scholarly journals The Rationale for the Intra-Articular Administration of Clodronate in Osteoarthritis

2021 ◽  
Vol 22 (5) ◽  
pp. 2693
Author(s):  
Antimo Moretti ◽  
Marco Paoletta ◽  
Sara Liguori ◽  
Walter Ilardi ◽  
Francesco Snichelotto ◽  
...  
Keyword(s):  
Animal Models ◽  
Scoping Review ◽  
Cartilage Damage ◽  
Joint Inflammation ◽  
Mechanisms Of Action ◽  
Clodronic Acid ◽  
Clinical Role ◽  
Knee Oa ◽  
Positive Effects ◽  
Scoping Reviews

Background: Several pharmacological therapeutic approaches have been proposed to manage osteoarthritis (OA), including intra-articular (IA) injections. Although the discovery of clodronate, a bisphosphonate, dates back to the 1960s and the effects of its IA administration have been investigated for decades in animal models, mechanisms of action of this drug are not quite clear, particularly in OA. This scoping review is an overview of the biological as well as the clinical role of clodronic acid in OA. Method: A scoping review based on the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model was performed to characterize the mechanisms of action of IA clodronate in OA and to evaluate its efficacy from a clinical point of view. Results: Several effects of clodronate have been observed in animal models of OA, including depletion of synovial lining cells that results in reduced production of chemokines (IL-1, TNF- α), growth factors (TGF-β, BMP 2/4), and metalloproteases (MMP 2/3/9); prevention of cartilage damage, synovial hyperplasia, and proteoglycans loss; reduction in joint inflammation, joint swelling, and osteophyte formation. From a clinical perspective, patients with knee OA treated with IA clodronate experienced improvements in pain and joint mobility. Conclusion: Clodronate appears to have different mechanisms of action interfering with the pathogenic processes contributing to OA development and progression. This intervention demonstrated positive effects for patients affected by knee OA.

scholarly journals The use of music for children and adolescents living with rare diseases in the healthcare setting: a scoping review study protocol

2021 ◽  
Vol 4 ◽  
pp. 52
Author(s):  
Simona Karpaviciute ◽  
Alison Sweeney ◽  
Aimee O‘Neill ◽  
Sandra McNulty ◽  
Thilo Kroll ◽  
...  
Keyword(s):  
Music Therapy ◽  
Rare Diseases ◽  
Scoping Review ◽  
Current Knowledge ◽  
Research Question ◽  
Healthcare Setting ◽  
Well Being ◽  
Positive Effects ◽  
Wide Range ◽  
Scoping Reviews

Background: Interest in the application of music in the health, social care and community contexts is growing worldwide. There is an emerging body of literature about the positive effects of music on the well-being and social relationships of children and adult populations. Music has also been found to promote social interaction, communication skills, and social-emotional behaviours of children with medically complex care needs. Despite significant advancements in the area, to the authors’ knowledge, this is the first scoping review to investigate the evidence for using music therapy and music-based interventions for children living with rare diseases in the healthcare setting. Therefore, the purpose of this study is to conduct a scoping review of the literature to map out the existing studies about the use of music therapy and music-based interventions with children who have rare diseases in the healthcare setting. This review will also identify gaps in current knowledge and use of these interventions. Method: This study follows the Joanna Briggs Institute’s methodology for scoping reviews, utilising Arksey and O’Malley’s six-stage scoping review framework: 1) identifying the research question; 2) identifying relevant studies; 3) study selection; 4) charting the data; 5) collating, summarising and reporting results; and 6) consulting with relevant stakeholders step. A comprehensive search will be conducted in CINAHL Complete; MEDLINE Complete; Psychology and Behavioral Sciences Collection; and PubMed Central databases. A search strategy with selected inclusion and exclusion criteria will be used to reveal a wide range of evidence. This study will include quantitative, qualitative and mixed research methods studies published in English from 2010 to 2020.

scholarly journals Explicit and implicit experience of own’s body in painful musculoskeletal disorders and rheumatic diseases: A scoping review protocol of available quantitative and qualitative evidence

2018 ◽  
Vol 6 ◽  
pp. 205031211882002 ◽  
Author(s):  
Antonello Viceconti ◽  
Eleonora Maria Camerone ◽  
Deborah Luzzi ◽  
Matteo Pardini ◽  
Diego Ristori ◽  
...  
Keyword(s):  
Scoping Review ◽  
Eligibility Criteria ◽  
Clinical Role ◽  
Body Experience ◽  
Scoping Reviews ◽  
Ethical Approval ◽  
Review Protocol ◽  
Research Questions ◽  
Meta Analyses ◽  
Population Concept

