scholarly journals Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters

2021 ◽  
Vol 22 (9) ◽  
pp. 4716
Author(s):  
Francesco Ciscato ◽  
Lavinia Ferrone ◽  
Ionica Masgras ◽  
Claudio Laquatra ◽  
Andrea Rasola
Keyword(s):  
Endoplasmic Reticulum ◽  
Aerobic Glycolysis ◽  
Neoplastic Progression ◽  
Malignant Growth ◽  
Hexokinase 2 ◽  
Genetic Ablation ◽  
Contact Points ◽  
Survival Pathways ◽  
The Family ◽  
Definition Of

Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family, mainly expressed in insulin-sensitive tissues. HK2 induction in most neoplastic cells contributes to their metabolic rewiring towards aerobic glycolysis, and its genetic ablation inhibits malignant growth in mouse models. HK2 can dock to mitochondria, where it performs additional functions in autophagy regulation and cell death inhibition that are independent of its enzymatic activity. The recent definition of HK2 localization to contact points between mitochondria and endoplasmic reticulum called Mitochondria Associated Membranes (MAMs) has unveiled a novel HK2 role in regulating intracellular Ca2+ fluxes. Here, we propose that HK2 localization in MAMs of tumor cells is key in sustaining neoplastic progression, as it acts as an intersection node between metabolic and survival pathways. Disrupting these functions by targeting HK2 subcellular localization can constitute a promising anti-tumor strategy.

REGULATION OF MARRIAGE RELATIONS IN THE TURKESTAN REGION

2019 ◽  
Vol 22 (2) ◽  
pp. 27-32
Author(s):  
Khurshida Tillahodjaeva ◽  
Keyword(s):  
The Family ◽  
Role Of Women ◽  
Family And Marriage ◽  
Material Conditions ◽  
Definition Of

In this article we will talk about the scale of family and marriage relations in the early XX century in the Turkestan region, their regulation, legislation. Clearly reveals the role of women and men in the family, the definition of which is based on the material conditions of society, equality of rights and freedoms and its features.

Innovative promotional strategies and diversification of flavoured mass merchandise cigar products: a case study of Swedish match

2021 ◽  
pp. tobaccocontrol-2020-056145 ◽  
Author(s):  
Ollie Ganz ◽  
Mary Hrywna ◽  
Kevin R J Schroth ◽  
Cristine D Delnevo
Keyword(s):  
Regulatory Authority ◽  
Business Practice ◽  
Smoking Prevention ◽  
Tobacco Products ◽  
The Family ◽  
Promotional Efforts ◽  
Promotional Strategies ◽  
Definition Of ◽  
The U.S

In 2009, the Family Smoking Prevention and Tobacco Control Act (TCA) granted the U.S. Food and Drug Administration (FDA) regulatory authority over tobacco products, although initially this only included cigarettes, smokeless tobacco and roll-your-own tobacco. In 2016, the deeming rule extended regulatory authority to include all tobacco products, including cigars. The deeming rule prohibited the introduction of new tobacco products into the marketplace without proper marketing authorisation and laid out pathways for tobacco companies to follow. The deeming rule should have frozen the cigar marketplace in 2016. In this paper, we describe how the cigarillo marketplace, nevertheless, continues to diversify with new brands, flavors, styles and packaging sizes entering the market regularly. As an example, we highlight recent promotional efforts by Swedish Match North America (Swedish Match) for their popular cigarillo brands, including White Owl, Night Owl and Garcia y Vega’s Game brand. We argue that ambiguities in the TCA make it unclear whether Swedish Match’s seemingly new cigarillos fit the definition of new tobacco products and, if so, whether they are on the market legally. Swedish Match and other cigarillo companies may be taking advantage of these ambiguities to promote a variety of cigarillo flavors and styles in innovative ways. Given that cigars are combustible tobacco products that pose many of the same risks as cigarettes, this business practice raises significant concerns regarding the protection of public health, particularly among young people.

