Post-Stroke Psychiatric and Cognitive Symptoms in West Asia, South Asia and Africa: A Systematic Review and Meta-Analysis

Recent research has shown that the prevalence of stroke incidents and the number of survivors in developing countries surpass those from developed countries. This study aimed to enumerate the prevalence of post-stroke psychiatric and cognitive symptoms among stroke survivors from West and South Asia and Africa through a systematic review and meta-analysis. Data from each country was systematically acquired from five major databases (PsycINFO, Web of Science, Scopus, PubMed/Medline, and Google Scholar (for any missing articles and grey literature)). Meta-analytic techniques were then used to estimate the prevalence of various post-stoke psychiatric and cognitive symptoms. A total of 36 articles were accrued from 11 countries, of which 25 were evaluated as part of the meta-analysis. The pooled prevalence of post-stroke depression as per the Hospital Anxiety and Depression Scale (HADS), Hamilton Depression Rating Scale, Patient Health Questionnaire, Schedules for Clinical Assessment in Neuropsychiatry (SCAN), Geriatric Depression Scale, and the Montgomery–Asberg Depression Rating Scale ranged from 28.00 to 50.24%. Pooled prevalence of post-stroke anxiety based on the HADS and SCAN was 44.19% and 10.96%, respectively. The pooled prevalence of post-stroke cognitive impairment as per the Mini-Mental Status Examination was 16.76%. This present review has suggested that both psychiatric and cognitive symptoms are common among stroke survivors. Concerted efforts are needed to institute robust studies using culturally sensitive measures to contemplate mechanisms that address the unmet needs of this vulnerable population.

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Aquatic Therapy for improving Lower Limbs Function in Post-stroke Survivors: A Systematic Review with Meta-Analysis

Topics in Stroke Rehabilitation ◽

10.1080/10749357.2021.1929011 ◽

2021 ◽

pp. 1-17

Author(s):

Mahboubeh Ghayour Najafabadi ◽

Ardalan Shariat ◽

Jan Dommerholt ◽

Azadeh Hakakzadeh ◽

Amin Nakhostin-Ansari ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Lower Limbs ◽

Stroke Survivors ◽

Aquatic Therapy ◽

Post Stroke

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Diabetes among tuberculosis patients and its impact on tuberculosis treatment in South Asia: a systematic review and meta-analysis

Scientific Reports ◽

10.1038/s41598-021-81057-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Sanju Gautam ◽

Nipun Shrestha ◽

Sweta Mahato ◽

Tuan P. A. Nguyen ◽

Shiva Raj Mishra ◽

...

Keyword(s):

Systematic Review ◽

Sri Lanka ◽

Treatment Failure ◽

South Asia ◽

Treatment Outcomes ◽

Meta Analysis ◽

Tb Treatment ◽

Effect Model ◽

Pooled Prevalence ◽

The Impact

AbstractThe escalating burden of diabetes is increasing the risk of contracting tuberculosis (TB) and has a pervasive impact on TB treatment outcomes. Therefore, we conducted this systematic review and meta-analysis to examine the burden of diabetes among TB patients and assess its impact on TB treatment in South Asia (Afghanistan, Bangladesh, Bhutan, Maldives, Nepal, India, Pakistan, and Sri Lanka). PubMed, Excerpta Medica Database (EMBASE), and CINAHL databases were systematically searched for observational (cross-sectional, case–control and cohort) studies that reported prevalence of diabetes in TB patients and published between 1 January 1980 and 30 July 2020. A random-effect model for computing the pooled prevalence of diabetes and a fixed-effect model for assessing its impact on TB treatment were used. The review was registered with PROSPERO number CRD42020167896. Of the 3463 identified studies, a total of 74 studies (47 studies from India, 10 from Pakistan, four from Nepal and two from both Bangladesh and Sri-Lanka) were included in this systematic review: 65 studies for the prevalence of diabetes among TB patients and nine studies for the impact of diabetes on TB treatment outcomes. The pooled prevalence of diabetes in TB patients was 21% (95% CI 18.0, 23.0; I2 98.3%), varying from 11% in Bangladesh to 24% in Sri-Lanka. The prevalence was higher in studies having a sample size less than 300 (23%, 95% CI 18.0, 27.0), studies conducted in adults (21%, 95% CI 18.0, 23.0) and countries with high TB burden (21%, 95% CI 19.0, 24.0). Publication bias was detected based on the graphic asymmetry of the funnel plot and Egger’s test (p < 0.001). Compared with non-diabetic TB patients, patients with TB and diabetes were associated with higher odds of mortality (Odds Ratio (OR) 1.7; 95% CI 1.2, 2.51; I2 19.4%) and treatment failure (OR 1.7; 95% CI 1.1, 2.4; I2 49.6%), but not associated with Multi-drug resistant TB (OR 1.0; 95% CI 0.6, 1.7; I2 40.7%). This study found a high burden of diabetes among TB patients in South Asia. Patients with TB-diabetes were at higher risk of treatment failure and mortality compared to TB alone. Screening for diabetes among TB patients along with planning and implementation of preventive and curative strategies for both TB and diabetes are urgently needed.