Introduction: Our body experience is organized at twofold levels: perceptual and cognitive-emotional. These higher-order processes are clearly different from the primary sensory processing of somatic stimuli (somatosensation). However, most of the available studies have mainly investigated the mechanisms of somatosensation. Moreover, disturbances of our body experience have been documented in some pathological conditions of interest for rehabilitative interventions, but their clinical role and relevance is yet to be clarified. Because in this field we have limited knowledge on perceptual and cognitive body experience, there emerges a need to better clarify this matter. The aim of the present scoping review is to systematically map this topic and to examine the magnitude and the nature of the available evidences. Materials and Methods: The scoping review will be performed following the six-stage methodology suggested by Arksey and O’Malley. Ten electronic databases will be investigated since their inception. The search strategy will be peer reviewed by PRESS 2015 Evidence-Based Checklist as a quality assurance step. All records retrieved will be screened by two independent reviewers. The Population, Concept, and Context method will be adopted for eligibility criteria and Preferred Reporting Items for Systematic Reviews and Meta-Analyses will be used for results reporting. Two reviewers with different background will perform the search process independently. One author will extract data, checked by a second reviewer checking the matching with the research questions and goals. Any disagreements will be solved by a third reviewer. Ethics and Dissemination: Ethical approval is not required for scoping reviews. Dissemination will include submission to peer-reviewed journal and presentations in conferences in the area of rehabilitation.

scholarly journals Diabetes self-management education interventions in the WHO African Region: A scoping review

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256123
Author(s):  
Emmanuel Kumah ◽  
Godfred Otchere ◽  
Samuel Egyakwa Ankomah ◽  
Adam Fusheini ◽  
Collins Kokuro ◽  
...  
Keyword(s):  
Scoping Review ◽  
Full Text ◽  
Management Education ◽  
Self Management ◽  
Critical Element ◽  
Cochrane Central Register ◽  
Limited Information ◽  
African Region ◽  
Positive Effects ◽  
Scoping Reviews

Introduction Diabetes mellitus (DM) is one of the commonest chronic diseases worldwide. Self-Management Education (SME) is regarded as a critical element of treatment for all people with diabetes, as well as those at risk of developing the condition. While a great variety of diabetes self-management education (DSME) interventions are available in high-income countries, limited information exists on educational programs for the prevention and management of diabetes complications in Africa. This study, therefore, aimed at synthesizing information in the literature to describe the state of the science of DSME interventions in the WHO African Region. Materials and methods The study is a scoping review, which followed the standard PRISMA guidelines for conducting and reporting scoping reviews. A systematic keyword and subject headings searches were conducted on six electronic databases (PubMed, Scopus, MEDLINE, EMBASE, PsychINFO and the Cochrane Central Register of Controlled Trials) to identify relevant English language publications on DSME from 2000 through 2020. Titles and abstracts of the search results were screened to select eligible papers for full text reading. All eligible papers were retrieved and full text screening was done by three independent reviewers to select studies for inclusion in the final analysis. Results Nineteen studies were included in the review. The interventions identified were individually oriented, group-based, individually oriented & group-based, and information technology-based DSME programs. Outcomes of the interventions were mixed. While the majority yielded significant positive results on HbA1c, diabetes knowledge, blood pressure, blood sugar and foot care practices; few demonstrated positive outcomes on self-efficacy, BMI, physical activity; self-monitoring of blood glucose, medication adherence, smoking and alcohol consumption. Conclusions The limited studies available indicate that DSME interventions in the WHO African Region have mixed effects on patient behaviors and health outcomes. That notwithstanding, the majority of the interventions demonstrated statistically significant positive effects on HbA1c, the main outcome measure in most DSME intervention studies.

scholarly journals Growing up with a Chronically Ill Family Member—The Impact on and Support Needs of Young Adult Carers: A Scoping Review

2022 ◽  
Vol 19 (2) ◽  
pp. 855
Author(s):  
Hinke M. van der Werf ◽  
Marie Louise A. Luttik ◽  
Alice de Boer ◽  
Petrie F. Roodbol ◽  
Wolter Paans
Keyword(s):  
Young Adults ◽  
Young Adult ◽  
Family Member ◽  
Scoping Review ◽  
Chronically Ill ◽  
Support Needs ◽  
Growing Up ◽  
Positive Effects ◽  
Scoping Reviews ◽  
The Impact

