scholarly journals External and Genetic Conditions Determining Male Infertility

2020 ◽  
Vol 21 (15) ◽  
pp. 5274
Author(s):  
Piotr Kamiński ◽  
Jędrzej Baszyński ◽  
Izabela Jerzak ◽  
Brendan P. Kavanagh ◽  
Ewa Nowacka-Chiari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cystic Fibrosis ◽  
Male Infertility ◽  
Semen Quality ◽  
Chemical Elements ◽  
Reproductive Potential ◽  
Environmental Stressors ◽  
Physical Factors ◽  
Defensive Responses ◽  
The Impact

We explain environmental and genetic factors determining male genetic conditions and infertility and evaluate the significance of environmental stressors in shaping defensive responses, which is used in the diagnosis and treatment of male infertility. This is done through the impact of external and internal stressors and their instability on sperm parameters and their contribution to immunogenetic disorders and hazardous DNA mutations. As chemical compounds and physical factors play an important role in the induction of immunogenetic disorders and affect the activity of enzymatic and non-enzymatic responses, causing oxidative stress, and leading to apoptosis, they downgrade semen quality. These factors are closely connected with male reproductive potential since genetic polymorphisms and mutations in chromosomes 7, X, and Y critically impact on spermatogenesis. Microdeletions in the Azoospermic Factor AZF region directly cause defective sperm production. Among mutations in chromosome 7, impairments in the cystic fibrosis transmembrane conductance regulator CFTR gene are destructive for fertility in cystic fibrosis, when spermatic ducts undergo complete obstruction. This problem was not previously analyzed in such a form. Alongside karyotype abnormalities AZF microdeletions are the reason of spermatogenic failure. Amongst AZF genes, the deleted in azoospermia DAZ gene family is reported as most frequently deleted AZF. Screening of AZF microdeletions is useful in explaining idiopathic cases of male infertility as well as in genetic consulting prior to assisted reproduction. Based on the current state of research we answer the following questions: (1) How do environmental stressors lessen the quality of sperm and reduce male fertility; (2) which chemical elements induce oxidative stress and immunogenetic changes in the male reproductive system; (3) how do polymorphisms correlate with changes in reproductive potential and pro-antioxidative mechanisms as markers of pathophysiological disturbances of the male reproductive condition; (4) how do environmental stressors of immunogenetic disorders accompany male infertility and responses; and (5) what is the distribution and prevalence of environmental and genetic risk factors.

scholarly journals The Ameliorating Effect of Berberine-Rich Fraction against Gossypol-Induced Testicular Inflammation and Oxidative Stress

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Samar R. Saleh ◽  
Rana Attia ◽  
Doaa A. Ghareeb
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Corn Oil ◽  
Semen Quality ◽  
Experimental Period ◽  
Male Rats ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Interleukin 12 ◽  
Sprague Dawley ◽  
And Oxidative Stress

This study was aimed at evaluating the efficacy of berberine-rich fraction (BF) as a protective and/or a therapeutic agent against inflammation and oxidative stress during male infertility. Sexually mature Sprague-Dawley male rats were divided into five groups treated with either corn oil, BF (100 mg/kg BW, orally, daily for 30 days), gossypol acetate (5 mg/kg BW, i.p.) eight times for 16 days, BF alone for 14 days then coadministered with gossypol acetate for the next 16 days (protected group), or gossypol acetate for 16 days then treated with BF for 30 days (treated group). All animals completed the experimental period (46 days) without obtaining any treatments in the gap period. Sperm parameters, oxidative index, and inflammatory markers were measured. Gossypol injection significantly decreased the semen quality and testosterone level that resulted from the elevation of testicular reactive oxygen and nitrogen species (TBARS and NO), TNF-α, TNF-α-converting enzyme, and interleukins (IL-1β, IL-6, and IL-18) by 230, 180, 12.5, 97.9, and 300%, respectively, while interleukin-12 and tissue inhibitors of metalloproteinases-3 were significantly decreased by 59 and 66%, respectively. BF (protected and treated groups) significantly improved the semen quality, oxidative stress, and inflammation associated with male infertility. It is suitable to use more advanced studies to validate these findings.

scholarly journals Coenzyme Q10, oxidative stress, and male infertility: A review

2021 ◽  
Vol 48 (2) ◽  
pp. 97-104
Author(s):  
Ahmed T. Alahmar ◽  
Aldo E. Calogero ◽  
Rajender Singh ◽  
Rossella Cannarella ◽  
Pallav Sengupta ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Coenzyme Q10 ◽  
Semen Quality ◽  
Sperm Count ◽  
Specific Treatment ◽  
Physiological Role ◽  
Semen Parameters ◽  
Sperm Dna Fragmentation ◽  
Male Reproductive Function

