scholarly journals Decreased Muscle-to-Fat Mass Ratio Is Associated with Low Muscular Fitness and High Alanine Aminotransferase in Children and Adolescent Boys in Organized Sports Clubs

2021 ◽  
Vol 10 (11) ◽  
pp. 2272
Author(s):  
Kai Ushio ◽  
Yukio Mikami ◽  
Hiromune Obayashi ◽  
Hironori Fujishita ◽  
Kouki Fukuhara ◽  
...  
Keyword(s):  
Body Composition ◽  
Children And Adolescents ◽  
Fat Mass ◽  
Alanine Aminotransferase ◽  
Mass Ratio ◽  
Adolescent Boys ◽  
Muscular Fitness ◽  
Children And Adolescent ◽  
Sports Clubs ◽  
Fat Mass Ratio

Decreased muscle-to-fat mass ratio (MFR) is associated with pediatric nonalcoholic fatty liver disease (NAFLD) and may reduce muscular fitness. Regular exercise in sports clubs has not led to reductions in obesity in children and adolescents; they may have decreased MFR. Decreased MFR could cause reduced muscular fitness, which may put them at risk for NAFLD development. We investigated whether MFR is related to muscular fitness and serum alanine aminotransferase (ALT), to determine whether MFR could be used to screen for NAFLD in children and adolescent boys belonging to sports clubs. Altogether, 113 participants (aged 7–17 years) who underwent body composition, laboratory, and muscular fitness measurements during a medical checkup were divided into tertiles according to their MFR. Lower extremity muscular fitness values were significantly decreased in the lowest MFR tertile (p < 0.001); conversely, serum ALT levels were significantly increased (p < 0.01). Decreased MFR significantly increased the risk of elevated ALT, which requires screening for NAFLD, after adjusting for age, obesity, muscular fitness parameters, and metabolic risk factors (odds ratio = 8.53, 95% confidence interval = 1.60–45.6, p = 0.012). Physical fitness and body composition assessments, focusing on MFR, can be useful in improving performance and screening for NAFLD in children and adolescents exercising in sports clubs.

scholarly journals Uric acid is associated with adiposity factors, especially with fat mass reduction during weight loss in obese children and adolescents

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Yang Niu ◽  
Xue-lin Zhao ◽  
Hui-juan Ruan ◽  
Xiao-meng Mao ◽  
Qing-ya Tang
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Uric Acid ◽  
Children And Adolescents ◽  
Body Fat ◽  
Fat Mass ◽  
Dietary Control ◽  
Obese Children ◽  
Fat Percentage ◽  
Before And After

Abstract Background Current adult studies suggest that uric acid (UA) is associated with body fat, but the relationship in obese children is unclear. Thus, we aim to evaluate the association between uric acid and body composition of obese children. Methods A total of 79 obese children were included in this study, and 52 children (34 boys and 18 girls) underwent a 6-week weight loss camp, including 34 boys and 18 girls. Six-week weight-loss interventions were performed on all participants through aerobic exercise and appropriate dietary control. Laboratory tests and body composition were collected before and after the intervention. Results Before the intervention, correlation analysis demonstrated that uric acid was positively correlated with height, weight, body mass index (BMI), waist circumference, hip circumference, fat mass (FM), and free fat mass (FFM) with adjusting for age and gender (P < 0.05). After 6 weeks of intervention, the participants gained 3.12 ± 0.85 cm in height, body fat percentage decreased by 7.23 ± 1.97%, and lost 10.30 ± 2.83 kg in weight. Univariate and multivariate analysis indicated that uric acid at baseline was associated with FM reduction during weight loss (P < 0.05). Conclusions This study is the first report that uric acid is associated with BMI and FM, and may play an important role in the reduction of FM during weight loss in obese children and adolescents. The interaction between UA and adiposity factors and its underlying mechanisms need to be further explored. Trial registration This study was registered in Clinical Trials.gov (NCT03490448) and approved by the Ethics Committee of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.

scholarly journals Grip Strength Moderates the Association between Anthropometric and Body Composition Indicators and Liver Fat in Youth with an Excess of Adiposity

