scholarly journals Anti-SARS-CoV-2 Strategies and the Potential Role of miRNA in the Assessment of COVID-19 Morbidity, Recurrence, and Therapy

2021 ◽  
Vol 22 (16) ◽  
pp. 8663
Author(s):  
Maria Narożna ◽  
Błażej Rubiś
Keyword(s):  
Potential Role ◽  
Therapeutic Strategies ◽  
Diagnostic Methods ◽  
The Other ◽  
Virus Elimination ◽  
High Importance ◽  
Technological Advances ◽  
Biological Potential ◽  
The Face

Recently, we have experienced a serious pandemic. Despite significant technological advances in molecular technologies, it is very challenging to slow down the infection spread. It appeared that due to globalization, SARS-CoV-2 spread easily and adapted to new environments or geographical or weather zones. Additionally, new variants are emerging that show different infection potential and clinical outcomes. On the other hand, we have some experience with other pandemics and some solutions in virus elimination that could be adapted. This is of high importance since, as the latest reports demonstrate, vaccine technology might not follow the new, mutated virus outbreaks. Thus, identification of novel strategies and markers or diagnostic methods is highly necessary. For this reason, we present some of the latest views on SARS-CoV-2/COVID-19 therapeutic strategies and raise a solution based on miRNA. We believe that in the face of the rapidly increasing global situation and based on analogical studies of other viruses, the possibility of using the biological potential of miRNA technology is very promising. It could be used as a promising diagnostic and prognostic factor, as well as a therapeutic target and tool.

Democratization in Serbia: An Analysis of Rational Choice and Structuralist Explanations

2015 ◽  
Author(s):  
Dunja Apostolov-Dimitrijevic
Keyword(s):  
Rational Choice ◽  
Path Dependence ◽  
Theoretical Perspective ◽  
Political Leadership ◽  
Decisive Role ◽  
The Other ◽  
Internal Factors ◽  
Transitional Societies ◽  
The Face

This paper explains political democratization in Post-Milosevic Serbia, utilizing two different accounts of the democratization process: one rooted in the rational choice framework and the other in structuralism. While rational choice explains the decisive role of political leadership in overcoming path dependence, the structuralist explanations show the transnational linkages that encourage democratization in the face of domestic setbacks. This particular debate between the two types of explanations represents the larger debate concerning the role of internal factors and external linkages in propelling democratization in transitional societies. The paper concludes by integrating the two sets of explanations offered by each theoretical perspective, in order to develop a coherent understanding of Serbia's democratization.   Full text available at: https://doi.org/10.22215/rera.v9i1.240

scholarly journals Contribution of the CK2 Catalytic Isoforms α and α’ to the Glycolytic Phenotype of Tumor Cells

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 181
Author(s):  
Francesca Zonta ◽  
Christian Borgo ◽  
Camila Paz Quezada Meza ◽  
Ionica Masgras ◽  
Andrea Rasola ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Therapeutic Strategies ◽  
The Other ◽  
Osteosarcoma Cell ◽  
Monomeric Form ◽  
New Information

CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α’) and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates several substrates related to the uncontrolled proliferation, motility, and survival of cancer cells. As a consequence, tumor cells are addicted to CK2, relying on its activity more than healthy cells for their life, and exploiting it for developing multiple oncological hallmarks. However, little is known about CK2 contribution to the metabolic rewiring of cancer cells. With this study we aimed at shedding some light on it, especially focusing on the CK2 role in the glycolytic onco-phenotype. By analyzing neuroblastoma and osteosarcoma cell lines depleted of either one (α) or the other (α’) CK2 catalytic subunit, we also aimed at disclosing possible pro-tumor functions which are specific of a CK2 isoform. Our results suggest that both CK2 α and α’ contribute to cell proliferation, survival and tumorigenicity. The analyzed metabolic features disclosed a role of CK2 in tumor metabolism, and suggest prominent functions for CK2 α isoform. Results were also confirmed by CK2 pharmacological inhibition. Overall, our study provides new information on the mechanism of cancer cells addiction to CK2 and on its isoform-specific functions, with fundamental implications for improving future therapeutic strategies based on CK2 targeting.

Potential Role of Gut Microbiota in ALS Pathogenesis and Possible Novel Therapeutic Strategies

2018 ◽  
Vol 52 ◽  
pp. S68-S70 ◽  
Author(s):  
Letizia Mazzini ◽  
Luca Mogna ◽  
Fabiola De Marchi ◽  
Angela Amoruso ◽  
Marco Pane ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Potential Role ◽  
Therapeutic Strategies ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Stem Cells from Human Exfoliated Deciduous Teeth and their Promise as Preventive and Therapeutic Strategies for Neurological Diseases and Injuries

2021 ◽  
Vol 17 ◽  
Author(s):  
Lingyi Huang ◽  
Zizhuo Zheng ◽  
Ding Bai ◽  
Xianglong Han
Keyword(s):  
Stem Cells ◽  
Potential Role ◽  
Neurological Diseases ◽  
Therapeutic Strategies ◽  
Deciduous Teeth ◽  
Research Attention ◽  
Considerable Potential ◽  
Prevention And Treatment ◽  
Human Exfoliated Deciduous Teeth

