scholarly journals Rodent Model of Gender-Affirming Hormone Therapies as Specific Tool for Identifying Susceptibility and Vulnerability of Transgender People and Future Applications for Risk Assessment

Author(s):  
Roberta Tassinari ◽  
Francesca Maranghi

Transgenders (TGs) are individuals with gender identity and behaviour different from the social norms; they often undergo gender-affirming hormone therapy (HT). HT for TG men involves testosterone treatment and, for TG women, oestrogen plus androgen-lowering agents. Due—but not limited—to the lifelong lasting HT, usually TG people experience several physical and behavioural conditions leading to different and specific susceptibility and vulnerability in comparison to general population, including the response to chemical contaminants present in daily life. In particular, the exposure to the widespread endocrine disrupters (EDs) may affect hormonal and metabolic processes, leading to tissue and organ damage. Since the endocrine system of TG people is overstimulated by HT and, often, the targets overlap with ED, it is reasonable to hypothesize that TG health deserves special attention. At present, no specific tools are available to study the toxicological effects of environmental contaminants, including EDs, and the potential long-term consequences of HT on TG people. In this context, the development of adequate and innovative animal models to mimic gender-affirming HT have a high priority, since they can provide robust data for hazard identification in TG women and men, leading to more reliable risk assessment.

2021 ◽  
Vol 68 (2) ◽  
pp. 157-161
Author(s):  
Anca A. Simionescu ◽  
◽  
Andreea Hetea ◽  
Maria Ghita ◽  
Ana Maria Alexandra Stanescu ◽  
...  

Postpartum depression remains a significant healthcare priority due to the social and family consequences. Research has shown that both mothers and fathers experience significant psychological changes during pregnancy and postnatally, including depressive disorders. Underdiagnosed in most cases, the short and long-term consequences involve infant and child development, family’s life and social disruption. Because this pathology may lead to deviation from behavioural and social norms, we want to emphasize that timely and appropriate diagnostic can improve the effectiveness of treatments and avoid complications.This may contribute to optimal social, emotional and behavioural child development that may occur consecutively to family members” emotional and psychological manifestations.


2021 ◽  
Vol 5 (1) ◽  
pp. 73-94
Author(s):  
Monika Frąckowiak-Sochańska

The first purpose of this paper is to analyze the direct and indirect, short- and long-term consequences of the COVID-19 pandemic for men. The second purpose is to identify the mechanisms underlying the present and predicted pandemic’s impact on men’s life and health (both somatic and mental). The author interprets the higher men's mortality due to coronavirus rates and the males' suicide rates that heightened from the beginning of the pandemic due to life-style that reflects the toxic masculinity norms. This paper's theoretical framework is determined by the social (cultural) trauma theory and the Critical Studies on Men and Masculinities. The method used for the present study is desk research based on the integrated literature review including the results of empirical research directly or indirectly addressing males’ experience of the COVID-19 pandemic from the years 2019 and 2020, the previous pandemics (SARS in 2002-2004 and Ebola in 2014), other social crises caused by economic and political processes, and research explaining men’s stress-related behaviors.


2021 ◽  
Vol 8 (3) ◽  
pp. 143-146
Author(s):  
Eirini Kotsalou ◽  
Athanasios Zafeirakis ◽  
Evaggelia Kotsalou

The worldwide predominance of coronavirus disease 2019 (COVID-19) pandemic will have tremendous consequences on bone health of the general population and specifically to the bone mineral density of both young and elderly adolescents, due to sedentary lifestyle resulting from the prolonged and repeated lockdown. Scientific articles argue about the short and long term consequences on bone health resulting from the social isolation and the subsequent sedentary behaviors, whereas experts focus their scientific interest at guidelines for diagnosis, management and prevention of osteoporosis in the era of the COVID-19 pandemic


2020 ◽  
Vol 63 (5) ◽  
pp. 646-650 ◽  
Author(s):  
Tracy BE Omorogiuwa

Dominating headlines in the last few months, global attention has been fixed on the coronavirus pandemic given its rampaging impact on social events and human affairs. More than any other groups, older adults have been disproportionately affected by the deadly contagion. This situation poses legitimate concerns to the social work profession, whose mandate is to liberate vulnerable people and promote social development. Although the COVID-19 pandemic has continued to take a devastating toll on older adults in the short-term, its long-term consequences may be far more profound unless urgent attention is directed to mitigate this situation. Given the promulgation of social distancing and shutdowns among a number of African countries, many social workers have found it increasingly difficult to address the difficulties faced by older adults. This article canvasses for the utilization of the mass media in initiating policy response to the challenges of older adults throughout the continent.


2021 ◽  
Vol 7 (33) ◽  
pp. eabg5995
Author(s):  
Mark M. Zaki ◽  
Emal Lesha ◽  
Khaled Said ◽  
Kiavash Kiaee ◽  
Lindsey Robinson-McCarthy ◽  
...  

