scholarly journals Impact of Different Operational Definitions of Sarcopenia on Prevalence in a Population-Based Sample: The Salus in Apulia Study

2021 ◽  
Vol 18 (24) ◽  
pp. 12979
Author(s):  
Luisa Lampignano ◽  
Ilaria Bortone ◽  
Fabio Castellana ◽  
Rossella Donghia ◽  
Vito Guerra ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Operational Definition ◽  
Population Based ◽  
Anthropometric Parameters ◽  
European Working ◽  
Prevalence Estimates ◽  
Obese Subjects ◽  
Laboratory Biomarkers ◽  
Metabolic Biomarkers ◽  
The Impact

Background: In 2010, the European Working Group on Sarcopenia in Older People (EWGSOP1) issued its first operational definition to diagnose sarcopenia. This was updated in 2019 with a revised sequence of muscle mass and muscle strength (EWGSOP2). The aim of the study was to investigate the impact of these different operational definitions on sarcopenia prevalence in a representative population-based sample. Methods: For each algorithm, the prevalence of sarcopenia-related categories was calculated and related to sociodemographic and lifestyle variables, anthropometric parameters, and laboratory biomarkers. The present analysis used data from the Salus in Apulia Study (Italy, 740 subjects, mean age 75.5 ± 5.9 years, 54% women). Results: The application of the EWGSOP1 adapted algorithm resulted in 85% [95% confidence intervals (CI): 82–88%] non-sarcopenic subjects, 10% (95% CI: 8–12%) pre-sarcopenic subjects, and 5% (95% CI: 3–7%) sarcopenic/severe sarcopenic subjects. The sarcopenia-related categories were inversely related to weight and body mass index (BMI), particularly in overweight/obese subjects, and these categories showed favorable metabolic biomarkers. The EWGSOP2 algorithm yielded 73% (95% CI: 69–76%) non-sarcopenic subjects, 24% (95% CI: 21–27%) probably sarcopenic subjects, and 4% (95% CI: 2–5%) sarcopenic subjects. Conclusions: The present study identified BMI as a potential confounder of the prevalence estimates of sarcopenia-related categories in population-based settings with different EWGSOP operational definitions.

scholarly journals Which body mass index is best associated with risk of diabetes mellitus and hypertension in a Japanese-Brazilian population?

2007 ◽  
Vol 23 (2) ◽  
pp. 297-304 ◽  
Author(s):  
Rosana Farah Simony ◽  
Suely Godoy Agostinho Gimeno ◽  
Sandra Roberta Gouveia Ferreira ◽  
Laércio Joel Franco
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Mass ◽  
Sensitivity And Specificity ◽  
Population Based ◽  
Cross Sectional Study ◽  
Odds Ratios ◽  
Cross Sectional ◽  
Japanese Brazilians ◽  
The Impact

The objective of this study was to evaluate the impact of different body mass index (BMI) ranges associated with the risk of diabetes and hypertension in Japanese-Brazilians. This cross-sectional study was based on data from 1,330 Japanese-Brazilians > 30 years of age who participated in a population-based survey on the prevalence of diabetes mellitus and associated diseases. Glucose tolerance status was classified according to WHO criteria and blood pressure levels according to the VI-JNC. Odds ratios for diabetes and hypertension were calculated for different BMI ranges; for different BMIs, sensitivity and specificity for percentiles 25, 50, 75, 90 and 95 were obtained. Increased odds ratios for diabetes mellitus and hypertension were observed with BMI values > 25kg/m². The 50th percentile corresponded to the highest sensitivity and specificity for the identification of risk for both diseases. Our results suggest that BMI values proposed by WHO should also be useful for this group of Japanese descendants in the assessment of risk for DM and hypertension.

scholarly journals The Impact of Eating Frequency and Time of Intake on Nutrient Quality and Body Mass Index: The INTERMAP Study, a Population-Based Study

