scholarly journals Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis

2021 ◽  
Vol 10 (15) ◽  
pp. 3251
Author(s):  
Juan J. Gagliardino ◽  
Martin R. Salazar ◽  
Walter G. Espeche ◽  
Paula E. Tolosa Chapasian ◽  
Daniela Gomez Gomez Garizoain ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Arterial Stiffness ◽  
Negative Impact ◽  
Cost Effective ◽  
Statin Treatment ◽  
Normal Glucose Tolerance ◽  
Complete Picture ◽  
Preventive Strategy ◽  
Metabolic Characteristics ◽  
Healthy Life Style

Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal glucose tolerance (NGT) or PreD. In each subgroup we also identified those with/out insulin resistance (IR) measured by the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collected for all participants. PWV was compared between subgroups using independent t test. Results: Women and men had comparable clinical and metabolic characteristics with obesity (BMI ≥ 30) and antihypertensive-statin treatment, almost half with either NGT or PreD. Whereas 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), 52% had PreD. PWV was significantly higher only in those with a complete picture of metabolic syndrome (MS). Conclusions: Since PWV was significantly impaired in people with a complete picture of MS, clinicians must carefully search for early diagnosis of this condition and prescribe a healthy life-style to prevent development/progression of CVD. This proactive attitude would provide a cost-effective preventive strategy to avoid CVD’s negative impact on patients’ quality of life and on health systems due to their higher care costs.

Role of Rasayana in Prevention of COVID-19 - A Review

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 716-722
Author(s):  
Sneha Dhakite ◽  
Sadhana Misar Wajpeyi
Keyword(s):  
Immune System ◽  
Respiratory System ◽  
Viral Infections ◽  
Cost Effective ◽  
The Body ◽  
Healthy Life ◽  
Vital Functions ◽  
Healthy Life Style ◽  
And Control

The “Coronavirus disease 19 (COVID-19)” is caused by “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)”, a newly discovered member of the Coronaviridae family of viruses which is a highly communicable. There is no effective medical treatment till date for Coronavirus disease hence prevention is the best way to keep disease away. Rasayana proved to be highly efficacious and cost effective for the Prevention and Control of viral infections when vaccines and standard therapies are lacking. Rasayana Chikitsa is one of the eight branches of Ashtanga Ayurveda which helps to maintain healthy life style. Rasayana improves immunity and performs many vital functions of human body. Vyadhikshamatva that is immune mechanism of the body is involved in Prevention of the occurrence of a new disease and it also decreases the virulence and progression of an existing disease. In COVID-19 the Respiratory system mainly get affected which is evident from its symptoms like cold, cough and breathlessness. Here the drugs help in enhancing immune system and strengthening functions of Respiratory system can be useful. For this purpose, the Rasayana like Chyavanprasha, Agastya Haritaki, Pippali Rasayana, Guduchi, Yashtimadhu, Haridra, Ashwagandha, Tulsi are used. Rasayana working on Respiratory system are best for Prevention of Coronavirus and boosting immune system. Rasayana Chikitsa can be effective in the Prevention as well as reducing symptoms of COVID-19.

Small dense LDL cholesterol is a robust therapeutic marker of statin treatment in patients with acute coronary syndrome and metabolic syndrome

2011 ◽  
Vol 412 (15-16) ◽  
pp. 1423-1427 ◽  
Author(s):  
Yoshifumi Fukushima ◽  
Satoshi Hirayama ◽  
Tsuyoshi Ueno ◽  
Tomotaka Dohi ◽  
Tetsuro Miyazaki ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Acute Coronary Syndrome ◽  
Ldl Cholesterol ◽  
Statin Treatment ◽  
Small Dense Ldl ◽  
Coronary Syndrome

Metabolic syndrome and cardiovascular risk in renal transplant recipients: effects of statin treatment

2009 ◽  
Vol 23 (6) ◽  
pp. 914-920 ◽  
Author(s):  
Inga Soveri ◽  
Sadollah Abedini ◽  
Hallvard Holdaas ◽  
Alan Jardine ◽  
Niclas Eriksson ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Renal Transplant ◽  
Statin Treatment ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

The metabolic syndrome is associated with carotid atherosclerosis and arterial stiffness in asymptomatic, nondiabetic postmenopausal women

2017 ◽  
Vol 34 (1) ◽  
pp. 78-82 ◽  
Author(s):  
Irene Lambrinoudaki ◽  
Aikaterini Kazani ◽  
Eleni Armeni ◽  
Demetrios Rizos ◽  
Areti Augoulea ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Arterial Stiffness ◽  
Postmenopausal Women ◽  
Carotid Atherosclerosis ◽  
The Metabolic Syndrome

scholarly journals The Endocrine and Metabolic Characteristics of a Large Bardet-Biedl Syndrome Clinic Population

2018 ◽  
Vol 103 (5) ◽  
pp. 1834-1841 ◽  
Author(s):  
Safa Mujahid ◽  
Katharine F Hunt ◽  
Yee S Cheah ◽  
Elizabeth Forsythe ◽  
Jonathan M Hazlehurst ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Subclinical Hypothyroidism ◽  
Matched Control ◽  
Genetic Diagnosis ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Bardet Biedl Syndrome ◽  
Metabolic Characteristics ◽  
Control Subjects ◽  
The Metabolic Syndrome

