scholarly journals In Experimental Dilated Cardiomyopathy Heart Failure and Survival Are Adversely Affected by a Lack of Sexual Interactions

2020 ◽  
Vol 21 (15) ◽  
pp. 5450
Author(s):  
Ranjana Tripathi ◽  
Ryan D. Sullivan ◽  
Tai-Hwang M. Fan ◽  
Radhika M. Mehta ◽  
Inna P. Gladysheva ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Sexual Activity ◽  
Systolic Function ◽  
Fluid Retention ◽  
Prolonged Survival ◽  
Plasma Testosterone ◽  
Testosterone Levels ◽  
Develop Heart Failure ◽  
Cardiac Contractile

Nearly one in three people in the U.S. will develop heart failure (HF), characterized by fluid retention (edema) in the lungs and elsewhere. This leads to difficult breathing, deterioration of physical capacity, restriction of normal activities and death. There is little data about the safety and effects of sexual interactions in patients with HF. We tested whether a lack of sexual interactions affected pathophysiological outcomes in a pre-clinical mouse model of dilated cardiomyopathy that recapitulates the progressive stages of human HF. Male mice were randomly given access to, or deprived from, sexual interactions with female mice, which were confirmed by videography and generation of offspring. Cohousing with access to sexual interactions markedly prolonged survival, while cohousing without access to sexual activity did not. Sexual interactions improved systolic function, reduced HF-associated edema, altered transcription of heart contractile protein genes and decreased plasma testosterone levels. To determine whether testosterone levels contributed to survival, testosterone levels were experimentally reduced. Reduction of testosterone levels significantly prolonged survival. Taken together, in mice with dilated cardiomyopathy, sexual activity altered cardiac contractile gene transcription, improved systolic function, reduced edema and prolonged survival which may be in part due to lower testosterone levels.

scholarly journals A reversible hypocalcemic dilated cardiomyopathy caused by primary hypoparathyroidism

2019 ◽  
Vol 10 (2) ◽  
pp. 65-68
Author(s):  
Zhenli Cheng ◽  
Shiv Kumar Yadav ◽  
Xiaoyan Liu ◽  
Qijian Yi
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Dilated Cardiomyopathy ◽  
Systolic Function ◽  
Myocardial Dysfunction ◽  
Case Presentation ◽  
Aggressive Management

Dilated cardiomyopathy (DCM) is characterized by dilation and impaired contraction of one or both ventricles. Affected patients have impaired systolic function and may or may not develop overt heart failure (HF). Prognosis is generally poor without heart transplantation. We experienced a case of a 10-year-old child with dilated cardiomyopathy (DCM) accompanied by undiagnosed primary hypoparathyroidism. In our case,aggressive management of hypoparathyroidism significantly improved the manifestations of DCM. The case presentation highlights the importance of considering hypoparathyroidism as a cause of reversible myocardial dysfunction.

scholarly journals Hyperthyroidism-induced dilated cardiomyopathy

2019 ◽  
Vol 7 (27) ◽  
pp. 64-66 ◽  
Author(s):  
Phumpattra Chariyawong ◽  
Angela Rao ◽  
Deepa Panikkath ◽  
Ragesh Panikkath
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Dilated Cardiomyopathy ◽  
Systolic Function ◽  
Cardiac Contractility ◽  
Contributing Factors ◽  
Endocrine Disorder ◽  
Hyperdynamic State ◽  
History Of ◽  
High Output

Hyperthyroidism is a common endocrine disorder with a prevalence of 1.3% in the generalpopulation, affecting more women than men. Prolonged hyperthyroidism without appropriatemanagement may lead to high output cardiac failure characterized by increases in heart rate,cardiac contractility, and cardiac output and by reductions in peripheral systemic vascularresistance. Dilated cardiomyopathy with impaired systolic function is rare and occurs in lessthan 1% of patients with thyrotoxicosis. The exact mechanism of hyperthyroidism-induceddilated cardiomyopathy is not well established. The combination of direct toxic effects of excessthyroid hormone along with prolonged tachycardia, arrhythmia, and a hyperdynamic state couldbe contributing factors. We present a case of a young woman with prolonged sinus tachycardiadue to a long history of medication non-compliance who developed dilated cardiomyopathywith low output heart failure. Early detection and management of hyperthyroidism are crucialto restore cardiac function.