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Prevalence and risk factors associated with birth asphyxia among neonates delivered in Ethiopia: A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0255488 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0255488

Author(s):

Ritbano Ahmed ◽

Hassen Mosa ◽

Mohammed Sultan ◽

Shamill Eanga Helill ◽

Biruk Assefa ◽

...

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Meta Analysis ◽

Grey Literature ◽

Birth Asphyxia ◽

Public Health Problem ◽

Cochrane Library ◽

Chronic Hypertension ◽

Factors Associated ◽

Pooled Prevalence

Background A number of primary studies in Ethiopia address the prevalence of birth asphyxia and the factors associated with it. However, variations were seen among those studies. The main aim of this systematic review and meta-analysis was carried out to estimate the pooled prevalence and explore the factors that contribute to birth asphyxia in Ethiopia. Methods Different search engines were used to search online databases. The databases include PubMed, HINARI, Cochrane Library and Google Scholar. Relevant grey literature was obtained through online searches. The funnel plot and Egger’s regression test were used to see publication bias, and the I-squared was applied to check the heterogeneity of the studies. Cross-sectional, case-control and cohort studies that were conducted in Ethiopia were also be included. The Joanna Briggs Institute checklist was used to assess the quality of the studies and was included in this systematic review. Data entry and statistical analysis were carried out using RevMan 5.4 software and Stata 14. Result After reviewing 1,125 studies, 26 studies fulfilling the inclusion criteria were included in the meta-analysis. The pooled prevalence of birth asphyxia in Ethiopia was 19.3%. In the Ethiopian context, the following risk factors were identified: Antepartum hemorrhage(OR: 4.7; 95% CI: 3.5, 6.1), premature rupture of membrane(OR: 4.0; 95% CI: 12.4, 6.6), primiparas(OR: 2.8; 95% CI: 1.9, 4.1), prolonged labor(OR: 4.2; 95% CI: 2.8, 6.6), maternal anaemia(OR: 5.1; 95% CI: 2.59, 9.94), low birth weight(OR = 5.6; 95%CI: 4.7,6.7), meconium stained amniotic fluid(OR: 5.6; 95% CI: 4.1, 7.5), abnormal presentation(OR = 5.7; 95% CI: 3.8, 8.3), preterm birth(OR = 4.1; 95% CI: 2.9, 5.8), residing in a rural area (OR: 2.7; 95% CI: 2.0, 3.5), caesarean delivery(OR = 4.4; 95% CI:3.1, 6.2), operative vaginal delivery(OR: 4.9; 95% CI: 3.5, 6.7), preeclampsia(OR = 3.9; 95% CI: 2.1, 7.4), tight nuchal cord OR: 3.43; 95% CI: 2.1, 5.6), chronic hypertension(OR = 2.5; 95% CI: 1.7, 3.8), and unable to write and read (OR = 4.2;95%CI: 1.7, 10.6). Conclusion According to the findings of this study, birth asphyxia is an unresolved public health problem in the Ethiopia. Therefore, the concerned body needs to pay attention to the above risk factors in order to decrease the country’s birth asphyxia. Review registration PROSPERO International prospective register of systematic reviews (CRD42020165283).

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The prevalence of fatigue after stroke: A systematic review and meta-analysis

International Journal of Stroke ◽

10.1177/1747493016669861 ◽

2016 ◽

Vol 11 (9) ◽

pp. 968-977 ◽

Cited By ~ 74

Author(s):

