scholarly journals Microfluidics-Based Four Fundamental Electronic Circuit Elements Resistor, Inductor, Capacitor and Memristor

Electronics ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 960 ◽  
Author(s):  
Stojanović ◽  
Paroški ◽  
Samardžić ◽  
Radovanović ◽  
Krstić

The microfluidics domain has been progressing rapidly recently, particularly considering its useful applications in the field of biomedicine. This paper presents a novel, microfluidics-based design for four fundamental circuit elements in electronics, namely resistor, inductor, capacitor, and memristor. These widely used passive components were fabricated using a precise and cost-effective xurography technique, which enables the construction of multi-layered structures on foil, with gold used as a conductive material. To complete their assembly, an appropriate fluid was injected into the microfluidic channel of each component: the resistor, inductor, capacitor, and memristor were charged with transformer oil, ferrofluid, NaCl solution, and TiO2 solution, respectively. The electrical performance of these components was determined using an Impedance Analyzer and Keithley 2410 High-Voltage Source Meter instrument and the observed characteristics are promising for a wide range of applications in the field of microfluidic electronics.


2017 ◽  
Vol 2017 (1) ◽  
pp. 000569-000575 ◽  
Author(s):  
André Cardoso ◽  
Raquel Pinto ◽  
Elisabete Fernandes ◽  
Steffen Kroehnert

Abstract Due to its versatility for high density, heterogeneous integration, Wafer Level Fan Out (WLFO) packaging has recently seen a tremendous growth in a broad array of applications, from telecommunications and automotive, to optical and environmental sensing, while addressing the challenges of the next big wave of the Internet of Things (IoT). In this context, WLFO is continuously being challenged to include new families of MEMS/NEMS/MOEMS sensors, low thermal budget devices and biochips with microfluidics for biomedical applications. Recent developments in WLFO technology by NANIUM [1] demonstrated the implementation of a keep-out-zone (KOZ) mechanism intended to 1st) protect sensitive sensor areas during the backend processing of WLFO wafers and 2nd) create open zones on the Re-Distribution Layers (RDL). This way, the KOZ mechanism provides a physical, direct path from the embedded device to the environment. This is a necessary feature for environment sensing (e.g., pressure) or to create optical paths free of dielectric and protected from the harsh chemistry steps of the WLFO process. This paper describes new developments on KOZ, implemented with SU-8 photoresist as a WLFO dielectric, whose application is a novelty in the WLFO platform. The use of SU-8 and the KOZ with it, addresses some gaps of the current WLFO technology towards the integration of chips with bio-sensitive areas and sensors with low thermal budget. Due to its well-known bio-compatibility and inert behavior, SU-8 can be used as a neutral dielectric to be in direct contact to target fluids (e.g., sera, blood). Also, due to its low curing temperature, SU-8 allows a very low temperature WLFO process and thus the embedding of temperature-limited devices that have been outside the WLFO realm, for example, magneto-resistive or magnetic-spin sensor chips, which degrades its performance above 160°C. More interestingly, SU-8 exhibits a particular non-conformal behavior, which creates very smooth surfaces even over the mildly rough mold compound area of a fan-out package. Adding to this, SU-8 is readily available in the market in a wide range of thicknesses, spanning from 0.5 μm to >100 μm, and further allowing multiple spin coatings to build thick layers. Thus, SU-8 can provide smooth and deep enough channels for microfluidic flow over the chip sensing areas and, at the same time, provide the necessary layer thickness discrimination for the KOZ mechanism. Combining these features, the SU-8 layers in WLFO can play the triple role of 1) RDL dielectric insulation, 2) KOZ mechanism and 3) embedded microfluidic channels as part of the RDL. In summary, besides the unprecedented use of SU-8 in WLFO packaging, KOZ implementation on SU-8 provides a true, attainable bridge between WLFO and integrated microfluidic applications, for biosensing and biomedical applications in general. Outlooking the potentialities of such a merge, a Fan-Out package can embed several chips interconnected by RDL lines, as it currently allows, and also connected by microfluidic channel for multi-point, multi-function biosensing, constituting a true Lab-on-Package, cost-effective solution. Instead of building all sensing areas and microfluidic channels over a large silicon (Si) chip, this solution builds the feed-in, feed-out areas of the microfluidic channel over the inexpensive fan-out area, minimizing the sensing chip area, with the consequent front-end cost reduction.