Coronavirus disease 2019 (COVID-19) continues to burden society worldwide. Despite most patients having a mild course, severe presentations have limited treatment options. COVID-19 manifestations extend beyond the lungs and may affect the cardiovascular, nervous, and other organ systems. Current treatments are nonspecific and do not address potential long-term consequences such as pulmonary fibrosis, demyelination, and ischemic organ damage. Cell therapies offer great potential in treating severe COVID-19 presentations due to their customizability and regenerative function. This review summarizes COVID-19 pathogenesis, respective areas where cell therapies have potential, and the ongoing 89 cell therapy trials in COVID-19 as of 1 January 2021.


2019 ◽  
Vol 47 (2) ◽  
pp. 166-174
Author(s):  
N. I. Volkova ◽  
I. Yu. Davidenko ◽  
Yu. S. Degtyareva

Understanding of people with impaired gender identity in society, academic and science world is constantly changing due to increased awareness, openness and availability of the information on transgender people and their life. It is known that the social and psychological state of transgenders depends at a  great extent on the quality of their medical care, including hormonal treatment. Unfortunately, until recently the awareness of this problem among many physicians (clinical psychologists, psychiatrists, endocrinologists, etc.) in the Russian Federation remained insufficient, and no unified standards of medical and psychological care for transgender people in Russia have been developed. As a  result, when referring to various specialists, people with impaired gender identity commonly do not receive adequate recommendations and proper comprehensive medical follow-up. An endocrinologist, who prescribes hormonal treatment and performs long-term (usually life-long) follow-up and monitoring of adverse events, is one of the key team members to provide medical care to transgender patients. The article presents current views on definitions, diagnostic criteria and principles of endocrine therapy for gender dysphoria and gender incongruence, as well as highlights medical risks, associated with hormonal treatment, and a monitoring plan for patients receiving corrective therapy.


2006 ◽  
Vol 05 (02) ◽  
pp. C06
Author(s):  
Massimo Pigliucci

The many facets of fundamentalism. There has been much talk about fundamentalism of late. While most people's thought on the topic go to the 9/11 attacks against the United States, or to the ongoing war in Iraq, fundamentalism is affecting science and its relationship to society in a way that may have dire long-term consequences. Of course, religious fundamentalism has always had a history of antagonism with science, and – before the birth of modern science – with philosophy, the age-old vehicle of the human attempt to exercise critical thinking and rationality to solve problems and pursue knowledge. “Fundamentalism” is defined by the Oxford Dictionary of the Social Sciences1 as “A movement that asserts the primacy of religious values in social and political life and calls for a return to a 'fundamental' or pure form of religion.” In its broadest sense, however, fundamentalism is a form of ideological intransigence which is not limited to religion, but includes political positions as well (for example, in the case of some extreme forms of “environmentalism”).


1983 ◽  
Vol 10 (2) ◽  
pp. 97-104 ◽  
Author(s):  
E-An Zen

Planning for the best use of land and its resources should take fully into consideration the long-term consequences of each type of use in order to stretch out most beneficially the well-being of society in the future, and to protect the integrity of the land and its biota. Three kinds of land-use can be distinguished for planning purposes. Reversible land-use leaves the land, after use, essentially as it was before; little or no man-induced modification remains. An example of reversible use in the United States is the designation of certain public lands as Wilderness. Terminal land-use commits the land to a chosen particular use, and any attempt at reversal requires either time-scales that are long compared with the expected lifespan of the social and political institution, or a commitment of resources that is too high for society to consider worth bearing. Examples of terminal land-use are location of metropolises and sites of toxic and/or radioactive waste disposals; by its nature the list grows monotonically. A current source of some social tension arises from the fact that Wilderness designation appears to assign a terminal-use status by legislative fiat, whereas in fact the land is being used reversibly.


2015 ◽  
Vol 23 (2) ◽  
pp. 47-59 ◽  
Author(s):  
Nadine Langguth ◽  
Tanja Könen ◽  
Simone Matulis ◽  
Regina Steil ◽  
Caterina Gawrilow ◽  
...  

During adolescence, physical activity (PA) decreases with potentially serious, long-term consequences for physical and mental health. Although barriers have been identified as an important PA correlate in adults, research on adolescents’ PA barriers is lacking. Thus reliable, valid scales to measure adolescents’ PA barriers are needed. We present two studies describing a broad range of PA barriers relevant to adolescents with a multidimensional approach. In Study 1, 124 adolescents (age range = 12 – 24 years) reported their most important PA barriers. Two independent coders categorized those barriers. The most frequent PA barriers were incorporated in a multidimensional questionnaire. In Study 2, 598 adolescents (age range = 13 – 21 years) completed this questionnaire and reported their current PA, intention, self-efficacy, and negative outcome expectations. Seven PA barrier dimensions (leisure activities, lack of motivation, screen-based sedentary behavior, depressed mood, physical health, school workload, and preconditions) were confirmed in factor analyses. A multidimensional approach to measuring PA barriers in adolescents is reliable and valid. The current studies provide the basis for developing individually tailored interventions to increase PA in adolescents.


Sign in / Sign up

Export Citation Format

Share Document