scholarly journals Analysis of DRD2 Gene Polymorphism in the Context of Personality Traits in a Group of Athletes

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1219
Author(s):  
Krzysztof Chmielowiec ◽  
Monika Michałowska-Sawczyn ◽  
Jolanta Masiak ◽  
Jolanta Chmielowiec ◽  
Grzegorz Trybek ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Personality Traits ◽  
Martial Arts ◽  
Receptor Gene ◽  
Harm Avoidance ◽  
Control Group ◽  
Reward Dependence ◽  
Dorsolateral Prefrontal ◽  
Pcr Method ◽  
Dependence Scale

The presented study showed the relationship between dopamine receptor gene polymorphism and personality traits in athletes training in martial arts. Behavioral modulation resulting from a balance of the neurotransmitters dopamine and norepinephrine to inactivation of the dorsolateral prefrontal cortex and dysregulation of various pathways involved in attention and impulse control processes; Methods: The study was conducted among martial arts athletes. The study group included 258 volunteers and 284 controls. The genetic test was performed using the real-time PCR method; psychological tests were performed using standardized TCI questionnaires. All analyses were performed using STATISTICA 13. Results: Interaction between martial arts and DRD2 rs1799732 (manual) G/-(VIC/FAM)-ins/del and RD- Harm avoidance and Reward Dependence scale were demonstrated. In athletes, a lower Reward Dependence scale score was associated with the DRD2 rs1799732 (manual)-/-polymorphism compared to the control group. ; Conclusions: It seems justified to study not only genetic aspects related to brain transmission dopamine in martial arts athletes. In the studied athletes, the features related to reward addiction and harm avoidance are particularly important in connection with the dopaminergic reward system in the brain.

scholarly journals Association between Polymorphism rs1799732 of DRD2 Dopamine Receptor Gene and Personality Traits among MMA Athletes

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1217
Author(s):  
Marta Niewczas ◽  
Anna Grzywacz ◽  
Katarzyna Leźnicka ◽  
Krzysztof Chmielowiec ◽  
Jolanta Chmielowiec ◽  
...  
Keyword(s):  
High Risk ◽  
Personality Traits ◽  
Dopamine Receptor ◽  
Martial Arts ◽  
Genetic Variants ◽  
Receptor Gene ◽  
Harm Avoidance ◽  
Novelty Seeking ◽  
Genes Encoding ◽  
Dopamine Receptor Gene

Four factors—namely, harm avoidance, novelty seeking, reward addiction and persistence—represent the nature of temperament that is not genetically determined in itself. It was shown in earlier studies that a strong propensity to look for novelty or a tendency to engage in risky behavior is correlated with genetic variants in the area of the genes encoding dopamine receptors. Therefore, the aim of this study is to determine whether there is a relationship between personality traits and genetic variants in the area of the DRD2 dopamine receptor gene in MMA athletes. The participants consisted of 85 mixed martial arts (MMA) athletes and 284 healthy, non-MMA male participants. Their personality traits were measured using the Revised Temperament and Character Inventory. Blood was collected for genetic assays and all samples were genotyped using the real-time PCR method. We observed a statistically significant effect of a complex factor of the DRD2 rs1799732 genotype on MMA participants’ control and reward dependence. Engaging in high-risk sport may be associated with several personality characteristics. The DRD2 rs1799732 polymorphism may be associated with reduced harm avoidance in martial arts athletes, thereby modulating athletes’ predisposition to participate in high-risk sport.

scholarly journals Association of MMP-2 (–1306 C/T) Gene Polymorphism with Predisposition to Optic Neuritis and Optic Neuritis Together with Multiple Sclerosis

Medicina ◽  
2018 ◽  
Vol 54 (2) ◽  
pp. 29 ◽  
Author(s):  
Rasa Liutkevičienė ◽  
Alvita Vilkevičiūtė ◽  
Mantas Banevičus ◽  
Raminta Miežytė ◽  
Loresa Kriaučiūnienė
Keyword(s):  
Multiple Sclerosis ◽  
Gene Polymorphism ◽  
Optic Neuritis ◽  
Vision Loss ◽  
Matrix Metalloproteinase 2 ◽  
Control Group ◽  
Autoimmune Inflammatory Disease ◽  
Pcr Method ◽  
Polymerase Chain ◽  
The Relationship

