scholarly journals Investigation of the Characteristics and Antibacterial Activity of Polymer-Modified Copper Oxide Nanoparticles

2021 ◽  
Vol 22 (23) ◽  
pp. 12913
Author(s):  
Nan-Fu Chen ◽  
Yu-Hsiang Liao ◽  
Pei-Ying Lin ◽  
Wu-Fu Chen ◽  
Zhi-Hong Wen ◽  
...  
Keyword(s):  
Copper Oxide ◽  
Surface Charge ◽  
Antibacterial Agents ◽  
Metal Oxide Nanoparticles ◽  
Copper Oxide Nanoparticles ◽  
Van Der Waals Interactions ◽  
Oxide Nanoparticles ◽  
Cuo Nps ◽  
Negative Surface ◽  
Negative Surface Charge

The proliferation of drug-resistant pathogens continues to increase, giving rise to serious public health concerns. Many researchers have formulated metal oxide nanoparticles for use as novel antibacterial agents. In the present study, copper oxide (CuO) was synthesized by simple hydrothermal synthesis, and doping was performed to introduce different polymers onto the NP surface for bacteriostasis optimization. The polymer-modified CuO NPs were analyzed further with XRD, FTIR, TEM, DLS and zeta potential to study their morphology, size, and the charge of the substrate. The results indicate that polymer-modified CuO NPs had a significantly higher bacteriostatic rate than unmodified CuO NPs. In particular, polydopamine (PDA)-modified CuO (CuO-PDA) NPs, which carry a weakly negative surface charge, exhibited excellent antibacterial effects, with a bacteriostatic rate of up to 85.8 ± 0.2% within 3 h. When compared to other polymer-modified CuO NPs, CuO-PDA NPs exhibited superior bacteriostatic activity due to their smaller size, surface charge, and favorable van der Waals interactions. This may be attributed to the fact that the CuO-PDA NPs had relatively lipophilic structures at pH 7.4, which increased their affinity for the lipopolysaccharide-containing outer membrane of the Gram-negative bacterium Escherichia coli.

scholarly journals Potential Use of Copper Oxide Nanoparticles from Solanum Trilobatum Against Pathogenic Bacteria

2021 ◽  
Vol 37 (4) ◽  
pp. 991-996
Author(s):  
M. Stella Bharathy ◽  
G. Dayana Jeyaleela ◽  
J. Rosaline Vimala ◽  
A. Agila ◽  
M. Hemadevi
Keyword(s):  
Copper Oxide ◽  
Plant Extract ◽  
Pathogenic Bacteria ◽  
Metal Oxide Nanoparticles ◽  
Spherical Shape ◽  
Inhibitory Effect ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Cuo Nps ◽  
Solanum Trilobatum

Recently, the biosynthesis of metal oxide nanoparticles using plant extract gained great attention compared to other methods. In this work, CuO nanomaterial was synthesized by using the leaf extract of Solanum trilobatum. Synthesized copper oxide nanoparticles were characterized by UV, FT-IR, XRD, SEM, and EDX to determine the functional group, crystalline size, shape, and elemental composition of the synthesized nanoparticles. The X-ray diffraction and SEM results confirmed that the synthesized CuO NPs were crystalline in nature and the average size was found to be 38.34 nm. The spherical shape of CuO NPs was reported in the green approach, but first-time pentagons, cubes, and elongated forms of CuO NPs are found in this work. The EDX studies showed that the Solanum trilobatum mediated CuO NPs contain 53.57 % of copper and 46.43% of oxygen. Synthesized CuO NPs were tested against the five pathogenic bacteria and they showed a very good zone of inhibition compared with copper sulfate and plant extract. Especially against Escherichia Coli, Solanum trilobatum mediated CuO NPs performed well inhibitory effect.

scholarly journals Plant-Based Biosynthesis of Copper/Copper Oxide Nanoparticles: An Update on Their Applications in Biomedicine, Mechanisms, and Toxicity

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 564
Author(s):  
Devanthiran Letchumanan ◽  
Sophia P. M. Sok ◽  
Suriani Ibrahim ◽  
Noor Hasima Nagoor ◽  
Norhafiza Mohd Arshad
Keyword(s):  
Copper Oxide ◽  
Low Cost ◽  
Metal Oxide Nanoparticles ◽  
Cost Effective ◽  
Copper Oxide Nanoparticles ◽  
Synthesis Process ◽  
Oxide Nanoparticles ◽  
Cuo Nps ◽  
Metal Metal ◽  
Reducing Properties

Plants are rich in phytoconstituent biomolecules that served as a good source of medicine. More recently, they have been employed in synthesizing metal/metal oxide nanoparticles (NPs) due to their capping and reducing properties. This green synthesis approach is environmentally friendly and allows the production of the desired NPs in different sizes and shapes by manipulating parameters during the synthesis process. The most commonly used metals and oxides are gold (Au), silver (Ag), and copper (Cu). Among these, Cu is a relatively low-cost metal that is more cost-effective than Au and Ag. In this review, we present an overview and current update of plant-mediated Cu/copper oxide (CuO) NPs, including their synthesis, medicinal applications, and mechanisms. Furthermore, the toxic effects of these NPs and their efficacy compared to commercial NPs are reviewed. This review provides an insight into the potential of developing plant-based Cu/CuO NPs as a therapeutic agent for various diseases in the future.