Toby B Cumming ◽

Marcie Packer ◽

Sharon F Kramer ◽

Coralie English

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Research Literature ◽

Rapid Expansion ◽

Stroke Survivors ◽

Contributing Factors ◽

Total N ◽

Post Stroke ◽

Prevalence Estimates ◽

Wide Variability

Background Fatigue is a common and debilitating symptom after stroke. The last decade has seen rapid expansion of the research literature on post-stroke fatigue, but prevalence remains unclear. Aims To estimate post-stroke fatigue prevalence and to identify the contributing factors to fatigue, by conducting a systematic review and meta-analysis. Summary of review We included all studies of adult stroke survivors that used a recognized assessment scale for fatigue (search date September 2014). Two reviewers independently reviewed all full texts for inclusion. Data were extracted by one reviewer and independently cross-checked by a second. Risk of bias was evaluated using a critical appraisal tool. From an overall yield of 921 studies, 101 full text papers were screened, and 49 of these met inclusion criteria. The most widely used measure of fatigue was the Fatigue Severity Scale ( n = 24 studies). Prevalence estimates at a cut-off score of > or ≥ 4 were available for 22 of these 24 studies (total n = 3491), and ranged from 25 to 85%. In random effects meta-analysis, the pooled prevalence estimate was 50% (95% CI 43–57%), with substantial heterogeneity (I2 = 94%). Neither depression status nor time point post-stroke explained the heterogeneity between studies. In post-hoc analysis, fatigue prevalence was found to be lower in the four Asian studies (35%; 95% CI 20–50; I2 = 96%). Conclusions Our results confirm that fatigue is a widespread issue for stroke survivors, although it may be less prevalent in Asia. Further research is needed to explain the wide variability in prevalence estimates between studies.

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Depression and Anxiety in Patients with Primary Biliary Cholangitis: A Systematic Review and Meta-analysis (Preprint)

10.2196/preprints.22657 ◽

2020 ◽

Author(s):

Xiao Shi ◽

Qi Chen ◽

Fen Wang

Keyword(s):

Systematic Review ◽

Psychiatric Symptoms ◽

Meta Analysis ◽

Depression Scale ◽

Cochrane Library ◽

Primary Biliary Cholangitis ◽

Depression And Anxiety ◽

Pooled Prevalence ◽

Newcastle Ottawa Scale ◽

Underlying Mechanisms

BACKGROUND Previous studies have implicated the co-existence of psychological disorders and primary biliary cholangitis (PBC). However, the exact magnitude of the prevalence and related score of depression and anxiety in patients with PBC are still unclear. OBJECTIVE We aimed to assess the prevalence and Hospital Anxiety and Depression Scale (HADS) scores for depression and anxiety in patients with PBC. METHODS A comprehensive search of studies published before June 10, 2020 was performed in databases of PUBMED, EMBASE, Cochrane Library and Web of Science. Methodological quality was assessed based on the Newcastle - Ottawa Scale (NOS) tool. RESULTS Twelve studies were identified, representing 933 patients with PBC. Pooled prevalence estimates were 27.59% (95% CI 16.75%-38.43%) for depression and 19.87% (95% CI 14.12%-25.62%) for anxiety. The scores of HADS-D and HADS-A were 5.60 (95% CI 4.67-6.52) and 6.56 (95% CI 4.89-8.23) among PBC suffers, respectively. CONCLUSIONS This systematic review and meta-analysis indicates that depression and anxiety are prevalent in PBC patients. Physicians should be vigilant for psychiatric symptoms among PBC suffers and provide appropriate interventions for them. Exploration of underlying mechanisms and interactions in the future investigations is warranted.

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Low level of knowledge about cervical cancer among Ethiopian women: a systematic review and meta-analysis

Infectious Agents and Cancer ◽

10.1186/s13027-021-00350-x ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Awoke Derbie ◽

Daniel Mekonnen ◽

Eyaya Misgan ◽

Yihun Mulugeta Alemu ◽

Yimtubezinash Woldeamanuel ◽

...

Keyword(s):

Systematic Review ◽

Cervical Cancer ◽

Meta Analysis ◽

Grey Literature ◽

Cervical Cancer Prevention ◽

The Public ◽

Screening Practice ◽

Pooled Prevalence ◽

Comprehensive Search ◽

Level Of Knowledge

Abstract Introduction Cervical cancer is one of the leading causes of malignancies among women in Ethiopia. Knowing the disease could empower women to make an informed decision regarding participation with cervical cancer prevention strategies. There is scarcity of compiled data in the field. Therefore, this systematic review aimed to provide an overview of knowledge about cervical cancer among Ethiopian women. Methods We conducted a systematic review of peer-reviewed articles on the knowledge of cervical cancer. Articles were systematically searched using comprehensive search strings from PubMed/Medline, SCOPUS, and grey literature from Google Scholar. Two reviewers assessed study eligibility, extracted data, and the risk of bias independently. Meta-analysis was performed using STATA v 14 to pool the overall knowledge of the women about cervical cancer. Results We included 26 articles published between 2013 and 2020 covering a total of 14,549 participants. All the included articles had good methodological quality. The proportion of participants who had heard of cervical cancer varied from 4.6 to 87.7% with the pooled estimate at 56% (95% CI: 47–66). Similarly, the proportion of participants who knew that HPV is the main cause of cervical cancer lied between 0 and 49.7% with the pooled result at 21% (95% CI: 13–30). Likewise, the pooled prevalence to identify at least one risk factor, one symptom of cervical cancer and ever heard of cervical cancer screening was gauged at 52% (95% CI: 39–64), 43% (95% CI: 26–60), and 39% (95% CI: 24–55), respectively. The overall pooled prevalence of good knowledge about cervical cancer was at 43% (95% CI: 33–53). On top of this, the prevalence of previous screening practice among the participants was at 14% (95% CI: 9–20). Conclusions Knowledge about cervical cancer among Ethiopian women is quite poor. Therefore, health education to provide sufficient and unbiased information about HPV and cervical cancer in general is required to the public.