Background and objective: Optic neuritis (ON) is characterized by painful, usually monocular vision loss with decreased visual acuity and defects of the visual field and color vision. The etiology and pathophysiology of ON is not completely clear. It is thought that a matrix metalloproteinase 2 (MMP-2) gene plays an essential role in this autoimmune inflammatory disease. The aim of this study was to determine the relationship between the MMP-2 (-1306 C/T) rs243865 gene polymorphism and ON, and that of ON with multiple sclerosis. Materials and methods: Patients with ON/ON and multiple sclerosis and a control group of healthy individuals were enrolled in this study. The genotyping test of the MMP-2 (-1306 C/T) was carried out using a real-time polymerase chain reaction (PCR) method. Results: Analysis revealed that T allele at the MMP-2 (-1306 C/T) was less frequent in the ON group compared to the control group (14.5% vs. 23.3%, p = 0.031), and was associated with decreased likelihood of ON development (OR = 0.566; 95% CI: 0.333-0.962; p = 0.036). No significant associations were revealed while comparing the subgroups of ON patients with and without multiple sclerosis. Conclusion: The MMP-2 (-1306 C/T) gene polymorphism was found to be associated with ON development.

Correlates of Tridimensional Personality Questionnaire Scales with Selected Minnesota Multiphasic Personality Inventory Scales

1992 ◽  
Vol 71 (3_suppl) ◽  
pp. 1027-1038 ◽  
Author(s):  
Richard D. Wetzel ◽  
Stephen L. Brown ◽  
Mary Ann Knesevich ◽  
Harold A. Wolff ◽  
Charles J. Horn ◽  
...  
Keyword(s):  
Minnesota Multiphasic Personality Inventory ◽  
Harm Avoidance ◽  
Personality Questionnaire ◽  
Novelty Seeking ◽  
Factor Scores ◽  
Convenience Sample ◽  
Response Set ◽  
Reward Dependence ◽  
Dependence Scale ◽  
One Year

The pattern of correlations between selected MMPI scales and the scales of the Tridimensional Personality Questionnaire were examined in a convenience sample of 88 patients who had received both tests. Time between tests (usually less than one year) did not affect the correlations, but MMPI response-set variables ( L, F, K, F–K) did. The Tridimensional Personality Questionnaire harm avoidance scale and subscales had many correlates on the MMPI. The Novelty seeking scale and subscales showed a number of moderate correlations with a smaller number of MMPI scales; these correlations did not significantly exceed the correlations with MMPI response-set variables. The Tridimensional Personality Questionnaire reward dependence scale and subscales had few, if any, significant MMPI correlates. It was also noted that no Tridimensional Personality Questionnaire scales were related to MMPI repression factor scores.

scholarly journals Personality traits mediate the association between perceived parental bonding and well-being in adult volunteers from the community

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Akiko Murakoshi ◽  
Nobuyuki Mitsui ◽  
Jiro Masuya ◽  
Yota Fujimura ◽  
Shinji Higashi ◽  
...  
Keyword(s):  
Personality Traits ◽  
Structural Equation ◽  
Parental Bonding ◽  
Well Being ◽  
Harm Avoidance ◽  
Subjective Well Being ◽  
Reward Dependence ◽  
Character Inventory ◽  
Self Transcendence ◽  
Adult Volunteers

Abstract Background Previous studies reported that subjective well-being in adulthood correlates with perceived parental bonding in childhood as well as personality traits. However, whether personality traits mediate the effect of perceived parental bonding on well-being or not has not been reported to date. In this study, we hypothesized that ‘parental care and overprotection’ in childhood affect ‘well-being’ in adulthood through various ‘personality traits’, and analyzed this using structural equation modeling. Methods A total of 402 adult volunteers from the community provided responses to the following questionnaires: 1) Parental Bonding Instrument, 2) Temperament and Character Inventory, and 3) The Subjective Well-being Inventory. Two structural equation models were designed and the maximum likelihood estimation method was used for covariance structure analysis. Results Parental care in childhood directly increased well-being in adulthood and indirectly increased it through personality traits (harm avoidance, reward dependence, and self-directedness). Parental overprotection in childhood had no direct effect on well-being in adulthood but decreased well-being in adulthood indirectly through personality traits (harm avoidance, reward dependence, and self-directedness) and increased it through one personality trait (self-transcendence). Conclusions This study showed that the influences of perceived parental bonding on well-being in adulthood are mediated by self-directedness, harm avoidance, reward dependence, and self-transcendence among the seven personality dimensions evaluated by the Temperament and Character Inventory.

