Reliability and Repeatability of Pressure Center Analysis with Low-Dye Taping Using Force Platform Podiatry Sensors in Feet with Excessive Pronation

Background: The analysis of the center of pressure (COP) is a method used to assess the foot function, but its reliability and repeatability have not been evaluated. COP can be altered by diverse conditions, like an excessive foot pronation. Low-Dye taping is commonly used for the treatment of symptoms related to an excessive pronation. To date, no study has evaluated the effects of the Low-Dye taping on COP and the duration of its effects. Thus, the main purpose of this manuscript was to assess the reliability and repeatability of the percentage of center of pressure locus area (%CLA) in feet with an excessive pronation, and secondarily, to assess that the Low-Dye taping modifies the %CLA during the immediate 48 h. Methods: An observational study of the reliability and repeatability of the %CLA variable with the Low-Dye taping in feet with excessive pronation was carried out. We used the EPS-Platform to evaluate the results of the variable in 6 conditions in a first session to evaluate the reliability of the results. We compared the results of the first session with the results in a second session to evaluate the repeatability of the results. We also carried out an ANOVA test to evaluate the changes that the taping produced in the variable between without taping with the rest of the 6 conditions. Results: For the %CLA, we observed a reliability greater than 0.80, measured by the interclass ratio index, both in the first session before taping, and in the second session before taping, thus being a repeatability variable. In the following times, with taping, at 10 min with tape, at 20 min with tape, at 24 h with tape and at 48 h with tape; an interclass ratio coefficient (ICC) higher than 0.80 was again obtained, thus being a reliable variable in all measurements made. The Low-Dye taping did not change %CLA from the time the tape was put in until 48 h (p-value = 1.000). Conclusions: The %CLA variable, in feet with excessive pronation, proved to be a reliable variable in all the measurements obtained before putting on the tape and during the following 48 h with the tape, and a repeatable variable. The Low-Dye taping did not change the %CLA from the time the tape was put in until 48 h.

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Foot Function Determination: Agreement Between Tests?

10.21203/rs.3.rs-958922/v1 ◽

2021 ◽

Author(s):

Damien Dodelin ◽

Claire Tourny ◽

Maxime L’Hermette

Keyword(s):

Center Of Pressure ◽

Dynamic Test ◽

Standing Position ◽

Kappa Coefficient ◽

Musculoskeletal Injuries ◽

Static Testing ◽

Foot Posture ◽

Foot Pronation ◽

Foot Function ◽

Level Of Agreement

Abstract Background: Foot pronation is generally linked to musculoskeletal injuries, especially in relation to joint deviation caused by pronation during dynamic activities. However, no consensus appeared in the methodological way to determine foot function, and several tests propose to identify foot pronation under different conditions, from static testing to running. The aim of this study was to determine the level of agreement between different foot function classification measures. Methods: One hundred and six subjects completed 5-foot function tests at standing position, walking and running. Foot Posture Index (FPI) was undertaken to determine foot function during static posture. The Center of Pressure Excursion Index (CPEI) and 3 Foot Balance tests (FBs) were realized during walking and running trials to assess pronation during dynamic activities. Agreement between the measures was determined using the Cohen’s Kappa coefficient (K) between 2 measures and the Fleiss Kappa (FK) between 3 or more measures. Results: Overall agreement between the measures reported a fair agreement (Kf = 0.2). Static and walking foot tests determination agreement was moderate (K = 0.5), while agreement between FPI and FBs tests were fair (K < 0.4). Fair results were also reported between walking and running tests (K < 0.4). The concordance between running tests classification was fair (Kf = 0.2). Conclusions: The lack of agreement between tests confirms the need for a consensus on an appropriate measurement of the foot function. Static foot tests are mainly used to determine foot function during dynamic activities. However, the lack of agreement between tests could question the relevance of the static foot function assessments. The FPI reported a moderate agreement with the walking classification test, but it should be accompanied by a dynamic test in order to limit the risk of misinterpretation.

