scholarly journals Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

2019 ◽  
Vol 20 (7) ◽  
pp. 1778 ◽  
Author(s):  
Sutunkova ◽  
Solovyeva ◽  
Minigalieva ◽  
Gurvich ◽  
Valamina ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Exposure Period ◽  
Lavage Fluid ◽  
Genotoxic Effect ◽  
Oxide Nanoparticles ◽  
Toxic Exposure ◽  
Olfactory Pathway ◽  
Nickel Oxide Nanoparticles ◽  
Nio Nps

Rats were exposed to nickel oxide nanoparticles (NiO-NP) inhalation at 0.23 ± 0.01 mg/m3 for 4 h a day 5 times a week for up to 10 months. The rat organism responded to this impact with changes in cytological and some biochemical characteristics of the bronchoalveolar lavage fluid along with a paradoxically little pronounced pulmonary pathology associated with a rather low chronic retention of nanoparticles in the lungs. There were various manifestations of systemic toxicity, including damage to the liver and kidneys; a likely allergic syndrome as indicated by some cytological signs; transient stimulation of erythropoiesis; and penetration of nickel into the brain from the nasal mucous membrane along the olfactory pathway. Against a picture of mild to moderate chronic toxicity of nickel, its in vivo genotoxic effect assessed by the degree of DNA fragmentation in nucleated blood cells (the RAPD test) was pronounced, tending to increasing with the length of the exposure period. When rats were given orally, in parallel with the toxic exposure, a set of innocuous substances with differing mechanisms of expected bioprotective action, the genotoxic effect of NiO-NPs was found to be substantially attenuated.

TOXIC EFFECTS ASSESSMENT OF NICKEL OXIDE NANOPARTICLES BY INHALATION

2018 ◽  
pp. 24-29 ◽  
Author(s):  
B.A. Katsnelson ◽  
M.P. Sutunkova ◽  
L.I. Privalova ◽  
S.N. Solovjeva ◽  
V.B. Gurvich ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Redox Balance ◽  
Systemic Toxicity ◽  
Laboratory Animals ◽  
Oxide Nanoparticles ◽  
Nickel Oxide Nanoparticles ◽  
White Rats ◽  
Liver And Kidney ◽  
Stimulation Of Erythropoiesis ◽  
Nio Nps

The article presents in an experiment obtained principal results based on repeated low-level inhalation exposures of laboratory animals (white rats, outbred) to nickel oxide nanoparticles with a diameter of (23 ± 5) nm, 4 hours a day, 5 times a week for up to 10 months in a «nose only» installation. It was shown that non-specific body reactions to the action of NiO NPs include: diverse manifestations of systemic toxicity with a particularly pronounced influence on liver and kidney function, redox balance, damage to some areas of brain tissue, associated with proven movement of the nanoparticles themselves from the nasal mucosa along the olfactory tract; some cytological signs of probable development for allergic syndrome; paradoxically low severity of pulmonary pathology by pneumoconiotic type explained by a small chronic delay of nanoparticles in the lungs; the genotoxic effect of the organismal level, even at those low levels of chronic exposure, at which systemic toxicity is rather poorly. Along with that, NiO NPs also induce phase-stimulation of erythropoiesis, which is relatively specific for the toxic nickel effects.

scholarly journals The inhibitory role of synthesized Nickel oxide nanoparticles against Hep-G2, MCF-7, and HT-29 cell lines: the inhibitory role of NiO NPs against Hep-G2, MCF-7, and HT-29 cell lines

2021 ◽  
Vol 14 (3) ◽  
pp. 443-453
Author(s):  
Mohammad Amin Jadidi Kouhbanani ◽  
Yasin Sadeghipour ◽  
Mina Sarani ◽  
Erfan Sefidgar ◽  
Saba Ilkhani ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Cell Lines ◽  
Oxide Nanoparticles ◽  
Hep G2 ◽  
Nickel Oxide Nanoparticles ◽  
Inhibitory Role ◽  
Nio Nps ◽  
Ht 29 ◽  
Mcf 7

Nickel oxide nanoparticles induce genotoxicity and cellular alterations in the ground beetle Blaps polycresta (Coleoptera: Tenebrionidae)