Serotonin 2A receptor gene polymorphism and personality traits: no evidence for significant association

2005 ◽  
Vol 15 (1) ◽  
pp. 67-69 ◽  
Author(s):  
Mamoru Tochigi ◽  
Tadashi Umekage ◽  
Chieko Kato ◽  
Tetsuya Marui ◽  
Takeshi Otowa ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Personality Traits ◽  
Receptor Gene ◽  
Serotonin 2A Receptor ◽  
Receptor Gene Polymorphism ◽  
Serotonin 2A

scholarly journals β-1-adrenoreceptor gene polymorphism role in the development of dilated cardiomyopathy

2020 ◽  
Vol 4 (7) ◽  
pp. 394-398
Author(s):  
O.O. Kuznetsova ◽  
◽  
S.Yu. Nikulina ◽  
A.A. Chernova ◽  
V.N. Maximov ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Dilated Cardiomyopathy ◽  
Ischemic Cardiomyopathy ◽  
Polymorphic Locus ◽  
Receptor Gene ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Control Group ◽  
Additional Risk Factor ◽  
Number Of Patients ◽  
The Common

Aim: to identify patterns of development of idiopathic dilated cardiomyopathy (IDC) and ischemic cardiomyopathy (ICM) by studying the rs 1801252 (Ser49Gly) polymorphic variant of the ADRB1 gene.Patients and Methods: a cohort of 221 patients (mean age — 55.30±9.69 years) was examined. All respondents underwent a standard set of laboratory and instrumental examinations, including coronary angiography. The first group included 111 patients with IDC, 99 of them (89.2%) were men, who were excluded from probable factors of dilated cardiomyopathy. The second group included 110 patients with IDC, including 100 (91.5%) men who had reliable signs of CHD. The control group included 221 people (mean age — 53.6±4.8 years) without signs of cardiovascular diseases. A molecular genetic study of the rs 1801252 (Ser49Gly) polymorphism of the ADRB1 gene was performed in all patients and in the control group. Results: among patients with IDC of both gender, 70.3% were carriers of the common homozygous A145A genotype, 27.0% of the heterozygous A145G genotype, and 2.7% of the rare homozygous G145G genotype. In the control group, there was also a predominant number of patients who carried the homozygous genotype for the common A145A allele — 71.9%. Carriers of the heterozygous A145G genotype were 25.3%, and the homozygous G145G genotype for a rare allele — 2.7%. The analysis of the genotypes frequency distribution of the polymorphic locus rs 1801252 (Ser49Gly) of the ADRB1 gene in patients with IDC and in the control group showed no differences. In the group of patients with ICM, the frequency of the common homozygous A145A genotype was 68.2%, there were fewer patients with the heterozygous A145G genotype — 29.1%, and the rare homozygous G145G genotype was detected in 2.7% of cases. There was no association with the ICM 1801252 (Ser49Gly) polymorphism of the ADRB1 gene in the group of patients with ICM, since the results of comparison with the control group data showed no statistically significant differences. At the same time, there were differences in the frequency of alleles of the polymorphic locus rs1801252 (Ser49Gly) of the ADRB1 gene: in male patients with IDC and ICM, the 145A allele was statistically significantly more common (p=0.0001) than in the control group.Conclusion: the data obtained suggest that the carrier of the 145A allele of the ADRB1 gene may serve as an additional risk factor for the development of dilated cardiomyopathy.KEYWORDS: dilated cardiomyopathy, ischemic cardiomyopathy, genetic polymorphism, β-1-adrenergic receptor gene, heart failure, genetic predisposition.FOR CITATION: Kuznetsova O.O., Nikulina S.Yu., Chernova A.A. et al. β-1-adrenoreceptor gene polymorphism role in the development of dilated cardiomyopathy. Russian Medical Inquiry. 2020;4(7):394–398. DOI: 10.32364/2587-6821-2020-4-7-394-398.

scholarly journals Analysis of Polymorphic Variants of the Dopamine Transporter (DAT1) Gene Polymorphism and Personality Traits Among Athletes

2020 ◽  
Vol 72 (1) ◽  
pp. 79-89
Author(s):  
Monika Michałowska-Sawczyn ◽  
Milena Lachowicz ◽  
Anna Grzywacz ◽  
Aleksandra Suchanecka ◽  
Jolanta Chmielowiec ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Personality Traits ◽  
Dopamine Transporter ◽  
Genetic Factors ◽  
Control Group ◽  
Biochemical Traits ◽  
Dat1 Gene ◽  
The Will ◽  
Polymorphic Variants ◽  
Selection Of

AbstractPersonality traits, especially in sport are modulatory factors of athletes’ behavior – his/ her conscientiousness, the will to achieve an aim, perseverance and motivation of activity. Not only are biological predispositions related to anatomical or biochemical traits of success, but they are also largely determined by personality traits that result from genetic factors. In our research we joined tests of athlete’s personality in correlation with genotypes of the dopamine transporter (DAT1) gene polymorphism. The selection of this polymorphism was based on previous reports connecting the influence of dopamine with motivation and numerous arguments supporting its correlation with human behavior. We observed significant differences among polymorphisms DAT 9/9, 9/10, 10/10 in terms of proportion of particular genotypes between athletes and the control group. We also found significant differences in the NEO FFI sten scale for conscientiousness. We noticed that anxiety was related with genotypic variants of DAT1, specifically the 9/10 VNTR variant, which conditioned lower levels of anxiety in the group of tested athletes. By contrast, the lower sten value of agreeability was statistically significant for the group of athletes that were carriers of the 10/10 VNTR genotype. Heterozygous 9/10 VNTR among athletes showed lower levels of anxiety in comparison with the control group, whereas agreeability determined using the NEO FFI scale represented a lower value among athletes that had the 10/10 polymorphism. We may thus conclude that the presence of polymorphic variants of the dopamine transporter gene corresponds to athletes’ personality traits.