ANTIBIOTIC PROFILE AND ANTIBACTERIAL ACTIVITY OF COPPER OXIDE NANOPARTICLES AGAINST Pseudomonas fluorescens ISOLATED FROM WOUND INFECTION

2019 ◽  
Vol 9 (o3) ◽  
Author(s):  
Haider Qassim Raheem ◽  
Takwa S. Al-meamar ◽  
Anas M. Almamoori
Keyword(s):  
Antibacterial Activity ◽  
Copper Oxide ◽  
Pseudomonas Fluorescens ◽  
Wide Spectrum ◽  
Copper Oxide Nanoparticles ◽  
Morphological Properties ◽  
Clinical Samples ◽  
Oxide Nanoparticles ◽  
Cuo Nps ◽  
Disk Diffusion Assay

Fifty specimens were collected from wound patients who visited Al-Hilla Teaching Hospital. The samples were grown on Blood and MacConkey agar for 24-48 hr at 37oC. The bacterial isolates which achieved as a pure and predominant growth from clinical samples as Pseudomonas fluorescens, were identified using morphological properties and Vitek2 system. The anti-bacterial activity of copper oxide nanoparticles (CuO NPs) against was tested by (disk diffusion assay) using dilutions of (400, 200, 100, 50, 25, and 12.5‎µ‎g/ml). The (MIC and MBC) of each isolate was determined. CuO NPs shows wide spectrum antibacterial activity against tested bacteria with rise zone of inhibition diameter that is proportionate with the increase in nanoparticle concentration. The MIC of CuO NPs extended from 100-200‎µ‎g/ml and the MBC ranged from 200-400‎µ‎g/ml. The antibiotic profile was determined by Viteck 2 compact system (Biomérieux). CuO NPs‎ found highly effective and safe in P. fluorescens wounds infections comparing with used antibiotics.

scholarly journals Green copper oxide nanoparticles for lead, nickel, and cadmium removal from contaminated water

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alaa El Din Mahmoud ◽  
Khairia M. Al-Qahtani ◽  
Sahab O. Alflaij ◽  
Salma F. Al-Qahtani ◽  
Faten A. Alsamhan
Keyword(s):  
Experimental Data ◽  
Copper Oxide ◽  
Copper Oxide Nanoparticles ◽  
Bet Surface Area ◽  
Oxide Nanoparticles ◽  
Cadmium Removal ◽  
Cuo Nps ◽  
Pseudo Second Order ◽  
Isotherm And Kinetic Models ◽  
Lead Nickel

AbstractEnvironmentally friendly copper oxide nanoparticles (CuO NPs) were prepared with a green synthesis route without using hazardous chemicals. Hence, the extracts of mint leaves and orange peels were utilized as reducing agents to synthesize CuO NPs-1 and CuO NPs-2, respectively. The synthesized CuO NPs nanoparticles were characterized using scanning electron microscopy (SEM), Energy Dispersive X-ray Analysis (EDX), BET surface area, Ultraviolet–Visible spectroscopy (UV–Vis), and Fourier Transform Infrared Spectroscopy (FT-IR). Various parameters of batch experiments were considered for the removal of Pb(II), Ni(II), and Cd(II) using the CuO NPs such as nanosorbent dose, contact time, pH, and initial metal concentration. The maximum uptake capacity (qm) of both CuO NPs-1 and CuO NPs-2 followed the order of Pb(II) > Ni(II) > Cd(II). The optimum qm of CuO NPs were 88.80, 54.90, and 15.60 mg g−1 for Pb(II), Ni(II), and Cd(II), respectively and occurred at sorbent dose of 0.33 g L−1 and pH of 6. Furthermore, isotherm and kinetic models were applied to fit the experimental data. Freundlich models (R2 > 0.97) and pseudo-second-order model (R2 > 0.96) were fitted well to the experimental data and the equilibrium of metal adsorption occurred within 60 min.

scholarly journals Green Synthesis of Copper Oxide Nanoparticles Using Protein Fractions from an Aqueous Extract of Brown Algae Macrocystis pyrifera

Processes ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 78
Author(s):  
Karla Araya-Castro ◽  
Tzu-Chiao Chao ◽  
Benjamín Durán-Vinet ◽  
Carla Cisternas ◽  
Gustavo Ciudad ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Copper Oxide ◽  
Green Synthesis ◽  
Aqueous Extract ◽  
Brown Algae ◽  
Copper Oxide Nanoparticles ◽  
Macrocystis Pyrifera ◽  
Protein Fractions ◽  
Oxide Nanoparticles ◽  
Cuo Nps