scholarly journals Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy

2021 ◽  
Vol 10 (11) ◽  
pp. 2289
Author(s):  
Angita Jain ◽  
Nadine Norton ◽  
Katelyn A. Bruno ◽  
Leslie T. Cooper ◽  
Paldeep S. Atwal ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sex Differences ◽  
Sex Ratio ◽  
Dilated Cardiomyopathy ◽  
Systolic Function ◽  
Pathogenic Variants ◽  
Research Findings ◽  
Reported Data ◽  
Chemotherapy Agents ◽  
Male To Female

Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle and impaired systolic function and is the second most common cause of heart failure after coronary heart disease. The etiology of DCM is diverse including genetic pathogenic variants, infection, inflammation, autoimmune diseases, exposure to chemicals/toxins as well as endocrine and neuromuscular causes. DCM is inherited in 20–50% of cases where more than 30 genes have been implicated in the development of DCM with pathogenic variants in TTN (Titin) most frequently associated with disease. Even though male sex is a risk factor for heart failure, few studies have examined sex differences in the pathogenesis of DCM. We searched the literature for studies examining idiopathic or familial/genetic DCM that reported data by sex in order to determine the sex ratio of disease. We found 31 studies that reported data by sex for non-genetic DCM with an average overall sex ratio of 2.5:1 male to female and 7 studies for familial/genetic DCM with an overall average sex ratio of 1.7:1 male to female. No manuscripts that we found had more females than males in their studies. We describe basic and clinical research findings that may explain the increase in DCM in males over females based on sex differences in basic physiology and the immune and fibrotic response to damage caused by mutations, infections, chemotherapy agents and autoimmune responses.

scholarly journals The Failing Heart in Pediatric Dilated Cardiomyopathy Caused by Excessive Water Drinking: A Case Report and Brief Review

2021 ◽  
Vol 03 ◽  
Author(s):  
Aditya Doni Pradana ◽  
Jarot Widodo
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Acute Heart Failure ◽  
Systolic Function ◽  
Pediatric Population ◽  
Left Ventricular ◽  
Initial Assessment ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Cardiothoracic Ratio

: Acute heart failure in dilated cardiomyopathy (DCM) is a rare cardiac disease in the pediatric population. A 15- year-old boy admitted to the emergency department of Kendal Islamic Hospital, Kendal, Indonesia on June 26th, 2020 with shortness of breath, tachycardia, and oxygen desaturation. The chest X-ray showed significant cardiomegaly with a cardiothoracic ratio was 70% and signs of pulmonary congestion. Transthoracic echocardiography revealed dilation of the left atrium and left ventricle (LV), decreased global LV systolic function with reduced left ventricular ejection fraction of 22%. Subsequently, he was diagnosed with acute heart failure in dilated cardiomyopathy and discharged on day sixth of hospitalization. Focus initial assessment and time-to-therapy in acute heart failure settings needs to be understood by all clinicians especially emergency care physicians.

Abstract 2911: T-182C Polymorphism in the Norepinephrine Transporter Gene (SLC6A2) and Risk of Cardiovascular Events in Patients with Dilated Cardiomyopathy: Association of the T allele with a Reduced Risk for Cardiovascular Events

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
TAKAYUKI NAGAI ◽  
Akiyoshi Ogimoto ◽  
Kazuhisa Nishimura ◽  
Akira Kurata ◽  
Jun Suzuki ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Cardiovascular Event ◽  
Cardiac Death ◽  
Cardiovascular Events ◽  
Protective Factor ◽  
Systolic Function ◽  
Norepinephrine Transporter ◽  
Left Ventricular ◽  
Adverse Cardiovascular Event

