Griseofulvin Solid Lipid Nanoparticles Based on Microemulsion Technique

2011 ◽  
Vol 197-198 ◽  
pp. 47-50 ◽  
Author(s):  
Lorwongngam Anurak ◽  
Gaysorn Chansiri ◽  
Dangprasert Peankit ◽  
Kongmuang Somlak
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Water Solubility ◽  
Chemical Properties ◽  
Lipid Nanoparticles ◽  
Spherical Particles ◽  
Solid Lipid ◽  
Dialysis Method ◽  
The Mean ◽  
Physical And Chemical ◽  
And Chemical Properties

The need for a topical drug delivery system of griseofulvin (GF) is dued to its poor oral bioavailability because of its low water solubility and excessively side effects. The preparation of griseofulvin-loaded into solid lipid nanoparticles (GF-SLNs) to nanometer range is expected to improve the dissolution rate by increasing the specific surface area. The aim of investigation was to produce griseofulvin-loaded into solid lipid nanoparticles by using a simple microemulsion technique, using glyceryl monostearate as solid lipid, polysorbate 20 as emulsifier, butanol and Transcutol HP®as co-emulsifiers. The GF-SLNs were evaluated for physical and chemical properties including GF release from GF-SLNs. The spherical particles were observed by TEM. The mean particle size of GF-SLNs was 165 nm and the zeta potential of GF-SLNs was -36 mV. There were interactions between GF and excipients in formula. The GF releasing profiles were obtained by a dialysis method with pH 5.5 phosphate buffer as medium, the release profile of GF was to be a prolong release of 63.53% within 12 hours.

Solid lipid nanoparticles of stearic acid for the drug delivery of paliperidone

RSC Advances ◽  
2015 ◽  
Vol 5 (84) ◽  
pp. 68743-68750 ◽  
Author(s):  
Sacheen Kumar ◽  
Jaspreet Kaur Randhawa
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Antipsychotic Drug ◽  
Solid Lipid Nanoparticles ◽  
Water Solubility ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Poor Water Solubility

Paliperidone is an antipsychotic drug having poor water solubility and bioavailability. Solid lipid nanoparticles of stearic acid loaded with paliperidone were prepared to enhance the bioavailability.

scholarly journals Semen characteristics of breeding bulls at the Central Cattle Breeding and Dairy Farm of Bangladesh

2012 ◽  
Vol 41 (1) ◽  
pp. 1-5
Author(s):  
ME Hossain ◽  
MM Khatun ◽  
MM Islam ◽  
OF Miazi
Keyword(s):  
Sperm Concentration ◽  
Chemical Properties ◽  
Dairy Farm ◽  
Mean Value ◽  
Cattle Breeding ◽  
Bull Semen ◽  
Before And After ◽  
The Mean ◽  
Physical And Chemical ◽  
And Chemical Properties

The experiment was conducted on 97 breeding bulls at the central cattle breeding and dairy farm, Savar, Dhaka to find out the physical and chemical properties of different bull semen. Out of 97 bulls, 9 were Local (L), 9 were Friesian (F), 13 were Sahiwal (SL), 12 were Local×Friesian (L×F), 10 were Sahiwal×Friesian (SL×F), 26 were Local×Friesian×Friesian (LF1×F), 18 were Local×Friesian× Friesian×Friesian (LF2×F) bulls. The semen of different crossbred and local bulls was examined for ejaculate volume, concentration, pH and motility percent of sperm before and after freezing. It was observed that, the maximum average ejaculate was obtained from SL×F and the mean value was 12.9 ml. However, the minimum average ejaculate was obtained from LF×F and the mean value was 7.4 ml. Before freezing, the maximum average sperm concentration was obtained from SL and the mean value was 1858.4 million/ml. The minimum average sperm concentration was obtained from LF1×F and the mean value was 1286.6 million/ml. The maximum average pH was obtained from LF2×F and the mean value was 6.5. The maximum average motility was obtained from SL and the mean value was 68.8%. However, the minimum average motility was obtained from L×F and the mean value was 63.7%. After freezing, sperm concentration, pH and motility reduced substantially irrespective of type of breed. It could therefore be inferred that freezing of semen should be undertaken with special care to maintain optimum semen quality.http://dx.doi.org/10.3329/bjas.v41i1.11968

Production of Ibuprofen-Loaded Solid Lipid Nanoparticles Using Rapid Expansion of Supercritical Solution

