scholarly journals Symptoms of Prenatal Depression Associated with Shorter Telomeres in Female Placenta

2021 ◽  
Vol 22 (14) ◽  
pp. 7458
Author(s):  
Isabel Garcia-Martin ◽  
Richard J. A. Penketh ◽  
Samantha M. Garay ◽  
Rhiannon E. Jones ◽  
Julia W. Grimstead ◽  
...  
Keyword(s):  
Telomere Length ◽  
Elective Caesarean Section ◽  
Depression Scale ◽  
Accelerated Aging ◽  
Cellular Aging ◽  
Prenatal Depression ◽  
Depression Symptoms ◽  
Maternal Mood ◽  
Length Analysis ◽  
The Relationship

Background. Depression is a common mood disorder during pregnancy impacting one in every seven women. Children exposed to prenatal depression are more likely to be born at a low birth weight and develop chronic diseases later in life. A proposed hypothesis for this relationship between early exposure to adversity and poor outcomes is accelerated aging. Telomere length has been used as a biomarker of cellular aging. We used high-resolution telomere length analysis to examine the relationship between placental telomere length distributions and maternal mood symptoms in pregnancy. Methods. This study utilised samples from the longitudinal Grown in Wales (GiW) study. Women participating in this study were recruited at their presurgical appointment prior to a term elective caesarean section (ELCS). Women completed the Edinburgh Postnatal Depression Scale (EPDS) and trait subscale of the State-Trait Anxiety Inventory (STAI). Telomere length distributions were generated using single telomere length analysis (STELA) in 109 term placenta (37–42 weeks). Multiple linear regression was performed to examine the relationship between maternally reported symptoms of depression and anxiety at term and mean placental telomere length. Results: Prenatal depression symptoms were significantly negatively associated with XpYp telomere length in female placenta (B = −0.098, p = 0.026, 95% CI −0.184, −0.012). There was no association between maternal depression symptoms and telomere length in male placenta (B = 0.022, p = 0.586, 95% CI −0.059, 0.103). There was no association with anxiety symptoms and telomere length for either sex. Conclusion: Maternal prenatal depression is associated with sex-specific differences in term placental telomeres. Telomere shortening in female placenta may indicate accelerated placental aging.

scholarly journals Evaluation of the relationship between perceived social support, coping strategies, anxiety, and depression symptoms among hospitalized COVID-19 patients

2020 ◽  
pp. 009121742098208
Author(s):  
Ali Kandeğer ◽  
Memduha Aydın ◽  
Kürşat Altınbaş ◽  
Alparslan Cansız ◽  
Özge Tan ◽  
...  
Keyword(s):  
Social Support ◽  
Coping Strategies ◽  
Perceived Social Support ◽  
Depression Scale ◽  
Negative Association ◽  
Anxiety And Depression ◽  
Control Group ◽  
Depression Symptoms ◽  
Adaptive Coping ◽  
The Relationship

Objective We aimed to evaluate the relationship between perceived social support, coping strategies, anxiety, and depression symptoms among hospitalized COVID-19 patients by comparing them with a matched control group in terms of age, gender, and education level. Method The patient group (n = 84) and the healthy controls (HCs, n = 92) filled in the questionnaire including the socio-demographic form, Hospital Anxiety Depression Scale, Multidimensional Perceived Social Support Scale, and Brief Coping Orientation to Problems Experienced through the online survey link. Results The COVID-19 patients had higher perceived social support and coping strategies scores than the HCs. However, anxiety and depression scores did not differ significantly between the two groups. In logistic regression analysis performed in COVID-19 patients, the presence of chest CT finding (OR = 4.31; 95% CI = 1.04–17.95) was a risk factor for anxiety and the use of adaptive coping strategies (OR = 0.86; 95% CI = 0.73–0.99) had a negative association with anxiety. In addition, the use of adaptive coping strategies (OR = 0.89; 95% CI = 0.79–0.98) and high perceived social support (OR = 0.97; 95% CI = 0.93– 0,99) had a negative association with depression symptoms. Conclusions Longitudinal studies involving the return to normality phase of the COVID-19 pandemic are needed to investigate the effects of factors such as coping strategies and perceived social support that could increase the psychological adjustment and resilience of individuals on anxiety and depression.

scholarly journals Telomere Shortening and Accelerated Aging in US Military Veterans