Amongst different living organisms studied as potential candidates for the green synthesis of copper nanoparticles, algal biomass is presented as a novel and easy-to-handle method. However, the role of specific biomolecules and their contribution as reductant and capping agents has not yet been described. This contribution reports a green synthesis method to obtain copper oxide nanoparticles (CuO-NPs) using separated protein fractions from an aqueous extract of brown algae Macrocystis pyrifera through size exclusion chromatography (HPLC-SEC). Proteins were detected by a UV/VIS diode array, time-based fraction collection was carried out, and each collected fraction was used to evaluate the synthesis of CuO-NPs. The characterization of CuO-NPs was evaluated by Dynamic Light Scattering (DLS), Z-potential, Fourier Transform Infrared (FTIR), Transmission Electron Microscope (TEM) equipped with Energy Dispersive X-ray Spectroscopy (EDS) detector. Low Molecular Weight (LMW) and High Molecular Weight (HMW) protein fractions were able to synthesize spherical CuO-NPs. TEM images showed that the metallic core present in the observed samples ranged from 2 to 50 nm in diameter, with spherical nanostructures present in all containing protein samples. FTIR measurements showed functional groups from proteins having a pivotal role in the reduction and stabilization of the nanoparticles. The highly negative zeta potential average values from obtained nanoparticles suggest high stability, expanding the range of possible applications. This facile and novel protein-assisted method for the green synthesis of CuO-NPs may also provide a suitable tool to synthesize other nanoparticles that have different application areas.

Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon Nanotubes

2008 ◽  
Vol 21 (9) ◽  
pp. 1726-1732 ◽  
Author(s):  
Hanna L. Karlsson ◽  
Pontus Cronholm ◽  
Johanna Gustafsson ◽  
Lennart Möller
Keyword(s):  
Carbon Nanotubes ◽  
Metal Oxide ◽  
Copper Oxide ◽  
Metal Oxide Nanoparticles ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Synthesis, Characterization, and Antimicrobial Activity of Copper Oxide Nanoparticles

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Maqusood Ahamed ◽  
Hisham A. Alhadlaq ◽  
M. A. Majeed Khan ◽  
Ponmurugan Karuppiah ◽  
Naif A. Al-Dhabi
Keyword(s):  
Antimicrobial Activity ◽  
Electron Microscope ◽  
Copper Oxide ◽  
Field Emission ◽  
Copper Oxide Nanoparticles ◽  
Klebsiella Pneumonia ◽  
Oxide Nanoparticles ◽  
Xrd Pattern ◽  
X Ray ◽  
Cuo Nps

We studied the structural and antimicrobial properties of copper oxide nanoparticles (CuO NPs) synthesized by a very simple precipitation technique. Copper (II) acetate was used as a precursor and sodium hydroxide as a reducing agent. X-ray diffraction patter (XRD) pattern showed the crystalline nature of CuO NPs. Field emission scanning electron microscope (FESEM) and field emission transmission electron microscope (FETEM) demonstrated the morphology of CuO NPs. The average diameter of CuO NPs calculated by TEM and XRD was around 23 nm. Energy dispersive X-ray spectroscopy (EDS) spectrum and XRD pattern suggested that prepared CuO NPs were highly pure. CuO NPs showed excellent antimicrobial activity against various bacterial strains (Escherichia coli,Pseudomonas aeruginosa,Klebsiella pneumonia,Enterococcus faecalis,Shigella flexneri,Salmonella typhimurium,Proteus vulgaris,andStaphylococcus aureus). Moreover,E. coliandE. faecalisexhibited the highest sensitivity to CuO NPs whileK. pneumoniawas the least sensitive. Possible mechanisms of antimicrobial activity of CuO NPs should be further investigated.

scholarly journals Development of non-enzymatic cholesterol electrochemical sensor based on CuO(NPs)-Polyaniline-Murexide composite

2021 ◽  
Author(s):  
Chedia Ben Ali Hassine ◽  
Hamza Kahri ◽  
Houcine Barhoumi
Keyword(s):  
Impedance Spectroscopy ◽  
Copper Oxide ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Linear Sweep Voltammetry ◽  
High Sensitivity ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Carbon Electrode ◽  
Cuo Nps

Abstract In this study, a novel non-enzymatic sensor based on copper oxide nanoparticles (CuO), polyaniline nanofibers (PANI) and murexide (Mu) modified glassy carbon electrode was developed and used for the detection of cholesterol. Copper oxide nanoparticles were deposited on the glassy carbon electrode through electrodeposition and electrochemical oxidation followed by electrodeposition of PANI-Mu composite. The as prepared CuO-PANI-Mu sensor was characterized using electrochemical, optical and morphological methods such as cyclic voltammetry (CV), impedance spectroscopy (EIS), linear sweep voltammetry (LSV), UV-visible and scanning electron microscopy (SEM). The elaborated composite matrix was used for cholesterol detection employing the impedance spectroscopy method. As a result, good analytical performances were obtained for cholesterol quantification with good stability and high sensitivity (5575 Ω/M) with a wide linear range from 0.5nM to 50mM.

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