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POS0441 DEVELOPMENT OF RHEUMATOID ARTHRITIS AMONG ANTI-CITRULLINATED PROTEIN ANTIBODIES POSITIVE ASYMPTOMATIC INDIVIDUALS: A PROSPECTIVE OBSERVATIONAL STUDY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.344 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 449.1-449

Author(s):

S. Mizuki ◽

K. Horie ◽

K. Imabayashi ◽

K. Mishima ◽

K. Oryoji

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Observational Study ◽

Rheumatoid Factor ◽

Prospective Observational Study ◽

Enzyme Linked Immunosorbent Assay ◽

P Value ◽

Healthy Population ◽

Asymptomatic Individuals ◽

Citrullinated Protein

Background:In the idividuals with genetic and enviromental risk factors, immune events at mucosal surfaces occur and may precede systemic autoimmunity. Anti-citrullinated protein antibodies (ACPA) are present in the serum for an average of 3-5 years prior to the onset of rheumatoid arthritis (RA) during an asymptomatic period. In ACPA-positivite individuals, the additional presence of RA-related risk factors appears to add significant power for the development of RA. To date, there have been few reports in which clinical courses of ACPA-positive asymptomatic individuals were investigated prospectively.Objectives:To observe the clinical time course of ACPA-positive healthy population for the development of RA.Methods:Healthy volunteers without joint pain or stiffness, who attended the comprehensive health screening of our hospital, were enrolled in this prospective observational study. The serum ACPA levels were quantified by Ig-G anti-cyclic citrullinated peptide enzyme-linked immunosorbent assay with levels > 4.4 U/mL considered positive. ACPA-positive subjects were followed by rheumatologists of our department clinically or a questionnaire sent by mail for screening to detect arthritis.Results:5,971 healthy individuals without joint symptons were included. Ninty-two (1.5%) were positive for ACPA. Of these, 19 (20.7%) developed RA and two were suspected as RA by mail questionnaire. Their average age were 58-years, and women were 68%. The average duration between the date of serum sampling and diagnosis was 10.7 months. ACPA-positive individuals who developed to RA had higher serum ACPA and Ig-M rheumatoid factor levels than ACPA-positive individuals who did not (P value by Mann-Whitney U test: 0.002, 0.005, respectively).Conclusion:Among ACPA-positive asymptomatic individuals, 20% developed RA. The higher titer of ACPA and Ig-M rheumatoid factor levels are risk factors for devoloping RA.Disclosure of Interests:None declared

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Helicobacter pylori eradication in patients with type 2 diabetes mellitus: Multicenter prospective observational study

SAGE Open Medicine ◽

10.1177/2050312119832093 ◽

2019 ◽

Vol 7 ◽

pp. 205031211983209 ◽

Cited By ~ 2

Author(s):

Seung-Joo Nam ◽

Sung Chul Park ◽

Sang Hoon Lee ◽

Dong Wook Choi ◽

Sung Joon Lee ◽

...

Keyword(s):

Helicobacter Pylori ◽

Observational Study ◽

Prospective Observational Study ◽

Eradication Rate ◽

Laboratory Data ◽

P Value ◽

Diabetic Patients ◽

Multicenter Prospective Observational Study ◽

H Pylori

Objective: To compare Helicobacter pylori ( H. pylori) eradication rate of type 2 diabetic patients with non-diabetic subjects. Methods: In this multicenter prospective observational study, H. pylori-infected subjects were enrolled from three university-affiliated hospitals. Eradication regimen was triple therapy with standard dose of proton pump inhibitors (b.i.d), amoxicillin (1.0 g b.i.d), and clarithromycin (500 mg b.i.d) for 7 days. Urea breath test was performed 4 weeks after treatment. Various clinical and laboratory data were collected for identification of factors associated with successful eradication. Results: Totally, 144 subjects were enrolled and 119 (85 non-diabetic and 34 diabetic patients) were finally analyzed. Eradication rate was 75.6% and there was no difference between diabetic patients and non-diabetic subjects (73.5% vs 76.5%, p value: 0.814). Adverse drug reactions were reported in 44.5% of patients. In multivariate analysis for predicting H. pylori eradication in diabetic patients, HbA1c (⩾7.5%) was a significant factor affecting eradication rate (adjusted odds ratio: 0.100, 95% confidence interval: 0.011–0.909, p value: 0.041). Conclusion: Diabetes itself is not a major factor affecting H. pylori eradication. However, poor glucose control may harmfully affect H. pylori eradication.

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Center of pressure estimation during running without a force platform

Journal of Biomechanics ◽

10.1016/0021-9290(92)90166-x ◽

1992 ◽

Vol 25 (6) ◽

pp. 671

Author(s):

B.P.E. David Andrews ◽

James J. Dowling

Keyword(s):

Center Of Pressure ◽

Force Platform ◽

Pressure Estimation

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Prospective observational study of prevalence, assessment and treatment of pancreatic exocrine insufficiency (PEI) in patients with advanced pancreatic cancer (aPC): PanDA.

