scholarly journals Proteomic Studies of Blood and Vascular Wall in Atherosclerosis. Review

2021 ◽  
Vol 22 (24) ◽  
pp. 13267
Author(s):  
Ekaterina Mikhailovna Stakhneva ◽  
Evgeniia Vitalievna Striukova ◽  
Yulia Igorevna Ragino
Keyword(s):  
Protein Structures ◽  
Clinical Manifestations ◽  
Vascular Wall ◽  
Pathological Process ◽  
Carotid Artery Atherosclerosis ◽  
Coronary Syndrome ◽  
Arduous Task ◽  
Atherosclerotic Cardiovascular Diseases ◽  
Disease Analysis ◽  
Potential Biomarkers

The review is devoted to the analysis of literature data related to the role of proteomic studies in the study of atherosclerotic cardiovascular diseases. Diagnosis of patients with atherosclerotic plaques before clinical manifestations is an arduous task. The review presents the results of research on the new proteomic potential biomarkers of coronary heart disease, coronary atherosclerosis, acute coronary syndrome, myocardial infarction, carotid artery atherosclerosis. Also, the analysis of literature data on proteomic studies of the vascular wall was carried out. To assess the involvement of proteins in the pathological process of atherosclerosis, it is important to investigate the specific relationships between proteins in the arteries, expression and concentration of proteins. The development of proteomic technologies has made it possible to analyse the number of proteins associated with the development of the disease. Analysis of the proteomic profile of the vascular wall in atherosclerosis can help to detect possible diagnostically significant protein structures or potential biomarkers of the disease and develop novel approaches to the diagnosis of atherosclerosis and its complications.

scholarly journals Modern Concepts of Fibromuscular Dysplasia of the Coronary Arteries

2019 ◽  
Vol 15 (3) ◽  
pp. 431-438
Author(s):  
E. L. Trisvetova
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Arteries ◽  
Fibromuscular Dysplasia ◽  
Clinical Manifestations ◽  
Intramural Hematoma ◽  
Vascular Wall ◽  
Vascular Lesion ◽  
Diagnostic Methods ◽  
International Consensus ◽  
Coronary Syndrome

Fibromuscular dysplasia of the coronary arteries is a rare non-atherosclerotic and non-inflammatory vascular lesion that is asymptomatic until serious complications develop: stenosis, dissection, rupture, sudden cardiac death. Since there are no long-term numerous clinical observations of patients with fibromuscular dysplasia of the coronary arteries, recommendations have not been developed for diagnosing and treating the disease, which often manifests with acute coronary syndrome. In 2014, the European Consensus was published, and in 2019, the first international consensus document on the diagnosis and treatment of fibromuscular dysplasia with lesions of vessels from different regions (renal, cerebrovascular, coronary, and others). The documents state that the development of fibromuscular dysplasia of the coronary arteries considers the participation of the PHACTR1 gene mutation and the transcriptional activity of the EDN1 gene, smoking, prolonged exertion of the vascular wall, and possibly female sex hormones. In the case of acute coronary syndrome, the most informative diagnostic method is computed tomography with angiography, which reveals a smooth narrowing of the lumen in the middle or distal section in the epicardial artery, often due to intramural hematoma, and also finds dissection, spasm, and tortuous vessel. Additional diagnostic methods ‒ intravascular ultrasound and optical coherence tomography allow differentiation of fibromuscular dysplasia with atherosclerosis of the coronary artery, vasculitis, and other diseases. The choice of treatment tactics for fibromuscular dysplasia of the coronary arteries depends on the severity of the clinical manifestations ‒ conservative medical treatment and interventional methods are used.