2015 ◽  
Vol 31 ◽  
pp. 15-29 ◽  
Author(s):  
Zahra Akbari ◽  
Massoud Amanlou ◽  
Javad Karimi-Sabet ◽  
Abolfazl Golestani ◽  
Mojtaba Shariaty Niassar
Keyword(s):  
Stearic Acid ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Rapid Expansion ◽  
Spherical Particles ◽  
Oral Drug ◽  
Dissolution Profile ◽  
Lipid Matrix ◽  
Solid Lipid ◽  
Supercritical Solution

The purpose of this study was to prepare ibuprofen loaded solid lipid nanoparticles (IBU-SLNs) that is, effective in oral drug delivery. IBU-SLNs were synthesized by co-precipitation of rapid expansion of supercritical solution (CO-RESS). The produced SLNs consisted of stearic acid as lipid matrix. The unprocessed stearic acid, ibuprofen and IBU-SLNs were characterized by means of scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), fourier transform infrared spectrophotometry (FTIR) and high performance liquid chromatography (HPLC). XRD patterns along with DSC showed that ibuprofen was present in both amorphous and crystalline form within lipid matrix. FTIR showed that molecular interactions that could alter the chemical structure of the IBU did not occur. The RESS process could produce ultrafine spherical particles of SLNs with high drug loading capacity. The IBU dissolution profile showed that the formulated SLNs have effectively increased the IBU solubility

scholarly journals Formulation, Characterization and in-vitro Evaluation of Famciclovir Loaded Solid Lipid Nanoparticles for Improved Oral Absorption

2020 ◽  
pp. 1-17
Author(s):  
Pavan Kumar Rawat ◽  
Chandra Kishore Tyagi ◽  
Sunil Kumar Shah ◽  
Arun Kumar Pandey
Keyword(s):  
Particle Size ◽  
Electron Microscope ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Spherical Particles ◽  
Average Particle ◽  
Preparation Technique ◽  
Solid Lipid ◽  
Freeze Dried

Famciclovir loaded Solid Lipid Nanoparticles (SLNs) using triglycerides as solid lipids were successfully prepared using the double emulsion-solvent evaporation technique. Formulation parameters like amount and type of lipid and level of surfactants affected the nanoparticle characters. It was observed that nanoparticle characters like average particle size and distribution, drug content, entrapment efficiency and release pattern were dependent on these formulation variables. The optimized formulations depicted the desired characters of low particle size, in the range of 140-170 nm in case of Glyceryl monostearate (GMS) and glyceryl distearate (GDS) SLNs and 250-340 nm in case of glyceryl behenate (GB) SLNs and entrapment efficiencies in the range of 35-48%. In vitro drug release was extended upto 8 h and the release profile was explained by the Baker-Lonsdale model for spherical particles. Morphological examination by Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) displayed homogenous solid, spherical and non- porous particles. The formulations depicted good redispersibility after lyophilization and presence of residual solvents in the formulations within the prescribed limits suggested suitability of the preparation technique. Freeze- dried formulations were found to be stable in terms of particle size and drug loading even after 6 months of storage at refrigerated conditions.

scholarly journals Surfactant Effect on the Physicochemical Characteristics of Solid Lipid Nanoparticles Based on Pillar[5]arenes

2022 ◽  
Vol 23 (2) ◽  
pp. 779
Author(s):  
Anastasia Nazarova ◽  
Luidmila Yakimova ◽  
Darya Filimonova ◽  
Ivan Stoikov
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Physicochemical Characteristics ◽  
Lipid Nanoparticles ◽  
Spherical Particles ◽  
Hydrodynamic Diameter ◽  
Solid Lipid ◽  
Molecular Scale ◽  
Dodecyltrimethylammonium Chloride ◽  
First Time ◽  
Average Hydrodynamic Diameter

Novel monosubstituted pillar[5]arenes containing both amide and carboxyl functional groups were synthesized. Solid lipid nanoparticles based on the synthesized macrocycles were obtained. Formation of spherical particles with an average hydrodynamic diameter of 250 nm was shown for pillar[5]arenes containing N-(amidoalkyl)amide fragments regardless of their concentration. It was established that pillar[5]arene containing N-alkylamide fragments can form spherical particles with two different sizes (88 and 223 nm) depending on its concentration. Mixed solid lipid nanoparticles based on monosubstituted pillar[5]arenes and surfactant (dodecyltrimethylammonium chloride) were obtained for the first time. The surfactant made it possible to level the effect of the macrocycle concentration. It was found that various types of aggregates are formed depending on the macrocycle/surfactant ratio. Changing the macrocycle/surfactant ratio allows to control the charge of the particles surface. This controlled property will lead to the creation of molecular-scale porous materials that selectively interact with various types of substrates, including biopolymers.