Journal of Clinical Oncology ◽

10.1200/jco.2020.39.28_suppl.196 ◽

2021 ◽

Vol 39 (28_suppl) ◽

pp. 196-196

Author(s):

Angela Lamarca ◽

Lindsay Carnie ◽

Dinakshi Shah ◽

Kate Vaughan ◽

Zainul Abedin Kapacee ◽

...

Keyword(s):

Pancreatic Cancer ◽

High Risk ◽

Observational Study ◽

Breath Test ◽

Cox Regression ◽

Pancreatic Enzyme ◽

Palliative Therapy ◽

Advanced Pancreatic Cancer ◽

P Value ◽

Screening Methods

196 Background: PEI in patients with advanced pancreatic cancer is well documented, but there is a lack of consensus regarding optimal screening. Methods: Eligible patients for this observational study (NCT03616431) were those diagnosed with aPC referred for consideration of palliative therapy who consented to evaluation by a research dietitian. In addition to symptom and full dietetic assessment (including Mid-Upper Arm Circumference (MUAC), handgrip and stair climb test), full nutritional blood panel, faecal elastase (FE) and 13C mixed triglyceride breath test (for diagnostic cohort (DiC)) were performed. Primary objectives: prospective assessment of PEI prevalence (dietitian-assessed; demographic cohort (DeC)), and to design (using breath test as gold standard; DiC) and validate (follow-up cohort (FuC)) the most suitable screening tool for PEI in patients with aPC. Logistic and Cox regression were used for statistical analysis (Stat v.12). Results: Between 1st July 2018 and 30th October 2020, 112 eligible patients [50 (DeC), 25 (DiC), 37 (FuC)]. Prevalence of PEI in the DeC was 64.0% (PEI-related symptoms were flatus (84.0%), weight loss (84.0%), abdominal discomfort (50.0%) and steatorrhea (48.0%)); 70.0% of patients required pancreatic enzyme replacement therapy and 74.0% had anorexia (low appetite); 44.0% and 18.0% had low vitamin D and vitamin A levels, respectively. Designed PEI screening panel (DiC; 19 patients with breath test completed) included FE [normal/missing (0 points); low (1 point)] and MUAC [normal/missing ( > percentile 25 for age/gender) (0 points); low (2 points)] and identified patients at high-risk (2-3 total points) of PEI [vs. low-medium risk (0-1 total points)]. When patients from DeC and DiC) were analysed together, those classified as “high-risk of PEI” according to the screening panel had shorter overall survival (multivariable Hazard Ratio (mHR) 1.86 (95% CI 1.03-3.36); p-value 0.040) when adjusted for other prognostic factors, including presence of PEI symptoms (mHR 2.28 (95% CI 1.19-4.35); p-value 0.013). The screening panel was tested in the FuC; 78.38% were classified as patients at “high-risk of PEI”; of these, 89.6% were confirmed to have PEI by the dietitian. The panel was feasible for use in clinical practice, (64.8% of patients completed fully the assessments required) and acceptability was high (87.5% of patients would do it again). The majority of patients (91.3%) recommended that all future patients with aPC should have dietitian input. Conclusions: PEI is present in the majority of patients with aPC, and early dietetic input is important to provide a holistic nutritional overview, including, but not limited to, PEI. This proposed screening panel could be used to prioritise patients at higher risk of PEI requiring urgent dietitian input. Its prognostic role needs further validation. Clinical trial information: NCT03616431.

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Effect of Ultrasound and Calf Stretching in relieving Gastrocnemius Tightness in subjects with Plantar Fascitis

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00529 ◽

2021 ◽

pp. 3025-3028

Author(s):

Sowmya M V ◽

Nandhini S ◽

Manigandan V

Keyword(s):

Functional Ability ◽

Combined Therapy ◽

Statistical Significance ◽

Mean Value ◽

P Value ◽

Functional Activities ◽

Post Test ◽

Foot Function ◽

The Difference ◽

Gastrocnemius Tightness

Objective: To evaluate the efficacy of ultrasound and calf stretching in subjects with gastrocnemius tightness in plantar fascitis to reduce pain and improve functional ability. Method: 30 patients with plantar fascitis selected from Saveetha college of physiotherapy and rehabilitation center (SPARC) based on inclusion and exclusion criteria. The patients were treated with ultrasound therapy and calf stretching. The pre and post test values of pain and functional ability was be calculated using Silfverskiold test and Foot Function Index as an outcome measure. Results: The mean value and standard errors were calculated for different variables and the difference in mean value was tested for statistical significance using paired t test. P value of <0.0001 was considered as statistically significant. Conclusion: From the statistical analysis and graphical interpretation the final derived results concluded that combined therapy of ultrasound and calf stretching is found to be effective in relieving gastrocnemius tightness in patient suffering with plantar fascitis and it can be used to improve the functional activities.