Male infertility has a complex etiopathology, which mostly remains elusive. Although research has claimed that oxidative stress (OS) is the most likely underlying mechanism of idiopathic male infertility, the specific treatment of OS-mediated male infertility requires further investigation. Coenzyme Q10 (CoQ10), a vitamin-like substance, has been found in measurable levels in human semen. It exhibits essential metabolic and antioxidant functions, as well as playing a vital role in mitochondrial bioenergetics. Thus, CoQ10 may be a key player in the maintenance of biological redox balance. CoQ10 concentrations in seminal plasma directly correlate with semen parameters, especially sperm count and sperm motility. Seminal CoQ10 concentrations have been shown to be altered in various male infertility states, such as varicocele, asthenozoospermia, and medical or surgical regimens used to treat male infertility. These observations imply that CoQ10 plays an important physiological role in the maintenance and amelioration of semen quality. The present article thereby aimed to review the possible mechanisms through which CoQ10 plays a role in the regulation of male reproductive function, and to concisely discuss its efficacy as an ameliorative agent in restoring semen parameters in male infertility, as well as its impact on OS markers, sperm DNA fragmentation, pregnancy, and assisted reproductive technology outcomes.

scholarly journals Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

2020 ◽  
Vol 2020 ◽  
pp. 1-22 ◽  
Author(s):  
Andy W. C. Man ◽  
Huige Li ◽  
Ning Xia
Keyword(s):  
Oxidative Stress ◽  
Metabolic Diseases ◽  
Healthy Lifestyle ◽  
Current Knowledge ◽  
Vascular Dysfunction ◽  
The Body ◽  
Physical Factors ◽  
Normal Functions ◽  
The Impact ◽  
And Oxidative Stress

Healthy lifestyle and diet are associated with significant reduction in risk of obesity, type 2 diabetes, and cardiovascular diseases. Oxidative stress and the imbalance between prooxidants and antioxidants are linked to cardiovascular and metabolic diseases. Changes in antioxidant capacity of the body may lead to oxidative stress and vascular dysfunction. Diet is an important source of antioxidants, while exercise offers many health benefits as well. Recent findings have evidenced that diet and physical factors are correlated to oxidative stress. Diet and physical factors have debatable roles in modulating oxidative stress and effects on the endothelium. Since endothelium and oxidative stress play critical roles in cardiovascular and metabolic diseases, dietary and physical factors could have significant implications on prevention of the diseases. This review is aimed at summarizing the current knowledge on the impact of diet manipulation and physical factors on endothelium and oxidative stress, focusing on cardiovascular and metabolic diseases. We discuss the friend-and-foe role of dietary modification (including different diet styles, calorie restriction, and nutrient supplementation) on endothelium and oxidative stress, as well as the potential benefits and concerns of physical activity and exercise on endothelium and oxidative stress. A fine balance between oxidative stress and antioxidants is important for normal functions in the cells and interfering with this balance may lead to unfavorable effects. Further studies are needed to identify the best diet composition and exercise intensity.

Gelatinases and their tissue inhibitors are associated with oxidative stress: a potential set of markers connected with male infertility

2016 ◽  
Vol 28 (7) ◽  
pp. 1029 ◽  
Author(s):  
Ewa M. Kratz ◽  
Anna Kałuża ◽  
Mirosława Ferens-Sieczkowska ◽  
Beata Olejnik ◽  
Renata Fiutek ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Seminal Plasma ◽  
Artificial Insemination ◽  
Male Fertility ◽  
Semen Quality ◽  
Reproductive Potential ◽  
Advanced Oxidation Protein Products ◽  
Tissue Inhibitors ◽  
Total Antioxidant ◽  
Infertile Patients

The expression and activity of matrix metalloproteinases (MMPs) may be regulated by oxidative stress in various pathophysiological processes; therefore, the aim of the present study was to analyse the associations between the expression of the gelatinases MMP-9 and MMP-2 and their tissue inhibitors TIMP-1, TIMP-2 and levels of total antioxidant capacity (TAC) and advanced oxidation protein products (AOPP) in seminal plasma prepared for artificial insemination. Levels of MMPs and TIMPs were evaluated using ELISA, whereas TAC and AOPP in the seminal plasma of 131 childless men and 38 fertile volunteers were determined spectrophotometrically. Seminal MMP-9 expression was higher in childless men than in fertile subjects, whereas there was no significant differences in MMP-2 expression between the analysed seminal groups. TIMP-1 and TIMP-2 expression was similar in all groups. However, TAC expression was significantly higher in infertile normozoospermic and oligozoospermic men and AOPP expression was higher in astheno-, oligo- and normozoospermic infertile patients than in fertile men. High AOPP, together with an increased MMP-9 : TIMP-1 ratio alters the oxidative–antioxidative balance of the ejaculate, thereby reducing male fertility, and therefore these parameters may serve as additional diagnostic markers of semen quality and male reproductive potential.