2021 ◽  
pp. 074823372110009
Author(s):  
Dalia Abdel Moneim Kheirallah ◽  
Awatef Mohamed Ali ◽  
Salah Eldein Osman ◽  
Amal Mohamed Shouman
Keyword(s):  
Nickel Oxide ◽  
Structural Changes ◽  
Ground Beetle ◽  
Biological Tissues ◽  
Treated Group ◽  
Sublethal Dose ◽  
Oxide Nanoparticles ◽  
Nickel Oxide Nanoparticles ◽  
Nio Nps ◽  
The Impact

Nickel nanoparticles (Ni-NPs) have advantageous applications in the industry; however, little is known of their adverse effects on biological tissues. In the present study, the ground beetle Blaps polycresta was employed as a sensitive indicator for nickel oxide nanoparticles (NiO-NPs) toxicity. Adult male beetles were injected with six dose levels of NiO-NPs (0.01, 0.02, 0.03, 0.04, 0.05, and 0.06 mg/g body weight). Mortality was reported daily over 30 days under laboratory conditions to establish an LD50. Nickel was detected in the testicular tissues of the beetles using X-ray analysis and transmission electronic microscopy. Beetles treated with the sublethal dose of 0.02 mg/g were selected to observe molecular, cellular, and subcellular changes. Gene transcripts of HSP70, HSP90, and MT1 were found to be increased >2.5-, 1.5-, and 2-fold, respectively, in the treated group compared with the controls. Decreased gene expression of AcPC01, AcPC02, and AcPC04 (≤1.5-, ≤2-, and < 2.5-fold, respectively, vs. controls) also were reported in the treated group. Under light microscopy, various structural changes were observed in the testicular tissues of the treated beetles. Ultrastructure observations using scanning and transmission electron microscopy showed severe damage to the subcellular organelles as well as deformities of the heads and flagella of the spermatozoa. Therefore, the present study postulated the impact of NiO-NPs in an ecological model.

scholarly journals Evaluation of the Biological Activity of Nickel Oxide Nanoparticles as Antibacterial and Anticancer Agents

2020 ◽  
pp. 2888-2896
Author(s):  
Maha Fakhry Altaee ◽  
Laith A. Yaaqoob ◽  
Zaid K. Kamona
Keyword(s):  
Antibacterial Activity ◽  
Nickel Oxide ◽  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Cancer Cell Lines ◽  
Oxide Nanoparticles ◽  
Caspase 9 ◽  
Nickel Oxide Nanoparticles ◽  
Nio Nps

In the present study, nickel oxide nanoparticles (NiO NPs) were evaluated as an antibacterial and anticancer agent. The nanoparticles of nikel oxide were synthesized using aloe vera leaves extract and characterized with AFM (showing an average diameter of 45.11 nm), XRD and FE-SEM analyses. Three different concentrations (125, 250 and 500 µg/ml) were prepared from the synthesized NiO NPs and investigated for their potential antibacterial activity against both Enterococcus faecalis (Gram-positive bacteria) and Acinobacter baumannii (Gram-negative bacteria). While cytotoxicity and apoptotic activity were measured on both MCF-7 and AMJ13 cancer cell lines by  MTT and caspase-9 luminescence assays. The results showed that NiO NPs inhibit bacterial growth, as indicated by large inhibition zones  against both tested bacteria, with all studied concentrations. Moreover, the results of cytotoxicity and caspase-9 activity assays were in concordance with those of  antibacterial activity, showing high cytotoxicity and apoptotic effects against both of the studied cancer cell lines and with all the tested concentrations of NiO NPs. Both the antibacterial and anticancer activities of NiO NPs were dose-dependent. 

Spectroscopic, Structural, and Morphology of Nickel Oxide Nanoparticles Prepared Using Physalis angulata Leaf Extract

2018 ◽  
Vol 917 ◽  
pp. 167-171 ◽  
Author(s):  
Najmawati Sulaiman ◽  
Yoki Yulizar
Keyword(s):  
Electron Microscopy ◽  
Particle Size ◽  
Nickel Oxide ◽  
Band Gap ◽  
Leaf Extract ◽  
Optical Band Gap ◽  
Oxide Nanoparticles ◽  
Nickel Oxide Nanoparticles ◽  
Microscopic Studies ◽  
Nio Nps

Green synthesis of nickel oxide nanoparticles (NiO NPs) usingPhysalisangulataleaf extract (PALE) as weak base sources and stabilizing agents has been reported. Chemical bonding and vibration spectroscopy, crystallographic structure, optical band gap, particle size and microscopic studies of NiO NPs were also investigated. Ni-O vibration modes of NiO NPs were analyzed by FTIR and Raman instrument at ~400 and ~900 cm-1wavenumber. XRD pattern of NiO NPs confirmed cubic crystal structure with space groupFm-3m.Optical band gap of NiO NPs determined by using Tauc plot method was about 3.42 eV. Particle size analyzer showed size distribution of NiO NPs was 64.13 nm which confirm NiO formed in nanoscale. Electron microscopic studies of NiO NPs were observed by using scanning electron microscopy and transmission electron microscopy.