2015 ◽  
Vol 115 (4) ◽  
pp. 528-536.e1 ◽  
Author(s):  
Ghadeer S. Aljuraiban ◽  
Queenie Chan ◽  
Linda M. Oude Griep ◽  
Ian J. Brown ◽  
Martha L. Daviglus ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Population Based ◽  
Population Based Study ◽  
Nutrient Quality ◽  
Eating Frequency ◽  
The Impact

The impact of body mass index andHelicobacter pyloriinfection on gastro-oesophageal reflux symptoms: A population-based study in Northern Norway

2009 ◽  
Vol 44 (9) ◽  
pp. 1060-1066 ◽  
Author(s):  
Ragnar K. Breckan ◽  
Eyvind J. Paulssen ◽  
Anne Mette Asfeldt ◽  
Liisa Mortensen ◽  
Bjørn Straume ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Population Based ◽  
Oesophageal Reflux ◽  
Population Based Study ◽  
Northern Norway ◽  
Reflux Symptoms ◽  
The Impact

scholarly journals New versus old guidelines for sarcopenia classification: What is the impact on prevalence and health outcomes?

2019 ◽  
Author(s):  
Fanny Petermann-Rocha ◽  
Minghao Chen ◽  
Stuart R Gray ◽  
Frederick K Ho ◽  
Jill P Pell ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Respiratory Disease ◽  
Operational Definition ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Incidence And Mortality ◽  
European Working ◽  
All Cause Mortality ◽  
The Uk ◽  
The Impact

Abstract Introduction recently, the European Working Group on Sarcopenia in Older People (EWGSOP) established a new operational definition and cut-off points for sarcopenia. The aim of this study was, therefore, to compare the prevalence of sarcopenia and its associations with different health outcomes using the old (EWGSOP1) and new (EWGSOP2) definitions of sarcopenia in the UK Biobank cohort. Methods sarcopenia was defined as low grip strength plus low muscle mass. Using both EWGSOP cut-off points, we created specific sarcopenia variables. Prevalence of sarcopenia derived using both EWGSOP definitions was calculated and compared as well as prospective health outcomes including all-cause mortality as well as incidence and mortality from cardiovascular disease (CVD), respiratory disease and chronic obstructive pulmonary disease (COPD). Results the prevalence of sarcopenia based on the EWGSOP1 and EWGSOP2 classifications were 8.14 and 0.36%, respectively. Sarcopenia defined by EWGSOP1 was associated with a higher risk of respiratory disease and COPD as well as mortality from all-cause, CVD and respiratory diseases. However, only respiratory incidence remained associated with sarcopenia when EWGSOP2 was used (HR: 1.32 [95% CI: 1.05–1.66]). Moreover, although individuals classified as sarcopenic using both classifications had the highest risk of all-cause mortality and respiratory disease, those with sarcopenia based on EWGSOP1 only experienced a more extensive range of poorer health outcomes. Conclusion in comparison with EWGSOP1, the new classification (EWGSOP2) produced a lower estimate of sarcopenia prevalence and fewer associations with adverse health outcomes. Although these associations were higher, many become non-significant.

scholarly journals Two Polymorphisms in the Peroxisome Proliferator-Activated Receptor-γ Gene Are Associated with Severe Overweight among Obese Women*

1999 ◽  
Vol 84 (10) ◽  
pp. 3708-3712 ◽  
Author(s):  
R. Valve ◽  
K. Sivenius ◽  
R. Miettinen ◽  
J. Pihlajamäki ◽  
A. Rissanen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Fat Mass ◽  
Adipocyte Differentiation ◽  
Population Based ◽  
Peroxisome Proliferator ◽  
Obese Women ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor ◽  
Obese Subjects ◽  
Pparγ Gene

