scholarly journals Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis

2021 ◽  
Vol 22 (22) ◽  
pp. 12394
Author(s):  
Yoshitaka Kimura ◽  
Daisuke Tsukui ◽  
Hajime Kono
Keyword(s):  
Uric Acid ◽  
Intracellular Signaling ◽  
Kidney Diseases ◽  
Epidemiological Studies ◽  
Cardiovascular Risks ◽  
Chronic Kidney Diseases ◽  
Intracellular Signaling Pathways ◽  
Atherosclerotic Lesions ◽  
Atherosclerosis Development ◽  
Molecular Signals

Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological studies have also demonstrated an association between cardiovascular risks and hyperuricemia. In hyperuricemia, reactive oxygen species (ROS) are produced simultaneously with the formation of uric acid by xanthine oxidases. Intracellular uric acid has also been reported to promote the production of ROS. The ROS and the intracellular uric acid itself regulate several intracellular signaling pathways, and alterations in these pathways may result in the development of atherosclerotic lesions. In this review, we describe the effect of uric acid on various molecular signals and the potential mechanisms of atherosclerosis development in hyperuricemia. Furthermore, we discuss the efficacy of treatments for hyperuricemia to protect against the development of atherosclerosis.

scholarly journals Serum Creatinine and Uric Acid Levels of Hypothyroid Patients

2013 ◽  
Vol 3 (2) ◽  
pp. 61-63 ◽  
Author(s):  
A Haque Khan ◽  
I Majumder
Keyword(s):  
Uric Acid ◽  
Serum Creatinine ◽  
Thyroid Hormones ◽  
Kidney Diseases ◽  
Clinical Syndrome ◽  
Chronic Kidney Diseases ◽  
Slowing Down ◽  
Hypothyroid Patients ◽  
Good Number ◽  
Biochemical Abnormalities

Hypothyroidism is a clinical syndrome resulting from a deficiency of thyroid hormones which, in turn, results in a generalized slowing down of metabolic processes. It is associated with many biochemical abnormalities including increased serum creatinine and uric acid levels. We reviewed more than 30 articles and a good number of textbooks to evaluate serum creatinine and uric acid levels in hypothyroid patients. We found both these parameters are significantly higher in hypothyroid patients. Chronic kidney diseases (CKDs) also affect thyroid function in many ways leading to decreased T3 and T4. So, it is important for clinicians to differentiate between chronic kidney diseases and hypothyroidism with respect to their causal and consequential entities. DOI: http://dx.doi.org/10.3329/bjmb.v3i2.13814 Bangladesh J Med Biochem 2010; 3(2): 61-63

Drinking water heavy metal toxicity and chronic kidney diseases: a systematic review

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Tahereh Farkhondeh ◽  
Kobra Naseri ◽  
Adeleh Esform ◽  
Hamed Aramjoo ◽  
Ali Naghizadeh
Keyword(s):  
Heavy Metals ◽  
Systematic Review ◽  
Drinking Water ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Epidemiological Studies ◽  
Chronic Kidney Diseases ◽  
Ovid Medline ◽  
Chromium Exposure ◽  
Cadmium Lead

AbstractHeavy metals in drinking water can threat human health and may induce several diseases. The association between heavy metals exposure and chronic kidney disease (CKD) has been indicated by few epidemiological studies. We conducted a systematic review of the epidemiologic publications of the association between exposure to heavy metals through drinking water and CKD. Keywords related to heavy metals and kidney diseases on MeSH were identified and searched in PubMed, Google Scholar, Scopus, Ovid-Medline and Web of Science until July 2020. 14 publications met our inclusion criteria and included in the current review. The included articles were conducted on the association between arsenic, cadmium, lead and chromium in drinking water and CKD. Our study could not find strong evidence between heavy exposure to through drinking water and CKD, except for arsenic. The negative association was found between arsenic and lead and glomerular filtration rate (eGFR). The positive correlation was observed between cadmium exposure and urinary N-acetyl-β-d-glucosaminidase (NAG) concentrations, and also arsenic and chromium exposure and kidney injury molecule (KIM-1). Assessment of studies showed an association between arsenic, cadmium, lead and chromium and albuminuria and proteinuria, without CKD outcomes. Current systematic study showed few evidence for exposure to arsenic, cadmium, lead and chromium through drinking water and incidence of kidney problems. However, more epidemiological studies are required to confirm this association.

scholarly journals Heart Rate As A Risk Factor for Development of Cardiovascular DiseasesA Review

2008 ◽  
Vol 14 (4) ◽  
pp. 324-331 ◽  
Author(s):  
A. A. Svistunov ◽  
T. V. Golovacheva ◽  
K. Yu. Skvortsov ◽  
O. S. Vervikishko
Keyword(s):  
Risk Factors ◽  
Heart Rate ◽  
Epidemiological Studies ◽  
Hemodynamic Changes ◽  
Atherosclerotic Lesions ◽  
Plaque Disruption ◽  
Cardiovascular Morbidity And Mortality ◽  
Atherosclerosis Development ◽  
Asymptomatic Individuals ◽  
Elevated Heart Rate

The results of clinical trials have proved that elevated heart rate (> 80-85 beats/min) at rest is directly related to the risk of arterial hypertension and atherosclerosis development, and it is a powerful predictor of cardiovascular morbidity and mortality. Epidemiological studies have shown that these relationships are independent of other risk factors of atherosclerosis and are present in asymptomatic individuals as well as in patients with cardiovascular diseases. The results of experimental and clinical studies suggest that hemodynamic changes due to elevated heart rate have a direct influence on the arterial wall, favouring the development of atherosclerotic lesions. Moreover, heart rate is directly related to the development of cardiovascular events associated with atherosclerotic plaque disruption. Based on these data we believe that heart rate should be listed among major risk factors for ischemic heart disease

Hyperuricemia as risk factor for cardiovascular disease – what’s new?

2020 ◽  
pp. 5-11
Author(s):  
Yu. V. Zhernakova
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Cardiovascular Risk ◽  
Epidemiological Studies ◽  
Point Of View ◽  
Medical Society ◽  
High Cardiovascular Risk ◽  
Management Algorithm ◽  
Russian Medical

A significant number of epidemiological studies have shown that hyperuricemia is highly associated with the risk of developing cardiovascular disease, chronic kidney disease, and diabetes. In this connection, increased attention is required to monitor serum uric acid levels in patients, not only from a rheumatological point of view, but also with regard to reducing cardiovascular and renal risks. This article is a review of studies on the association of hyperuricemia with cardiovascular risk and a new consensus for the management of patients with hyperuricemia and high cardiovascular risk, published in december 2019 by a group of experts of the Russian Medical Society for Arterial Hypertension, which, among other things, includes a management algorithm of this category of patients.

Sign in / Sign up

Export Citation Format

Share Document