Disseminated intravascular coagulation syndrome

2020 ◽  
pp. 22-40
Author(s):  
A. Kulikov
Keyword(s):  
Clinical Practice ◽  
Disseminated Intravascular Coagulation ◽  
Blood Cells ◽  
Physical State ◽  
Clinical Manifestations ◽  
Vascular Wall ◽  
Stages Of Development ◽  
Intravascular Coagulation ◽  
Hemostatic Disorder

Presented material reveals main links in the pathogenesis of hemostatic disorder. In particular, attention is paid to the role of the lungs, liver and other organs in the development of this process. Role of vascular wall and blood cells in regulation of the physical state of blood is described in detail. The most frequent factors leading to hypercoagulation are indicated. Difference between hypercoagulation and thrombophilia is shown. The latter is found in clinical practice quite often, but at the same time, it is poorly diagnosed. Such a terrible complication of hemostatic disorder as disseminated intravascular coagulation is described. Its classification, stages of development, clinical manifestations are offered to the readers.

scholarly journals Hepatic involvement in sarcoidosis

2019 ◽  
Vol 91 (4) ◽  
pp. 4-12
Author(s):  
V V Fomin ◽  
M Yu Brovko ◽  
M V Kalashnikov ◽  
V I Sholomova ◽  
T P Rozina ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Pathological Process ◽  
Unknown Etiology ◽  
Primary Biliary Cholangitis ◽  
Treatment Protocols ◽  
Hepatic Involvement ◽  
Wide Range ◽  
Hepatic Sarcoidosis

Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Liver is frequently involved in the pathological process. Wide range of clinical manifestations can be seen: from asymptomatic lesion with normal liver function tests to cirrhosis with portal hypertension. Biopsy plays the key role in diagnosis of the hepatic sarcoidosis. It is essential for morphological diagnosis to exclude other causes of granulomatous liver disease, most often - primary biliary cholangitis. Nowadays there are no standard treatment protocols for patients with hepatic sarcoidosis.

scholarly journals Heat Therapy to Reduce Chest-Pain Among Patients with Acute Coronary Syndromes (ACS): A Literature Review

2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Aan Nur'aeni ◽  
Yanny Trisyani ◽  
Donny Nurhamsyah ◽  
Oman Hendi ◽  
Rahmalia Amni ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Chest Pain ◽  
Literature Review ◽  
Meta Analysis ◽  
Clinical Manifestations ◽  
Inclusion Criteria ◽  
Coronary Syndrome ◽  
Heat Therapy ◽  
Nonpharmacological Intervention ◽  
Analgesic Opioids

The main clinical manifestations of patients with Acute Coronary Syndrome (ACS) during the acute period is chest pain. Handling complaints of pain patients with ACS definitively done with medication; however, it is possible to do additional nonpharmacological therapies to optimize the results. Nonpharmacological treatment can be performed in various ways, one of them with heat therapy. This literature review aimed to determine the use of heat therapy as an additional nonpharmacological intervention in reducing the intensity of chest pain in patients with ACS. Four electronic databases were used to carry out systematic searches on articles, namely Proquest, Science Direct, Pubmed, and CINAHL-Ebsco. The combination of keywords was "heat therapy" AND "chest pain" AND "acute coronary syndrome" NOT "Literature review" OR "Literature review" OR "Overview" OR "Systematic Review" OR "Meta-analysis." The inclusion criteria used were experimental study articles, peer-reviewed articles, and research articles written in English and performed in the period between 2014-2019. The search results obtained three articles that met the inclusion criteria and analyzed. The results of the study found that heat therapy effective in reducing the intensity of chest pain, the use of analgesic opioids, and improving the patient's hemodynamics. In conclusion, the therapy can be considered used as adjunctive therapy to reduce chest pain in patients with ACS with certain criteria. In addition, further research is also needed to see the effectiveness of this therapy if it is implemented with more frequent frequencies and compare its effectiveness in reducing chest pain if the application is given to the anterior or posterior of the chest.

scholarly journals Structural composition and clinical features of dermatological patients with keratinocytic skin tumors

2021 ◽  
Vol 67 (1) ◽  
pp. 91-96
Author(s):  
Rustem Khasanov ◽  
Elena Faizullina ◽  
Irina Khismatulina ◽  
Azat Murtazin
Keyword(s):  
Skin Cancer ◽  
Medical Care ◽  
Clinical Features ◽  
Basal Cell ◽  
Clinical Manifestations ◽  
Pathological Process ◽  
Skin Tumors ◽  
Long Period ◽  
Nasal Region ◽  
Common Malignancy