2020 ◽  
pp. 1192-1198
Author(s):  
M.S. Mohammad ◽  
Tibebe Tesfaye ◽  
Kim Ki-Seong

Ultrasonic thickness gauges are easy to operate and reliable, and can be used to measure a wide range of thicknesses and inspect all engineering materials. Supplementing the simple ultrasonic thickness gauges that present results in either a digital readout or as an A-scan with systems that enable correlating the measured values to their positions on the inspected surface to produce a two-dimensional (2D) thickness representation can extend their benefits and provide a cost-effective alternative to expensive advanced C-scan machines. In previous work, the authors introduced a system for the positioning and mapping of the values measured by the ultrasonic thickness gauges and flaw detectors (Tesfaye et al. 2019). The system is an alternative to the systems that use mechanical scanners, encoders, and sophisticated UT machines. It used a camera to record the probe’s movement and a projected laser grid obtained by a laser pattern generator to locate the probe on the inspected surface. In this paper, a novel system is proposed to be applied to flat surfaces, in addition to overcoming the other limitations posed due to the use of the laser projection. The proposed system uses two video cameras, one to monitor the probe’s movement on the inspected surface and the other to capture the corresponding digital readout of the thickness gauge. The acquired images of the probe’s position and thickness gauge readout are processed to plot the measured data in a 2D color-coded map. The system is meant to be simpler and more effective than the previous development.



Author(s):  
Norman J. Armendariz ◽  
Carolyn McCormick

Abstract Via in pad PCB (Printed Circuit board) technology for passive components such as chip capacitors and resistors, provides the potential for improved signal routing density and reduced PCB area. Because of these improvements there is the potential for PCB cost reduction as well as gains in electrical performance through reduced impedance and inductance. However, not long after the implementation, double digit unit failures for solder joint electrical opens due to capacitor “tombstoning” began to occur. Failure modes included via fill material (solder mask) protrusion from the via as well as “out gassing” and related “tombstoning.” This failure analysis involved investigating a strong dependence on PCB supplier and, less obviously, manufacturing site. Other factors evaluated included via fill material, drill size, via fill thermal history and via fill amount or fill percent. The factor most implicated was incomplete cure of the via fill material. Previous thermal gravimetric analysis methods to determine level of polymerization or cure did not provide an ability to measure and demonstrate via fill cure level in small selected areas or its link to the failures. As a result, there was a metrology approach developed to establish this link and root-cause the failures in the field, which was based on microhardness techniques and noncontact via fill measuring metrologies.



Author(s):  
Allan Matthews ◽  
Adrian Leyland

Over the past twenty years or so, there have been major steps forward both in the understanding of tribological mechanisms and in the development of new coating and treatment techniques to better “engineer” surfaces to achieve reductions in wear and friction. Particularly in the coatings tribology field, improved techniques and theories which enable us to study and understand the mechanisms occurring at the “nano”, “micro” and “macro” scale have allowed considerable progress to be made in (for example) understanding contact mechanisms and the influence of “third bodies” [1–5]. Over the same period, we have seen the emergence of the discipline which we now call “Surface Engineering”, by which, ideally, a bulk material (the ‘substrate’) and a coating are combined in a way that provides a cost-effective performance enhancement of which neither would be capable without the presence of the other. It is probably fair to say that the emergence and recognition of Surface Engineering as a field in its own right has been driven largely by the availability of “plasma”-based coating and treatment processes, which can provide surface properties which were previously unachievable. In particular, plasma-assisted (PA) physical vapour deposition (PVD) techniques, allowing wear-resistant ceramic thin films such as titanium nitride (TiN) to be deposited on a wide range of industrial tooling, gave a step-change in industrial productivity and manufactured product quality, and caught the attention of engineers due to the remarkable cost savings and performance improvements obtained. Subsequently, so-called 2nd- and 3rd-generation ceramic coatings (with multilayered or nanocomposite structures) have recently been developed [6–9], to further extend tool performance — the objective typically being to increase coating hardness further, or extend hardness capabilities to higher temperatures.