Evaluation of the genotoxic properties of nickel oxide nanoparticles in vitro and in vivo

2018 ◽  
Vol 836 ◽  
pp. 47-53 ◽  
Author(s):  
Raíne F. De Carli ◽  
Débora dos S. Chaves ◽  
Tatiane R. Cardozo ◽  
Ana Paula de Souza ◽  
Allan Seeber ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Oxide Nanoparticles ◽  
Nickel Oxide Nanoparticles

Biological Activity and Characterization of Green Synthesized Nickel Oxide Nanoparticles Derived from Sterculia foetida Leaf Extract

2019 ◽  
Vol 17 (12) ◽  
pp. 977-981
Author(s):  
K. Subashini ◽  
S. Prakash ◽  
V. Sujatha
Keyword(s):  
Antibacterial Activity ◽  
Nickel Oxide ◽  
Leaf Extract ◽  
Combustion Method ◽  
Oxide Nanoparticles ◽  
Solution Combustion ◽  
Nickel Oxide Nanoparticles ◽  
Pxrd Pattern ◽  
Stretching Vibration ◽  
Nio Nps

The catalytic, optical and thermal properties are based on the size of the nanoparticles. Nickel oxide nanoparticles have unique optical property and excellent antibacterial activity. The present study aims for the synthesis of Nickel oxide nanoparticles (NiO NPs) using Sterculia foetida (S. foetida) leaf extract as reducing agent by solution combustion method. The synthesized Nickel oxide nanoparticles (NiO NPs) were confirmed by UV-Visible spectroscopy (UV) with the peak at 370 nm and at the temperature of 450 ± 10 °C, Fourier transform infrared (FTIR) wavelength was observed at 1418 cm–1 1027 cm–1 shows C–O stretching vibration and at 507 cm–1 vibration of Ni–O bond found. Crystalline structure and the formation of monoclinic phase revealed by Powder X-ray diffraction (PXRD) pattern, the percentage of nickel and oxygen of NiO NPs were confirmed with EDAX analysis. The Scanning electron microscopy (SEM) and Transmission electron microscope (TEM) images indicate the shape of Nickel oxide nanoparticles (NiO NPs) with the size range of 10–51 nm. Staphylococcus aureus (S. aureus) (Gram positive) and Escherichia coli (E. coli) (Gram negative) bacteria's were taken to study about antibacterial activity against the green synthesized Nickel oxide nanoparticles (NiO NPs). The Nickel oxide nanoparticles have pharmaceutical and other biomedical applications.

scholarly journals Characterization of Nickel Oxide Nanoparticles Synthesized under Low Temperature

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1168
Author(s):  
Sung-Jei Hong ◽  
Hyuk-Jun Mun ◽  
Byeong-Jun Kim ◽  
Young-Sung Kim
Keyword(s):  
Low Temperature ◽  
Nickel Oxide ◽  
Oxide Nanoparticles ◽  
X Ray Diffraction ◽  
Nickel Oxide Nanoparticles ◽  
Temperature Method ◽  
Bet Specific Surface Area ◽  
Heat Treated ◽  
Nio Nps ◽  
Xrd Patterns

In this study, ultrafine nickel oxide nanoparticles (NiO NPs) were well synthesized using a simple wet chemical method under low temperature, 300 °C. An Ni(OH)2 precursor was well precipitated by dropping NH4OH into an Ni(Ac)2 solution. TG-DTA showed that the weight of the precipitate decreases until 300 °C; therefore, the precursor was heat-treated at 300 °C. X-ray diffraction (XRD) patterns indicated that hexagonal-structured NiO NPs with (200) preferred orientation was synthesized. In addition, BET specific surface area (SSA) and HRTEM analyses revealed that spherical NiO NPs were formed with SSA and particle size of 60.14 m2/g and ca. 5–15 nm by using the low temperature method. FT-IR spectra of the NiO NPs showed only a sharp vibrating absorption peak at around 550 cm−1 owing to the Ni-O bond. Additionally, in UV-vis absorption spectra, the wavelength for absorption edge and energy band gap of the ultrafine NiO NPs was 290 nm and 3.44 eV.

