Prevalence and Associated Factors of Depressive Symptoms Among Patients With Chronic Low Back Pain: A Cross-Sectional Study

Background: Few studies have focused on depressive symptoms among patients with chronic low back pain in China. The aim of this cross-sectional study was to assess the prevalence and associated factors of depressive symptoms in patients with chronic low back pain.Methods: From May to August 2021, 1,172 patients with chronic low back pain were recruited in China. Depressive symptoms were assessed through the Patient Health Questionnaire. Associations of demographic characteristics, clinical characters and social-psychological factors with depressive symptoms were investigated among patients with chronic low back pain.Results: The prevalence of depressive symptoms was 25.00%. Logistic regression analysis found that duration of pain in 1-5 years (1-3 years: OR = 2.91, 95%CI: 1.65-5.14, 3-5 years: OR = 3.09, 95%CI: 1.55-6.15) and more severe pain (OR = 1.13, 95%CI: 1.10-1.17) were associated with higher risks of depressive symptoms. Better family function (good family function: OR = 0.25, 95%CI: 0.15-0.41, moderate family dysfunction: OR = 0.47, 95%CI: 0.29-0.77) and higher pain self-efficacy (OR = 0.94, 95%CI: 0.93-0.95) were associated with lower risks of depressive symptoms.Conclusion: Patients with chronic low back pain have a high prevalence of depressive symptoms in China. Duration of pain, pain severity, family function and pain self-efficacy were predictors of depressive symptoms among chronic low back pain patients in China. Early identification of the associated factors may be helpful for the timely management of depressive symptoms.

The Mediational Role of Self-Support Personality in the Association of Family Function and School Belonging in Adolescents

Some previous studies have explored the impact of family function on school belonging. However, little is known about the parallel mediating relationship underlying them. This study aims to investigate the formation mechanism of school beginning in a sample of Chinese adolescents and examined the parallel mediating role of interpersonal self-support and individual self-support in the link between family function and school belonging. A cross-sectional study was conducted in four schools of the district of Hunan province in China, and 741 students were surveyed using cluster sampling. Family cohesion and adaptability scale (FACES), Adolescent students self-supporting personality scale (SSPS-AS), School belonging scale were applied. The results indicated that interpersonal self-support and individual self-support, together, and uniquely, parallel mediated the relationship between family function and school belonging. It can be concluded that family function not only has direct effects on school belonging but also has indirect effects through interpersonal self-support and individual self-support.

The Association Between Family Function and Adolescents' Depressive Symptoms in China: A Longitudinal Cross-Lagged Analysis

The complex interrelationships between family function and adolescents' depressive symptoms are not yet fully clarified, especially in China. Based on the family systems theory, this study explored the relationships between family function and Chinese adolescents' depressive symptoms by a 3-year longitudinal study design. Three waves of data were collected from 1,301 Chinese middle school students in Grade 7 to Grade 9. All participants completed the Chinese Family Assessment Instrument (CFAI) and the Center for Epidemiologic Studies Depression Scale (CES-D) once a year during the junior middle school period. Our results showed that both family function and adolescent depressive symptoms were stable in Grade 7 and Grade 8, but in Grade 9, family function increased and depressive symptoms declined. Furthermore, we found that the family function in Grade 7 negatively influenced depressive symptoms of adolescents in Grade 8, while adolescent depressive symptoms in Grade 8 negatively impacted subsequent family function in Grade 9, namely there was a circular effect between family function and adolescent depressive symptoms. These findings suggest that the associations between family function and adolescents' depressive symptoms are dynamic and time-dependent. Our study contributes to the intervention aimed at the reduction of adolescent depressive symptoms from the family perspective.

