: It was concluded that the efforts put in developing a viable COVID-19 vaccine could be undermined due to the current nature of the Nigerian pharmaceutical supply chain, the nature of porous borders in place, absence of an apparent drug distribution system, among others.  This study also concludes that the supply chain's current structure needs more regulatory and structural interventions by the Nigerian government than blockchain technology. In other words, with the current nature of the supply chain, blockchain technology adoption would not be effective in delivering the said benefits reported by scholars because the atmosphere is not conducive for successful blockchain adoption.

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