Biostatistics ◽  
2019 ◽  
Author(s):  
Dane R Van Domelen ◽  
Emily M Mitchell ◽  
Neil J Perkins ◽  
Enrique F Schisterman ◽  
Amita K Manatunga ◽  
...  

SUMMARYMeasuring a biomarker in pooled samples from multiple cases or controls can lead to cost-effective estimation of a covariate-adjusted odds ratio, particularly for expensive assays. But pooled measurements may be affected by assay-related measurement error (ME) and/or pooling-related processing error (PE), which can induce bias if ignored. Building on recently developed methods for a normal biomarker subject to additive errors, we present two related estimators for a right-skewed biomarker subject to multiplicative errors: one based on logistic regression and the other based on a Gamma discriminant function model. Applied to a reproductive health dataset with a right-skewed cytokine measured in pools of size 1 and 2, both methods suggest no association with spontaneous abortion. The fitted models indicate little ME but fairly severe PE, the latter of which is much too large to ignore. Simulations mimicking these data with a non-unity odds ratio confirm validity of the estimators and illustrate how PE can detract from pooling-related gains in statistical efficiency. These methods address a key issue associated with the homogeneous pools study design and should facilitate valid odds ratio estimation at a lower cost in a wide range of scenarios.



Author(s):  
Mamou Diallo ◽  
Servé W. M. Kengen ◽  
Ana M. López-Contreras

AbstractThe Clostridium genus harbors compelling organisms for biotechnological production processes; while acetogenic clostridia can fix C1-compounds to produce acetate and ethanol, solventogenic clostridia can utilize a wide range of carbon sources to produce commercially valuable carboxylic acids, alcohols, and ketones by fermentation. Despite their potential, the conversion by these bacteria of carbohydrates or C1 compounds to alcohols is not cost-effective enough to result in economically viable processes. Engineering solventogenic clostridia by impairing sporulation is one of the investigated approaches to improve solvent productivity. Sporulation is a cell differentiation process triggered in bacteria in response to exposure to environmental stressors. The generated spores are metabolically inactive but resistant to harsh conditions (UV, chemicals, heat, oxygen). In Firmicutes, sporulation has been mainly studied in bacilli and pathogenic clostridia, and our knowledge of sporulation in solvent-producing or acetogenic clostridia is limited. Still, sporulation is an integral part of the cellular physiology of clostridia; thus, understanding the regulation of sporulation and its connection to solvent production may give clues to improve the performance of solventogenic clostridia. This review aims to provide an overview of the triggers, characteristics, and regulatory mechanism of sporulation in solventogenic clostridia. Those are further compared to the current knowledge on sporulation in the industrially relevant acetogenic clostridia. Finally, the potential applications of spores for process improvement are discussed.Key Points• The regulatory network governing sporulation initiation varies in solventogenic clostridia.• Media composition and cell density are the main triggers of sporulation.• Spores can be used to improve the fermentation process.



2000 ◽  
Vol 6 (S2) ◽  
pp. 226-227
Author(s):  
Duarte-Moller A. ◽  
F. Espinosa-Maganña ◽  
R. Martínez-S´anchez ◽  
O. Contreras

Titanium nitride coatings were grown in a physical vapor deposition system assisted by a direct current reactive magnetron sputtering technique. The vacuum chamber was evacuated with a mechanical pump and cryopump to a base pressure of 10-7 Torr. The Sputtering was performed with a direct current high voltage source (0-1 Kev and 1 A) on a titanium target (99.98% purity). The titanium target was sputtered with a high purity argon -nitrogen mixture. The films were deposited on monocrystalline silicon (mc-Si) (111) substrates at different nitrogen partial pressures from 0.08 mTorr to 1.5 mTorr. Total pressure, power applied to target and substrate temperature were keep constant in all the experiments.EXEELFS analysis were done using the standard procedure [1,2]. In this case, we are find that the atomic concentration is in good agreement with the respective established stoichioinetry N/T=0.99. Figure 1 shows the window of high energy loss where appears their respective N K-edge and Ti -L23.