Abstract: Stem cells from human exfoliated deciduous teeth (SHEDs) are relatively easy to isolate from exfoliated deciduous teeth, which are obtained via dental therapy as biological waste. SHEDs originate from the embryonic neural crest and therefore have considerable potential for neurogenic differentiation. Currently, an increasing amount of research attention is focused on the therapeutic applications of SHEDs in neurological diseases and injuries. In this article, we summarize the biological characteristics of SHEDs and the potential role of SHEDs and their derivatives, including conditioned medium from SHEDs and the exosomes they secrete, in the prevention and treatment of neurological diseases and injuries.

scholarly journals The Grand Challenge of Corporate Control: Opening strategy to the normative pressures of networked professionals

2020 ◽  
Vol 1 (4) ◽  
pp. 263178772096969
Author(s):  
Richard Whittington ◽  
Basak Yakis-Douglas
Keyword(s):  
Potential Role ◽  
Corporate Control ◽  
Labour Markets ◽  
The Other ◽  
Grand Challenge ◽  
Big Business ◽  
Research Themes ◽  
The One ◽  
Open Strategy

We propose that the pre-eminent ‘grand challenge’ for organization theorists today is the societal control of powerful corporations. This grand challenge is the more urgent because of the contemporary inadequacies of markets, hierarchies and regulations as instruments of control. We argue for the potential role of ‘open strategy’ in mobilizing normative controls over big business. We develop a distinction between the managed and unmanaged practices of open strategy. Both can help expose corporations to normative pressures, but we highlight the unmanaged open practices of collective subpolitics and individualist whistleblowing. Especially when mobilized by globally networked professionals, these unmanaged practices can subject corporations to normative pressures where markets, hierarchies and regulations fail. We propose two broad research themes relevant to the effectiveness of managed and unmanaged practices of strategic openness: on the one hand, there are material issues to do with labour markets, organizing and technologies; on the other hand, there are discursive questions of authenticity, capability and identity.

Preliminary Studies on Bemitradine-Induced Cardiotoxicity in Female Rats

1991 ◽  
Vol 10 (5) ◽  
pp. 511-523 ◽  
Author(s):  
S. Levin ◽  
D. Semler ◽  
S. Gad ◽  
E. Burton ◽  
G. Walsh ◽  
...  
Keyword(s):  
Potential Role ◽  
The Other ◽  
Female Rats ◽  
Separate Experiment ◽  
Direct Effects ◽  
Primary Metabolite ◽  
T Wave ◽  
Mixed Function Oxidases ◽  
Circulating Levels

The mechanism of bemitradine (SC-33643) cardiotoxicity in female rats was investigated in the set of preliminary experiments reported here. Specifically, the involvement of bemitradine metabolites and the potential role of adrenal epinephrine release were examined. Desethylbemi-tradine (the primary metabolite of bemitradine) was shown to be cardiotoxic at oral dosages greater than 300 mg/kg for 7 days. In a separate experiment, a major metabolite (bemitradine glycol) unique to the rat was not cardiotoxic at dosages up to 600 mg/kg for 7 days. Treatment of rats with SKF 525-A enhanced the lethality and the cardiotoxicity of bemitradine. In contrast, prior treatments of rats with phenobarbital resulted in decreased cardiotoxicity of both bemitradine and desethylbemitradine (a bemitradine metabolite presumably further metabolized by the microsomal mixed function oxidases). In other independent experiments, bemitradine-induced cardiotoxicity was shown to be accompanied by adrenal damage and decreases in adrenal epinephrine. Propranolol (a β-antagonist) treatment protected rats against cardiotoxicity. Bemitradine also had a direct effect on the heart, as evidenced in an experiment in which bemitradine caused dose-related increases in the T-wave of the rat ECG complex. These data suggest that (1) both bemitradine and desethylbemitradine may be responsible for the cardiotoxicity, and the other downstream metabolites are not and (2) cardiotoxicity may be due to the combination of direct effects of bemitradine on the rat heart and the bemitradine-mediated release of adrenal epinephrine (a known cardiotoxin at high circulating levels).