Evaluation of Psychosocial Pathways to Family Adaptation of Chinese Patients With Liver Cancer Using the McCubbin's Family Resilience Model

Background and Aim: With the prolonged survival time of patients with liver cancer, these families may face tremendous pressure and development dilemmas that can easily lead to family adaptation crises. Correspondingly, family adaptation crises adversely affect the quality of life of patients and family members. Basing on McCubbin's resilience model of family stress, adjustment, and adaptation, and considering the key factors affecting family resilience based on a review of literature, this study involved a construction of a family adaptation influencing factors model in Chinese liver cancer patients, which was then verified and revised.Methods: This cross-sectional study was conducted between August and December 2020. Using convenience sampling, we selected 265 liver cancer families from the liver tumor center of a teaching hospital affiliated with a university in Shanghai, China. Data from 252 patients with liver cancer and their caregivers were used to identify the factors and pathways associated with family adaptation. The relationships were modeled using structural equations.Results: A total of 265 liver cancer families participated in the survey, and 252 valid questionnaires were returned, with a response rate of 95.09%. The pathway regression coefficients of six factors (family burden, individual resilience, family problem-solving and coping, inner family support, outer family social support, and family function) in the model were found to be statistically significant (P < 0.05), indicating that all of them were significantly associated with family adaptation. Among them, inner family support, outer family social support, and family function were direct influencing factors, while the others were indirect. The path coefficients of the total effect of the determinants on family adaptation were as follows (from largest to smallest): individual resilience (0.562), family function (0.483), outer family social support (0.345), family burden (−0.300), inner family support (0.293), family problem-solving and coping (0.127).Conclusions: Our findings suggest that clinical nurses should not only pay particular attention to direct influencing factors, develop strategies to strengthen the overall family function, encourage patients and caregivers to utilize inner family and outer family social support, but should also consider indirect influence factors, focus on the vital role of the individual, and promote patients' and caregivers' personal and family coping ability.

Penerapan Fungsi Keluarga Dalam Kemampuan Merawat Anggota Keluarga Dengan Stroke

ABSTRACT : APPLICATION OF FAMILY FUNCTIONS IN ABILITY TO CARE FOR MEMBERS FAMILIES WITH STROKES Background: Stroke is a non-communicable disease that is one of the leading causes of death and disability rates in the world. Stroke becomes a health threat due to impaired cerebral function, both focal and global, which lasts quickly and lasts more than 24 hours or ends in death without the discovery of the disease other than vascular disorders (World Health, 2017). World Health Organization (2018) stroke sufferers are increasing every year.. It shows that every year there are 13.7 million new cases of stroke, and about 5.5 million deaths occur from stroke. About 70% of strokes and 87% of stroke deaths and disabilities occur in low- and middle-income countries.Objective: Identified Application of Family Function Intervention in the Ability to Care for Family Members With Stroke in the Puskesmas Area of North Meruya Village of West JakartaMethod: This type of research is case studydesign research that according to Basuki Case Study is a form of research on a problem that has the nature of specificity with individual or group targets, even the wider community. In this study, researchers conducted family function interventions in four families with strokes, namely the same four sufferers were given family function interventions.Results: The results of research conducted the influence of affective function, socialization function, economic function, and health care function with the application of nursing care in stroke patients.Conclusion: The conclusion of this study results in the application of family functions in the ability to care for family members with stroke experienced significant changes to intervention. Keywords: Family Function, Caring Ability, Stroke INTISARI : PENERAPAN FUNGSI KELUARGA DALAM KEMAMPUAN MERAWAT ANGGOTA KELUARGA DENGAN STROKE Latar Belakang: Stroke merupakan penyakit tidak menular yang menjadi salah satu penyebab utama angka kematian dan kecacatan di dunia. Stroke menjadi ancaman kesehatan karena gangguan fungsi serebral, baik fokal maupun global, yang berlangsung dengan cepat dan lebih dari 24 jam atau berakhir dengan kematian tanpa ditemukannya penyakit selain dari pada gangguan vaskular (World Health Organization, 2017). World Health Organization (2018) penderita stroke semakin meningkat setiap tahunnya. Menunjukkan bahwa setiap tahunnya ada 13,7 juta kasus baru stroke, dan sekitar 5,5 juta kematian terjadi akibat penyakit stroke. Sekitar 70% penyakit stroke dan 87% kematian dan disabilitas akibat stroke terjadi pada negara berpendapatan rendah dan menengah.Tujuan: Teridentifikasi Penerapan Intervensi Fungsi Keluarga Dalam Kemampuan Merawat Anggota Keluarga Dengan Stroke di Wilayah Puskesmas Kelurahan Meruya Utara Jakarta BaratMetode: Jenis penelitian ini adalah penelitian case studydesign yaitu menurut Basuki Case Study adalah bentuk penelitian suatu masalah yang memiliki sifat kekhususan dengan sasaran perorangan ataupun kelompok, bahkan masyarakat luas.Pada penelitian ini Peneliti melakukan Intervensi Fungsi keluarga pada empat keluarga dengan stroke yaitu keempat penderita sama – sama diberikan Intervensi Fungsi Keluarga.Hasil: Hasil penelitian yang dilakukan adanya pengaruh fungsi afektif, fungsi sosialisasi, fungsi ekonomi, dan fungsi perawatan kesehatan dengan penerapan asuhan keperawatan pada pasien stroke.Kesimpulan: Kesimpulan dari penelitian ini hasil penerapan fungsi keluarga dalam kemampuan merawat anggota keluarga dengan stroke mengalami perubahan yang signifikan terhadap intervensi. Kata Kunci : Fungsi Keluarga, Kemampuan Merawat, Stroke