2018 ◽  
Vol 66 (10) ◽  
pp. 1487-1491 ◽  
Author(s):  
Jean B Nachega ◽  
Nadia A Sam-Agudu ◽  
Lynne M Mofenson ◽  
Mauro Schechter ◽  
John W Mellors

Abstract Although significant progress has been made, the latest data from low- and middle-income countries show substantial gaps in reaching the third “90%” (viral suppression) of the UNAIDS 90-90-90 goals, especially among vulnerable and key populations. This article discusses critical gaps and promising, evidence-based solutions. There is no simple and/or single approach to achieve the last 90%. This will require multifaceted, scalable strategies that engage people living with human immunodeficiency virus, motivate long-term treatment adherence, and are community-entrenched and ‑supported, cost-effective, and tailored to a wide range of global communities.



Geophysics ◽  
2014 ◽  
Vol 79 (4) ◽  
pp. T243-T255 ◽  
Author(s):  
James W. D. Hobro ◽  
Chris H. Chapman ◽  
Johan O. A. Robertsson

We present a new method for correcting the amplitudes of arrivals in an acoustic finite-difference simulation for elastic effects. In this method, we selectively compute an estimate of the error incurred when the acoustic wave equation is used to approximate the behavior of the elastic wave equation. This error estimate is used to generate an effective source field in a second acoustic simulation. The result of this second simulation is then applied as a correction to the original acoustic simulation. The overall cost is approximately twice that of an acoustic simulation but substantially less than the cost of an elastic simulation. Because both simulations are acoustic, no S-waves are generated, so dispersed converted waves are avoided. We tested the characteristics of the method on a simple synthetic model designed to simulate propagation through a strong acoustic impedance contrast representative of sedimentary geology. It corrected amplitudes to high accuracy for reflected arrivals over a wide range of incidence angles. We also evaluated results from simulations on more complex models that demonstrated that the method was applicable in realistic sedimentary models containing a wide range of seismic contrasts. However, its accuracy was reduced for wide-angle reflections from very high impedance contrasts such as a shallow top-salt interface. We examined the influence of modeling at coarse grid resolutions, in which converted S-waves in the equivalent elastic simulation are dispersed. These results provide some validation for the accuracy of the method when applied using finite-difference grids designed for acoustic modeling. The method appears to offer a cost-effective means of modeling elastic amplitudes for P-wave arrivals in a useful range of velocity models. It has several potential applications in imaging and inversion.



Author(s):  
Raffaele Falsaperla ◽  
Valentina Giacchi ◽  
Maria Giovanna Aguglia ◽  
Janette Mailo ◽  
Maria Grazia Longo ◽  
...  

AbstractCongenital heart disease (CHD), the most common major congenital anomaly, is associated with a genetic syndrome (chromosomal anomalies, genomic disorders, or monogenic disease) in 30% of patients. The aim of this systematic review is to evaluate if, in the neonatal setting, clinical clues that orient the diagnostic path can be identified. For this purpose, we revised the most frequent dysmorphic features described in newborns with CHD, comparing those associated with monogenic syndromes (MSG) with the ones reported in newborns with genomic disorders. For this systematic review according to PRISMA statement, we used PubMed, Medline, Google Scholar, Scopus database, and search terms related to CHD and syndrome. We found a wide range of dysmorphisms (ocular region, ears, mouth, and/or palate and phalangeal anomalies) detected in more than half of MSGs were found to be associated with CHDs, but those anomalies are also described in genomic rearrangements syndromes with equal prevalence. These findings confirm that etiological diagnosis in newborns is challenging, and only the prompt and expert recognition of features suggestive of genetic conditions can improve the selection of appropriate, cost-effective diagnostic tests. However, in general practice, it is crucial to recognize clues that can suggest the presence of a genetic syndrome, and neonatologists often have the unique opportunity to be the first to identify abnormalities in the neonate.



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