The Great Complement Shift and the role of understood subjects: The case of fearful

2019 ◽  
Vol 53 (1) ◽  
pp. 51-86 ◽  
Author(s):  
Caroline Gentens ◽  
Juhani Rudanko
Keyword(s):  
The Other ◽  
Explanatory Factors ◽  
Diachronic Change ◽  
The Face ◽  
The Senses ◽  
Control Patterns ◽  
The One

Abstract This article reports on a corpus-based study of diachronic change and constructional competition in the system of English complementation, with a focus on variation in non-finite complements of the adjective fearful. Fearful occurs with prepositional (of -ing) subject-controlled gerunds and with to-infinitives, which can further be distinguished into subject extraposition, subject control, and tough-constructions. Recent decades show a drastic decline of the to-infinitival patterns, concomitant to the loss of one of the senses of fearful. We examine the diachronic distribution and competition of the two construction pairs that show functional overlap, i.e. tough-constructions and extraposition constructions on the one hand, and infinitival and gerundial subject-control patterns on the other. This allows us to show the import of the ‘Great Complement Shift’ in the face of constructional attrition and to investigate new principles motivating the choice for either the to-infinitival or the gerundial subject-control construction. More specifically, the study provides further evidence for the ‘Choice Principle’, which involves the (lack of) agentivity of the understood subject in the event described by the lower clause. In this way, the study adds new explanatory factors and descriptive insights to our knowledge of the broader diachronic change known as the Great Complement Shift.

scholarly journals Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias

2009 ◽  
Vol 27 (26) ◽  
pp. 4422-4432 ◽  
Author(s):  
Mustafa Benekli ◽  
Heinz Baumann ◽  
Meir Wetzler
Keyword(s):  
Potential Role ◽  
Cellular Transformation ◽  
Therapeutic Strategies ◽  
Signal Transducer ◽  
Stat Proteins ◽  
Constitutive Activation ◽  
Targeting Signal ◽  
Novel Therapeutic Strategies ◽  
Stat Pathway

Signal transducer and activator of transcription (STAT) proteins comprise a seven-member family of latent cytoplasmic transcription factors that are activated through tyrosine phosphorylation by a variety of cytokines and growth factors. Aberrant activation of STATs accompanies malignant cellular transformation with resultant leukemogenesis. Constitutive activation of STATs has been demonstrated in various leukemias. A better understanding of the mechanisms of dysregulation of the STAT pathway and understanding of the cause and effect relationship in leukemogenesis may serve as a basis for designing novel therapeutic strategies directed against STATs. Mechanisms of STAT activation, the potential role of STAT signaling in leukemogenesis, and recent advances in drug discovery targeting the STAT pathway are the focus of this review.

scholarly journals Consistency of the Disposition Index in the Face of Diet Induced Insulin Resistance: Potential Role of FFA

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e18134 ◽  
Author(s):  
Darko Stefanovski ◽  
Joyce M. Richey ◽  
Orison Woolcott ◽  
Maya Lottati ◽  
Dan Zheng ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Potential Role ◽  
Disposition Index ◽  
The Face

scholarly journals EDUCAR NO PRESENTE EFÊMERO PARA UM FUTURO INCERTO

2019 ◽  
Vol 5 (5) ◽  
pp. 145-167
Author(s):  
José Lauro Martins
Keyword(s):  
21St Century ◽  
Digital Technologies ◽  
The Other ◽  
Technological Advances ◽  
Palabras Clave ◽  
School Model ◽  
The One ◽  
Educational Debate

A crítica de alguns autores quanto ao papel da escola na nova realidade educativa perante as possibilidades de interação e informação, chega a extremos. Há autores que consideram que a escola, diante dos avanços tecnológicos capazes de distribuir com eficiência a informação, perde a razão de existir (PERELMAN, 1992). Embora entenda que este seja um posicionamento reducionista e obtuso, uma vez que o papel da escola não é ou não pode ser apenas o de informar. No contexto deste artigo propomos um viés para o debate educacional para a educação no século XXI: por um lado as tecnologias digitais de comunicação e informação que abalam as estruturas centenárias da educação e por outro a autonomia que esta tecnologia possibilita contrasta com o modelo de escola e da educação oficial que temos.   PALAVRAS-CHAVE: Tecnologias digitais; autonomia, educação.     ABSTRACT The critique of some authors regarding the role of the school in the new educational reality towards the possibilities of interaction and information, reaches to extremes. There are authors who consider that the school, given the technological advances capable of efficiently distributing information, loses its existence reason  (Perelman, 1992). Although understands that this is a reductionist and obtuse position, since the role of the school is not or cannot be just to inform. In the context of this article we propose a bias towards the educational debate for education in the 21st century: on the one side the digital technologies of communication and information that undermine the centennial structures of education and on the other the autonomy that this technology allows contrasts with the school model and the official education we have.   KEYWORDS: Digital technologies; autonomy, education.   RESUMEN La crítica de algunos autores respecto al rol de la escuela en la nueva realidad educativa delante de las posibilidades de interacción e información, llega a extremos. Hay autores que consideran que la escuela, frente a los avances tecnológicos capaces de repartir con eficiencia la información, pierde la razón de existir (PERELMAN, 1992). No obstante entienda que este sea un posicionamiento reduccionista y obtuso, una vez que el rol de la escuela no es o no puede ser solamente el de informar. En el contexto de este artículo proponemos un sesgo para el debate educacional hacia la educación en el siglo XXI: por un lado las tecnologías digitales de comunicación e información que tiemblan las estructuras centenarias de la educación y por otro la autonomía que esta tecnología posibilita y contrasta con el modelo de escuela y de educación oficial que tenemos.   PALABRAS CLAVE: Tecnologías digitales; autonomía, educación.

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