scholarly journals The Role of Filippi’s Glands in the Silk Moths Cocoon Construction

2021 ◽  
Vol 22 (24) ◽  
pp. 13523
Author(s):  
Hana Sehadova ◽  
Radka Zavodska ◽  
Lenka Rouhova ◽  
Michal Zurovec ◽  
Ivo Sauman
Keyword(s):  
Posttranslational Modifications ◽  
Proteomic Analysis ◽  
Significant Contribution ◽  
Chain Molecule ◽  
Secretory Structures ◽  
Silk Cocoon ◽  
Silk Moth ◽  
Silk Glands ◽  
Formation Behavior

Filippi’s glands (FGs), formerly also called Lyonet’s glands, are accessory secretory structures of the labial (silk) glands of lepidopteran caterpillars, which were implicated to play an important role in the maturation of the silk material and the construction of the cocoon. In our previous study, we have identified several species of giant silk moths that completely lack the FGs. Interestingly, the absence of FGs in these species correlates with the construction of a loose cocoon architecture. We investigated the functions of FGs by their surgical extirpation in the last instar larvae of the silkworm, Bombyx mori. We found that the absence of FGs altered the structure of the resulting cocoon, in which the different layers of silk were separated. In further experiments, we found no effects of the absence of FGs on larval cocoon formation behavior or on changes in cocoon mass or lipid content. Differential proteomic analysis revealed no significant contribution of structural proteins from FGs to silk cocoon material, but we identified several low abundance proteins that may play a role in posttranslational modifications of some silk proteins. Proteomic analysis also revealed a difference in phosphorylation of the N-terminal sequence of fibroin-heavy chain molecule. Thus, FGs appear to affect silk stickiness during spinning by regulating posttranslational modifications. This could also explain the link that exists between the absence of these glands and the formation of loose cocoons in some giant silk moth species.

scholarly journals The Filippi’s Glands of Giant Silk Moths: To Be or Not to Be?

Insects ◽  
2021 ◽  
Vol 12 (11) ◽  
pp. 1040
Author(s):  
Hana Sehadova ◽  
Radka Zavodska ◽  
Michal Zurovec ◽  
Ivo Sauman
Keyword(s):  
Larval Development ◽  
Larval Growth ◽  
Light And Electron Microscopy ◽  
Phylogenetic Position ◽  
Complex Type ◽  
Silk Cocoon ◽  
Hawk Moth ◽  
Silk Moth ◽  
Silk Glands ◽  
Moth Species

The Filippi’s glands (FGs), formerly “Lyonet’s glands”, are paired accessory organs associated with the silk glands. They are unique to Lepidoptera caterpillars and their exact role is not clear. The FGs are thought to be involved in the construction of a silk cocoon in bombycoid moths. FGs can differ in size and shape, therefore, in this study we attempt to find a correlation between FG morphology and phylogenetic position within the Bombycoidea. We use light and electron microscopy to examine the presence and morphology of FGs in a range of wild (giant) silk moths and several related species. Our results confirm that the majority of studied silk moth species have complex type of FGs that continuously increase in size during larval development. We identified several species of giant silk moths and two hawk moth species that completely lack FGs throughout their larval development. Finally, in several hawk moth species in which FGs are well developed during the first larval stage, these glands do not grow and remain small during later larval growth. Our results suggest that FGs are not critical for spinning and that loss of FGs occurred several times during the evolution of saturniids and sphingids. Comparison of FGs in different moths is an important first step in the elucidation of their physiological significance.

Economic Development of Bangladesh: The Role of IBBL

IIUC Studies ◽  
2015 ◽  
Vol 9 ◽  
pp. 323-334
Author(s):  
Shafiqur Rahman ◽  
Nicholas McDonald
Keyword(s):  
Economic Development ◽  
Content Analysis ◽  
Foreign Trade ◽  
Rural Economy ◽  
Significant Contribution ◽  
Annual Report ◽  
Housing Sector

This paper presents the role of Islami Bank Bangladesh Limited (IBBL) to the recent economic development in Bangladesh. The study analyses published texts, articles, websites and annual report of this bank through a content analysis. Key findings of this study manifest the contribution of this bank in different areas of economic development in Bangladesh like generating employment, earning foreign remittance, strengthening rural economy, promoting ecology and green banking, boosting industrialization, developing the SMEs, assisting in foreign trade (import-export), developing the housing sector etc. This study also identifies IBBL’s significant contribution to the national exchequer. This paper contributes to the field of economic development of Bangladesh and the role of IBBL behind it and fills the gap of literature in this specific area.IIUC Studies Vol.9 December 2012: 323-334