This scoping review provides an overview of the impact of growing up with a chronically ill family member on young adults (18–25 years old), and their specific needs. Young adults represent an important life stage involving a transition to adulthood, during which individuals’ family situations can affect their future. We searched relevant studies following the guideline of Arskey and O’Mailley’s methodological framework and the PRISMA statement guidelines for scoping reviews in PubMed, PsychInfo and reference lists to identify articles for inclusion. Studies from 2005 to 2020 were included in this review. Of the 12 studies, six qualitative studies, five quantitative studies and one mixed method study were included. Eight studies discussed the impact, including consequences at a physical and mental level, at their personal development and future perspectives, but also positive effects, such as being capable of organizing their lives. Four studies discussed the needs of young adult carers, including emotional needs, support needs with regard to stimulating autonomy (arising from internal conflicts) and developing their own identity, and the concerned attitude of involved professionals. An unambiguous definition of the target group and further well-designed research are needed to improve clarity about the role of support, so that future professionals can adequately address the needs and wishes of young adults who grow up with an ill family member.

scholarly journals Effectiveness of Social Media-Based Interventions for the Promotion of Physical Activity: Scoping Review

2021 ◽  
Vol 18 (24) ◽  
pp. 13018
Author(s):  
Liane Günther ◽  
Sarah Schleberger ◽  
Claudia R. Pischke
Keyword(s):  
Physical Activity ◽  
Social Media ◽  
Scoping Review ◽  
Underserved Populations ◽  
Population Level ◽  
World Health ◽  
Positive Effects ◽  
Promising Tool ◽  
Scoping Reviews ◽  
Social Media Platforms

A global target of the World Health Organization (WHO) is to reduce physical inactivity among all adults and adolescents by approximately fifteen percent by 2030. Social media could have an impact in this effort because of its enormous reach, potentially addressing underserved populations in need for physical activity (PA) interventions. This scoping review provides a broad overview of social media-based interventions and systematically maps the evidence regarding their effectiveness for PA promotion and other health outcomes. Scopus and Medline were searched using the terms “physical activity” and “social media” and the names of key social media platforms. Following the PRISMA guidelines for scoping reviews, abstracts and full texts were screened for eligibility. In total, 12,321 publications were identified and 53 met the inclusion criteria. The use of Facebook was most prevalent in PA interventions, followed by study-specific platforms. More than one third of the studies revealed positive effects regarding the promotion of PA. Additionally, social media-based interventions positively affected other physical dimensions of health (e.g., weight or blood pressure). Results pertaining to feasibility were heterogeneous. Social media seems to be a promising tool for increasing PA at the population level. Future studies should take the abundance of platforms into account and select social media platforms consciously.

scholarly journals Universal mindfulness training in schools for adolescents: A scoping review and conceptual model of moderators, mediators and implementation factors

2021 ◽  
Author(s):  
Kate Tudor ◽  
Anam Raja ◽  
Shannon Maloney ◽  
Ruth Baer ◽  
Sarah-Jayne Blakemore ◽  
...  
Keyword(s):  
Conceptual Model ◽  
Scoping Review ◽  
Mindfulness Training ◽  
Mediating Effect ◽  
Current Evidence ◽  
Future Research ◽  
Positive Effects ◽  
Scoping Reviews ◽  
Pupil Outcomes ◽  
Implementation Factors

There is evidence that universal school-based mindfulness training (SBMT) can have positive effects for young people. However, it is unknown who benefits most from such training, how implementation quality impacts effects, and how training exerts effects. No known scoping reviews have comprehensively reviewed moderation, mediation and implementation factors of SBMT. This study aimed to provide an overview of the evidence on the mediators, moderators, and implementation factors of SBMT and propose a conceptual model that can be used both to summarize the evidence and provide a framework for future research. A scoping review was performed based on methodology outlined by the Joanna Briggs Institute’s Manual. Six databases and grey literature were searched. Inclusion and exclusion criteria were applied to select relevant material. Quantitative and qualitative information was extracted from eligible articles and reported in accordance with PRISMA-ScR guidelines. The search produced 5, 479 articles, of which 37 were eligible and included in the review. Eight studies assessed moderators of SBMT on pupil outcomes, with mixed findings for all variables tested. Four studies examined the mediating effect of specific variables on pupil outcomes, with evidence that increases in trait mindfulness and decreases in cognitive reactivity and self-criticism post-intervention are related to better pupil outcomes at follow-up. Twenty-five studies assessed implementation factors. We discuss key methodological shortcomings of included studies of SBMT, and integrate our findings with existing implementation frameworks to propose a conceptual model. Widespread interest in universal SBMT has led to increased research over recent years, exploring who SBMT works for and how it might work, but the current evidence is limited. We make recommendations for future research and provide a conceptual model to guide theory-led developments and research in SBMT.