Abstract Peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear receptor that regulates adipocyte differentiation. Variations in the PPARγ gene may affect the function of the PPARγ and, therefore, body adipocity. We investigated the frequencies of the Pro12Ala polymorphism in exon B and the silent CAC478CAT polymorphism in exon 6 of the PPARγ gene and their effects on body weight, body composition, and energy expenditure in obese Finns. One hundred and seventy obese subjects [29 men and 141 women; body mass index (BMI), 35.7 ± 3.8 kg/m2; age, 43 ± 8 yr; mean ± sd) participated in the study. The frequencies of the Ala12 allele in exon B and CAT478 allele in exon 6 were not significantly different between the obese and population-based control subjects (0.14 vs. 0.13 and 0.19 vs. 0.21, respectively). The polymorphisms were associated with increased BMI [Pro12Pro, 34.5 ± 3.8; Pro12Ala, 34.8 ± 3.1; Ala12Ala, 39.2± 4.6 kg/m2 (P = 0.011); CAC478CAC, 34.5 ± 3.8; CAC478CAT, 34.5 ± 3.3; CAT478CAT, 37.7 ± 4.1 kg/m2 (P = 0.046)]. In addition, the women with both Ala12Ala and CAT478CAT genotypes (n = 5) were significantly more obese compared with the women having both Pro12Pro and CAC478CAC genotypes (n = 85; BMI, 40.6 ± 3.3 vs. 34.4 ± 3.9 kg/m2; P = 0.001), and they had increased fat mass (46.8 ± 9.1 vs. 36.8 ± 7.5 kg; P = 0.005). In conclusion, the Pro12Ala and CAC478CAT polymorphisms in the PPARγ gene are associated with severe overweight and increased fat mass among obese women.

scholarly journals Rationale and methodology for a population-based study of diabetes and common eye diseases in a rural area in Bangladesh: Bangladesh Population based Diabetes and Eye Study (BPDES)

2015 ◽  
Vol 14 (4) ◽  
pp. 367-375 ◽  
Author(s):  
Rahul Chakrabarti ◽  
Robert P Finger ◽  
Ecosse Lamoureux ◽  
M Tauhidul Islam ◽  
Mohamed Dirani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Formal Education ◽  
Multinomial Logistic Regression ◽  
Adult Population ◽  
Medical Science ◽  
Population Based ◽  
Anthropometric Parameters ◽  
Diabetes Status ◽  
The Impact

Objectives: The purpose of this study were (i) to assess the knowledge, attitudes and practice (KAP) and impact of socioeconomic factors upon the prevalence of pre-diabetes and diabetes (ii) compute a diabetes risk score and (iii) estimate the undiagnosed prevalence of hypertension amongst a large adult population in rural Bangladesh. Methods/design: A sample of 3104 adults aged ?30 years were interviewed from a cluster sample of 18 villages in the Banshgram Union of the Narail District, Bangladesh. Each participant was interviewed using a semi-structured questionnaire that assessed participant knowledge, attitudes and practice (KAP) regarding diabetes, its risk factors, complications and management. Data on demographic details, education, socioeconomic status, medical history, dietary and lifestyle behavior was obtained. Fasting capillary glucose, blood pressure, presenting vision and anthropometric parameters were measured. Participants were stratified into those without diabetes, pre-diabetes, and diagnosed diabetes (known and newly diagnosed). The association of KAP components and other risk factors with diabetes status was assessed. Logistic regression analysis allowed for the development of a non-invasive risk-stratification tool to be developed and implemented for the rural Bangladeshi community. Multinomial logistic regression was applied to report the associations of risk factors with the severity of hypertension. Results and discussion: In Banshgram, over 95% people had not undergone any previous diabetes screening. Baseline demographics estimated the prevalence of diabetes in the sample was 3.2% (n=99). 47% of participants had no formal education. Whilst there is literature on the prevalence of diabetes in urban and semi-urban Bangladesh there is a paucity of evidence examining the impact of KAP of diabetes amongst the general community. We believe that the BPDES has developed a methodology to provide new evidence to guide health policy and targeted population-based interventions in these rural areas.Bangladesh Journal of Medical Science Vol.14(4) 2015 p.367-375