The associations between infertility-related stress, family adaptability and family cohesion in infertile couples

To explore the association between infertility-related stress, family adaptability and family cohesion in infertile couples and the determinants of infertility-related stress in infertile couples. Fertility Problem Inventory (FPI) and Family Adaptability and Cohesion Evaluation Scales (FACESII-CV) were used to measure the infertility-related stress and family adaptability and cohesion of infertile couples. T-test, ANOVA and multiple comparisons (LSD) were conducted to compare the FPI scores of different demographic characteristics subgroups. Stepwise multivariate linear regression was used to explore the determinants of infertility-related stress. Women had greater global stress than men (P < 0.001). Women scored higher on desired family adaptability, cohesion dissatisfaction and adaptive dissatisfaction than men (P = 0.039, P = 0.036, P = 0.008). FPI scores were higher in men and women who lived in rural (P < 0.001, P < 0.001). Family cohesion and education level was negatively correlated with infertility-related stress in men. Family adaptability and education level was negatively correlated with infertility-related stress in women. Healthcare providers should pay more attention and give more support to infertile couples who lived in rural or with low education level, and provide easier medical accessing for them. Moreover, healthcare providers should value more the family function and family support in intervention of reducing infertility-related stress.

Dormant spores sense amino acids through the B subunits of their germination receptors

Bacteria from the orders Bacillales and Clostridiales differentiate into stress-resistant spores that can remain dormant for years, yet rapidly germinate upon nutrient sensing. How spores monitor nutrients is poorly understood but in most cases requires putative membrane receptors. The prototypical receptor from Bacillus subtilis consists of three proteins (GerAA, GerAB, GerAC) required for germination in response to L-alanine. GerAB belongs to the Amino Acid-Polyamine-Organocation superfamily of transporters. Using evolutionary co-variation analysis, we provide evidence that GerAB adopts a structure similar to an L-alanine transporter from this superfamily. We show that mutations in gerAB predicted to disrupt the ligand-binding pocket impair germination, while mutations predicted to function in L-alanine recognition enable spores to respond to L-leucine or L-serine. Finally, substitutions of bulkier residues at these positions cause constitutive germination. These data suggest that GerAB is the L-alanine sensor and that B subunits in this broadly conserved family function in nutrient detection.