2018 ◽  
Vol 7 (10) ◽  
pp. 347 ◽  
Author(s):  
Robinson Ramírez-Vélez ◽  
Mikel Izquierdo ◽  
Jorge Correa-Bautista ◽  
Alejandra Tordecilla-Sanders ◽  
María Correa-Rodríguez ◽  
...  
Keyword(s):  
Body Composition ◽  
Liver Disease ◽  
Children And Adolescents ◽  
Grip Strength ◽  
Body Mass ◽  
Fat Mass ◽  
Muscular Strength ◽  
Liver Fat ◽  
Alcoholic Fatty Liver ◽  
Fat Deposits

Paediatric non-alcoholic fatty liver disease (NAFLD) is considered the most common early driver of chronic liver disease. The aim of this study was to examine whether grip strength moderates the association between anthropometric and body composition parameters and controlled attenuation parameter (CAP), an indicator of fat deposits in the liver, in children and adolescents with excess of adiposity. A total of 127 adolescents (67% girls) aged between 11 and 17, attending two public schools in Bogotá (Colombia), who had an axiological evaluation of obesity were included in this study. A grip strength test was assessed as an indicator of muscular strength, and cardiorespiratory fitness by maximal oxygen uptake was assessed using the 20 m shuttle-run test. Waist circumference (WC), waist-to-height ratio (WHtR), fat mass, and visceral adipose tissue (VAT) (cm3) were included as anthropometric and body composition measures. CAP was determined with a FibroScan® 502 Touch device (Echosens, Paris, France). The anthropometric and body composition parameters including WC, WHtR, fat mass, and VAT were positively associated with the CAP (range β = 0.423 to 0.580), slightly reduced after being adjusted for handgrip strength/weight. The Johnson-Neyman technique revealed a significant inverse relationship between WC, WHtR, VAT, and CAP when grip strength normalized by body mass was above but not equal to or below 0.475 (8.1% of the sample), 0.469 (8.9% of the sample), and 0.470 (8.5% of the sample), respectively. In conclusion, grip strength adjusted by body mass, has a moderating effect on the association between anthropometric and body composition parameters (including WC, WHtR, and VAT) and CAP in in children and adolescents with excess of adiposity, suggesting the importance of promoting muscular strength during paediatric population in order to prevent NAFLD.

scholarly journals Changes in Body Fat Distribution in Antiretroviral-Naive HIV-Positive Individuals Initiating Current ART Regimens

2018 ◽  
Vol 104 (3) ◽  
pp. 900-905 ◽  
Author(s):  
Juan Tiraboschi ◽  
Antonio Navarro-Alcaraz ◽  
Dolors Giralt ◽  
Carmen Gomez-Vaquero ◽  
Maria Saumoy ◽  
...  
Keyword(s):  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
The Body ◽  
Strand Transfer ◽  
Mass Ratio ◽  
Total Fat ◽  
Fat Mass Ratio

Abstract Objectives To describe the changes in body fat distribution (BFD) occurring over 60 months in a group of antiretroviral therapy (ART)-naive individuals starting different antiretroviral regimens. Methods A prospective ongoing fat change assessment including clinical evaluation and dual X-ray absorptiometry scan is being conducted in all consecutive patients initiating ART from January 2008. Arm, leg, trunk, and total fat as well as fat mass ratio were determined. Results A total of 146 patients were included (80% male, 40% MSM). Mean age was 44 years, HIV-1 RNA was 4.98 log10 copies/mL, and CD4 count was 254 cells/μL. The most common initial antiretroviral combination included non-nucleoside reverse transcription inhibitor (NNRTI) drugs followed by protease inhibitor (PI) and integrase strand transfer inhibitor (INSTI)-based regimens. At month 36, an increase was seen in the body mass index (BMI), total fat, trunk fat, and limb fat. The fat mass ratio (FMR) also showed a significant increase in both men and women (P = 0.001). In patients receiving NNRTI- or INSTI-based regimens (but not PIs), there was a marginal but statistically significant increase in the FMR (0.10 and 0.07, respectively; P = 0.01). Sixty-two subjects completed 60 months of follow-up. FMR showed a significant increase even in the PI group at this time point (P &lt; 0.03). Conclusions We observed a significant increase in the fat and lean body mass in all compartments and treatment groups over 36 and 60 months. Clinically irrelevant differences were found in fat distribution regardless of the treatment group and baseline characteristics. The data suggest that current antiretroviral regimens have little impact on BFD during the first years of treatment.