2021 ◽  
Vol 18 (4) ◽  
pp. 1743
Author(s):  
Jeffrey T. Howard ◽  
Jud C. Janak ◽  
Alexis R. Santos-Lozada ◽  
Sarah McEvilla ◽  
Stephanie D. Ansley ◽  
...  
Keyword(s):  
Telomere Length ◽  
Military Service ◽  
Accelerated Aging ◽  
Cellular Aging ◽  
Veterans Health ◽  
Cvd Risk ◽  
Base Pairs ◽  
Telomere Shortening ◽  
Race Ethnicity ◽  
Service Data

A growing body of literature on military personnel and veterans’ health suggests that prior military service may be associated with exposures that increase the risk of cardiovascular disease (CVD), which may differ by race/ethnicity. This study examined the hypothesis that differential telomere shortening, a measure of cellular aging, by race/ethnicity may explain prior findings of differential CVD risk in racial/ethnic groups with military service. Data from the first two continuous waves of the National Health and Nutrition Examination Survey (NHANES), administered from 1999–2002 were analyzed. Mean telomere length in base pairs was analyzed with multivariable adjusted linear regression with complex sample design, stratified by sex. The unadjusted mean telomere length was 225.8 base shorter for individuals with prior military service. The mean telomere length for men was 47.2 (95% CI: −92.9, −1.5; p < 0.05) base pairs shorter for men with military service after adjustment for demographic, socioeconomic, and behavioral variables, but did not differ significantly in women with and without prior military service. The interaction between military service and race/ethnicity was not significant for men or women. The results suggest that military service may contribute to accelerated aging as a result of health damaging exposures, such as combat, injury, and environmental contaminants, though other unmeasured confounders could also potentially explain the results.

Relationship between perceptions of treatment goals and psychological distress in patients with advanced cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 11621-11621
Author(s):  
Amanda L. Jankowski ◽  
Deborah Anne Forst ◽  
Joseph Greer ◽  
Ryan David Nipp ◽  
Lauren Waldman ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Cognitive Dissonance ◽  
Advanced Cancer ◽  
Depression Scale ◽  
Cross Sectional Study ◽  
Treatment Goal ◽  
Depression Symptoms ◽  
Cross Sectional ◽  
Patients At Risk ◽  
The Relationship

11621 Background: Several studies have demonstrated discordance between how patients perceive their goal of treatment versus how they perceive their oncologist’s goal. Studies evaluating the extent and risk factors of this discordance are lacking. Methods: We conducted a cross-sectional study of 559 patients with incurable lung, gastrointestinal, breast, and brain cancers. We used the Perception of Treatment and Prognosis Questionnaire to assess patients’ perceptions of both their treatment goal and their oncologist’s goal and categorized responses: 1) patients who reported that both their goal and their oncologist’s goal was concordant (either to cure or not to cure); and 2) patients who reported discordant perceptions of their goal versus their oncologist’s goal. We assessed patients’ psychological distress using the Hospital-Anxiety-and-Depression-Scale and used linear regression to assess the relationship between patients’ perceptions of their treatment goal and psychological outcomes. Results: 61.7% of patients reported that both their goal and their oncologist’s goal was non-curative; 19.3% reported that both their goal and their oncologist’s goal was to cure their cancer; and 19.0% reported discordance between their goal and their perception of the oncologist’s goal. Older age (OR = 0.98, P = 0.01), non-Hispanic ethnicity (OR = 0.31, P = 0.049), and higher education (OR = 0.62, P = 0.042) were associated with lower likelihood of reporting discordant goals. Patients with discordant perceptions of their goal and their oncologist’s goal reported higher anxiety (B = 1.56, P = 0.003) compared to those who reported that both their goal and their oncologist’s goal was curative. Patients who reported both their goal and the oncologist’s goal was non-curative had higher depression symptoms (B = 1.06, P = 0.013) compared to those who reported that both their goal and the oncologists’ goal was curative. Conclusions: One-fifth of patients with advanced cancer report discrepancies between their perceptions of their own and their oncologists’ treatment goal which is associated with psychological distress. Tools are needed to identify patients at risk of cognitive dissonance about their prognosis.

scholarly journals Persistence of anxiety symptoms after elective caesarean delivery

BJPsych Open ◽  
2018 ◽  
Vol 4 (5) ◽  
pp. 354-360 ◽  
Author(s):  
Anna B. Janssen ◽  
Katrina A. Savory ◽  
Samantha M. Garay ◽  
Lorna Sumption ◽  
William Watkins ◽  
...  
Keyword(s):  
Elective Caesarean Section ◽  
Depression Scale ◽  
Well Being ◽  
Anxiety Symptoms ◽  
University Hospital ◽  
Depression Symptoms ◽  
Maternal Characteristics ◽  
Prevalence Of Depression ◽  
Expectant Mothers ◽  
The Uk