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Immediate and delayed complications of adenotonsillectomy

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20192722 ◽

2019 ◽

Vol 5 (4) ◽

pp. 1013

Author(s):

Gerald P. Sebastian ◽

Balasubramanian Thiagarajan ◽

Pethuru Devadason

Keyword(s):

Postoperative Complications ◽

Observational Study ◽

Endotracheal Tube ◽

Surgical Complications ◽

Surgical Complication ◽

P Value ◽

Secondary Haemorrhage ◽

Delayed Complications ◽

Primary Hemorrhage ◽

Anesthetic Complications

Background: Tonsillectomy with or without adenoidectomy is the commonest pediatric otorhinolaryngological procedure. The aim of the present study was to compare the intraoperative (immediate) and postoperative (delayed) complications between in conventional and coablation tonsillectomy in children.Methods: This observational study was conducted among 100 children between 5 and 15 years who had conventional tonsillectomy and 50 children who had coblation tonsillectomy. Intraoperative and postoperative complications were observed and compared between two groups. Results: Of the total 150 children, 64 (42.7%) were males and 86 (57.3%) were females with mean age of 9.42±2.67 years. Common preoperative symptoms were odynophagia (96.0%), throat pain (95.3%) and difficult swallowing (89.3%). Among the intraoperative anesthetic complications, compression of endotracheal tube was observed in 19 (12.7%), accidental extubation in 10 (6.7%) and dislodging of loose tooth in 9 (6.0%) patients. Regarding intraoperative surgical complications, primary hemorrhage was seen in 43 (28.7%), edema uvula in 39 (26.0%) and pillar injury in 33 (22.0%) patients. Commonest postoperative complication was oropharyngeal pain (18.7%) followed by primary hemorrhage (14.0%) and nausea, vomiting (13.3%). Immediate complications like primary haemorrhage (p value 0.0001) and uvula edema (p value 0.018) were significantly associated with conventional tonsillectomy group while delayed complications like secondary haemorrhage (p value 0.011) and referred otalgia (p value 0.0001) were with coblation tonsillectomy group.Conclusions: Compression of endotracheal tube and primary hemorrhage were the commonest intraoperative anesthetic and surgical complication respectively. Immediate complications were significantly associated with conventional tonsillectomy group while delayed complications were with coblation tonsillectomies.

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Comparison of hospitalizations in patients on first generation versus second generation long acting injectable (LAI) antipsychotics

BJPsych Open ◽

10.1192/bjo.2021.753 ◽

2021 ◽

Vol 7 (S1) ◽

pp. S283-S283

Author(s):

Seemab Rasool ◽

Paster Venan

Keyword(s):

Drug Abuse ◽

Observational Study ◽

First Generation ◽

Second Generation ◽

Hospital Admissions ◽

Paranoid Schizophrenia ◽

Bipolar Affective Disorder ◽

Community Treatment ◽

P Value ◽

Targeted Interventions

AimsThere is limited data on the comparison of efficacy between first and second antipsychotic LAIs. One good indicator of efficacy is the rates of hospitalization. Some studies have shown that second generation depot antipsychotics, significantly reduce hospitalizations as compared to conventional depots.Our aim was to compare hospitalizations in patients on first and second generation LAI antipsychotics.MethodA retrospective observational study was done by reviewing the records of all the depot clinics in South Essex, United Kingdom. A list of patients enrolled and receiving LAI antipsychotics was obtained from the 6 depot clinics. Data were collected by going through the electronic records of the patients on the depot clinic lists and taking down the demographics, diagnosis and the hospital admissions. Other variables like comorbid drug abuse were also recorded.ResultAmongst a total of 346 patients 223 (64 %) were males and 123 (36%) were females. Average age was 50.3 (range 21 to 88 years) and 290 (83%) patients were single. An overwhelming majority of patients 299 (87 %) were not in employment. Regarding the diagnosis, the majority, 237 patients were diagnosed with Paranoid Schizophrenia, 49 patients were diagnosed with Schizoaffective disorder, 38 patients were diagnosed with Bipolar affective disorder, 20 patients had a diagnosis of Delusional disorder and only 2 patients had a primary diagnosis of Mental and Behavioral disorders due to substance abuse. Of the total 346 only 17 patients were on a Community treatment Order.Risperidone was the most commonly used second generation LAI at 26%,Aripiprazole in 10% and Paliperidone was used in 5% patients. Olanzapine LAI was only used in 2 patients. Amongst first generation LAIs Zuclopenthixol, Fluclopentixol were both used in 24%, and Haloperidol in 10% patients. 21 % of patients were reported to be actively abusing drugs.65 (32.6%) of the total 200 patients on Ist Generation LAIs had hospital admissions55 (39.8%) of the total 138 patients on 2nd Generation LAIs had hospital admissionsThis difference was not statistically significant (Z test)- P value of 0.082427ConclusionThe results in our observational study are equivocal, both LAIs providing equitable decrease in the hospital admissions albeit with a slightly favourable outcome (not statistically significant though) attributable to the first generation LAIs. There was a high incidence of unemployment and drug abuse in our cohort of patients, thus targeted interventions can be established in rehabilitation of such individuals.