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The D614G virus mutation enhances anosmia in COVID-19 patients: Evidence from a systematic review and meta-analysis of studies from South Asia

10.1101/2021.08.11.21261934 ◽

2021 ◽

Author(s):

Christopher S von Bartheld ◽

Molly M Hagen ◽

Rafal Butowt

Keyword(s):

Systematic Review ◽

South Asia ◽

South Asian ◽

Virus Entry ◽

Meta Analysis ◽

Virus Binding ◽

Asian Populations ◽

Ethnic Populations ◽

Pooled Prevalence ◽

Virus Strains

The prevalence of chemosensory dysfunction in patients with COVID-19 varies greatly between populations. It is unclear whether such differences are due to factors at the level of the human host, or at the level of the coronavirus, or both. At the host level, the entry proteins which allow virus binding and entry have variants with distinct properties, and the frequency of such variants differs between ethnicities. At the level of the virus, the D614G mutation enhances virus entry to the host cell. Since the two virus strains (D614 and G614) co-existed in the first six months of the pandemic in most populations, it has been difficult to distinguish between contributions of the virus and contributions of the host for anosmia. To answer this question, we conducted a systematic review and meta-analysis of studies in South Asian populations when either the D614 or the G614 virus was dominant. We show that populations infected predominantly with the G614 virus had a much higher prevalence of anosmia (pooled prevalence of 31.8%) compared with the same ethnic populations infected mostly with the D614 virus strain (pooled anosmia prevalence of 5.3%). We conclude that the D614G mutation is a major contributing factor that increases the prevalence of anosmia in COVID-19, and that this enhanced effect on olfaction constitutes a previously unrecognized phenotype of the D614G mutation. The new virus strains that have additional mutations on the background of the D614G mutation can be expected to cause a similarly increased prevalence of chemosensory dysfunctions.

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Male involvement in family planning use and its determinants in Ethiopia. A systematic review and meta-analysis protocol

10.21203/rs.3.rs-699111/v2 ◽

2021 ◽

Author(s):

Etsay Woldu Anbesu ◽

Setognal Birara Aychiluhm ◽

Znabu Hadush Kahsay

Keyword(s):

Systematic Review ◽

Family Planning ◽

Contraceptive Use ◽

Meta Analysis ◽

Grey Literature ◽

Random Effect ◽

Random Effect Model ◽

Health Indicators ◽

Male Involvement ◽

Pooled Prevalence

Abstract Background The need to include males that required joint spousal decision is critical in achieving key reproductive health indicators. Low involvement of males in family planning use is one of the contributing factors for low contraceptive use in Ethiopia. Despite this, there are inconsistent findings on the prevalence and determinates of males involvement in family planning use in Ethiopia. Thus, this systematic review and meta-analysis aimed to determine the pooled prevalence of mal involvement in family planning use and its determinants in Ethiopia. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline will be used to develop the protocol. Online databases PubMed, CINAHL, Google Scholar, and unpublished grey literature will be searched to retrieve available articles from April 10-August 11/2021. The two authors will conduct selection of studies, data extraction, and quality assessment. The quality of the studies will be assessed using Joanna Briggs Institute checklist. Chi-squared test and I-squared statistic will be used to examine heterogeneity among studies. Sources of heterogeneity will be investigated using subgroup analyses and meta-regression based on regions and residence (urban and rural). Publication bias will be examined by observation using funnel plots and statistically by Begg’s and Egger’s tests. A random-effect model will be used to estimate the pooled prevalence and its determinants of male involvement in family planning use. Discussion The role of the male in family planning and participation in contraceptive use improves women’s uptake and continuity of family planning use. Though there are studies on male involvement in family planning use, there is no synthesis research findings on the pooled prevalence of male involvement in family planning use and its determinants in Ethiopia. Therefore, the finding from this systematic review and meta-analysis will help the national health sector transformational plane to emphasize the pooled prevalence and its determinants that drive low male involvement in family planning use in Ethiopia.