BackgroundIn the UK, 11.8% of expectant mothers undergo an elective caesarean section (ELCS) representing 92 000 births per annum. It is not known to what extent this procedure has an impact on mental well-being in the longer term.AimsTo determine the prevalence and postpartum progression of anxiety and depression symptoms in women undergoing ELCS in Wales.MethodPrevalence of depression and anxiety were determined in women at University Hospital Wales (2015–16; n = 308) through completion of the Edinburgh Postnatal Depression Scale (EPDS; ≥13) and State-Trait Anxiety Inventory (STAI; ≥40) questionnaires 1 day prior to ELCS, and three postpartum time points for 1 year. Maternal characteristics were determined from questionnaires and, where possible, confirmed from National Health Service maternity records.ResultsUsing these criteria the prevalence of reported depression symptoms was 14.3% (95% CI 10.9–18.3) 1 day prior to ELCS, 8.0% (95% CI 4.2–12.5) within 1 week, 8.7% (95% CI 4.2–13.8) at 10 weeks and 12.4% (95% CI 6.4–18.4) 1 year postpartum. Prevalence of reported anxiety symptoms was 27.3% (95% CI 22.5–32.4), 21.7% (95% CI 15.8–28.0), 25.3% (95% CI 18.5–32.7) and 35.1% (95% CI 26.3–44.2) at these same stages. Prenatal anxiety was not resolved after ELCS more than 1 year after delivery.ConclusionsWomen undergoing ELCS experience prolonged anxiety postpartum that merits focused clinical attention.Declaration of interestNone.

scholarly journals Family function fully mediates the relationship between social support and perinatal depression in rural Southwest China

2021 ◽  
Author(s):  
Yilin Huang ◽  
Yan Liu ◽  
Yu Wang ◽  
Danping Liu
Keyword(s):  
Social Support ◽  
Negative Correlation ◽  
Structural Equation ◽  
Southwest China ◽  
Perinatal Depression ◽  
Depression Scale ◽  
Depression Symptoms ◽  
Family Function ◽  
Modifiable Factors ◽  
The Relationship

Abstract Background: Perinatal depression is the most common complication of gestation and childbearing affecting women and their families, and good social support and family function are considered the protective and modifiable factors. This study aimed to investigate the depression status and explore inter-relationships between social support and perinatal depression considering the influence of family function in rural areas of Southwest China.Methods: This is a cross-sectional study. The following instruments were used: the Edinburgh Postpartum Depression Scale, the APGAR Family Care Index Scale, and the Social Support Rate Scale. A structural equation modelling was used to test the hypothesis relationships among the variables. Results: A total of 490 rural antenatal (N=249) and postpartum(N=241) women (age: 28.17± 5.12) participated. We found that the prevalence of depression symptoms was 10.4%. Path analysis showed that family function had a direct negative correlation with depression (β =-0.251, 95%CI: -0.382 to -0.118). Social support had a direct positive correlation with family function (β =0.293, 95%CI: 0.147 to 0.434) and had an indirect negative correlation with depression (β =-0.074, 95%CI: -0.139 to -0.032), family function fully mediated the relationship between social support and depression. Conclusions: Findings of this study highlight that family function should be considered as the key target for interventions aiming to lower the prevalence of perinatal depression. Family members interventions are critical to reduce depression among antenatal and postpartum women.

scholarly journals Predictive statistical model for the factors associated with prenatal depression among pregnant adolescents in Maha Sarakham province, Thailand

F1000Research ◽  
2020 ◽  
Vol 8 ◽  
pp. 1921
Author(s):  
Bhanwasa Jantasin ◽  
Witaya Yoosook ◽  
Supawadee Thaewpia
Keyword(s):  
Depressive Symptoms ◽  
Statistical Model ◽  
Community Health Centers ◽  
Goodness Of Fit ◽  
Depression Scale ◽  
Prenatal Depression ◽  
Depression Symptoms ◽  
Goodness Of Fit Test ◽  
Pregnant Adolescents ◽  
Cross Sectional