scholarly journals Production of Extrudate Food with Mango By-Products (Mangifera indica): Analysis of Physical, Chemical, and Sensorial Properties

Processes ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1660
Author(s):  
Esther Alicia Medina-Rendon ◽  
Guadalupe María Guatemala-Morales ◽  
Eduardo Padilla-Camberos ◽  
Rosa Isela Corona-González ◽  
Enrique Arriola-Guevara ◽  
...  
Keyword(s):  
Water Solubility ◽  
Mangifera Indica ◽  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Corn Flour ◽  
Mango Kernel ◽  
Mango Peel ◽  
Physical And Chemical ◽  
By Products ◽  
And Chemical Properties

The novelty of this work is the use of two mango by-products, mango peel and kernel, to obtain an extruded food. As well as the development of this food through a design of mixtures, we conducted sensorial analysis of the food through a hedonic test, in order not only to develop an extruded food with mango by-products, but also to develop a food that will be accepted by the consumer. A simple lattice mixture design was carried out with 14 mixtures, where the components were white corn flour (WCF), mango peel flour (MPF) and mango kernel flour (MKF), both from the Tommy Atkins mango variety. Physical and chemical properties such as the expansion index (EI), hardness, water absorption index (WAI), water solubility index (WSI), total phenols, DPPH and ABTS were evaluated. An optimization region was found that included 3 design points. Mixtures 1, 6 and 12 were evaluated using a nine-point hedonic scale to determine the acceptability of the product. Appearance, taste, and texture of the extrudates was evaluated. The extrudate with the best overall acceptability and the optimum physical and chemical properties contained 58.33% white corn flour, 33.33% mango peel flour and 8.33% mango kernel flour.

scholarly journals The cloudbow of planet Earth observed in polarisation

2020 ◽  
Vol 639 ◽  
pp. A89
Author(s):  
Michael F. Sterzik ◽  
Stefano Bagnulo ◽  
Claudia Emde ◽  
Mihail Manev
Keyword(s):  
Liquid Water ◽  
Chemical Properties ◽  
Phase Curve ◽  
Physical And Chemical Properties ◽  
Molecular Scattering ◽  
Droplet Sizes ◽  
The Mean ◽  
Physical And Chemical ◽  
Phase Angles ◽  
And Chemical Properties

Context. Scattering processes in the atmospheres of planets cause characteristic features that can be particularly well observed in polarisation. For planet Earth, both molecular scattering (Rayleigh) and scattering by small particles (Mie) imprint specific signatures in its phase curve. Polarised phase curves allow us to infer physical and chemical properties of the atmosphere like the composition of the gaseous and liquid components, droplet sizes, and refraction indices. Aims. An unequivocal prediction of a liquid-water-loaded atmosphere is the existence of a rainbow feature at a scattering angle of around 138–144°. Earthshine allows us to observe the primary rainbow in linear polarisation. Methods. We observed polarisation spectra of Earthshine using FORS2 at the Very Large Telescope for phase angles from 33° to 65° (Sun–Earth–Moon angle). The spectra were used to derive the degree of polarisation in the B, V, R, and I passbands and the phase curve from 33° to 136°. The new observations extend to the smallest phases that can be observed from the ground. Results. The degree of polarisation of planet Earth is increasing for decreasing phase angles downwards of 45° in the B, V, R, and I passbands. From comparison of the phase curve observed with models of an Earth-type atmosphere we are able to determine the refractive index of water and to constrain the mean water droplet sizes to 6−7μm. Furthermore, we can retrieve the mean cloud fraction of liquid water clouds to 0.3, and the mean optical depth of the water clouds to values between 10 and 20. Conclusions. Our observations allow us to discern two fundamentally different scattering mechanisms of the atmosphere of planet Earth: molecular and particle scattering. The physical and chemical properties can be retrieved with high fidelity through suitable inversion of the phase curve. Observations of polarimetric phase curves of planets beyond the Solar System shall be extremely valuable for a thorough characterisation of their atmospheres.