The limits of the family Evaniidae (Insecta: Hymenoptera) and a new genus from Lebanese Amberamber

2002 ◽  
Vol 33 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Hasan H. Basibuyuk ◽  
Mike G. Fitton ◽  
Alexandr P. Rasnitsyn ◽  
Donald L.J. Quicke
Keyword(s):  
Fore Wing ◽  
New Genus ◽  
Cladistic Analysis ◽  
Wing Venation ◽  
New Genus And Species ◽  
Ground Plan ◽  
The Family ◽  
Definition Of

AbstractThe definition of the family Evaniidae is revised and Cretevaniidae are synonymised with Evaniidae based on evidence derived from recently described Mesozoic taxa and a new genus and species, Lebanevania azari, described here from Lebanese amber. A fore leg with a long trochanter and a 12-segmented antenna are autapomorphies of the new genus. A large, high and wide head and a high and short mesosoma are derived characters shared with other Evaniidae. The new genus also has complete fore wing venation and lacks a tubular petiole, which are ground plan features of the Evanioidea. A cladistic analysis of fossil and extant members of the superfamily Evanioidea and notes on fossil taxa are presented.

XV.—The Placoderm Fish Rhachiosteus pterygiatus Gross and its Relationships

1966 ◽  
Vol 66 (15) ◽  
pp. 377-392 ◽  
Author(s):  
Roger S. Miles
Keyword(s):  
Sensory System ◽  
System A ◽  
The Family ◽  
Definition Of

SynopsisThe holotype and only known specimen of Rhachiosteus pterygiatus Gross is partially redescribed and new restorations are given. Attention is drawn to important points in its osteology and the possible development of a cutaneous sensory system. A definition of the family Rhachiosteidsæ Stensiö is given. This family differs from all other described groups of euarthrodires in the lack of posterior lateral and posterior dorsolateral flank plates. Rhachiosteus is a pachyosteomorph brachythoracid, as defined in the text, and may be fairly closely related in some way to the (coccosteomorph) family Coccosteidsæ. There is no indication that it is closely related to any other known pachyosteomorph, or to other groups of arthrodires, such as the Rhenanida and Ptyctodontida, in which there are no posterior flank plates.

International Conference on Child Day-Care Health: Opening Remarks

PEDIATRICS ◽  
1994 ◽  
Vol 94 (6) ◽  
pp. 987-987
Author(s):  
Hu Ching-Li
Keyword(s):  
Child Health ◽  
Child Nutrition ◽  
Well Being ◽  
Fundamental Rights ◽  
World Health ◽  
Child Day Care ◽  
Infant And Young Child ◽  
The Family ◽  
Definition Of ◽  
Health Organization

It is important to recall the definition of health embodied in the Constitution of the World Health Organization (WHO) over 45 years ago: "Health is a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity. The enjoyment of the highest attainable standard of health is one of the fundamental rights of every human being without distinction of race, religion, political belief, economic, or social condition." Among the Organization's mandated functions is "to promote maternal and child health and welfare and to foster the ability to live harmoniously in a changing total environment." The challenge of that task is no less today than it was then. Historically, societies have evolved various patterns of family structure for social and economic functions. In preindustrial societies there evolved a great concordance between these functions, with many of the health, developmental, and socialization functions taking place first within the family and then within the immediate community. The rapid social changes of both the industrial and information revolutions have changed drastically the functions of the family, and have shifted many of the health, developmental, and social functions to nonfamily institutions, from which families are often excluded or marginally involved. Much of the international attention to child health in this last decade has been directed at simple interventions to prevent the nearly 13 million deaths each year of children under 5: universal child immunization; the control of diarrheal and acute respiratory diseases; and infant and young child nutrition, particularly breast-feeding.

Capitale sociale e salute

2012 ◽  
pp. 135-154
Author(s):  
Luigi Tronca
Keyword(s):  
Social Capital ◽  
Health Outcomes ◽  
Detailed Analysis ◽  
Health Research ◽  
Perceived Health ◽  
Operational Definition ◽  
Causal Processes ◽  
The Family ◽  
Definition Of ◽  
Consumption Strategies

This paper provides a sociological overview of the concept of social capital and explores how it is related to the notion of health. The theoretical section of the study addresses the issue of an operational definition of social capital and conducts detailed analysis of the dimensions and forms of the concept that stand out in terms of importance in the field of health research. It also takes into consideration the most significant causal mechanisms identified between social capital and health outcomes. The empirical part of the paper features analysis of data on the connection between social capital and self-perceived health, collected during the first survey conducted in Italy by the Osservatorio sulle Strategie di Consumo delle Famiglie (Observatory on Consumption Strategies in the Family). The survey shows that community social capital, generally expressed in terms of family trust, may, depending on the subject's social milieu of origin, not play any role in determining the level of self-perceived health in Italy. Alternatively, it may play either of two roles, acting as a multiplier or a substitute with regard to positive causal processes determined by parameters of a socio-demographic nature.

