scholarly journals Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration

2020 ◽  
Vol 21 (6) ◽  
pp. 2251
Author(s):  
Hamid-Reza Ahmadi-Ashtiani ◽  
Parisa Bishe ◽  
Anna Baldisserotto ◽  
Piergiacomo Buso ◽  
Stefano Manfredini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Topical Administration ◽  
Therapeutic Interventions ◽  
Skin Cancers ◽  
Basic And Applied Research ◽  
Hair Follicle Growth ◽  
Novel Drug ◽  
Physical And Chemical ◽  
Cell Gene

Cutaneous stem cells, gained great attention in the field of regenerative medicine as a potential therapeutic target for the treatment of skin and hair disorders and various types of skin cancers. Cutaneous stem cells play a key role in several processes like the renovation of skin structures in the condition of homeostasis and after injuries, the hair follicle growth and the reconstruction and production of melanocytes. Thus, gaining effective access to skin stem cells for therapeutic interventions that often involve active molecules with non-favorable characteristics for skin absorption is a valuable achievement. The topical route with high patient compliance and several other benefits is gaining increasing importance in basic and applied research. However, the major obstacle for topical drug delivery is the effective barrier provided by skin against penetration of the vast majority of exogenous molecules. The research in this field is focusing more and more on new strategies to circumvent and pass this barrier effectively. In this article the existing approaches are discussed considering physical and chemical methods along with utilization of novel drug delivery systems to enhance penetration of drugs to the skin. In particular, attention has been paid to studies finalized to the delivery of molecules to cutaneous stem cells with the aim of transferring signals, modulating their metabolic program, inducing physiological modifications and stem cell gene therapy.

scholarly journals Topical Antiacne Drugs Delivery Systems

2016 ◽  
Vol 10 (1) ◽  
pp. 85-95
Author(s):  
Tesfaye Gabriel
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Topical Therapy ◽  
Topical Administration ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Solid Lipid ◽  
First Choice ◽  
Novel Drug

Background: Acne vulgaris (commonly called acne) is the most prevalent skin complication of different causes with a higher prevalence in adolescents. Topical administration is used as first-choice therapy in mild acne, whereas for moderate and severe acne, systemic administration is required in addition to topical therapy. Mechanisms by which treatments act are: normalizing shedding into the pore to prevent obstruction, destruction of P.acnes, suppression of inflammation, and hormonal management. Objective: This review focuses on the novel drug delivery systems displaying a strong ground for topical treatment of acne in order to enhance the therapeutic performance of the topical antiacne agents with improved patience compliance and a concomitant reduction in the side effects. Method: This literature review was obtained from electronic search on Pubmed, Google Scholars, Researchgate, Scimago, CABI, DOAJ, CiteFactor, GLOBAL HEALTH, Universal Impact Factor, Hinari among many others and also search was conducted on individual journals and manuals. Conclusion: Amongst various novel drug delivery systems, vesicular carriers like liposomes and niosomes, micro sponges, microemulsions, solid lipid nanoparticles, hydrogels, emulsifier-free formulations, fullerenes and aerosol foams have been reported as novel topical administration of antiacne drugs. Liposomes have been extensively explored and their ability to optimize and improve topical therapy has been proved by several clinical trials. Microemulsions, microsponges, solid lipid nanoparticles and hydrogels also exhibit a tremendous potential for commercialization.

scholarly journals Silymarin Loaded Novel Drug Delivery for Oral and Topical Administration

2020 ◽  
Vol 10 (3-s) ◽  
pp. 262-270
Author(s):  
Ankita Arun Gorhe ◽  
Abhijeet Kulkarni ◽  
Kandalkar Pallavi ◽  
Jagtap Snehal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Aqueous Solubility ◽  
Topical Administration ◽  
Route Of Administration ◽  
Pharmacological Properties ◽  
Active Components ◽  
Novel Drug Delivery System ◽  
Novel Drug

Silymarin is polyphenolic flavonoid obtained from the seeds of silybum marianum plant. It has various pharmacological properties such as hepatoprotective, anti-inflammatory, antioxidant, anti-carcinogenic, hypolipidemic properties. Silymarin has recently reported to be neuroprotective agent against neurodegenerative disease such as Alzheimer, Parkinson’s and cerebral ischemia. It contains eight active components, among which silibinin is the most active component. However, silymarin is BCS class II drug which having poor bioavailability due to extensive phase II metabolism, poor aqueous solubility, low permeability across intestinal epithelial cells and rapid excretion in bile and urine.  Therefore, it is necessary to understand all formulations and analytical aspects including all possible future prospects. In this review a potential approach to enhance solubility, bioavailability and to develop a robust formulation is studied. The number of studies describes novel drug delivery system (NDDS) based formulations have been significantly increased. The raise in novel drug delivery exploitation is essentially due to defeated barriers within technological process of lipid based nanoparticles formulations and increased knowledge of underlying mechanisms of transport of NDDS via different route of administration. This review focuses on pharmacological properties of silymarin, challenges, benefits and application of novel drug delivery system. To reduce the adverse effects and toxicities novel drug delivery will be an attractive approach of current therapies. Keywords: Silymarin, route of administration, novel drug delivery, bioavailability, solubility

scholarly journals Novel Drug Delivery Strategies for the Treatment of Onychomycosis