Preparation of Lipid Nanoparticles Based on Phase Behaviors of Hot Microemulsions

2007 ◽  
Vol 121-123 ◽  
pp. 847-850 ◽  
Author(s):  
Qiang Xia ◽  
Yang Yan Lu ◽  
Ning Gu
Keyword(s):  
Deoxycholic Acid ◽  
Drug Loading ◽  
Lipid Nanoparticles ◽  
Spherical Particles ◽  
Solid Lipid ◽  
Particle Dimension ◽  
Insoluble Drugs ◽  
The Mean ◽  
Phase Behaviors ◽  
Controllable Preparation

The solid lipid nanoparticles (SLNs) were prepared based on the phase behaviors of hot microemulsions which were quite different from normal microemulisons for the solid lipid as oil phase. The pseudoternary phase diagrams for the system Brij78/deoxycholic acid sodium (DAS)/ glycerol monostearate (GMS)/water with and without the addition of retinoic acid (RA) were obtained at 60 using home-made apparatus with temperature control. O/W and W/O region were all found in the phase diagram. The introduction of RA has increased the O/W microemulsion region greatly. GMS-SLN and RA-GMS-SLN were prepared by direct cooling of hot O/W microemulsion obtained according to the phase behaviors results. The mean particle size of GMS-SLN and RA-GMS-SLN investigated by PCS is about 10 nm. TEM images indicated that both SLNs were spherical particles with diameter about 10 nm. PCS results showed that the particle dimension was kept almost the same after three months, proving good stability of both SLNs. The study on the phase behaviors of drug-loading hot microemulsions has been proved to be very significative for the controllable preparation of SLNs which could be used as nanoscale drug delivery system (DDS) for water insoluble drugs.

scholarly journals Improved brain delivery of pueraria flavones via intranasal administration of borneol-modified solid lipid nanoparticles

Nanomedicine ◽  
2019 ◽  
Vol 14 (16) ◽  
pp. 2105-2119 ◽  
Author(s):  
Liping Wang ◽  
Xiao Zhao ◽  
Junfeng Du ◽  
Mei Liu ◽  
Jianfang Feng ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Intranasal Administration ◽  
Brain Area ◽  
Area Under The Curve ◽  
Lipid Nanoparticles ◽  
Brain Delivery ◽  
Solid Lipid ◽  
Physical And Chemical

Aim: To improve the drug delivery to the brain with borneol (Bo)-modified solid lipid nanoparticles (SLNs) of pueraria flavones (PTF) via intranasal administration. Materials & methods: PTF-loaded SLNs were modified with Bo by physical and chemical methods to synthesize PTF-Bo-SA-SLNs and PTF-Bo-SLNs. The prepared SLNs were characterized and their brain delivery effects were evaluated in vitro and in vivo. Results: There was a more pronounced accumulation of PTF-Bo-SA-SLNs in Caco-2 cells. Following intranasal administration, more coumarin-6 was found in the rat brain carried by Bo-SA-SLNs. Brain area under the curve and Cmax of PTF-Bo-SA-SLN were 7.31- and 7.29-times higher than those of PTF-SLN, respectively. Conclusion: PTF-Bo-SA-SLNs are a promising therapeutic carrier for brain disease after intranasal administration.

Relationship Between Particle Size Distribution and Specific Surface Area of Urban Roadway Stormwater Solids

1997 ◽  
Vol 1601 (1) ◽  
pp. 95-108 ◽  
Author(s):  
John J. Sansalone ◽  
Steven G. Buchberger ◽  
Joseph M. Koran ◽  
Joseph A. Smithson
Keyword(s):  
Particle Size ◽  
Specific Surface ◽  
Surface Area ◽  
Particle Surface ◽  
Chemical Properties ◽  
Spherical Particles ◽  
Particle Surface Area ◽  
Surface Areas ◽  
Physical And Chemical ◽  
And Chemical Properties

Surface area is a primary factor in determining many physical and chemical properties of solids, especially particles. In urban and highway runoff, solids can mediate the partitioning between the dissolved and particulate-bound phases of metal elements and organic compounds. Solids are also capable of adversely affecting roadway drainage appurtenances through sedimentation and clogging. Solids characteristics of primary importance for both solute adsorption and clogging and sedimentation are particle size distributions (PSDs), specific surface areas (SSAs), and mass loadings. PSD and SSA results are presented for rainfall and snowmelt solids from a heavily traveled urban roadway in Cincinnati. Integration of the PSD and SSA results indicates that particle surface area is greatest for the midrange (> 100 μm) to the coarser end (<2000 μm) of the gradation. SSA results determined using the assumption of smooth spherical particles are indicated to grossly underestimate actual SSA values.

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