Abstract Context Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder in which previous reports have described obesity and a metabolic syndrome. Objective We describe the endocrine and metabolic characteristics of a large BBS population compared with matched control subjects. Design We performed a case-control study. Setting This study was performed at a hospital clinic. Patients Study patients had a clinical or genetic diagnosis of BBS. Main Outcome Measurements Our study determined the prevalence of a metabolic syndrome in our cohort. Results A total of 152 subjects were studied. Eighty-four (55.3%) were male. Mean (± standard deviation) age was 33.2 ± 1.0 years. Compared with age-, sex-, and body mass index–matched control subjects, fasting glucose and insulin levels were significantly higher in subjects with BBS (glucose: BBS, 5.2 ± 1.2 mmol/L vs control, 4.9 ± 0.9 mmol/L, P = 0.04; insulin: BBS, 24.2 ± 17.0 pmol/L vs control, 14.2 ± 14.8 pmol/L, P < 0.001). Serum triglycerides were significantly higher in subjects with BBS (2.0 ± 1.2 mmol/L) compared with control subjects (1.3 ± 0.8 mmol/L; P < 0.001), but total cholesterol, high-density lipoprotein, and low-density lipoprotein were similar in both groups. Systolic blood pressure was higher in the BBS group (BBS, 135 ± 18 mm Hg vs control subjects, 129 ± 16 mm Hg; P = 0.02). Alanine transaminase was raised in 34 (26.8%) subjects with BBS, compared with five (8.9%) control subjects (P = 0.01). The rate of metabolic syndrome, determined using International Diabetes Federation criteria, was significantly higher in the BBS group (54.3%) compared with control subjects (26% P < 0.001). Twenty-six (19.5%) of male subjects with BBS were hypogonadal (serum testosterone, 9.9 ± 5.3 mmol/L), but significant pituitary abnormalities were uncommon. Subclinical hypothyroidism was present in 24 of 125 (19.4%) patients with BBS, compared with 3 of 65 (4.6%) control subjects (P = 0.01). Conclusions Insulin resistance and the metabolic syndrome are increased in adult patients with BBS compared with matched control subjects. Increased subclinical hypothyroidism in the BBS cohort needs further investigation.

scholarly journals Metabolic Syndrome and Reproduction

2021 ◽  
Vol 22 (4) ◽  
pp. 1988
Author(s):  
Francesco Lotti ◽  
Sara Marchiani ◽  
Giovanni Corona ◽  
Mario Maggi
Keyword(s):  
Metabolic Syndrome ◽  
Male Fertility ◽  
English Language ◽  
Negative Impact ◽  
Reproductive Potential ◽  
Underlying Mechanism ◽  
Semen Parameters ◽  
Preclinical Studies ◽  
Medline Search ◽  
High Prevalence

Metabolic syndrome (MetS) and infertility are two afflictions with a high prevalence in the general population. MetS is a global health problem increasing worldwide, while infertility affects up to 12% of men. Despite the high prevalence of these conditions, the possible impact of MetS on male fertility has been investigated by a few authors only in the last decade. In addition, underlying mechanism(s) connecting the two conditions have been investigated in few preclinical studies. The aim of this review is to summarize and critically discuss available clinical and preclinical studies on the role of MetS (and its treatment) in male fertility. An extensive Medline search was performed identifying studies in the English language. While several studies support an association between MetS and hypogonadism, contrasting results have been reported on the relationship between MetS and semen parameters/male infertility, and the available studies considered heterogeneous MetS definitions and populations. So far, only two meta-analyses in clinical and preclinical studies, respectively, evaluated this topic, reporting a negative association between MetS and sperm parameters, testosterone and FSH levels, advocating, however, larger prospective investigations. In conclusion, a possible negative impact of MetS on male reproductive potential was reported; however, larger studies are needed.

Optimising postoperative discharge plans for patients undergoing surgical treatment for gastric cancer: a literature review

2021 ◽  
Vol 19 (1) ◽  
pp. 34-40
Author(s):  
Lorena Chaparro-Diaz ◽  
Maria Zoraida Rojas ◽  
Sonia Patricia Carreño-Moreno
Keyword(s):  
Gastric Cancer ◽  
Literature Review ◽  
Psychosocial Support ◽  
Negative Impact ◽  
Gastrointestinal Surgery ◽  
Partial Gastrectomy ◽  
Cost Effective ◽  
Essential Elements ◽  
Cochrane Central Register ◽  
Gastric Cancer Patients

Background: Gastric (stomach) cancer is common, difficult to detect and has a high mortality rate. Many gastric cancers are treatable with invasive gastrointestinal surgery, including total or partial gastrectomy. These patients face many postoperative challenges, including pain, nausea and nutritional difficulties, as well as consequent anxiety and socio-economic challenges. Some healthcare institutions have implemented discharge plans as a cost-effective strategy to improve postoperative care. Aim: This systematic literature review aimed to identify essential elements to incorporate in the design and implementation of discharge plans for post-surgical gastric cancer patients. Methods: A systematic literature search was performed on the Cochrane Central Register of Controlled Studies, Elsevier Scopus and the library database of the National University of Colombia. These articles were assessed for relevance and underwent thematic analysis. Findings: The search returned nine relevant articles in English and Spanish. They suggested that discharge plans should start from first contact with a nurse and integrate the patient and their family and carers into the process of home self-care and recovery. These plans should also guide nurses to provide ongoing patient education, nutritional interventions and psychosocial support, as well as prevention of thromboembolism and assistance with symptom management and coming to terms with a new life situation. Conclusions: Discharge plans reduce the negative impact of the disease and invasive procedures on patients, families and health systems, reducing unplanned hospitalisation and readmission. There is a need to develop and test supportive care programmes that are designed to meet the needs of patients and focus on improving patients' quality of life after this life-changing surgery.

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