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Menstrual hygiene practice and its determinants among Adolescent Girls in Sub-Saharan Africa. A systematic review and meta-analysis protocol

10.21203/rs.3.rs-640932/v1 ◽

2021 ◽

Author(s):

Etsay Woldu Anbesu ◽

Setognal Birara Aychiluhm

Keyword(s):

Systematic Review ◽

Adolescent Girls ◽

Meta Analysis ◽

Grey Literature ◽

Random Effect Model ◽

Sub Saharan Africa ◽

Hygiene Practice ◽

Menstrual Hygiene ◽

Pooled Prevalence ◽

Sub Saharan

Abstract Background: Poor menstrual hygiene practices can lead to gynecological problems, psychosocial stress, and reduced access to school. Menstrual hygiene has not received adequate attention in Sub-Saharan Africa. Moreover, there were fragmented and inconsistent findings. Therefore, this systematic review and meta-analysis aimed to estimate the pooled prevalence of menstrual hygiene practice and identify its associated factors among adolescent girls in Sub-Saharan Africa.Methods: The protocol for this review had registered at PROSPERO with registration number: CRD42020165628. In this study, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline will be used. Online electronic databases PubMed, Google Scholar, CINAHL and grey literature will be searched to retrieve available studies. Joanna Briggs Institute checklist will be used to assess the quality of the studies. Heterogeneity among studies will be examined using a chi-squared test and I-squared statistic.To investigate sources of heterogeneity, subgroup analyses and meta-regression will be performed. Sensitivity analysis will be conducted to identify influential studies. Publication bias will be examined by funnel plots and Egger’s test. The statistical analysis will be conducted using STATA version-16 software. A random-effect model will be used to estimate the pooled prevalence, and statistical significance will be determined at a p-value of <0.05.Discussion: Poor menstrual hygiene practice affects the health of millions of adolescent girls in developing countries. Currently, there are no synthesis research findings on the overall pooled prevalence of menstrual hygiene practice and its associated factor in Sub-Saharan Africa. Therefore, this systematic review and meta-analysis will be used to inform policy-makers, programmers, planners, clinicians, and researchers to design appropriate strategies.

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Menstrual hygiene practice and its determinants among Adolescent Girls in Sub-Saharan Africa. A systematic review and meta-analysis protocol

10.21203/rs.3.rs-640932/v4 ◽

2021 ◽

Author(s):

Etsay Woldu Anbesu ◽

Setognal Birara Aychiluhm

Keyword(s):

Systematic Review ◽

Adolescent Girls ◽

Meta Analysis ◽

Grey Literature ◽

Random Effect Model ◽

Sub Saharan Africa ◽

Hygiene Practice ◽

Menstrual Hygiene ◽

Pooled Prevalence ◽

Sub Saharan

Abstract Background: Poor menstrual hygiene practices can lead to gynecological problems, psychosocial stress, and reduced access to school. Menstrual hygiene has not received adequate attention in Sub-Saharan Africa. Despite this, there are fragmented and inconsistent findings in Sub-Saharan Africa. Therefore, this systematic review and meta-analysis aimed to estimate the pooled prevalence of good menstrual hygiene practice and identify its associated factors among adolescent girls in Sub-Saharan Africa. Methods: The protocol for this review was registered at PROSPERO with registration number: CRD42020165628. In this study, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline will be used to report the protocol. Online electronic databases PubMed, Google Scholar, CINAHL and unpublished grey literature will be searched to retrieve available studies from January 1-May/2021. The selection, data extraction, and quality assessment of studies will be carried by two authors. Joanna Briggs Institute checklist will be used to assess the quality of the studies. Heterogeneity among studies will be examined using a chi-squared test and I-squared statistic. To investigate sources of heterogeneity, subgroup analyses and meta-regression will be done based on region and sample size. Sensitivity analysis will be conducted to identify influential studies. Publication bias will be examined by funnel plots and Egger’s test. The statistical analysis will be conducted using STATA version-14 software. A random-effect model will be used to estimate the pooled prevalence, and statistical significance will be determined at a p-value of <0.05.Discussion: Poor menstrual hygiene practice affects the health of millions of adolescent girls in developing countries. Currently, there are no synthesis research findings on the pooled prevalence of menstrual hygiene practice and its associated factor in Sub-Saharan Africa. Therefore, the findings of this systematic review and meta-analysis will be helpful to inform policy-makers, planners, and researchers to design appropriate interventions.

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