Basal cell skin cancer (BCС) is the most common malignancy that is found in dermatological practice. The purpose of the study: to determine the structure of clinical manifestations of BCС in ambulant dermatological patients. The study was conducted from 2015 to 2017 in a private clinic in Kazan, which has a license to provide medical care in the specialties "dermatovenerology" and "surgery". We studied the results of examination of 2730 patients with skin tumors available in outpatient cards. 101 patients with histologically verified BCС were examined, including 29% of men (n=29) and 71% of women (n=72), the average age was 59.7±14.9 years (median – 61.5 years). The percentage of patients with BCС among patients with all skin malignancies at the dermatological reception was 95.3% (n=101). Most often, patients aged 60-74 years suffered from BCС: women – in 21.0% (n=21) and men – in 16.0% (n=16), respectively. The proportion of women aged 45-59 years was significantly higher – 20.0%, than the proportion of men – 9.0% (p<0.05). Men were significantly more likely to see a dermatologist – 55.0% in less than a year from the onset of the disease, than women – 21.4% (p<0.01). The proportion of women (44.6%) who noted the appearance of a tumor over a long period (≥5 years) was significantly less than the proportion of men 15.0% (p<0.05). The most common variant of BCС was the nodular form n=77 (76.2%), in which the primary elements of 80.5% were identified by dermatologists as single 5-10 mm papules. The oculo-fronto-nasal region was involved in the pathological process in 47.5% (n=48) of cases, which is significantly more frequent than in other localisations (p<0.05). Dermatoscopy improved the visualization of the atypical vascular network.

Diseases of cardiovascular system in patients with severe and moderatesevere forms of psoriasis

2021 ◽  
pp. 21-23
Author(s):  
A. A. Hotko ◽  
M. Yu. Pomazanova ◽  
Y. V. Kozyr
Keyword(s):  
Skin Lesions ◽  
Pathological Process ◽  
Practical Significance ◽  
Case Histories ◽  
Cardiac Pathology ◽  
Coronary Syndrome ◽  
Organ Systems ◽  
Body Organ ◽  
Krasnodar Region ◽  
Medical Histories

Psoriasis is one of the most common chronic recurrent dermatoses, which is not limited to skin lesions, leading to a violation of the functions of various body organ systems. The article presents the results of the analysis of the medical histories of patients of Clinical dermatovenerologic dispensary (Krasnodar Region of Russia) with moderate-severe and severe forms of psoriasis and concomitant cardiological pathology. The article presents data from 70 case histories of patients with moderate to severe psoriasis, the analysis of which shows the clinical and practical significance of comorbidity of psoriasis. From the analysis, we conclude that there is a direct relationship between the severity of the course of the cutaneous pathological process and the aggravation of the cardiological diagnosis. The higher the severity of psoriasis, the higher the risk of developing acute coronary syndrome, myocardial infarction and other cardiac pathology.

scholarly journals Compositional and micromorphological features of hypoplastic enamel in children’s permanent teeth

2020 ◽  
Vol 22 ◽  
pp. 02013
Author(s):  
Natalya Ozhgikhina ◽  
Daria Kiseleva ◽  
Evgeny Shagalov ◽  
Evgenia Bimbas ◽  
Natalya Myagkova
Keyword(s):  
Protein Structures ◽  
Clinical Manifestations ◽  
Local Environment ◽  
Comparative Investigation ◽  
Permanent Teeth ◽  
Common Disease ◽  
Enamel Hypoplasia ◽  
Globular Structure ◽  
Prismatic Structure ◽  
Irregular Structure

Enamel hypoplasia is the most common disease of hard tooth tissues of non-carious origin emerging before their eruption. It develops as a result of a delayed and perverse function of ameloblasts leading to the violation of the processes of formation and mineralization of tooth protein structures. The clinical manifestations of enamel hypoplasia are spots, defects in the form of pits, cup-shaped depressions, grooves on various surfaces of child’s teeth. The work is devoted to a comparative investigation of microstructural and compositional features of intact and hypoplastic enamel in children’s permanent teeth using analytical scanning electron microscopy with energy-dispersive X-ray spectroscopy. The hypoplastic enamel is enriched in organic substance and has an irregular structure without keyhole-shaped prismatic structure. Mineral deposition is indicated for hypoplastic enamel including hydroxyapatite with globular structure and calcite and halite, which might have been caused by the violation of extracellular local environment probably due to the enamel hypoplasia development.

scholarly journals Spontaneous psoas abscess: presenting with phlegmasia cerulea dolens