scholarly journals Redox Balance in Male Infertility: Excellence through Moderation—“Μέτρον ἄριστον”

Antioxidants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1534
Author(s):  
Evangelos N. Symeonidis ◽  
Evangelini Evgeni ◽  
Vasileios Palapelas ◽  
Dimitra Koumasi ◽  
Nikolaos Pyrgidis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Medical Condition ◽  
Wide Spectrum ◽  
Semen Analysis ◽  
Redox Balance ◽  
Male Reproduction ◽  
Specific Patient ◽  
Reductive Stress ◽  
The Impact

Male infertility, a relatively common and multifactorial medical condition, affects approximately 15% of couples globally. Based on WHO estimates, a staggering 190 million people struggle with this health condition, and male factor is the sole or contributing factor in roughly 20–50% of these cases. Nowadays, urologists are confronted with a wide spectrum of conditions ranging from the typical infertile male to more complex cases of either unexplained or idiopathic male infertility, requiring a specific patient-tailored diagnostic approach and management. Strikingly enough, no identifiable cause in routine workup can be found in 30% to 50% of infertile males. The medical term male oxidative stress infertility (MOSI) was recently coined to describe infertile men with abnormal sperm parameters and oxidative stress (OS), including those previously classified as having idiopathic infertility. OS is a critical component of male infertility, entailing an imbalance between reactive oxygen species (ROS) and antioxidants. ROS abundance has been implicated in sperm abnormalities, while the exact impact on fertilization and pregnancy has long been a subject of considerable debate. In an attempt to counteract the deleterious effects of OS, urologists resorted to antioxidant supplementation. Mounting evidence indicates that indiscriminate consumption of antioxidants has led in some cases to sperm cell damage through a reductive-stress-induced state. The “antioxidant paradox”, one of the biggest andrological challenges, remains a lurking danger that needs to be carefully avoided and thoroughly investigated. For that reason, oxidation-reduction potential (ORP) emerged as a viable ancillary tool to basic semen analysis, measuring the overall balance between oxidants and antioxidants (reductants). A novel biomarker, the Male infertility Oxidative System (MiOXSYS®), is a paradigm shift towards that goal, offering a quantification of OS via a quick, reliable, and reproducible measurement of the ORP. Moderation or “Μέτρον” according to the ancient Greeks is the key to successfully safeguarding redox balance, with MiOXSYS® earnestly claiming its position as a guarantor of homeostasis in the intracellular redox milieu. In the present paper, we aim to offer a narrative summary of evidence relevant to redox regulation in male reproduction, analyze the impact of OS and reductive stress on sperm function, and shed light on the “antioxidant paradox” phenomenon. Finally, we examine the most up-to-date scientific literature regarding ORP and its measurement by the recently developed MiOXSYS® assay.

scholarly journals Methods of Physiotherapy in the Treatment of Patients with Erectile Dysfunction

2020 ◽  
Vol 100 (6) ◽  
pp. 75-80
Author(s):  
A.D. Fesyun ◽  
D.B. Kulchitskaya ◽  
T.V. Konchugova ◽  
V.A. Kiyatkin
Keyword(s):  
Erectile Dysfunction ◽  
Drug Therapy ◽  
Reproductive Potential ◽  
Modern Medicine ◽  
Scientific Data ◽  
Physical Factors ◽  
Basic Drug ◽  
Rehabilitation Programs ◽  
Comprehensive Programs ◽  
The Impact

The problem of treating patients with erectile dysfunction (ED) is highly relevant, since it is directly related to the reproductive potential of Russia. Despite the existence of different perspectives regarding the factors determining the occurrence of ED – organic or psychogenic, most researchers agree that this problem should be addressed in a comprehensive manner, involving not only the modern advances of drug therapy, but also various methods of physiotherapy. The accumulated experience of natural and preformed physical factors usage to correct ED requires generalization, since in modern medicine, questions of the reliability of evidence obtained fromthe results of scientific research come to the fore. The article analyzes scientific data on the effectiveness of various physiotherapy methods for ED correction, published in specialized Russian and foreign journals over the past 10 years. A number of studies are devoted to the impact of electrotherapy, ultrasound therapy and laser therapy not only in the form of monotherapy against the background of basic drug therapy, but also in the form of complex effects on the circulatory state, functional disorders and quality of life of patients with ED. Most scientific papers deal with rehabilitation treatment of patients with ED caused by a metabolic syndrome. Studies onthe influence of physical factors on erectile function in patients with chronic prostatitis are also presented. The review provides information concerning advantages of rehabilitation programs for sanatorium treatment of ED patients in comparison with outpatient treatment. Based on the analysis of scientific data, the authors conclude that further research on the study and development of new comprehensive programs, including physiotherapy methods, for the treatment of ED patients is appropriate and promising.