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A prospective observational study conducted in tertiary teaching hospital of Uttar Pradesh to compare safety and efficacy of PPIUCD and interval IUCD (380A)

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20185442 ◽

2018 ◽

Vol 8 (1) ◽

pp. 295

Author(s):

Nidhi Gupta ◽

Akanksha .

Keyword(s):

Observational Study ◽

Prospective Observational Study ◽

Uttar Pradesh ◽

P Value ◽

Efficacy And Safety ◽

Puerperal Sepsis ◽

Medical College ◽

Tertiary Teaching ◽

Reversible Method ◽

Tertiary Teaching Hospital

Background: The objective of this study was to compare the efficacy and safety of PPIUCD and interval IUCD.Methods: This was a prospective observational study conducted on women attending the OPD and indoor services of S.N. Medical college, Agra. 800 women willing for PPIUCD insertion were included in the study after informed consent excluding chorioamnionitis, PROM>18 hours, unresolved PPH and puerperal sepsis. Another 200 willing women were inserted interval IUCD according to MEC criteria of WHO. All were followed up for 1 year.Results: It was found that rate of expulsion was more in PPIUCD group compared to interval IUCD group (6%vs 1.5% p value <.05),rate of removal was almost similar in both groups (11.5%inPPIUCD and 14%in interval IUCD group), cause of removal was mainly social in PPIUCD group while bleeding was more in interval IUCD group compared to PPIUCD (85.7%vs26%).Conclusions: Postpartum insertion of IUCD is a safe effective, feasible and reversible method of contraception.

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Effectiveness of Homoeopathy in Tinea corporis and Tinea cruris – A Prospective, Longitudinal Observational Study

International Journal of Advanced Ayurveda Yoga Unani Siddha and Homeopathy ◽

10.23953/cloud.ijaayush.488 ◽

2021 ◽

Vol 10 (1) ◽

pp. 618-627

Author(s):

Yogeshwari Gupta ◽

◽

Sonia Tuteja ◽

Ankita Acharya ◽

Vikrant Tripathi ◽

...

Keyword(s):

Observational Study ◽

Fungal Infection ◽

Clinical Symptom ◽

Fungal Infections ◽

Tinea Corporis ◽

P Value ◽

Tinea Cruris ◽

Longitudinal Observational Study ◽

Before And After ◽

Prospective Longitudinal

Dermatophytoses refers to superficial fungal infection of keratinized tissues caused by keratinophilic dermatophytes. According to observations worldwide, dermatophytoses are the most common of the superficial fungal infections. It is common in tropics and may present in epidemic proportions in areas with high rates of humidity. This prospective, longitudinal, observational study was conducted at SKHMC, Jaipur for a period of 1 year (April 2018 to March 2019), aiming to ascertain the effectiveness of homoeopathic medicines in the treatment of Tinea corporis and Tinea cruris. In this study, 65 cases of Tinea Infection (33 cases of Tinea cruris & 32 cases of Tinea corporis) were treated with homoeopathic medicines prescribed on the basis of totality of the symptoms. Treatment outcomes were assessed using Clinical Symptom Score, designed for this study & approved by Institutional Ethical Committee. Out of 65 patients, 41 patients (63.1%) got improved; 19 patients (29.2%) were at status quo and 05 patients (07.7%) became worse. Maximum patients were found to be in the age group of 11-40 years (n=50; 76.9%). Males were observed to be affected more as compared to females. Paired t-test was conducted on the Clinical Symptom Scores obtained before and after treatment and the result showed that p value is < 0.05 & value of t (11.623) is greater than the tabulated value in t-table at df = 64 (1.997), which was statistically significant and which also concluded that homoeopathic medicines were effective in treating Tinea corporis and Tinea cruris. Keywords Homeopathy; Dermatophytoses; Fungal infection; Observational study

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