2019 ◽  
Vol 7 (1) ◽  
pp. 24-38 ◽  
Author(s):  
Rupinder K. Dhamoon ◽  
Harvinder Popli ◽  
Madhu Gupta
Keyword(s):  
Drug Delivery ◽  
Topical Therapy ◽  
Treatment Options ◽  
Polymeric Films ◽  
Prolonged Treatment ◽  
The Novel ◽  
Delivery Strategies ◽  
Novel Drug ◽  
Physical And Chemical ◽  
Made In

Onychomycosis accounts for 50% of all nail disease cases and is commonly caused by dermatophytes. It was primarily considered a cosmetic problem but has been garnering attention lately due to its persistent nature and difficult treatment with relapses. With prolonged treatment duration and high cost involved in treating onychomycosis, several attempts have been made in overcoming the rigid nail barrier. The conventional treatment of onychomycosis involves oral and topical therapy. The oral antifungal agents though quite effective, are hepato-toxic and cause drug-drug interactions. Topical therapy is more patient compliant being devoid of such adverse effects but it suffers from another setback of improper nail penetration. Amorolfine and ciclopirox nail lacquers are popular market products. Since decades, efforts have been made to enhance topical delivery for efficiently treating onychomycosis. Mechanical, physical and chemical methods have been employed. Despite all the attempts made, the nail delivery issues are far from being solved. Recently, the focus has shifted to novel drug delivery systems like nanoparticles, microemulsions, polymeric films and nail lacquers for enhanced drug permeation and localized therapy. The research around the world is exploring their potential as effective treatment options. This review intends to further explore the novel delivery strategies to treat a persistent fungal infection like onychomycosis.

scholarly journals AN UPDATED REVIEW ON THE APPLICATION OF DENDRIMERS AS SUCCESSFUL NANOCARRIERS FOR BRAIN DELIVERY OF THERAPEUTIC MOIETIES

2021 ◽  
pp. 1-9
Author(s):  
SARANYA SASI ◽  
SHARON KUNNATH JOSEPH ◽  
ARYA MANGALATH ARIAN ◽  
SACHIN THOMAS ◽  
AMRUTHA V. U. ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Genetic Material ◽  
Review Article ◽  
Wide Range ◽  
The Central Nervous System ◽  
Systemic Side Effects ◽  
High Degree ◽  
Novel Drug ◽  
Physical And Chemical ◽  
The Brain

It’s been nearly 100 y of effort to study the organization and role of the blood brain-barrier and still, we strive to find better techniques to overcome this barrier to deliver the drugs to the brain effectively with reduced systemic side effects. The advances in nanotechnology have given newer horizons in achieving this goal since the nano-scaled systems can modify an existing drug to have a high degree of sensitivity to the physiological conditions and specificity to reach the target organ. Among the various nanocarriers, dendrimers owing to their unique physical and chemical characteristics, represent a potential therapeutic tool in biomedical and pharmaceutical science. Dendrimers, an established polymeric nanocarrier system of the time, can deliver both drugs and genetic material and are being extensively studied to target the brain. The surface modification of dendrimers can reduce their innate toxicity problems and increase the therapeutic efficacy of brain disorders. This review article is an attempt to update on the potential of dendrimers explored in the past five years as a drug delivery avenue that can be considered as a promising solution in the management of a wide range of disorders affecting the central nervous system, including neoplastic, degenerative, and ischemic conditions. The following search criteria were used to expand the review article with the keywords dendrimers, novel drug delivery, nanoparticles, site-specific drug delivery etc.

scholarly journals Novel study in fast dissolving drug delivery system: a review

2015 ◽  
Vol 3 (01) ◽  
pp. 93-107
Author(s):  
Sparsh Gupta ◽  
Rakesh Roshan Mali ◽  
Vashali Goel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Route ◽  
Conventional Tablet ◽  
System A ◽  
Tablet Disintegration ◽  
Novel Drug ◽  
Physical And Chemical ◽  
Fast Disintegrating Tablets

Novel drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and bio-chemical parameters pertinent to their performance. Despite tremendous advancements in drug delivery, the oral route remains the perfect route for the administration. Novel drug delivery system assists to achieve better patient compliance. Fast dissolving tablets are one of them.FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. FDDT formulation combines the advantage of both liquid and conventional tablet formulation while also offering advantage over both traditional dosage forms. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast- dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate.

Novel drug delivery approaches in treating pulmonary fibrosis

2018 ◽  
Vol 60 (4) ◽  
Author(s):  
Kamal Dua ◽  
Rajendra Awasthi ◽  
Jyotsana R. Madan ◽  
Dinesh K. Chellappan ◽  
Buchi N. Nalluri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pulmonary Fibrosis ◽  
Novel Drug

A Review on Fast Dissolving Tablet

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Sagar T. Malsane ◽  
Smita S. Aher ◽  
R. B. Saudagar
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Research Area ◽  
Oral Route ◽  
Dosage Forms ◽  
The Novel ◽  
The Past ◽  
Orally Disintegrating Tablets ◽  
Novel Drug ◽  
Experience Difficulty

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orally disintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. One such problem can be solved in the novel drug delivery system by formulating “Fast dissolving tablets” (FDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for FDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area.

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