scholarly journals Green synthesis of nickel oxide nanoparticles using Allium cepa peels for degradation of Congo Red Direct Dye: an environmental remedial approach

2021 ◽  
Author(s):  
Muhammad Asim Rafique ◽  
Shumaila Kiran ◽  
Sadia Javed ◽  
Ikram Ahmad ◽  
Sumaira Yousaf ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Allium Cepa ◽  
Congo Red ◽  
Oxide Nanoparticles ◽  
Percent Reduction ◽  
Direct Dyes ◽  
Nickel Oxide Nanoparticles ◽  
Direct Dye ◽  
Nio Nps ◽  
Optimized Conditions

Abstract Direct dyes are used in different textile operations and processings. The textile industries are disposing of unused direct dyes into the aquatic environment which is posing a serious alarming threat to aquatic lives. The current study deals with the synthesis of nickel oxide nanoparticles using Allium cepa peels aqueous extract. Nickel oxide nanoparticles (NiO-NPs) were characterized by SEM. Synthesized NiO-NPs were used to remove Congo red direct dye. Various experimental factors like concentration of dye & nanoparticles, pH, and temperature were optimized. Congo red direct dye was decolorized up to 90% at optimized conditions (Congo Red Direct dye concentration 0.02%, catalyst dose 0.003 g·L−1, pH 6, and temperature (50 °C). The real textile industry effluent disclosed 70% decolorization at optimized conditions. The percent reduction in TOC and COD were found to be 73.24% and 74.56%, in the case of congo red dye catalytic treatment & the percent reduction in TOC and COD were found to be 62.47% and 60.23%, respectively in the treatment of textile effluent using nickel oxide nanoparticles as a catalyst. Treated and untreated dye samples were exposed to FTIR and UV-Visible spectral analyses too. The reaction products were studied by degradation pathway.

scholarly journals Effect of Engineered Nickel Oxide Nanoparticles on Antioxidant Enzymes in Freshwater Fish, Labeo rohita

2021 ◽  
Vol 41 (03) ◽  
pp. 424-428
Author(s):  
Sana Aziz
Keyword(s):  
Superoxide Dismutase ◽  
Nickel Oxide ◽  
Labeo Rohita ◽  
Aquatic Organisms ◽  
Lethal Concentration ◽  
Oxide Nanoparticles ◽  
Human Beings ◽  
Nickel Oxide Nanoparticles ◽  
X Ray ◽  
Nio Nps

Nickel oxide nanoparticles (NiO-NPs) are abundantly utilized on a large scale in different applications due to positive attributes and cause environmental pollution that may affect not only aquatic organisms but also the human beings. The co-precipitation method was used to synthesize NiO-NPs and particles were characterized through Fourier-transform infrared (FTIR) analysis, Scanning electron microscope (SEM) and X-ray diffraction (XRD). FTIR and SEM confirmed the attached functional group and crystal structure of synthesized nanoparticles, respectively. From XRD pattern, average particle size, X-ray density, lattice parameters (a, b and c) and volume of unit cell of nickel oxide nanoparticles were found to be 53.44 nm, 6.65 g/cm3, (a =b=c=4.56 Å) and 94.81 Å3, respectively. During this study, the acute toxicity of NiO-NPs was determined by using fish, Labeo rohita. The mean 96-h LC50 and lethal concentration were measured as 418.26 and 634.94 mg/L, respectively. The activity of catalase and superoxide dismutase was determined in fish gills and liver after chronic exposure to sub-lethal concentration of NiO-NPs for 90 days and sampling was done in 15, 30, 45, 60, 75 and 90 days. Significant time dependent variations in the activity of catalase and superoxide dismutase were determined in tissues of the gills and liver than control group during studied time interval. The overall results indicated that induced toxicity of NiO-NPs in aquatic organisms may be due to release of Ni ions from NiO-NPs and NPs induce toxicity in cells through oxidative stress under long term exposure.

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