Backgrounds: The increase in sympathetic activity is one of the hallmarks of the chronic heart failure and has been shown to have an important impact on survival in patients with dilated cardiomyopathy (DCM). Norepinephrine transporter (NET) recaptures as much as 90% of released norepinephrine in the heart, making it a critical mediator of norepinephrine inactivation and presynaptic catecholamine homeostasis. Recently, the polymorphism of NET T-182C was reported to be associated with the improvement of left ventricular systolic function by beta-blockers in patients with DCM. However, the association between the incidence of cardiovascular events and the NET polymorphism in patients DCM has not been understood. The purpose of this study was to evaluate the effect of this polymorphism on the incidence of cardiovascular events in patients with DCM. Methods: Eighty-three genetically unrelated patients with nonfamilial DCM (64 males, mean age at initial clinical evaluation 59 ± 14 years) were enrolled in this study. An adverse cardiovascular event was defined as cardiac death or hospitalization for cardiac reasons. The time to the first adverse cardiovascular event was analyzed by the Kaplan-Meier method. The TaqMan polymerase chain reaction method was used for the determination of genotypes of the NET T-182C gene (SLC6A2) (rs#2242446). Results: The distribution of the NET T-182C genotypes (T/T, T/C, and C/C) was 43%, 45%, and 12%, respectively. The NET T-182C T allele frequency was 0.63. During a mean follow-up period of 45 months, 20 cardiovascular events had occurred. Eight patients died from cardiac cause (1 from pump failure and 7 from sudden cardiac death) and there were 12 hospitalizations for new onset or worsening of heart failure symptoms. The cardiovascular event rate of the patients carrying the T allele (T/T and T/C genotype, n = 73) was significantly lower than that of the patients not carrying the T allele (C/C genotype, n = 10) (p = 0.03). Conclusion: Our data suggested that the T allele of the NET T-182C gene may be a protective factor against cardiovascular events in patients with DCM.

Serelaxin for infant heart failure in congenital dilated cardiomyopathy

2018 ◽  
Vol 28 (5) ◽  
pp. 734-736 ◽  
Author(s):  
Patrick O. Myers ◽  
Alice Bordessoule ◽  
Cécile Tissot
Keyword(s):  
Heart Failure ◽  
Extracorporeal Membrane Oxygenation ◽  
Dilated Cardiomyopathy ◽  
Marked Improvement ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Compassionate Use ◽  
Ventricular Systolic Function ◽  
Membrane Oxygenation

AbstractSerelaxin has been studied in trials in adults with acute heart failure, but not in children. We report the first compassionate use of serelaxin in an infant. A 6-month-old girl with dilated cardiomyopathy was placed on extracorporeal membrane oxygenation following cardiac arrest unresponsive to medical treatment. Extracorporeal membrane oxygenation weaning failed despite maximal ino-dilator therapy. During the 48-hour infusion of serelaxin, we observed marked improvement in brain natriuretic peptide, left ventricular systolic function, and dilatation. The patient was successfully weaned from extracorporeal membrane oxygenation 24 hours later. The child died after a second extracorporeal membrane oxygenation run owing to sepsis.

scholarly journals Dilated Cardiomyopathy Induced by Chronic Starvation and Selenium Deficiency

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Soham Dasgupta ◽  
Ashraf M. Aly
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Defense Mechanisms ◽  
Rare Case ◽  
Antioxidant Defense ◽  
Systolic Function ◽  
Protein Energy Malnutrition ◽  
Selenium Deficiency ◽  
Protein Energy

Protein energy malnutrition (PEM) has been rarely documented as a cause of cardiovascular abnormalities, including dilated cardiomyopathy. Selenium is responsible for antioxidant defense mechanisms in cardiomyocytes, and its deficiency in the setting of PEM and disease related malnutrition (DRM) may lead to exacerbation of the dilated cardiomyopathy. We report a rare case of a fourteen-year-old boy who presented with symptoms of congestive heart failure due to DRM and PEM (secondary to chronic starvation) along with severe selenium deficiency. An initial echocardiogram showed severely depressed systolic function consistent with dilated cardiomyopathy. Aggressive nutritional support and replacement of selenium and congestive heart failure medications that included diuretics and ACE inhibitors with the addition of carvedilol led to normalization of the cardiac function within four weeks. He continues to have significant weight gain and is currently completely asymptomatic from a cardiovascular standpoint.

Sign in / Sign up

Export Citation Format

Share Document