Participation of ABCA1 transporter in development of chronic obstructive pulmonary disease

2020 ◽  
Vol 28 (3) ◽  
pp. 360-370
Author(s):  
Stanislav N. Kotlyarov ◽  
Anna A. Kotlyarova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Significant Contribution ◽  
Modern Medicine ◽  
Lipid Homeostasis ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Reverse Transport ◽  
Current Paradigm

Despite all achievements of the modern medicine, the problem of chronic obstructive pulmonary disease (COPD) does not lose its relevance. The current paradigm suggests a key role of macrophages in inflammation in COPD. Macrophages are known to be heterogeneous in their functions. This heterogeneity is determined by their immunometabolic profile and also by peculiarities of lipid homeostasis of cells. Aim. To analyze the role of the ABCA1 transporter, a member of the ABC A subfamily, in the pathogenesis of COPD. The expression of ABCA1 in lung tissues is on the second place after the liver, which shows the important role of the carrier and of lipid homeostasis in the function of lungs. Analysis of the literature shows that participation of the transporter in inflammation consists in regulation of the content of cholesterol in the lipid rafts of the membranes, in phagocytosis and apoptosis. Conclusion. Through regulation of the process of reverse transport of cholesterol in macrophages of lungs, ABCA1 can change their inflammatory response, which makes a significant contribution to the pathogenesis of COPD.

scholarly journals Site-specific ubiquitylation acts as a regulator of linker histone H1

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Eva Höllmüller ◽  
Simon Geigges ◽  
Marie L. Niedermeier ◽  
Kai-Michael Kammer ◽  
Simon M. Kienle ◽  
...  
Keyword(s):  
Posttranslational Modifications ◽  
Histone H1 ◽  
Linker Histone ◽  
Active Chromatin ◽  
Site Specific ◽  
Linker Histone H1 ◽  
Fundamental Process ◽  
Core Histones ◽  
Wide Scale

AbstractDecoding the role of histone posttranslational modifications (PTMs) is key to understand the fundamental process of epigenetic regulation. This is well studied for PTMs of core histones but not for linker histone H1 in general and its ubiquitylation in particular due to a lack of proper tools. Here, we report on the chemical synthesis of site-specifically mono-ubiquitylated H1.2 and identify its ubiquitin-dependent interactome on a proteome-wide scale. We show that site-specific ubiquitylation of H1 at position K64 modulates interactions with deubiquitylating enzymes and the deacetylase SIRT1. Moreover, it affects H1-dependent chromatosome assembly and phase separation resulting in a more open chromatosome conformation generally associated with a transcriptionally active chromatin state. In summary, we propose that site-specific ubiquitylation plays a general regulatory role for linker histone H1.

Tackling Rape Culture in Québec Universities: A Network of Feminist Resistance

2019 ◽  
Vol 25 (11) ◽  
pp. 1290-1308 ◽  
Author(s):  
Sandrine Ricci ◽  
Manon Bergeron
Keyword(s):  
Sexual Violence ◽  
Significant Contribution ◽  
Political Agenda ◽  
The Political ◽  
Feminist Activism ◽  
University Campuses ◽  
Government Institutions ◽  
University Communities ◽  
Dual Perspective

Québec university communities are facing intensified pressure to address the incidence of sexual violence on campus. The ESSIMU ( Enquête Sexualité, Sécurité et Interactions en Milieu Universitaire) survey (2016) revealed that one third of respondents (students and employees from six universities, all genders combined) reported having experienced at least one form of sexual violence since arriving at university, committed by someone affiliated with the same university. As the issue is becoming increasingly institutionalized, a process that often erodes activism, this article highlights the role feminist activism has played in placing sexual violence on university campuses on the political agenda. From the dual perspective of feminist activists and researchers on the ESSIMU team, the article explores the backdrop of this mobilization, and the network of feminist resistance that fostered the ESSIMU study, itself a significant contribution to the increased recognition of sexual violence in universities. It also considers the role of university and government institutions in (re)producing such violence and the role of media in making it a public issue.