Artificial Intelligence for Skin Cancer Detection: A Scoping Review (Preprint)

2020 ◽  
Author(s):  
Abdulrahman Takiddin ◽  
Jens Schneider ◽  
Yin Yang ◽  
Alaa Abd-Alrazaq ◽  
Mowafa Househ
Keyword(s):  
Artificial Intelligence ◽  
Skin Cancer ◽  
Scoping Review ◽  
Performance Metrics ◽  
Data Extraction ◽  
Characteristic Curve ◽  
Evaluation Metrics ◽  
Cancer Type ◽  
Computer Algorithms ◽  
Scoping Reviews

BACKGROUND Skin cancer is the most common cancer type affecting humans. Traditional skin cancer diagnosis methods are costly, require a professional physician, and take time. Hence, to aid in diagnosing skin cancer, Artificial Intelligence (AI) tools are being used, including shallow and deep machine learning-based techniques that are trained to detect and classify skin cancer using computer algorithms and deep neural networks. OBJECTIVE The aim of this study is to identify and group the different types of AI-based technologies used to detect and classify skin cancer. The study also examines the reliability of the selected papers by studying the correlation between the dataset size and number of diagnostic classes with the performance metrics used to evaluate the models. METHODS We conducted a systematic search for articles using IEEE Xplore, ACM DL, and Ovid MEDLINE databases following the PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines. The study included in this scoping review had to fulfill several selection criteria; to be specifically about skin cancer, detecting or classifying skin cancer, and using AI technologies. Study selection and data extraction were conducted by two reviewers independently. Extracted data were synthesized narratively, where studies were grouped based on the diagnostic AI techniques and their evaluation metrics. RESULTS We retrieved 906 papers from the 3 databases, but 53 studies were eligible for this review. While shallow techniques were used in 14 studies, deep techniques were utilized in 39 studies. The studies used accuracy (n=43/53), the area under receiver operating characteristic curve (n=5/53), sensitivity (n=3/53), and F1-score (n=2/53) to assess the proposed models. Studies that use smaller datasets and fewer diagnostic classes tend to have higher reported accuracy scores. CONCLUSIONS The adaptation of AI in the medical field facilitates the diagnosis process of skin cancer. However, the reliability of most AI tools is questionable since small datasets or low numbers of diagnostic classes are used. In addition, a direct comparison between methods is hindered by a varied use of different evaluation metrics and image types.

scholarly journals Applied sport science and medicine of women’s rugby codes: a systematic-scoping review and consensus on future research priorities protocol

2021 ◽  
Vol 7 (3) ◽  
pp. e001108
Author(s):  
Omar Heyward ◽  
Stacey Emmonds ◽  
Gregory Roe ◽  
Sean Scantlebury ◽  
Keith Stokes ◽  
...  
Keyword(s):  
Scoping Review ◽  
Research Priorities ◽  
Consensus Method ◽  
Future Research ◽  
Delphi Consensus ◽  
Medicine Research ◽  
Sport Science ◽  
Priority Areas ◽  
Wide Range ◽  
Scoping Reviews

Women’s rugby (rugby league, rugby union and rugby sevens) has recently grown in participation and professionalisation. There is under-representation of women-only cohorts within applied sport science and medicine research and within the women’s rugby evidence base. The aims of this article are: Part 1: to undertake a systematic-scoping review of the applied sport science and medicine of women’s rugby, and Part 2: to develop a consensus statement on future research priorities. This article will be designed in two parts: Part 1: a systematic-scoping review, and Part 2: a three-round Delphi consensus method. For Part 1, systematic searches of three electronic databases (PubMed (MEDLINE), Scopus, SPORTDiscus (EBSCOhost)) will be performed from the earliest record. These databases will be searched to identify any sport science and medicine themed studies within women’s rugby. The Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews will be adhered to. Part 2 involves a three-round Delphi consensus method to identify future research priorities. Identified experts in women’s rugby will be provided with overall findings from Part 1 to inform decision-making. Participants will then be asked to provide a list of research priority areas. Over the three rounds, priority areas achieving consensus (≥70% agreement) will be identified. This study has received institutional ethical approval. When complete, the manuscript will be submitted for publication in a peer-reviewed journal. The findings of this article will have relevance for a wide range of stakeholders in women’s rugby, including policymakers and governing bodies.