scholarly journals Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction

2018 ◽  
Vol 96 (3) ◽  
pp. 308-312 ◽  
Author(s):  
Isabelle Côté ◽  
Sara M. Green ◽  
Drake Morgan ◽  
Christy S. Carter ◽  
Nihal Tümer ◽  
...  
Keyword(s):  
Food Intake ◽  
Mass Loss ◽  
Body Mass ◽  
Fat Mass ◽  
Control Level ◽  
Mass Ratio ◽  
Melanocortin System ◽  
Body Mass Loss ◽  
Fat Mass Ratio

Recent evidence indicate that melanotan II (MTII) reduces body mass independently of caloric reduction. Because MTII induces a transient hypophagia, caloric reduction is still considered a primary mechanism for MTII-mediated body mass loss. To examine the contribution of caloric reduction to long-term body mass loss in response to MTII, we centrally infused MTII or vehicle in ad libitum fed (MTII and Control) animals in comparison with a group of animals that were pair-fed (PF) to the MTII group. Food intake and body mass were recorded daily, and body composition was assessed biweekly. The present study demonstrates that central MTII-mediated body mass loss is only partially mediated by caloric restriction, and the long-term body mass loss is independent of the initial hypophagia. More importantly, central MTII administration induced a rapid but sustained fat mass loss, independently of caloric reduction. MTII-treated animals preserved their lean/fat mass ratio throughout the study, whereas PF animals underwent a transient reduction of lean/fat mass ratio that was only normalized when food intake returned to Control level. In summary, it can be concluded that activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.

Fat Mass Ratio: An Objective Tool to Define Lipodystrophy in HIV-Infected Patients Under Antiretroviral Therapy

2010 ◽  
Vol 13 (2) ◽  
pp. 197-203 ◽  
Author(s):  
Paula Freitas ◽  
Ana Cristina Santos ◽  
Davide Carvalho ◽  
Jorge Pereira ◽  
Rui Marques ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Fat Mass ◽  
Mass Ratio ◽  
Fat Mass Ratio ◽  
Objective Tool

scholarly journals Number of children and body composition in later life among men and women: Results from a British birth cohort study

2018 ◽  
Author(s):  
Charis Bridger Staatz ◽  
Rebecca Hardy
Keyword(s):  
Body Mass Index ◽  
Body Composition ◽  
Body Mass ◽  
Fat Mass ◽  
Lean Mass ◽  
Biological Effects ◽  
Later Life ◽  
Birth Cohort Study ◽  
Mass Ratio ◽  
Number Of Children

Background Although research has found associations between increasing number of children and higher body mass index (BMI), there has been limited research investigating the association with body composition despite abdominal fat being associated with cardiovascular and metabolic risk independently of general adiposity. Most existing research has focussed on women, but investigating the relationship in men can help distinguish biological effects of pregnancy from social pathways related to parenthood. Methods Using the MRC National Survey of Health and Development (NSHD) multiple regression models were applied to test associations between number of children and body composition at age 60-64 (N=2229) and body mass index (BMI) and waist circumference (WC) at ages 60-64 and 69 (N=2149). Results In adjusted models, associations were observed between increasing numbers of children and increasing fat-adjusted lean mass index in women (p=0.06). Among men, those with children had 0.59kg (95% CI: 0.15 to 1.02) greater lean mass index than those without and fat:lean mass ratio was greater in those with 4+ children because of their slightly higher mean fat mass. Weak evidence of a higher android:gynoid mass ratio in women with children (0.03, 95% CI: 0.00,0.06, p=0.1) was observed with no associations with fat mass index or android or gynoid fat mass. Increasing BMI was observed with increasing parity in women at 60-64 and more strongly at 69 years where associations among men were also observed more clearly. Conclusion There was little evidence of a consistent association between number of children and body composition in early old age. The strongest associations are observed for lean, rather than fat mass, and in men rather than women, suggesting little evidence of biological effects of pregnancy in women. The results indicate social pathways associated with parenthood are the likely underlying mechanisms, with suggestion there may be selection into parenthood among men.

Switching from zidovudine/lamivudine to tenofovir/emtricitabine improves fat distribution as measured by fat mass ratio

HIV Medicine ◽  
2014 ◽  
Vol 16 (6) ◽  
pp. 370-374 ◽  
Author(s):  
E Martínez ◽  
E Ribera ◽  
B Clotet ◽  
V Estrada ◽  
J Sanz ◽  
...  
Keyword(s):  
Fat Mass ◽  
Fat Distribution ◽  
Mass Ratio ◽  
Fat Mass Ratio
Sign in / Sign up

Export Citation Format

Share Document