How glycosylation affects glycosylation: the role of N-glycans in glycosyltransferase activity

Glycobiology ◽  
2020 ◽  
Vol 30 (12) ◽  
pp. 941-969 ◽  
Author(s):  
Krzysztof Mikolajczyk ◽  
Radoslaw Kaczmarek ◽  
Marcin Czerwinski
Keyword(s):  
Posttranslational Modifications ◽  
Intracellular Localization ◽  
Profound Impact ◽  
Full Activity ◽  
New Therapy ◽  
Complex Group ◽  
Growing Body

Abstract N-glycosylation is one of the most important posttranslational modifications of proteins. It plays important roles in the biogenesis and functions of proteins by influencing their folding, intracellular localization, stability and solubility. N-glycans are synthesized by glycosyltransferases, a complex group of ubiquitous enzymes that occur in most kingdoms of life. A growing body of evidence shows that N-glycans may influence processing and functions of glycosyltransferases, including their secretion, stability and substrate/acceptor affinity. Changes in these properties may have a profound impact on glycosyltransferase activity. Indeed, some glycosyltransferases have to be glycosylated themselves for full activity. N-glycans and glycosyltransferases play roles in the pathogenesis of many diseases (including cancers), so studies on glycosyltransferases may contribute to the development of new therapy methods and novel glycoengineered enzymes with improved properties. In this review, we focus on the role of N-glycosylation in the activity of glycosyltransferases and attempt to summarize all available data about this phenomenon.

scholarly journals Corrigendum: Physiological and Proteomic Analysis of the Rice Mutant cpm2 Suggests a Negative Regulatory Role of Jasmonic Acid in Drought Tolerance

2018 ◽  
Vol 9 ◽  
Author(s):  
Rohit Dhakarey ◽  
Manish L. Raorane ◽  
Achim Treumann ◽  
Preshobha K. Peethambaran ◽  
Rachel R. Schendel ◽  
...  
Keyword(s):  
Drought Tolerance ◽  
Jasmonic Acid ◽  
Proteomic Analysis ◽  
Regulatory Role ◽  
Rice Mutant ◽  
Negative Regulatory Role

TRANSFORMATION OF THE INTERNAL AUDIT IS AN EFFECTIVE WAY TO INCREASE THE CONTRIBUTION TO THE SUSTAINABLE DEVELOPMENT OF A BUSINESS ENTITY

2021 ◽  
Vol 2 (2) ◽  
pp. 114-119
Author(s):  
PHAN THI THANH QUYEN ◽  
Keyword(s):  
Sustainable Development ◽  
Business Model ◽  
Significant Contribution ◽  
Internal Audit ◽  
Governance Structure ◽  
Sustainable Business ◽  
Corporate Governance Structure ◽  
The Sustainable Development ◽  
Internal Auditors

The role of internal audit in ensuring sustainable development of economic entities is indisputable. How-ever, the biggest challenge faced by internal auditors is how the level of their contribution can truly be weighed against the ability and role recognized by society, especially as most economic actors move from a traditional business model to a sustainable business model. The article highlights the main approaches to the transfor-mation of internal audit in order to make it an integral part of the corporate governance structure and make a significant contribution to sustainable development.

scholarly journals Epigenetic regulation by the menin pathway

2017 ◽  
Vol 24 (10) ◽  
pp. T147-T159 ◽  
Author(s):  
Zijie Feng ◽  
Jian Ma ◽  
Xianxin Hua
Keyword(s):  
Transcription Factors ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Gene Transcription ◽  
Epigenetic Regulation ◽  
Posttranslational Modifications ◽  
Genetic Model ◽  
Mirna Biogenesis ◽  
Endocrine Organs

There is a trend of increasing prevalence of neuroendocrine tumors (NETs), and the inherited multiple endocrine neoplasia type 1 (MEN1) syndrome serves as a genetic model to investigate how NETs develop and the underlying mechanisms. Menin, encoded by the MEN1 gene, at least partly acts as a scaffold protein by interacting with multiple partners to regulate cellular homeostasis of various endocrine organs. Menin has multiple functions including regulation of several important signaling pathways by controlling gene transcription. Here, we focus on reviewing the recent progress in elucidating the key biochemical role of menin in epigenetic regulation of gene transcription and cell signaling, as well as posttranslational regulation of menin itself. In particular, we will review the progress in studying structural and functional interactions of menin with various histone modifiers and transcription factors such as MLL, PRMT5, SUV39H1 and other transcription factors including c-Myb and JunD. Moreover, the role of menin in regulating cell signaling pathways such as TGF-beta, Wnt and Hedgehog, as well as miRNA biogenesis and processing will be described. Further, the regulation of the MEN1 gene transcription, posttranslational modifications and stability of menin protein will be reviewed. These various modes of regulation by menin as well as regulation of menin by various biological factors broaden the view regarding how menin controls various biological processes in neuroendocrine organ homeostasis.

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