Factors Related to Positive Memory Count Among Trauma-Exposed Individuals: A Scoping Review

2021 ◽  
pp. 152483802110131
Author(s):  
Ateka A. Contractor ◽  
Stephanie V. Caldas ◽  
Megan Dolan ◽  
Nicole H. Weiss
Keyword(s):  
Scoping Review ◽  
Stress Disorder ◽  
Acute Stress ◽  
Longitudinal Research ◽  
Trauma Exposure ◽  
Memory Specificity ◽  
Scoping Reviews ◽  
Meta Analyses ◽  
Study Designs ◽  
Positive Memories

To examine the existing knowledge base on trauma experiences and positive memories, we conducted a scoping review of trauma and post-trauma factors related to positive memory count. In July 2019, we searched PubMed, Medline, PsycINFO, Web of Science, Cumulative Index of Nursing and Allied Health Literature, Embase, and PTSDpubs for a combination of words related to “positive memories/experiences,” “trauma/posttraumatic stress disorder (PTSD),” and “number/retrieval.” Twenty-one articles met inclusion criteria (adult samples, original articles in English, peer-reviewed, included trauma-exposed group or variable of trauma exposure, trauma exposure examined with a trauma measure/methodology, assessed positive memory count, empirical experimental/non-experimental study designs). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines, two authors reviewed abstracts, completed a secondary search, and independently extracted data. Our review indicated (1) that depression and PTSD were most researched; (2) no conclusive relationships of positive memory count with several psychopathology (depression, acute stress disorder, eating disorder, and anxiety), cognitive/affective, neurobiological, and demographic factors; (3) trends of potential relationships of positive memory count with PTSD and childhood interpersonal traumas (e.g., sexual and physical abuse); and (4) lower positive memory specificity as a potential counterpart to greater overgeneral positive memory bias. Given variations in sample characteristics and methodology as well as the limited longitudinal research, conclusions are tentative and worthy of further investigations.

scholarly journals Mapping evidence on the effects of gender-affirming hormone therapy on the hard and soft tissues of the craniofacial complex in transgender people: a protocol for a scoping review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
M. F. Van den Bosch ◽  
C. M. Wiepjes ◽  
M. Den Heijer ◽  
L. J. Schoonmade ◽  
R. E. G. Jonkman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Scoping Review ◽  
Soft Tissues ◽  
Grey Literature ◽  
Cochrane Library ◽  
Sex Characteristics ◽  
Transgender People ◽  
Link Type ◽  
Scoping Reviews ◽  
Craniofacial Complex

Abstract Background Gender-affirming hormone (GAH) therapy aims to support the transition of transgender people to their gender identity. GAHs can induce changes in their secondary sex characteristics such as the development of breasts in transgender females and increased muscle mass in transgender males. The face and its surrounding tissues also have an important role in gender confirmation. The aim of this scoping review is to systematically map the available evidence in order to provide an overview of the effects of GAH therapy on the hard and soft tissues of the craniofacial complex in transgender people. Methods/design The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA) extension for Scoping Reviews was consulted for reporting this protocol. The methods were based on the Arksey and O’Malley’s framework and the Reviewer’s Manual of the Joanna Briggs Institute for conducting scoping reviews. Ten transgender people were involved in the development of the primary research question through short interviews. The eligibility criteria were defined for transgender people undergoing GAH therapy and for quantitative and qualitative outcomes on the hard and soft tissues of the craniofacial complex. Eligible sources of evidence include observational, experimental, qualitative, and mixed method studies. No exclusion criteria will be applied for the language of publication and the setting. To identify eligible sources of evidence, we will conduct searches from inception onwards in PubMed, Embase.com, the Cochrane Library, Web of Science Core Collection, Scopus, CINAHL, LIVIVO, and various grey literature sources such as Google Scholar. Two reviewers will independently select eligible studies in these information sources and will subsequently conduct data extraction. The same operators will chart, categorize, and summarize the extracted data. A narrative summary of findings will be conducted. Frequency counts of quantitative and qualitative data on items such as concepts, populations, interventions, and other characteristics of the eligible sources will be given. Where possible, these items will be mapped descriptively. Discussion We chose the scoping review over the systematic review approach, because the research questions are broad-spectrum and the literature is expected to be widely scattered. No systematic review has previously assessed this topic. Identifying knowledge gaps in this area and summarizing and disseminating research findings are important for a wide spectrum of stakeholders, in particular, for transgender people who want to undergo additional interventions such as plastic or orthognathic surgery or orthodontics. Systematic review registration This protocol was registered in the Open Science Framework: https://osf.io/e3qj6

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