It's about Family: The Death of a Close Family Friend

2009 ◽  
Vol 90 (2) ◽  
pp. 227-230 ◽  
Author(s):  
Joan Beder
Keyword(s):  
Family Structure ◽  
Family Member ◽  
Family Relationships ◽  
Extended Family ◽  
Entire System ◽  
The Family ◽  
Counseling Interventions ◽  
Definition Of ◽  
Close Family

When an individual dies, the role of the family member(s) is clearly prescribed by society: support, presence, caring, and remembrance. Traditionally, the definition of “family” has broadened to create the “extended family” or “expanded family” with members defined by deep bonds, relationships, and friendships. Currently, close friends who become the extended/expanded family, can be as central as kin to family structure and stability. Therefore, when one member of an extended family dies, the death resonates throughout the entire system affecting not only the lives of the immediate family members, but also those in the expanded circle of family relationships. This article describes the relationships in one extended family and discusses the struggles and counseling interventions used when one member of an extended family suddenly dies.

scholarly journals PREGARSIDE MONOIDS AND GROUPS, PARABOLICITY, AMALGAMATION, AND FC PROPERTY

2013 ◽  
Vol 23 (06) ◽  
pp. 1431-1467
Author(s):  
EDDY GODELLE ◽  
LUIS PARIS
Keyword(s):  
Parabolic Subgroup ◽  
Parabolic Subgroups ◽  
Basic Study ◽  
The Family ◽  
Definition Of ◽  
Amalgamated Product

We define the notion of preGarside group slightly lightening the definition of Garside group so that all Artin–Tits groups are preGarside groups. This paper intends to give a first basic study on these groups. Firstly, we introduce the notion of parabolic subgroup, we prove that any preGarside group has a (partial) complemented presentation, and we characterize the parabolic subgroups in terms of these presentations. Afterwards we prove that the amalgamated product of two preGarside groups along a common parabolic subgroup is again a preGarside group. This enables us to define the family of preGarside groups of FC type as the smallest family of preGarside groups that contains the Garside groups and that is closed by amalgamation along parabolic subgroups. Finally, we make an algebraic and combinatorial study on FC type preGarside groups and their parabolic subgroups.

scholarly journals Pollen, Tapetum, and Orbicule Development inColletia paradoxaandDiscaria americana(Rhamnaceae)

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
M. Gotelli ◽  
B. Galati ◽  
D. Medan
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Endoplasmic Reticulum ◽  
Pollen Grains ◽  
Pollen Grain ◽  
Ultrastructural Changes ◽  
Transmission Electron ◽  
The Family ◽  
Tapetal Cells ◽  
Grain Formation

Tapetum, orbicule, and pollen grain ontogeny inColletia paradoxaandDiscaria americanawere studied with transmission electron microscopy (TEM). The ultrastructural changes observed during the different stages of development in the tapetal cells and related to orbicule and pollen grain formation are described. The proorbicules have the appearance of lipid globule, and their formation is related to the endoplasmic reticulum of rough type (ERr). This is the first report on the presence of orbicules in the family Rhamnaceae. Pollen grains are shed at the bicellular stage.

One step up and two steps back? The Italian debate on secularization, heteronormativity and LGBTQ citizenship

2018 ◽  
Vol 65 (5) ◽  
pp. 591-607 ◽  
Author(s):  
Elisa Bellè ◽  
Caterina Peroni ◽  
Elisa Rapetti
Keyword(s):  
Critical Discourse Analysis ◽  
Political Conflict ◽  
Interesting Case ◽  
Critical Discourse ◽  
Political Events ◽  
The Family ◽  
One Step ◽  
Definition Of ◽  
Shed Light

The aim of this article is to furnish insights of the Italian public debate on the recognition of LGBTQ rights, which can be understood as an interesting case study of the complex relationship between (multi)secularisation processes and re/definition of citizenship models. More specifically, the article analyses two political events related to this debate that took place in Rome in June 2015. The first is the Family Day demonstration, promoted by conservative Catholic groups; the second is the LGBTQ Pride parade, promoted by various gay, lesbian and transsexual/gender associations. We analyse the official statements issued by the two organising committees of the demonstrations, adopting the framework and methods of the Critical Discourse Analysis. Above and beyond an evident political conflict between the two discourses, we try to shed light on their mutual construction on the basis of what we call ‘naturalization’ and ‘universalization’ processes.

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