scholarly journals Phenotypic manifestations of arterial hypertension according to polymorphism of vitamin D receptor gene

2021 ◽  
Vol 25 (1(97)) ◽  
pp. 89-94
Author(s):  
Yu. Repchuk ◽  
L. Sydorchuk
Keyword(s):  
Vitamin D ◽  
Gene Polymorphism ◽  
Arterial Hypertension ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Control Group ◽  
Vitamin D Receptor Gene ◽  
Vdr Gene ◽  
Qualitative Polymerase Chain Reaction ◽  
Vdr Gene Polymorphism

Objective. To determine the phenotypic manifestations of essential arterial hypertension (EAH) according to the vitamin D receptor gene polymorphism (VDR rs10735810, rs2228570).Material and methods. The case-control study involved 100 patients with EAH stage II, 1-3 degrees of blood pressure (BP), high and very high cardiovascular risk, 21% (21) men, 79% (79) women. The mean age of patients was 59.86 ± 6.22 y.o. The control group consisted of 60 healthy individuals, comparable in age and gender. To study the VDR gene polymorphism (rs10735810, rs2228570) performed a qualitative polymerase chain reaction in real-time. Results. Almost half of the patients with elevated normal BP (44.4%) and 34% of patients with EAH 2-3 d. there is concomitant diabetes mellitus (DM) type 2, while for EAH 1 d. it is only 19%. Obesity of 1-3 degrees was shown in 53% of patients with EAH: average EAH of 1 d. - 21%, among the EAH 2-3 d. - 25%. In the control group, 16% suffered from obesity. The distribution of VDR gene polymorphism genotypes according to the presence of DM showed that it was present in 35% of patients with AA-genotype, which is 1.6 times more often than in patients with GG-genotype (22%). Most smokers among patients with GG-genotype (26%), which is twice as common as those with AA- and AG-genotype (13% and 14%, respectively). Obesity of 1-3 degrees most often met among carriers of GG-genotype - 74%, and in the control group 14%. An elevated level of waist-hip ratio (WHR) among women with EAH was in 80% of the AA-genotype carriers, in the control group, all women had normal values. In 76% of the AG-genotype carriers and in 81% of the GG-genotype carriers, the WHR was increased by 2.3 and 2.8 times, respectively, that in the control group. Deviations of systolic and diastolic BP according to the VDR gene polymorphic variants have not been established.Conclusions. The AA-genotype is associated with DM 2 and with elevated WHR in women; GG-genotype - with elevated BMI, especially in men.

The dopamine D2 receptor gene TaqI A polymorphism is not associated with Novelty Seeking, Harm Avoidance and Reward Dependence in healthy subjects

1998 ◽  
Vol 13 (8) ◽  
pp. 427-430 ◽  
Author(s):  
B de Brettes ◽  
I Berlin ◽  
C Laurent ◽  
JP Lépine ◽  
J Mallet ◽  
...  
Keyword(s):  
Substance Abuse ◽  
Personality Trait ◽  
Dopamine D2 Receptor ◽  
Receptor Gene ◽  
D2 Receptor ◽  
Harm Avoidance ◽  
Novelty Seeking ◽  
Dopamine D2 ◽  
Reward Dependence ◽  
History Of

SummaryAllele A1 of the TaqI A restriction fragment length polymorphism (RFLP) of the dopamine D2 receptor gene has been found to be associated with substance abuse and alcoholism. The personality trait of Novelty Seeking (NS) is also associated with substance abuse and dependence. We hypothesised, on the basis of involvement of dopaminergic mechanisms in substance abuse, that the presence of allele A1 of the dopamine D2 receptor gene may represent a genetic predisposition for the NS personality trait. We investigated, therefore, whether the allele A1 of the TaqI A RFLP of the dopamine D2 receptor gene is associated with the NS dimension of the Tridimensional Personality Questionnaire (TPQ) in healthy Caucasian subjects with no history of alcohol or substance abuse or dependence. We genotyped 204 subjects aged 18 to 30 years. There was no association between any of the alleles of the D2 receptor genes and any of the TPQ scores (NS, Harm Avoidance, Reward Dependence). We conclude that allele A1 of the TaqI A RFLP of the dopamine D2 receptor is not associated with NS personality trait in healthy Caucasian subjects.

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