2011 ◽  
Vol 93 (4) ◽  
pp. e15-e16 ◽  
Author(s):  
Jagwinder Dhaliwal ◽  
Ajanta Jayatunga
Keyword(s):  
Lower Extremity ◽  
Complete Resolution ◽  
Early Recognition ◽  
Psoas Abscess ◽  
Pathological Condition ◽  
Clinical Manifestations ◽  
Pathological Process ◽  
Successful Outcome ◽  
Life Threatening ◽  
Phlegmasia Cerulea Dolens

Phlegmasia cerulea dolens (PCD) is a limb-threatening venous disorder involving massive proximal venous thrombosis. The clinical manifestations are of oedema, cyanosis and pain of lower extremity. Patients presenting with PCD have an underlying pathological condition that predisposes to the thrombotic process. We report a diabetic patient who presented with PCD and septicaemia due to a spontaneous psoas abscess. Anticoagulation with heparin and treatment of the underlying psoas abscess led to complete resolution of symptoms. An understanding of the underlying pathological process responsible is vital to early recognition and successful outcome in this rare limb- and life-threatening venous disorder.

5-LIPOOXYGENASE ACTIVITY IN THE HUMAN VESSEL WALL

1987 ◽  
Author(s):  
WALL R De Caterina ◽  
D Giannessi ◽  
G Lazzerini ◽  
A Mazzone ◽  
A Azzara ◽  
...  
Keyword(s):  
White Blood Cells ◽  
Clinical Manifestations ◽  
Calcium Ionophore ◽  
Vascular Wall ◽  
Blood Stream ◽  
Selective Exposure ◽  
Mechanical Agitation ◽  
Standard Curve ◽  
Saphenous Veins ◽  
Inner Vessel

5-lipooxygenase products have been identified from a variety of cells and may play a role in the progression of atherosclerosis and in its clinical manifestations (spasm, thrombosis). We investigated whether human vascular fragments, freshly obtained at surgery, are able to produce leukotriene (LT) B4, a definite end product of 5-lipooxygenase, provided with biological activity. Fragments obtained from human saphenous veins (n=21) or aorta (fibrous plaques, n=15, atheromas, n=16) were incubated in buffer at 37°C with mechanical agitation sequentially in the absence (15 min) and in the presence (15 min) of 10 jjM calcium ionophore A-23187. At the end of each incubation, the buffer was sampled to be assayed by a specific radioimmunassay (RIA) for LTB4 (sensitivity 4.3+0.9 pg). Validation of the assay was performed by comparison with a chemotactic bioassay in Boyden chambers, by interpolation of a standard curve evaluating the chemotactic response of neutrophils to a standard LTB4 preparation. RIA resulted the only practicable method to detect concentrations lower than 2.5 ng/ml, compared both to bioassay and to HPLC, all three performed in the incubation media from 8 vascular fragments. Incubations were also performed in a chamber with selective exposure of the endothelial surface in order to detect possible production of LTB4 on the luminal site of the vessel. Both unstimulated and ionophore-stimulated LTB4 were higher (P< 0.01) in atheromas (2.7±1.2 and 6.3±1.8) than in fibrous plaques (0.51±0.22 and 1.19±0.38) or saphenous veins (0.74±0.34 and 3.07±1.39) (ng/g wet weight, mean±SD). Detectable spontaneous and stimulated LTB4 productions were also found in the incubation media of the chamber with atheromas (40±14 and 324±85 pg/cm2 area, respectively). Histology of the fragments confirmed a higher cellularity (macrophages, atherocytes) in atheromas as compared to fibrous plaques and veins. The human vascular wall is a definite site of 5-lipooxygenase activity, possibly arising from white cell infiltration. LTB4 production, able to reach the inner vessel surface and the blood stream, is a possible factor in the progression of the lesion by increasing vascular permeability or recruiting white blood cells.

Tu-P8:298 Protein structures for regeneration of vascular wall

2006 ◽  
Vol 7 (3) ◽  
pp. 250
Author(s):  
E. Filova ◽  
E. Brynda ◽  
L. Bacakova ◽  
M. Houska ◽  
T. Riedel
Keyword(s):  
Protein Structures ◽  
Vascular Wall
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