Background: The rate of adolescent pregnancy has steadily increased in Thailand over the years and depression is considered an important psychological problem in many pregnant adolescents. The aims of this study were to determine the proportion of pregnant adolescents with depressive symptoms and to identify a predictive statistical model for the factors related to prenatal depression among adolescents at antenatal care clinics in 10 community health centers in Maha Sarakham Province. Methods: A cross-sectional study was conducted in 230 randomly selected participants who were pregnant adolescents who volunteered to participate in the research, those aged ≤19 years, and had an estimated gestational age of ≤18 weeks. Those with severe obstetrics complications or a psychiatric disorder were excluded. The subjects were asked to complete a demographic questionnaire and the Thai version of the Edinburgh Postnatal Depression Scale. The mean age of participants was 17.0 (±1.4) years. Results: Overall, 43.9% of the adolescents had a cut off score of ≥11, suggestive of prenatal depressive symptoms. Multivariate analysis identified that pregnant adolescents at a primary school education level were 6.5 times more likely to experience depression symptoms than those with a diploma. Those who were emotionally supported by their husband or partner compared to relatives had a five times higher chance of presenting depressive symptoms, and those with a perceived bad relationship with their husband or partner had seven times higher. The model was well-calibrated (goodness-of-fit test, p = 0.675) and had high discriminative power (ROC curve = 0.73 (95%CI = 0.67 to 0.79). Conclusions: More attention is needed to reduce the known problems with pregnant adolescents and to ensure they continue with their education.  Lastly, public education to support mental health initiatives for individuals and families should be encouraged.

scholarly journals Delay discounting, genetic sensitivity, and leukocyte telomere length

2016 ◽  
Vol 113 (10) ◽  
pp. 2780-2785 ◽  
Author(s):  
Onn-Siong Yim ◽  
Xing Zhang ◽  
Idan Shalev ◽  
Mikhail Monakhov ◽  
Songfa Zhong ◽  
...  
Keyword(s):  
Decision Making ◽  
Estrogen Receptor ◽  
Telomere Length ◽  
Delay Discounting ◽  
Receptor Gene ◽  
Cellular Aging ◽  
Leukocyte Telomere Length ◽  
Psychological Resources ◽  
Oxytocin Receptor Gene ◽  
The Relationship

In a graying world, there is an increasing interest in correlates of aging, especially those found in early life. Leukocyte telomere length (LTL) is an emerging marker of aging at the cellular level, but little is known regarding its link with poor decision making that often entails being overly impatient. Here we investigate the relationship between LTL and the degree of impatience, which is measured in the laboratory using an incentivized delay discounting task. In a sample of 1,158 Han Chinese undergraduates, we observe that steeper delay discounting, indexing higher degree of impatience, is negatively associated with LTL. The relationship is robust after controlling for health-related variables, as well as risk attitude—another important determinant of decision making. LTL in females is more sensitive to impatience than in males. We then asked if genes possibly modulate the effect of impatient behavior on LTL. The oxytocin receptor gene (OXTR) polymorphism rs53576, which has figured prominently in investigations of social cognition and psychological resources, and the estrogen receptor β gene (ESR2) polymorphism rs2978381, one of two gonadal sex hormone genes, significantly mitigate the negative effect of impatience on cellular aging in females. The current results contribute to understanding the relationship between preferences in decision making, particularly impatience, and cellular aging, for the first time to our knowledge. Notably, oxytocin and estrogen receptor polymorphisms temper accelerated cellular aging in young females who tend to make impatient choices.

scholarly journals Active And Avoidant Coping Profiles In Children And Their Relationship With Anxiety And Depression During The COVID-19 Pandemic: A Longitudinal Study

2021 ◽  
Author(s):  
Qiaochu Zhang ◽  
Samuel M.Y. Ho ◽  
Yanlin Zhou
Keyword(s):  
Longitudinal Study ◽  
Internalizing Symptoms ◽  
Coping Styles ◽  
Child Anxiety ◽  
Mainland China ◽  
Depression Scale ◽  
Avoidant Coping ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
The Relationship

Abstract Active and avoidant coping styles are important dispositional factors for the development of anxiety and depression symptoms. Children use both active and avoidant coping together in daily life. No studies have investigated the relationship between active-avoidant coping profiles and internalizing symptoms of children in the COVID-19 pandemic. The present study aimed to investigate children’s active-avoidant coping profiles and assess the relationship of active-avoidant coping profiles to anxiety and depression symptoms in the COVID-19 pandemic. A two-wave longitudinal study was conducted among 322 Chinese children in mainland China during the COVID-19 pandemic. Participants completed the Children’s Coping Strategies Checklist – Revised1 in Time 1 and the Revised Child Anxiety and Depression Scale in Time 1 and 6 months later (Time 2). Four active-avoidant coping profiles were revealed: Low Active copers, High Active copers, Balanced copers, and Avoidant copers. Low and High Active copers were related to lower levels of anxiety and depression symptoms than Balanced copers and Avoidant copers. Avoidant copers showed less decrease in depression symptoms than Balanced copers and High Active copers. It is important to improve children's active-avoidant coping profiles for relieving anxiety and depression symptoms during the COVID-19 pandemic.