Pretreatment steroid use and completion of immunotherapy: A population-based study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 9567-9567
Author(s):  
Grace L. Lu-Yao ◽  
Nikita Nikita ◽  
Jennifer Maria Johnson ◽  
Scott W. Keith ◽  
Kuang-Yi Wen ◽  
...  
Keyword(s):  
Large Scale ◽  
Negative Impact ◽  
Population Based ◽  
Steroid Use ◽  
Population Based Study ◽  
Prevalence Estimates ◽  
Melanoma Patients ◽  
Pre Treatment ◽  
The Impact ◽  
The Relationship

9567 Background: The relationship between immunosuppressants and immunotherapy (IO) is an active area of research. Here we study the impact of pre-treatment steroid use on the completion of ipilimumab (ipi) therapy. Methods: This population-based study identified patients diagnosed with melanoma and treated with ipi (brand name Yervoy) in 2010-2014 from the linked Surveillance, Epidemiology and End Result-Medicare files. “Completion of IO on time” was defined as receiving 4 cycles of IO within 90 days. Otherwise, the patients were considered to have delayed or incomplete IO. The frequencies of patients completing each dose, up to 4 doses were tabulated. Exact Clopper-Pearson 95% confidence intervals (CI) were computed for prevalence estimates. A crude relative risk (RR) for completing IO was calculated. Results: We identified 1,205 melanoma patients treated with ipi with a median age of 71 years. Among 709 patients with no pre-treatment steroids, 35.7% had completed 4th dose of IO, compared to 20.3% of patients who received pre-treatment steroids within 1 month of IO (Table). In these patients, having no exposure to steroids in the year prior to initiating IO was associated with a 28% increased probability of completing the IO regimen (RR=1.28, 95% CI: 1.07-1.53). Conclusions: This large scale real-world study demonstrated both the overall completion rate of ipi in melanoma patients as well as the negative impact of pre-treatment steroids on rate of treatment completion. Further studies on treatment outcomes associated with pre-IO steroids use are warranted. [Table: see text]

scholarly journals Quantifying the impact of genes on body mass index during the obesity epidemic: longitudinal findings from the HUNT Study

BMJ ◽  
2019 ◽  
pp. l4067 ◽  
Author(s):  
Maria Brandkvist ◽  
Johan Håkon Bjørngaard ◽  
Rønnaug Astri Ødegård ◽  
Bjørn Olav Åsvold ◽  
Erik R Sund ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Genetic Predisposition ◽  
Population Based ◽  
Health Study ◽  
Obesogenic Environment ◽  
Birth Cohorts ◽  
The Difference ◽  
The 1960S ◽  
The Impact

AbstractObjectivesTo study the trajectories of body mass index (BMI) in Norway over five decades and to assess the differential influence of the obesogenic environment on BMI according to genetic predisposition.DesignLongitudinal study.SettingGeneral population of Nord-Trøndelag County, Norway.Participants118 959 people aged 13-80 years who participated in a longitudinal population based health study (Nord-Trøndelag Health Study, HUNT), of whom 67 305 were included in analyses of association between genetic predisposition and BMI.Main outcome measureBMI.ResultsObesity increased in Norway starting between the mid-1980s and mid-1990s and, compared with older birth cohorts, those born after 1970 had a substantially higher BMI already in young adulthood. BMI differed substantially between the highest and lowest fifths of genetic susceptibility for all ages at each decade, and the difference increased gradually from the 1960s to the 2000s. For 35 year old men, the most genetically predisposed had 1.20 kg/m2 (95% confidence interval 1.03 to 1.37 kg/m2) higher BMI than those who were least genetically predisposed in the 1960s compared with 2.09 kg/m2 (1.90 to 2.27 kg/m2) in the 2000s. For women of the same age, the corresponding differences in BMI were 1.77 kg/m2 (1.56 to 1.97 kg/m2) and 2.58 kg/m2 (2.36 to 2.80 kg/m2).ConclusionsThis study provides evidence that genetically predisposed people are at greater risk for higher BMI and that genetic predisposition interacts with the obesogenic environment resulting in higher BMI, as observed between the mid-1980s and mid-2000s. Regardless, BMI has increased for both genetically predisposed and non-predisposed people, implying that the environment remains the main contributor.

Sign in / Sign up

Export Citation Format

Share Document