scholarly journals A Review on Male Infertility - Environmental Factors, Pathophysiological and Oxidative Stress

2021 ◽  
Vol 10 (44) ◽  
pp. 3798-3804
Author(s):  
Lata Kanyal Butola ◽  
Archana Dhok ◽  
Deepika Kanyal ◽  
Anjali Vagga
Keyword(s):  
Oxidative Stress ◽  
Environmental Factors ◽  
Male Infertility ◽  
Illicit Drugs ◽  
Semen Quality ◽  
Coffee Consumption ◽  
Paternal Age ◽  
Industrial Chemicals ◽  
Nutrition Intake ◽  
Poor Nutrition

Male infertility is one of the rising global problems with an increasing decline in male semen quality among men living in Asia, Europe, Africa and North America. Infertility is defined as the failure of conception after at least 12 months of unprotected intercourse. Globally 70 million people are affected by infertility. Environmental, occupational and modifiable lifestyle factors may contribute to this decline of male fertility. Various factors associated with male infertility include smoking cigarettes, alcohol intake, use of illicit drugs, obesity, genetic factors, heavy metals, psychological stress, exposure to pesticides and industrial chemicals, poor nutrition intake, oxidative stress, sedentary lifestyle, advanced paternal age, diet and coffee consumption. KEY WORDS Infertility, Antioxidant, Environmental Factors, Endocrine Factors

COPPER AS AN ANSWER ON THE IMPACT OF OXYDESS STRESS ON THE EYES

2018 ◽  
Vol 172 (52) ◽  
pp. 23-28
Author(s):  
Katarzyna Kempka ◽  
Piotr Kamiński ◽  
Grażyna Malukiewicz ◽  
Maria Bogdzińska
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Environmental Conditions ◽  
Defense Mechanisms ◽  
Chemical Elements ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
State Of Emergency ◽  
The Impact ◽  
And Oxidative Stress

The eyes are exposed to many factors, that contribute to the deterioration of their condition. These include environmental conditions and the influence of reactive oxygen species ROS and oxidative stress. Research shows, that one of the most important tasks of created in such way state of emergency is maintenance of relative balance between oxidants (contributing to the formation of ROS) and antioxidants (restraining their effect). Some chemical elements, especially copper, play a key role in blocking ROS and presents an overview of information on the impact of oxidative stress on the eyes and the defense mechanisms with the participation of copper.

scholarly journals Quorum-Sensing Antagonistic Activities of Azithromycin in Pseudomonas aeruginosa PAO1: a Global Approach

2006 ◽  
Vol 50 (5) ◽  
pp. 1680-1688 ◽  
Author(s):  
Yusuf Nalca ◽  
Lothar Jänsch ◽  
Florian Bredenbruch ◽  
Robert Geffers ◽  
Jan Buer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Virulence Factor ◽  
Biofilm Formation ◽  
Great Promise ◽  
Factor Production ◽  
The Impact ◽  
Virulence Factor Production

ABSTRACT The administration of macrolides such as azithromycin for chronic pulmonary infection of cystic fibrosis patients has been reported to be of benefit. Although the mechanisms of action remain obscure, anti-inflammatory effects as well as interference of the macrolide with Pseudomonas aeruginosa virulence factor production have been suggested to contribute to an improved clinical outcome. In this study we used a systematic approach and analyzed the impact of azithromycin on the global transcriptional pattern and the protein expression profile of P. aeruginosa PAO1 cultures versus those in untreated controls. The most remarkable result of this study is the finding that azithromycin exhibited extensive quorum-sensing antagonistic activities. In accordance with the inhibition of the quorum-sensing systems, virulence factor production was diminished and the oxidative stress response was impaired, whereas the type III secretion system was strongly induced. Moreover, P. aeruginosa motility was reduced, which probably accounts for the previously observed impaired biofilm formation capabilities of azithromycin-treated cultures. The interference of azithromycin with quorum-sensing-dependent virulence factor production, biofilm formation, and oxidative stress resistance in P. aeruginosa holds great promise for macrolide therapy in cystic fibrosis. Clearly quorum-sensing antagonist macrolides should be paid more attention in the management of chronic P. aeruginosa infections, and as quorum-sensing antagonists, macrolides might gain vital importance for more general application against chronic infections.

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