scholarly journals The Relationship Between Family Support with Depression Levels for HIV/AIDS Patients

2015 ◽  
Vol 2 (2) ◽  
pp. 130-135
Author(s):  
Wiwin Martiningsih ◽  
Fransnedo Dhiky Kurnia C ◽  
Sri Winarni
Keyword(s):  
Family Support ◽  
Depression Scale ◽  
Depression Symptoms ◽  
Inclusion Criteria ◽  
Significance Level ◽  
Symptoms Of Depression ◽  
Clinical Conditions ◽  
The Relationship ◽  
Hiv Aids

AIDS is a collection of specific clinical conditions that are the end result of infection by HIV. This raises the issue of psychiatric illness, namely depression. Depression is what causes the quality of life of patients with HIV / AIDS become less well. To handle this condition needed social support from family. The purposes of this study were to identify family support and levels of depression, and analyzed the correlation between the two variables. This study used correlative as research design. Purposive sampling is used to get samples. The total of study subjects were 34 people who registered in the registration book in January to October 2013, and visited hospitals in Cendana Polyclinic Ngudi Waluyo Hospital Wlingi and included the inclusion criteria. Family support data was obtained base of questionnaire and depression levels was obtained by The Zung Self-Rating Depression Scale questionnaire. Data showed that 94,1% respondents got family support well and  97,1% respondent have not depression symptoms. The correlation between family support with depression levels analyzed using Spearman's rho test with a significance level of p = 0.000, showed that the correlation between family support for the patient's level of depression of HIV / AIDS significantly. From this study can be concluded that the respondents with good family support did not experience symptoms of depression. Families need to provide support for its members who suffer from HIV / AIDS in order to prevent depression.

Relationship between perceptions of treatment goals and psychological distress in patients with advanced cancer.

2018 ◽  
Vol 36 (34_suppl) ◽  
pp. 44-44
Author(s):  
Areej El-Jawahri ◽  
Joseph Greer ◽  
Deborah Anne Forst ◽  
Ryan David Nipp ◽  
Lauren Waldman ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Cognitive Dissonance ◽  
Advanced Cancer ◽  
Depression Scale ◽  
Cross Sectional Study ◽  
Treatment Goal ◽  
Depression Symptoms ◽  
Cross Sectional ◽  
Patients At Risk ◽  
The Relationship

44 Background: Several studies have demonstrated discordance between how patients perceive their goal of treatment versus how they perceive their oncologist’s goal. Studies evaluating the extent and risk factors of this discordance are lacking. Methods: We conducted a cross-sectional study of 559 patients with incurable lung, gastrointestinal, breast, and brain cancers. We used the Perception of Treatment and Prognosis Questionnaire to assess patients’ perceptions of both their treatment goal and their oncologist’s goal and categorized responses: 1) patients who reported that both their goal and their oncologist’s goal was concordant (either to cure or not to cure); and 2) patients who reported discordant perceptions of their goal versus their oncologist’s goal. We assessed patients’ psychological distress using the Hospital-Anxiety-and-Depression-Scale and used linear regression to assess the relationship between patients’ perceptions of their treatment goal and psychological outcomes. Results: 61.7% of patients reported that both their goal and their oncologist’s goal was non-curative; 19.3% reported that both their goal and their oncologist’s goal was to cure their cancer; and 19.0% reported discordance between their goal and their perception of the oncologist’s goal. Older age (OR = 0.98, P = 0.01), non-Hispanic ethnicity (OR = 0.31, P = 0.049), and higher education (OR = 0.62, P = 0.042) were associated with lower likelihood of reporting discordant goals. Patients with discordant perceptions of their goal and their oncologist’s goal reported higher anxiety (B = 1.56, P = 0.003) compared to those who reported that both their goal and their oncologist’s goal was curative. Patients who reported both their goal and the oncologist’s goal was non-curative had higher depression symptoms (B = 1.06, P = 0.013) compared to those who reported that both their goal and the oncologists’ goal was curative. Conclusions: One-fifth of patients with advanced cancer report discrepancies between their perceptions of their own and their oncologists’ treatment goal which is associated with psychological distress. Tools are needed to identify patients at risk of cognitive dissonance about their prognosis.

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